Novel 4-phenylpiperidine-2,6-dione derivatives. Ligands for α1-adrenoceptor subtypes

European Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2011, Pages 2676-2690

  Romeo, Giuseppe ^a   Materia, Luisa ^a   Modica, Maria N ^a   Pittalà, Valeria ^a   Salerno, Loredana ^a   Siracusa, Maria A ^a   Manetti, Fabrizio ^b   Botta, Maurizio ^b   Minneman, Kenneth P ^c,d  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Saudi Arabia)

Author keywords

4 Phenylpiperidine 2,6 dione; Ligands; Pharmacophoric model

Indexed keywords

1 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL] 4 PHENYLPIPERIDINE 2,6 DIONE; 1 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL] 4 PHENYLPIPERIDINE 2,6 DIONE; 1 [3 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL] 4 PHENYLPIPERIDINE 2,6 DIONE; 1 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 4 (4 NITROPHENYL)PIPERIDINE 2,6 DIONE; 1 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 4 PHENYLPIPERIDINE 2,6 DIONE; 1 [3 [4 (5 CHLORO 2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL] 4 PHENYLPIPERIDINE 2,6 DIONE; 1 [4 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]BUTYL] 4 PHENYLPIPERIDINE 2,6 DIONE; 1 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL] 4 (4 NITROPHENYL)PIPERIDINE 2,6 DIONE; 1 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL] 4 PHENYLPIPERIDINE 2,6 DIONE; 1 [4 [4 (5 CHLORO 2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL] 4 PHENYLPIPERIDINE 2,6 DIONE; 1 [5 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PENTYL] 4 PHENYLPIPERIDINE 2,6 DIONE; 4 (4 CHLOROPHENYL) 1 [2 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]ETHYL]PIPERIDINE 2,6 DIONE; 4 (4 CHLOROPHENYL) 1 [2 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]ETHYL]PIPERIDINE 2,6 DIONE; 4 (4 CHLOROPHENYL) 1 [3 [4 (2 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL]PIPERIDINE 2,6 DIONE; 4 (4 CHLOROPHENYL) 1 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL]PIPERIDINE 2,6 DIONE; 4 (4 CHLOROPHENYL) 1 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL]PIPERIDINE 2,6 DIONE; 4 PHENYLPIPERIDINE 2,6 DIONE DERIVATIVE; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; NORADRENALIN; PHOSPHATIDYLINOSITIDE; UNCLASSIFIED DRUG; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; INOSITOL PHOSPHATE; ISOPROTEIN; LIGAND; PIPERAZINE DERIVATIVE; PIPERIDONE DERIVATIVE; TRITIUM;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HEK293 CELL LINE; HYDROLYSIS; METABOLISM; RADIOASSAY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; HEK293 CELLS; HUMANS; HYDROLYSIS; INOSITOL PHOSPHATES; LIGANDS; NOREPINEPHRINE; PIPERAZINES; PIPERIDONES; PROTEIN ISOFORMS; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-1; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

EID: 79957511285     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.03.054     Document Type: Article

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