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Volumn 45, Issue 17, 2002, Pages 3603-3611

α1-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives

(10) Betti, Laura a Botta, Maurizio b Corelli, Federico b Floridi, Monia c Giannaccini, Gino a Maccari, Laura b Manetti, Fabrizio b Strappaghetti, Giovannella c Tafi, Andrea b Corsano, Stefano c

a UNIVERSITY OF PISA (Italy)

b UNIVERSITY OF SIENA (Italy)

c UNIVERSITY OF PERUGIA (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BENZIMIDAZOLE DERIVATIVE; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; INDOLOPIPERAZINE; PIPERAZINE DERIVATIVE; TRAZODONE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PHARMACOPHORE; RAT; REACTION ANALYSIS; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CEREBRAL CORTEX; IMIDAZOLES; MODELS, MOLECULAR; PIPERAZINES; PYRIDAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037103143 PISSN: 00222623 EISSN: None Source Type: Journal
DOI: 10.1021/jm011077g Document Type: Article

Times cited : (51)

References (29)

1
- 0037059926
- 1-adrenoceptor antagonists, rational design, synthesis and biological evaluation of new trazodone-like compounds
- (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 437-440
- Betti, L.¹ Botta, M.² Corelli, F.³ Floridi, M.⁴ Fossa, P.⁵ Giannaccini, G.⁶ Manetti, F.⁷ Strappaghetti, G.⁸ Corsano, S.⁹

2
- 0035927444
- 1-adrenoceptors
- (2001) J. Med. Chem. , vol.44 , pp. 2118-2132
- Barbaro, R.¹ Betti, L.² Botta, M.³ Corelli, F.⁴ Giannaccini, G.⁵ Maccari, L.⁶ Manetti, F.⁷ Strappaghetti, G.⁸ Corsano, S.⁹

3
- 0036132213
- 1-adrenoceptor antagonists
- (2002) Bioorg. Med. Chem. , vol.10 , pp. 361-369
- Barbaro, R.¹ Betti, L.² Botta, M.³ Corelli, F.⁴ Giannaccini, G.⁵ Maccari, L.⁶ Manetti, F.⁷ Strappaghetti, G.⁸ Corsano, S.⁹

4
- 0028178962
- 1-adrenoceptor classification: Sharpening Occam's razor
- (1994) Trends Pharmacol. Sci. , vol.15 , pp. 167-170
- Ford, A.P.D.W.¹ Williams, T.J.² Blue, D.R.³ Clarke, D.E.⁴

5
- 0000054564
- 1-adrenoceptors: Consensus update
- (1995) Pharmacol. Rev. , vol.47 , pp. 266-270
- Hieble, J.P.¹ Bylund, D.B.² Clarke, A.E.³ Eikenberg, D.C.⁴ Langer, S.Z.⁵ Lefkowitz, R.J.⁶ Minneman, K.P.⁷ Ruffolo R.R., Jr.⁸

6
- 0029824446
- 2-adrenoceptors
- (1996) Prog. Drug Res. , vol.47 , pp. 81-130
- Hieble, J.P.¹ Ruffolo R.R., Jr.²

7
- 0027326003
- 1 adrenergic subtypes in human prostate
- (1993) J. Urol. , vol.250 , pp. 546-551
- Price, D.T.¹ Schwinn, D.A.² Lomasney, J.W.³ Allen, L.F.⁴ Caron, M.G.⁵ Lefkowitz, R.J.⁶

8
- 0026343225
- The emerging role of alpha antagonists in the therapy of benign prostatic hyperplasia
- (1991) J. Androl. , vol.12 , pp. 389-394
- Lepor, H.¹

9
- 0030913442
- Pharmacological options in the treatment of benign prostatic hyperplasia
- (1997) J. Med. Chem. , vol.40 , pp. 1293-1315
- Kenny, B.¹ Ballard, S.² Blagg, J.³ Fox, D.⁴

10
- 0025351645
- Alpha-adrenergic blockers for the treatment of benign prostatic hyperplasia
- (1990) Urol. Clin. North Am. , vol.17 , pp. 641-649
- Caine, M.¹

11
- 0033869072
- 1a-adrenergic receptor antagonists
- (2000) Bioorg. Med. Chem. , vol.8 , pp. 2263-2275
- Kuo, G.-H.¹ Prouty, C.² Murray, W.V.³ Pulito, V.⁴ Jolliffe, L.⁵ Cheung, P.⁶ Varga, S.⁷ Evangelisto, M.⁸ Shaw, C.⁹

12
- 0035821422
- 1D receptor
- (2001) Bioorg. Med. Chem. Lett. , vol.11 , pp. 1119-1121
- Carroll, W.A.¹ Sippy, K.B.² Esbenshade, T.A.³ Buckner, S.A.⁴ Hancock, A.A.⁵ Meyer, M.D.⁶

13
- 0035913051
- 1 adrenoceptor antagonists
- (2001) J. Med. Chem. , vol.44 , pp. 2403-2410
- Barlocco, D.¹ Cignarella, G.² Dal Piaz, V.³ Giovannoni, M.P.⁴ De Benedetti, P.G.⁵ Fanelli, F.⁶ Montesano, F.⁷ Poggesi, E.⁸ Leonardi, A.⁹

14
- 0035821588
- 1a adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia
- (2001) J. Med. Chem. , vol.44 , pp. 1971-1985
- Meyer, M.D.¹ Altenbach, R.J.² Bai, H.³ Basha, F.Z.⁴ Carroll, W.A.⁵ Kerwin J.F., Jr.⁶ Lebold, S.A.⁷ Lee, E.⁸ Pratt, J.K.⁹ Sippy, K.B.¹⁰ Tietje, K.¹¹ Wendt, M.D.¹² Brune, M.E.¹³ Buckner, S.A.¹⁴ Hancock, A.A.¹⁵ Drizin, I.¹⁶

15
- 0003641220
- Accelrys, Inc., 9685 Scranton Road, San Diego, CA
- Catalyst, version 4.6

16
- 0034011690
- 2-adrenoceptors
- (2000) BJU Int. , vol.85 , pp. 959-961
- Krege, S.¹ Goepel, M.² Sperling, H.³ Michel, M.C.⁴

17
- 0032974891
- 1 receptor binding activity
- (1999) J. Med. Chem. , vol.42 , pp. 336-345
- Giannangeli, M.¹ Cazzolla, N.² Luparini, M.R.³ Magnani, M.⁴ Mabilia, M.⁵ Picconi, G.⁶ Tomaselli, M.⁷ Baiocchi, L.⁸

18
- 0000503408
- 1A receptors
- (1995) Med. Chem. Res. , vol.5 , pp. 479-486
- Paluchowska, M.H.¹ Deren-Wesolek, A.² Charakchieva-Minol, S.³ Chojnacka-Wojcik, E.⁴ Mokrosz, J.L.⁵

19
- 0030255033
- 1A receptor ligands
- (1996) Arch. Pharm. Pharm. Med. Chem. , vol.329 , pp. 451-456
- Paluchowska, M.H.¹ Deren-Wesolek, A.² Mokrosz, J.L.³ Charakchieva-Minol, S.⁴ Chojnacka-Wojcik, E.⁵

20
- 0030835390
- 1A affinity/selectivity
- (1997) J. Med. Chem. , vol.40 , pp. 2653-2656
- Lopez-Rodriguez, M.L.¹ Morcillo, M.J.² Fernandez, E.³ Porras, E.⁴ Murcia, M.⁵ Sanz, A.M.⁶ Orensanz, L.⁷

21
- 0030751331
- 1-adrenoceptor affinity
- (1997) Arch. Pharm. Pharm. Med. Chem. , vol.330 , pp. 177-180
- Mokrosz, M.J.¹ Paluchowska, M.H.² Charakchieva-Minol, S.³ Bien, S.⁴

22
- 0030969250
- 1 receptors. A comparison of CoMFA models
- (1997) J. Med. Chem. , vol.40 , pp. 1648-1656
- Lopez-Rodriguez, M.L.¹ Rosado, M.L.² Benhamu, B.³ Morcillo, M.J.⁴ Fernandez, E.⁵ Schaper, K.-J.⁶

23
- 0019722850
- Synthesis and antihypertensive activity of new 6-heteroaryl-3-hydrazinopyridazine derivatives
- (1981) J. Med. Chem. , vol.24 , pp. 59-63
- Steiner, G.¹ Gries, J.² Lenke, D.³

24
- 0023608482
- Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activity
- (1987) J. Med. Chem. , vol.30 , pp. 1955-1962
- Sircar, I.¹ Weishaar, R.E.² Kobylarz, D.³ Moos, W.H.⁴ Bristol, J.A.⁵

25
- 0000529327
- Alkylation of piperazine in N-N-dimethylformamide
- (1968) Bull. Soc. Chim. Fr. , vol.8 , pp. 3246-3249
- Bourdais, J.¹

26
- 0035905854
- 2 antagonist properties
- (2001) J. Med. Chem. , vol.44 , pp. 186-197
- Lopez-Rodriguez, M.L.¹ Morcillo, M.J.² Fernandez, E.³ Porras, E.⁴ Orensanz, L.⁵ Beneytez, M.E.⁶ Manzanares, J.⁷ Fuentes, J.A.⁸

27
- 0033552888
- Novel adrenoceptor antagonists with tricyclic pyrrolodipyridazine skeleton
- (1999) J. Med. Chem. , vol.42 , pp. 173-177
- Barlocco, D.¹ Cignarella, G.² Montesano, F.³ Leonardi, A.⁴ Mella, M.⁵ Toma, L.⁶

28
- 0025856972
- 1 adrenoceptor ligands
- (1991) J. Med. Chem. , vol.34 , pp. 1850-1854
- Russo, F.¹ Romeo, G.² Guccione, S.³ De Blasi, A.⁴

29
- 0015861774
- 50) of an enzymatic reaction
- (1973) Biochem. Pharmacol. , vol.22 , pp. 3099-3108
- Cheng, Y.C.¹ Prusoff, W.H.²

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