In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: Comparison with prazosin, a known α1- adrenoceptor antagonist

Vascular Pharmacology

Volumn 40, Issue 2, 2003, Pages 97-108

  Orallo, Francisco ^a   Garcia Ferreiro, Tomas ^a   Enguix, Maria Jose ^a   Tristan, Helena ^a   Masaguer, Cristian ^a   Ravina, Enrique ^a   Cadavid, Isabel ^a   Loza, Maria Isabel ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Anaesthetized normotensive rats; Isolated smooth muscle tissues; Prazosin; QF0301B; 1 Adrenoceptor antagonist

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM IODIDE; 2 [2 [N 4 (2 METHOXYPHENYL) N 1 PIPERAZINYL]ETHYL] 1 TETRALONE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BETHANECHOL; CALCIUM ANTAGONIST; CLONIDINE; HISTAMINE; KETANSERIN; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; NORADRENALIN; PRAZOSIN; QF 0301 B; SEROTONIN; SEROTONIN 3 AGONIST; TALIPEXOLE; TERAZOSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MONITORING; BRADYCARDIA; CARDIOVASCULAR EFFECT; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG COMPETITION; DRUG EFFECT; DRUG INHIBITION; DRUG POTENTIATION; DRUG SELECTIVITY; ELECTROSTIMULATION; GUINEA PIG; HEART CONTRACTION; HEART MUSCLE CONTRACTILITY; HEART RATE; HYPERTENSION; ILEUM; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SMOOTH MUSCLE; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; STOMACH; VAS DEFERENS; VASCULAR RING;

EID: 0142165744     PISSN: 15371891     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1537-1891(02)00337-3     Document Type: Article

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