A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype

eLife

Volumn 2014, Issue 3, 2014, Pages

  Serra, Ryan W ^a,b   Fang, Minggang ^a,b   Park, Sung Mi ^a,b   Hutchinson, Lloyd ^a   Green, Michael R ^a,b  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEUBIQUITINASE; PHOSPHOTRANSFERASE; ZINC BINDING PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR; TRANSCRIPTION FACTOR; UBIQUITIN THIOLESTERASE; USP28 PROTEIN, HUMAN; ZNF304 PROTEIN, HUMAN;

ARF GENE; ARTICLE; ASSAY; CARCINOGENESIS; CELL DIFFERENTIATION; CHIP ASSAY; COLORECTAL CANCER; CONTROLLED STUDY; DNA METHYLATION; GENE; GENE SEQUENCE; GENE SILENCING; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INK4 GENE; PHENOTYPE; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; CPG ISLAND; GENETIC TRANSCRIPTION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; ONCOGENE RAS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CPG ISLANDS; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; DNA METHYLATION; GENE SILENCING; GENES, RAS; HUMANS; MOLECULAR SEQUENCE DATA; PHENOTYPE; RNA INTERFERENCE; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; UBIQUITIN THIOLESTERASE; UP-REGULATION;

EID: 84898740640     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.02313     Document Type: Article

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