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Volumn 14, Issue 5, 2014, Pages 663-686

Non-BRAF-targeted therapy, immunotherapy, and combination therapy for melanoma

Author keywords

Adoptive T cell transfer; Combination therapy; Immunotherapy; Melanoma; Targeted therapy

Indexed keywords

AMP 224; BENDAMUSTINE; BEVACIZUMAB; BMS 936559; BMS 986016; CANCER VACCINE; CP 870893; DABRAFENIB; DACARBAZINE; DACETUZUMAB; DOCETAXEL; EVEROLIMUS; FOTEMUSTINE; GLYCOPROTEIN GP 100; INDIUM 111; INTERLEUKIN 2; IPILIMUMAB; LAMBROLIZUMAB; LUCATUMUMAB; MEDI 4736; MELANOMA ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MPDL 3280A; NIVOLUMAB; OX40 LIGAND; PHOSPHATIDYLINOSITOL 3 KINASE; PIDILIZUMAB; TEMOZOLOMIDE; TICILIMUMAB; TRAMETINIB; UNCLASSIFIED DRUG; URELUMAB; VEMURAFENIB; B RAF KINASE; BRAF PROTEIN, HUMAN;

EID: 84898732158     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2014.890586     Document Type: Review
Times cited : (16)

References (218)
  • 1
    • 84860110928 scopus 로고    scopus 로고
    • The stable traits of melanoma genetics: An alternate approach to target discovery
    • Spivey TL, De Giorgi V, Zhao Y, et al. The stable traits of melanoma genetics: An alternate approach to target discovery. BMC Genomics 2012;13:156
    • (2012) BMC Genomics , vol.13 , pp. 156
    • Spivey, T.L.1    De Giorgi, V.2    Zhao, Y.3
  • 2
    • 66149090765 scopus 로고    scopus 로고
    • Molecular pathogenesis of cutaneous melanocytic neoplasms
    • Ibrahim N, Haluska FG. Molecular pathogenesis of cutaneous melanocytic neoplasms. Annu Rev Pathol 2009;4:551-79
    • (2009) Annu Rev Pathol , vol.4 , pp. 551-579
    • Ibrahim, N.1    Haluska, F.G.2
  • 4
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 2011;364:2507-16
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 5
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-54
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 6
    • 84883104349 scopus 로고    scopus 로고
    • Heterogeneous distribution of BRAF/NRAS mutations among Italian patients with advanced melanoma
    • Colombino M, Lissia A, Capone M, et al. Heterogeneous distribution of BRAF/NRAS mutations among Italian patients with advanced melanoma. J Transl Med 2013;11:202
    • (2013) J Transl Med , vol.11 , pp. 202
    • Colombino, M.1    Lissia, A.2    Capone, M.3
  • 7
    • 84898751560 scopus 로고    scopus 로고
    • The immune-related role of BRAF mutation in melanoma [abstract p788]
    • Tomei S, Civini S, Bedognetti D, et al. The immune-related role of BRAF mutation in melanoma [abstract p788]. J Immuno Therapy of Cancer 2012;23:9
    • (2012) J Immuno Therapy of Cancer , vol.23 , pp. 9
    • Tomei, S.1    Civini, S.2    Bedognetti, D.3
  • 8
    • 0037228055 scopus 로고    scopus 로고
    • High frequency of BRAF mutations in nevi
    • Pollock PM, Harper UL, Hansen KS, et al. High frequency of BRAF mutations in nevi. Nat Genet 2003;33:19-20
    • (2003) Nat Genet , vol.33 , pp. 19-20
    • Pollock, P.M.1    Harper, U.L.2    Hansen, K.S.3
  • 10
    • 84863116743 scopus 로고    scopus 로고
    • Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib
    • Sosman JA, Kim KB, Schuchter L, et al. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med 2012;366:707-14
    • (2012) N Engl J Med , vol.366 , pp. 707-714
    • Sosman, J.A.1    Kim, K.B.2    Schuchter, L.3
  • 11
    • 84865068182 scopus 로고    scopus 로고
    • Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma
    • Suppl): Abstract 8502
    • Chapman PB, Hauschild A, Robert C, et al. Updated overall survival (OS) results for BRIM-3, a phase III randomized, open-label, multicenter trial comparing BRAF inhibitor vemurafenib (vem) with dacarbazine (DTIC) in previously untreated patients with BRAFV600E-mutated melanoma. J Clin Oncol 2012:30(Suppl): Abstract 8502
    • (2012) J Clin Oncol , vol.30
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 12
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A, Grob JJ, Demidov LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial. Lancet 2012;380:358-65
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3
  • 13
    • 84891648456 scopus 로고    scopus 로고
    • Phase II trial (BREAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma
    • Ascierto PA, Minor D, Ribas A, et al. Phase II trial (BREAK-2) of the BRAF inhibitor dabrafenib (GSK2118436) in patients with metastatic melanoma. J Clin Oncol 2013;31:3205-11
    • (2013) J Clin Oncol , vol.31 , pp. 3205-3211
    • Ascierto, P.A.1    Minor, D.2    Ribas, A.3
  • 15
    • 75849124774 scopus 로고    scopus 로고
    • Avaialable from
    • Clinical Trials. Avaialable from http:// clinicaltrial.gov/
    • Clinical Trials
  • 16
  • 17
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711-23
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 19
    • 0018766101 scopus 로고
    • Chemotherapy of malignant melanoma
    • Benjamin RS. Chemotherapy of malignant melanoma. World J Surg 1979;3:321-8
    • (1979) World J Surg , vol.3 , pp. 321-328
    • Benjamin, R.S.1
  • 20
    • 0015442330 scopus 로고
    • Chemotherapy of malignant melanoma
    • Luce JK. Chemotherapy of malignant melanoma. Cancer 1972;30:1604-15
    • (1972) Cancer , vol.30 , pp. 1604-1615
    • Luce, J.K.1
  • 21
    • 79952613370 scopus 로고    scopus 로고
    • Systematic review of medical treatment in melanoma: Current status and future prospects
    • Garbe C, Eigentler TK, Keilholz U, et al. Systematic review of medical treatment in melanoma: Current status and future prospects. Oncologist 2011;16:5-24
    • (2011) Oncologist , vol.16 , pp. 5-24
    • Garbe, C.1    Eigentler, T.K.2    Keilholz, U.3
  • 22
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 2011;364:2517-26
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 23
    • 84863673204 scopus 로고    scopus 로고
    • Improved survival with MEK inhibition in BRAF-mutated melanoma
    • Flaherty KT, Robert C, Hersey P, et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 2012;367:107-14
    • (2012) N Engl J Med , vol.367 , pp. 107-114
    • Flaherty, K.T.1    Robert, C.2    Hersey, P.3
  • 24
    • 84881221698 scopus 로고    scopus 로고
    • Melanoma patients in a phase i clinic: Molecular aberrations targeted therapy and outcomes
    • Henary H, Hong DS, Falchook GS, et al. Melanoma patients in a phase I clinic: Molecular aberrations, targeted therapy and outcomes. Ann Oncol 2013;24(8):2158-65
    • (2013) Ann Oncol , vol.24 , Issue.8 , pp. 2158-2165
    • Henary, H.1    Hong, D.S.2    Falchook, G.S.3
  • 26
    • 84864042630 scopus 로고    scopus 로고
    • BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma
    • Colombino M, Capone M, Lissia A, et al. BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma. J Clin Oncol 2012;30:2522-9
    • (2012) J Clin Oncol , vol.30 , pp. 2522-2529
    • Colombino, M.1    Capone, M.2    Lissia, A.3
  • 28
    • 29244482591 scopus 로고    scopus 로고
    • Review: Melanocyte migration and survival controlled by SCF/c-kit expression
    • Yoshida H, Kunisada T, Grimm T, et al. Review: Melanocyte migration and survival controlled by SCF/c-kit expression. J Investig Dermatol Symp Proc 2001;6:1-5
    • (2001) J Investig Dermatol Symp Proc , vol.6 , pp. 1-5
    • Yoshida, H.1    Kunisada, T.2    Grimm, T.3
  • 29
    • 3042525225 scopus 로고    scopus 로고
    • Imatinib mesylate (Glivec, Gleevec in the treatment of chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors (GIST)
    • Hochhaus A. Imatinib mesylate (Glivec, Gleevec) in the treatment of chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors (GIST). Ann Hematol 2004;83(Suppl 1):S65-6
    • (2004) Ann Hematol , vol.83 , Issue.SUPPL. 1
    • Hochhaus, A.1
  • 30
    • 58149260596 scopus 로고    scopus 로고
    • KIT gene mutations and copy number in melanoma subtypes
    • Beadling C, Jacobson-Dunlop E, Hodi FS, et al. KIT gene mutations and copy number in melanoma subtypes. Clin Cancer Res 2008;14:6821-8
    • (2008) Clin Cancer Res , vol.14 , pp. 6821-6828
    • Beadling, C.1    Jacobson-Dunlop, E.2    Hodi, F.S.3
  • 31
    • 79958066836 scopus 로고    scopus 로고
    • KIT as a therapeutic target in metastatic melanoma
    • Carvajal RD, Antonescu CR, Wolchok JD, et al. KIT as a therapeutic target in metastatic melanoma. JAMA 2011;305:2327-34
    • (2011) JAMA , vol.305 , pp. 2327-2334
    • Carvajal, R.D.1    Antonescu, C.R.2    Wolchok, J.D.3
  • 32
    • 0026793058 scopus 로고
    • Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor
    • Natali PG, Nicotra MR, Winkler AB, et al. Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor. Int J Cancer 1992;52:197-201
    • (1992) Int J Cancer , vol.52 , pp. 197-201
    • Natali, P.G.1    Nicotra, M.R.2    Winkler, A.B.3
  • 33
    • 0141958794 scopus 로고    scopus 로고
    • Analysis of protein tyrosine kinase expression in melanocytic lesions by tissue array
    • Shen SS, Zhang PS, Eton O, Prieto VG. Analysis of protein tyrosine kinase expression in melanocytic lesions by tissue array. J Cutan Pathol 2003;30:539-47
    • (2003) J Cutan Pathol , vol.30 , pp. 539-547
    • Shen, S.S.1    Zhang, P.S.2    Eton, O.3    Prieto, V.G.4
  • 34
    • 84855482946 scopus 로고    scopus 로고
    • C-KIT receptor expression is strictly associated with the biological behaviour of thyroid nodules
    • Tomei S, Mazzanti C, Marchetti I, et al. c-KIT receptor expression is strictly associated with the biological behaviour of thyroid nodules. J Transl Med 2012;10:7
    • (2012) J Transl Med , vol.10 , pp. 7
    • Tomei, S.1    Mazzanti, C.2    Marchetti, I.3
  • 35
    • 34548061196 scopus 로고    scopus 로고
    • Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor
    • Guo T, Agaram NP, Wong GC, et al. Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor. Clin Cancer Res 2007;13:4874-81
    • (2007) Clin Cancer Res , vol.13 , pp. 4874-4881
    • Guo, T.1    Agaram, N.P.2    Wong, G.C.3
  • 36
    • 33646432734 scopus 로고    scopus 로고
    • Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate
    • Prenen H, Cools J, Mentens N, et al. Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate. Clin Cancer Res 2006;12:2622-7
    • (2006) Clin Cancer Res , vol.12 , pp. 2622-2627
    • Prenen, H.1    Cools, J.2    Mentens, N.3
  • 37
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-Type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
    • Schittenhelm MM, Shiraga S, Schroeder A, et al. Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-Type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 2006;66:473-81
    • (2006) Cancer Res , vol.66 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3
  • 38
    • 21044460131 scopus 로고    scopus 로고
    • Lack of clinical efficacy of imatinib in metastatic melanoma
    • Ugurel S, Hildenbrand R, Zimpfer A, et al. Lack of clinical efficacy of imatinib in metastatic melanoma. Br J Cancer 2005;92:1398-405
    • (2005) Br J Cancer , vol.92 , pp. 1398-1405
    • Ugurel, S.1    Hildenbrand, R.2    Zimpfer, A.3
  • 39
    • 50249141632 scopus 로고    scopus 로고
    • Phase II trial of imatinib mesylate in patients with metastatic melanoma
    • Kim KB, Eton O, Davis DW, et al. Phase II trial of imatinib mesylate in patients with metastatic melanoma. Br J Cancer 2008;99:734-40
    • (2008) Br J Cancer , vol.99 , pp. 734-740
    • Kim, K.B.1    Eton, O.2    Davis, D.W.3
  • 40
    • 33646268037 scopus 로고    scopus 로고
    • Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy
    • Wyman K, Atkins MB, Prieto V, et al. Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy. Cancer 2006;106:2005-11
    • (2006) Cancer , vol.106 , pp. 2005-2011
    • Wyman, K.1    Atkins, M.B.2    Prieto, V.3
  • 41
    • 79960708519 scopus 로고    scopus 로고
    • Phase II, open-label, single-Arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification
    • Guo J, Si L, Kong Y, et al. Phase II, open-label, single-Arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol 2011;29:2904-9
    • (2011) J Clin Oncol , vol.29 , pp. 2904-2909
    • Guo, J.1    Si, L.2    Kong, Y.3
  • 42
    • 84860214530 scopus 로고    scopus 로고
    • From genes to drugs: Targeted strategies for melanoma
    • Flaherty KT, Hodi FS, Fisher DE. From genes to drugs: Targeted strategies for melanoma. Nat Rev Cancer 2012;12:349-61
    • (2012) Nat Rev Cancer , vol.12 , pp. 349-361
    • Flaherty, K.T.1    Hodi, F.S.2    Fisher, D.E.3
  • 43
    • 84885022736 scopus 로고    scopus 로고
    • The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma
    • Kaufman HL, Kirkwood JM, Hodi FS, et al. The Society for Immunotherapy of Cancer consensus statement on tumour immunotherapy for the treatment of cutaneous melanoma. Nat Rev Clin Oncol 2013;10:588-98
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 588-598
    • Kaufman, H.L.1    Kirkwood, J.M.2    Hodi, F.S.3
  • 44
    • 78650003580 scopus 로고    scopus 로고
    • The GIST paradigm: Lessons for other kinase-driven cancers
    • Antonescu CR. The GIST paradigm: Lessons for other kinase-driven cancers. J Pathol 2011;223:251-61
    • (2011) J Pathol , vol.223 , pp. 251-261
    • Antonescu, C.R.1
  • 45
    • 84877114887 scopus 로고    scopus 로고
    • MERTK receptor tyrosine kinase is a therapeutic target in melanoma
    • Schlegel J, Sambade MJ, Sather S, et al. MERTK receptor tyrosine kinase is a therapeutic target in melanoma. J Clin Invest 2013;123:2257-67
    • (2013) J Clin Invest , vol.123 , pp. 2257-2267
    • Schlegel, J.1    Sambade, M.J.2    Sather, S.3
  • 46
    • 0021258276 scopus 로고
    • Transforming ras genes from human melanoma: A manifestation of tumour heterogeneity?
    • Albino AP, Le Strange R, Oliff AI, et al. Transforming ras genes from human melanoma: A manifestation of tumour heterogeneity? Nature 1984;308:69-72
    • (1984) Nature , vol.308 , pp. 69-72
    • Albino, A.P.1    Le Strange, R.2    Oliff, A.I.3
  • 47
    • 77954358935 scopus 로고    scopus 로고
    • A mouse model of melanoma driven by oncogenic KRAS
    • Milagre C, Dhomen N, Geyer FC, et al. A mouse model of melanoma driven by oncogenic KRAS. Cancer Res 2010;70:5549-57
    • (2010) Cancer Res , vol.70 , pp. 5549-5557
    • Milagre, C.1    Dhomen, N.2    Geyer, F.C.3
  • 48
    • 84880302935 scopus 로고    scopus 로고
    • Association between HRAS rs12628 and rs112587690 polymorphisms with the risk of melanoma in the North American population
    • Tomei S, Adams S, Uccellini L, et al. Association between HRAS rs12628 and rs112587690 polymorphisms with the risk of melanoma in the North American population. Med Oncol 2012;29:3456-61
    • (2012) Med Oncol , vol.29 , pp. 3456-3461
    • Tomei, S.1    Adams, S.2    Uccellini, L.3
  • 50
    • 84879141399 scopus 로고    scopus 로고
    • NRAS mutant melanoma-undrugable?
    • Posch C, Ortiz-Urda S. NRAS mutant melanoma-undrugable? Oncotarget 2013;4:494-5
    • (2013) Oncotarget , vol.4 , pp. 494-495
    • Posch, C.1    Ortiz-Urda, S.2
  • 51
    • 78651404680 scopus 로고    scopus 로고
    • The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells
    • Niessner H, Beck D, Sinnberg T, et al. The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells. J Invest Dermatol 2011;131:468-79
    • (2011) J Invest Dermatol , vol.131 , pp. 468-479
    • Niessner, H.1    Beck, D.2    Sinnberg, T.3
  • 52
    • 84872396402 scopus 로고    scopus 로고
    • Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104)
    • Gajewski TF, Salama AK, Niedzwiecki D, et al. Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104). J Transl Med 2012;10:246
    • (2012) J Transl Med , vol.10 , pp. 246
    • Gajewski, T.F.1    Salama, A.K.2    Niedzwiecki, D.3
  • 53
    • 73949083834 scopus 로고    scopus 로고
    • MEK1 mutations confer resistance to MEK and B-RAF inhibition
    • Emery CM, Vijayendran KG, Zipser MC, et al. MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci USA 2009;106:20411-16
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20411-20416
    • Emery, C.M.1    Vijayendran, K.G.2    Zipser, M.C.3
  • 54
    • 84884597338 scopus 로고    scopus 로고
    • MEK Inhibition in the treatment of advanced melanoma
    • Salama AK, Kim KB. MEK Inhibition in the treatment of advanced melanoma. Curr Oncol Rep 2013;15:473-82
    • (2013) Curr Oncol Rep , vol.15 , pp. 473-482
    • Salama, A.K.1    Kim, K.B.2
  • 55
    • 84856009717 scopus 로고    scopus 로고
    • Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma
    • Kirkwood JM, Bastholt L, Robert C, et al. Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma. Clin Cancer Res 2012;18:555-67
    • (2012) Clin Cancer Res , vol.18 , pp. 555-567
    • Kirkwood, J.M.1    Bastholt, L.2    Robert, C.3
  • 56
    • 84879717023 scopus 로고    scopus 로고
    • Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: A phase 2 double-blind randomised study
    • Robert C, Dummer R, Gutzmer R, et al. Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: A phase 2 double-blind randomised study. Lancet Oncol 2013;14:733-40
    • (2013) Lancet Oncol , vol.14 , pp. 733-740
    • Robert, C.1    Dummer, R.2    Gutzmer, R.3
  • 57
    • 84874777853 scopus 로고    scopus 로고
    • Phase II study of the MEK1/ MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor
    • Kim KB, Kefford R, Pavlick AC, et al. Phase II study of the MEK1/ MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor. J Clin Oncol 2013;31:482-9
    • (2013) J Clin Oncol , vol.31 , pp. 482-489
    • Kim, K.B.1    Kefford, R.2    Pavlick, A.C.3
  • 58
    • 84875235432 scopus 로고    scopus 로고
    • MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A nonrandomised, open-label phase 2 study
    • Ascierto PA, Schadendorf D, Berking C, et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: A nonrandomised, open-label phase 2 study. Lancet Oncol 2013;14:249-56
    • (2013) Lancet Oncol , vol.14 , pp. 249-256
    • Ascierto, P.A.1    Schadendorf, D.2    Berking, C.3
  • 59
    • 84898747417 scopus 로고    scopus 로고
    • Pimasertib (msc1936369bas703026) a selective oral mek12 inhibitor shows clinical activity in cutaneous and uveal metastatic melanoma in the phase i program [abstract c07]
    • Lebbe C, Lesimple T, Raymond E, et al. Pimasertib (MSC1936369B/AS703026), a selective oral MEK1/2 inhibitor, shows clinical activity in cutaneous and uveal metastatic melanoma in the phase I program [abstract C07]. EADO 2012 Annual Meeting; 2012
    • (2012) EADO 2012 Annual Meeting
    • Lebbe, C.1    Lesimple, T.2    Raymond, E.3
  • 60
    • 84890296879 scopus 로고    scopus 로고
    • In vivo MAPK reporting reveals the heterogeneity in tumoral selection of resistance to RAF inhibitors
    • Basile KJ, Abel EV, Dadpey N, et al. In vivo MAPK reporting reveals the heterogeneity in tumoral selection of resistance to RAF inhibitors. Cancer Res 2013;73(23):7101-10
    • (2013) Cancer Res , vol.73 , Issue.23 , pp. 7101-7110
    • Basile, K.J.1    Abel, E.V.2    Dadpey, N.3
  • 61
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation
    • Nazarian R, Shi H, Wang Q, et al. Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation. Nature 2010;468:973-7
    • (2010) Nature , vol.468 , pp. 973-977
    • Nazarian, R.1    Shi, H.2    Wang, Q.3
  • 62
    • 84880254869 scopus 로고    scopus 로고
    • Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors
    • Morris EJ, Jha S, Restaino CR, et al. Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov 2013;3:742-50
    • (2013) Cancer Discov , vol.3 , pp. 742-750
    • Morris, E.J.1    Jha, S.2    Restaino, C.R.3
  • 64
    • 84865849911 scopus 로고    scopus 로고
    • Therapeutic implications of targeting akt signaling in melanoma
    • Madhunapantula SV, Robertson GP. Therapeutic Implications of Targeting AKT Signaling in Melanoma. Enzyme Res 2011;2011:327923
    • (2011) Enzyme Res , vol.2011 , pp. 327923
    • Madhunapantula, S.V.1    Robertson, G.P.2
  • 65
    • 34247163550 scopus 로고    scopus 로고
    • Chemically targeting the PI3K family
    • Knight ZA, Shokat KM. Chemically targeting the PI3K family. Biochem Soc Trans 2007;35:245-9
    • (2007) Biochem Soc Trans , vol.35 , pp. 245-249
    • Knight, Z.A.1    Shokat, K.M.2
  • 66
    • 23844476134 scopus 로고    scopus 로고
    • CCI-779 in metastatic melanoma: A phase II trial of the California Cancer Consortium
    • Margolin K, Longmate J, Baratta T, et al. CCI-779 in metastatic melanoma: A phase II trial of the California Cancer Consortium. Cancer 2005;104:1045-8
    • (2005) Cancer , vol.104 , pp. 1045-1048
    • Margolin, K.1    Longmate, J.2    Baratta, T.3
  • 67
    • 84857073184 scopus 로고    scopus 로고
    • Randomized phase II trial of sorafenib with temsirolimus or tipifarnib in untreated metastatic melanoma (S0438)
    • Margolin KA, Moon J, Flaherty LE, et al. Randomized phase II trial of sorafenib with temsirolimus or tipifarnib in untreated metastatic melanoma (S0438). Clin Cancer Res 2012;18:1129-37
    • (2012) Clin Cancer Res , vol.18 , pp. 1129-1137
    • Margolin, K.A.1    Moon, J.2    Flaherty, L.E.3
  • 68
    • 78651388423 scopus 로고    scopus 로고
    • Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo
    • Werzowa J, Koehrer S, Strommer S, et al. Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo. J Invest Dermatol 2011;131:495-503
    • (2011) J Invest Dermatol , vol.131 , pp. 495-503
    • Werzowa, J.1    Koehrer, S.2    Strommer, S.3
  • 69
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007;356:2271-81
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 70
    • 24944480788 scopus 로고    scopus 로고
    • The Akt-mTOR tango and its relevance to cancer
    • Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005;8:179-83
    • (2005) Cancer Cell , vol.8 , pp. 179-183
    • Hay, N.1
  • 71
    • 84862732834 scopus 로고    scopus 로고
    • Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations
    • Greger JG, Eastman SD, Zhang V, et al. Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations. Mol Cancer Ther 2012;11:909-20
    • (2012) Mol Cancer Ther , vol.11 , pp. 909-920
    • Greger, J.G.1    Eastman, S.D.2    Zhang, V.3
  • 72
    • 84874613332 scopus 로고    scopus 로고
    • Combined targeting of MEK and PI3K/ mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo
    • Posch C, Moslehi H, Feeney L, et al. Combined targeting of MEK and PI3K/ mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo. Proc Natl Acad Sci USA 2013;110:4015-20
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 4015-4020
    • Posch, C.1    Moslehi, H.2    Feeney, L.3
  • 73
    • 33750600634 scopus 로고    scopus 로고
    • Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: The Oblimersen Melanoma Study Group
    • Bedikian AY, Millward M, Pehamberger H, et al. Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: The Oblimersen Melanoma Study Group. J Clin Oncol 2006;24:4738-45
    • (2006) J Clin Oncol , vol.24 , pp. 4738-4745
    • Bedikian, A.Y.1    Millward, M.2    Pehamberger, H.3
  • 74
    • 84877879081 scopus 로고    scopus 로고
    • Survival in a phase III, randomized, double-blind study of dacarbazine with or without oblimersen (Bcl-2 antisense) in patients with advanced melanoma and low-normal serum lactate dehydrogenase (LDH; AGENDA)
    • Suppl):abstract 8531
    • Bedikian AY, Lebbe C, Robert C, et al. Survival in a phase III, randomized, double-blind study of dacarbazine with or without oblimersen (Bcl-2 antisense) in patients with advanced melanoma and low-normal serum lactate dehydrogenase (LDH; AGENDA). J Clin Oncol 2011;29(Suppl):abstract 8531
    • (2011) J Clin Oncol , vol.29
    • Bedikian, A.Y.1    Lebbe, C.2    Robert, C.3
  • 75
    • 84874191269 scopus 로고    scopus 로고
    • TERT promoter mutations in familial and sporadic melanoma
    • Horn S, Figl A, Rachakonda PS, et al. TERT promoter mutations in familial and sporadic melanoma. Science 2013;339:959-61
    • (2013) Science , vol.339 , pp. 959-961
    • Horn, S.1    Figl, A.2    Rachakonda, P.S.3
  • 76
    • 84874189784 scopus 로고    scopus 로고
    • Highly recurrent TERT promoter mutations in human melanoma
    • Huang FW, Hodis E, Xu MJ, et al. Highly recurrent TERT promoter mutations in human melanoma. Science 2013;339:957-9
    • (2013) Science , vol.339 , pp. 957-959
    • Huang, F.W.1    Hodis, E.2    Xu, M.J.3
  • 77
    • 34547451603 scopus 로고    scopus 로고
    • A randomized phase 2 trial of bevacizumab with or without daily lowdose interferon alfa-2b in metastatic malignant melanoma
    • Varker KA, Biber JE, Kefauver C, et al. A randomized phase 2 trial of bevacizumab with or without daily lowdose interferon alfa-2b in metastatic malignant melanoma. Ann Surg Oncol 2007;14:2367-76
    • (2007) Ann Surg Oncol , vol.14 , pp. 2367-2376
    • Varker, K.A.1    Biber, J.E.2    Kefauver, C.3
  • 78
    • 84862908265 scopus 로고    scopus 로고
    • BEAM: A randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untreated advanced melanoma
    • Kim KB, Sosman JA, Fruehauf JP, et al. BEAM: A randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untreated advanced melanoma. J Clin Oncol 2012;30:34-41
    • (2012) J Clin Oncol , vol.30 , pp. 34-41
    • Kim, K.B.1    Sosman, J.A.2    Fruehauf, J.P.3
  • 79
    • 84863918824 scopus 로고    scopus 로고
    • Bevacizumab advanced melanoma (BEAM) was a positive trial
    • 302023 author reply
    • Minor DR. Bevacizumab advanced melanoma (BEAM) was a positive trial. J Clin Oncol 2012;30:2023; author reply 2023-2024
    • (2012) J Clin Oncol , pp. 2023-2024
    • Minor, D.R.1
  • 80
    • 78650337037 scopus 로고    scopus 로고
    • Bevacizumab plus fotemustine as first-line treatment in metastatic melanoma patients: Clinical activity and modulation of angiogenesis and lymphangiogenesis factors
    • Del Vecchio M, Mortarini R, Canova S, et al. Bevacizumab plus fotemustine as first-line treatment in metastatic melanoma patients: Clinical activity and modulation of angiogenesis and lymphangiogenesis factors. Clin Cancer Res 2010;16:5862-72
    • (2010) Clin Cancer Res , vol.16 , pp. 5862-5872
    • Del Vecchio, M.1    Mortarini, R.2    Canova, S.3
  • 81
    • 80052544390 scopus 로고    scopus 로고
    • A phase I trial of ipilimumab plus bevacizumab in patients with unresectable stage III or stage IV melanoma
    • Suppl):abstract 8511
    • Hodi FS, Friedlander PA, Atkins MB, et al. A phase I trial of ipilimumab plus bevacizumab in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 2011;29(Suppl):abstract 8511
    • (2011) J Clin Oncol , vol.29
    • Hodi, F.S.1    Friedlander, P.A.2    Atkins, M.B.3
  • 82
    • 84873346707 scopus 로고    scopus 로고
    • Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma
    • Flaherty KT, Lee SJ, Zhao F, et al. Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma. J Clin Oncol 2013;31:373-9
    • (2013) J Clin Oncol , vol.31 , pp. 373-379
    • Flaherty, K.T.1    Lee, S.J.2    Zhao, F.3
  • 83
    • 67649909568 scopus 로고    scopus 로고
    • Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A, Agarwala SS, Trefzer U, et al. Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 2009;27:2823-30
    • (2009) J Clin Oncol , vol.27 , pp. 2823-2830
    • Hauschild, A.1    Agarwala, S.S.2    Trefzer, U.3
  • 84
    • 82555173114 scopus 로고    scopus 로고
    • Multicenter, phase II study of axitinib, a selective second-generation inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, in patients with metastatic melanoma
    • Fruehauf J, Lutzky J, McDermott D, et al. Multicenter, phase II study of axitinib, a selective second-generation inhibitor of vascular endothelial growth factor receptors 1, 2, and 3, in patients with metastatic melanoma. Clin Cancer Res 2011;17:7462-9
    • (2011) Clin Cancer Res , vol.17 , pp. 7462-7469
    • Fruehauf, J.1    Lutzky, J.2    McDermott, D.3
  • 85
    • 79954506645 scopus 로고    scopus 로고
    • Phase I dose-escalation study of E7080, a selective tyrosine kinase inhibitor, administered orally to patients with solid tumors
    • 15s(Suppl):abstract 2540
    • Hong DS, Koetz BS, Kurzrock R, et al. Phase I dose-escalation study of E7080, a selective tyrosine kinase inhibitor, administered orally to patients with solid tumors. J Clin Oncol 2010;28:15s(Suppl):abstract 2540
    • (2010) J Clin Oncol , vol.28
    • Hong, D.S.1    Koetz, B.S.2    Kurzrock, R.3
  • 86
    • 79952825157 scopus 로고    scopus 로고
    • Targeting angiogenesis in melanoma: Prospects for the future
    • Corrie PG, Basu B, Zaki KA. Targeting angiogenesis in melanoma: Prospects for the future. Ther Adv Med Oncol 2010;2:367-80
    • (2010) Ther Adv Med Oncol , vol.2 , pp. 367-380
    • Corrie, P.G.1    Basu, B.2    Zaki, K.A.3
  • 88
    • 84884270901 scopus 로고    scopus 로고
    • Immune alterations in malignant melanoma and current immunotherapy concepts
    • Shimanovsky A, Jethava A, Dasanu CA. Immune alterations in malignant melanoma and current immunotherapy concepts. Expert Opin Biol Ther 2013;13:1413-27
    • (2013) Expert Opin Biol Ther , vol.13 , pp. 1413-1427
    • Shimanovsky, A.1    Jethava, A.2    Dasanu, C.A.3
  • 89
    • 84863393623 scopus 로고    scopus 로고
    • Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma
    • Wilmott JS, Long GV, Howle JR, et al. Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma. Clin Cancer Res 2012;18:1386-94
    • (2012) Clin Cancer Res , vol.18 , pp. 1386-1394
    • Wilmott, J.S.1    Long, G.V.2    Howle, J.R.3
  • 90
    • 33746092947 scopus 로고    scopus 로고
    • Immune Suppression in the tumor microenvironment
    • Gajewski TF, Meng Y, Harlin H. Immune Suppression in the tumor microenvironment. J Immunother 2006;29:233-40
    • (2006) J Immunother , vol.29 , pp. 233-240
    • Gajewski, T.F.1    Meng, Y.2    Harlin, H.3
  • 91
    • 77955345138 scopus 로고    scopus 로고
    • Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells
    • Krieg C, Letourneau S, Pantaleo G, Boyman O. Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells. Proc Natl Acad Sci USA 2010;107:11906-11
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11906-11911
    • Krieg, C.1    Letourneau, S.2    Pantaleo, G.3    Boyman, O.4
  • 92
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • Atkins MB, Lotze MT, Dutcher JP, et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 1999;17:2105-16
    • (1999) J Clin Oncol , vol.17 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3
  • 93
    • 0021837706 scopus 로고
    • Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2
    • Rosenberg SA, Mule JJ, Spiess PJ, et al. Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2. J Exp Med 1985;161:1169-88
    • (1985) J Exp Med , vol.161 , pp. 1169-1188
    • Rosenberg, S.A.1    Mule, J.J.2    Spiess, P.J.3
  • 94
    • 0035425425 scopus 로고    scopus 로고
    • Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma
    • Phan GQ, Attia P, Steinberg SM, et al. Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma. J Clin Oncol 2001;19:3477-82
    • (2001) J Clin Oncol , vol.19 , pp. 3477-3482
    • Phan, G.Q.1    Attia, P.2    Steinberg, S.M.3
  • 95
    • 53049088033 scopus 로고    scopus 로고
    • Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines
    • Smith FO, Downey SG, Klapper JA, et al. Treatment of metastatic melanoma using interleukin-2 alone or in conjunction with vaccines. Clin Cancer Res 2008;14:5610-18
    • (2008) Clin Cancer Res , vol.14 , pp. 5610-5618
    • Smith, F.O.1    Downey, S.G.2    Klapper, J.A.3
  • 96
    • 84155171313 scopus 로고    scopus 로고
    • Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanoma
    • Joseph RW, Sullivan RJ, Harrell R, et al. Correlation of NRAS mutations with clinical response to high-dose IL-2 in patients with advanced melanoma. J Immunother 2012;35:66-72
    • (2012) J Immunother , vol.35 , pp. 66-72
    • Joseph, R.W.1    Sullivan, R.J.2    Harrell, R.3
  • 97
    • 77954321165 scopus 로고    scopus 로고
    • Melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Dummer R, Hauschild A, Guggenheim M, et al. Melanoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010;21(Suppl 5):v194-7
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 5
    • Dummer, R.1    Hauschild, A.2    Guggenheim, M.3
  • 98
    • 66849095271 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy
    • Sabatino M, Kim-Schulze S, Panelli MC, et al. Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy. J Clin Oncol 2009;27:2645-52
    • (2009) J Clin Oncol , vol.27 , pp. 2645-2652
    • Sabatino, M.1    Kim-Schulze, S.2    Panelli, M.C.3
  • 99
    • 84898748845 scopus 로고    scopus 로고
    • Pre-Treatment serum vascular endothelial growth factor is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab
    • Yuan J, Zhou J, Dong Z, et al. Pre-Treatment serum vascular endothelial growth factor is associated with clinical response and overall survival in advanced melanoma patients treated with ipilimumab. J Immuno Ther Cancer 2013;1(Suppl 1):P247
    • (2013) J Immuno Ther Cancer , vol.1 , Issue.SUPPL. 1
    • Yuan, J.1    Zhou, J.2    Dong, Z.3
  • 100
    • 14644387383 scopus 로고    scopus 로고
    • Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma metastases to systemic IL-2 administration
    • RESEARCH0035
    • Panelli MC, Wang E, Phan G, et al. Gene-expression profiling of the response of peripheral blood mononuclear cells and melanoma metastases to systemic IL-2 administration. Genome Biol 2002;3:RESEARCH0035
    • (2002) Genome Biol , vol.3
    • Panelli, M.C.1    Wang, E.2    Phan, G.3
  • 101
    • 3242888623 scopus 로고    scopus 로고
    • Forecasting the cytokine storm following systemic interleukin (IL)-2 administration
    • Panelli MC, White R, Foster M, et al. Forecasting the cytokine storm following systemic interleukin (IL)-2 administration. J Transl Med 2004;2:17
    • (2004) J Transl Med , vol.2 , pp. 17
    • Panelli, M.C.1    White, R.2    Foster, M.3
  • 102
    • 0036645090 scopus 로고    scopus 로고
    • Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness
    • Wang E, Miller LD, Ohnmacht GA, et al. Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness. Cancer Res 2002;62:3581-6
    • (2002) Cancer Res , vol.62 , pp. 3581-3586
    • Wang, E.1    Miller, L.D.2    Ohnmacht, G.A.3
  • 103
    • 82555205468 scopus 로고    scopus 로고
    • Molecular insights on the peripheral and intratumoral effects of systemic high-dose rIL-2 (aldesleukin) administration for the treatment of metastatic melanoma
    • Weiss GR, Grosh WW, Chianese-Bullock KA, et al. Molecular insights on the peripheral and intratumoral effects of systemic high-dose rIL-2 (aldesleukin) administration for the treatment of metastatic melanoma. Clin Cancer Res 2011;17:7440-50
    • (2011) Clin Cancer Res , vol.17 , pp. 7440-7450
    • Weiss, G.R.1    Grosh, W.W.2    Chianese-Bullock, K.A.3
  • 104
  • 106
    • 0344823724 scopus 로고    scopus 로고
    • Dissecting tumor responsiveness to immunotherapy: The experience of peptide-based melanoma vaccines
    • Mocellin S, Rossi CR, Nitti D, et al. Dissecting tumor responsiveness to immunotherapy: The experience of peptide-based melanoma vaccines. Biochim Biophys Acta 2003;1653:61-71
    • (2003) Biochim Biophys Acta , vol.1653 , pp. 61-71
    • Mocellin, S.1    Rossi, C.R.2    Nitti, D.3
  • 107
    • 41149108247 scopus 로고    scopus 로고
    • The role of vaccine therapy in the treatment of melanoma
    • Lens M. The role of vaccine therapy in the treatment of melanoma. Expert Opin Biol Ther 2008;8:315-23
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 315-323
    • Lens, M.1
  • 108
    • 34748849509 scopus 로고    scopus 로고
    • Vaccine therapy for melanoma: Current status and future directions
    • Terando AM, Faries MB, Morton DL. Vaccine therapy for melanoma: Current status and future directions. Vaccine 2007;25(Suppl 2):B4-16
    • (2007) Vaccine , vol.25 , Issue.SUPPL. 2
    • Terando, A.M.1    Faries, M.B.2    Morton, D.L.3
  • 109
    • 80054110110 scopus 로고    scopus 로고
    • Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68
    • Ascierto ML, Worschech A, Yu Z, et al. Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68. BMC Cancer 2011;11:451
    • (2011) BMC Cancer , vol.11 , pp. 451
    • Ascierto, M.L.1    Worschech, A.2    Yu, Z.3
  • 110
    • 84878746275 scopus 로고    scopus 로고
    • Correlates between host and viral transcriptional program associated with different oncolytic vaccinia virus isolates
    • Reinboth J, Ascierto ML, Chen NG, et al. Correlates between host and viral transcriptional program associated with different oncolytic vaccinia virus isolates. Hum Gene Ther Methods 2012;23:285-96
    • (2012) Hum Gene Ther Methods , vol.23 , pp. 285-296
    • Reinboth, J.1    Ascierto, M.L.2    Chen, N.G.3
  • 112
    • 0024166189 scopus 로고
    • Use of tumorinfiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report
    • Rosenberg SA, Packard BS, Aebersold PM, et al. Use of tumorinfiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report. N Engl J Med 1988;319:1676-80
    • (1988) N Engl J Med , vol.319 , pp. 1676-1680
    • Rosenberg, S.A.1    Packard, B.S.2    Aebersold, P.M.3
  • 113
    • 63449089473 scopus 로고    scopus 로고
    • A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
    • van der Bruggen P, Traversari C, Chomez P, et al. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. J Immunol 2007;178:2617-21
    • (2007) J Immunol , vol.178 , pp. 2617-2621
    • Van Der Bruggen, P.1    Traversari, C.2    Chomez, P.3
  • 114
    • 0026645959 scopus 로고
    • A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E
    • Traversari C, van der Bruggen P, Luescher IF, et al. A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E. J Exp Med 1992;176:1453-7
    • (1992) J Exp Med , vol.176 , pp. 1453-1457
    • Traversari, C.1    Van Der Bruggen, P.2    Luescher, I.F.3
  • 115
    • 77954959943 scopus 로고    scopus 로고
    • Immunotherapy for melanoma: Current status and perspectives
    • Alexandrescu DT, Ichim TE, Riordan NH, et al. Immunotherapy for melanoma: Current status and perspectives. J Immunother 2010;33:570-90
    • (2010) J Immunother , vol.33 , pp. 570-590
    • Alexandrescu, D.T.1    Ichim, T.E.2    Riordan, N.H.3
  • 116
    • 41149088426 scopus 로고    scopus 로고
    • Spontaneous and treatment-induced cancer rejection in humans
    • Wang E, Selleri S, Sabatino M, et al. Spontaneous and treatment-induced cancer rejection in humans. Expert Opin Biol Ther 2008;8:337-49
    • (2008) Expert Opin Biol Ther , vol.8 , pp. 337-349
    • Wang, E.1    Selleri, S.2    Sabatino, M.3
  • 117
    • 84880745167 scopus 로고    scopus 로고
    • Prediction of response to anticancer immunotherapy using gene signatures
    • Wang E, Bedognetti D, Marincola FM. Prediction of response to anticancer immunotherapy using gene signatures. J Clin Oncol 2013;31:2369-71
    • (2013) J Clin Oncol , vol.31 , pp. 2369-2371
    • Wang, E.1    Bedognetti, D.2    Marincola, F.M.3
  • 118
    • 84888049920 scopus 로고    scopus 로고
    • Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment
    • Iida N, Dzutsev A, Stewart CA, et al. Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science 2013;342:967-70
    • (2013) Science , vol.342 , pp. 967-970
    • Iida, N.1    Dzutsev, A.2    Stewart, C.A.3
  • 120
    • 84862326540 scopus 로고    scopus 로고
    • Reflections upon human cancer immune responsiveness to T cell-based therapy
    • Wang E, Tomei S, Marincola FM. Reflections upon human cancer immune responsiveness to T cell-based therapy. Cancer Immunol Immunother 2012;61:761-70
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 761-770
    • Wang, E.1    Tomei, S.2    Marincola, F.M.3
  • 121
    • 84880704621 scopus 로고    scopus 로고
    • The continuum of cancer immunosurveillance: Prognostic, predictive, and mechanistic signatures
    • Galon J, Angell HK, Bedognetti D, Marincola FM. The continuum of cancer immunosurveillance: Prognostic, predictive, and mechanistic signatures. Immunity 2013;39:11-26
    • (2013) Immunity , vol.39 , pp. 11-26
    • Galon, J.1    Angell, H.K.2    Bedognetti, D.3    Marincola, F.M.4
  • 123
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med 2010;363:411-22
    • (2010) N Engl J Med , vol.363 , pp. 411-422
    • Kantoff, P.W.1    Higano, C.S.2    Shore, N.D.3
  • 124
    • 79951826832 scopus 로고    scopus 로고
    • Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: The growth rate constant as an indicator of therapeutic efficacy
    • Stein WD, Gulley JL, Schlom J, et al. Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: The growth rate constant as an indicator of therapeutic efficacy. Clin Cancer Res 2011;17:907-17
    • (2011) Clin Cancer Res , vol.17 , pp. 907-917
    • Stein, W.D.1    Gulley, J.L.2    Schlom, J.3
  • 125
    • 84860188105 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines: Current status and moving forward
    • Schlom J. Therapeutic cancer vaccines: Current status and moving forward. J Natl Cancer Inst 2012;104:599-613
    • (2012) J Natl Cancer Inst , vol.104 , pp. 599-613
    • Schlom, J.1
  • 126
    • 84880757177 scopus 로고    scopus 로고
    • Deciphering and reversing tumor immune Suppression
    • Motz GT, Coukos G. Deciphering and reversing tumor immune Suppression. Immunity 2013;39:61-73
    • (2013) Immunity , vol.39 , pp. 61-73
    • Motz, G.T.1    Coukos, G.2
  • 127
    • 84879555935 scopus 로고    scopus 로고
    • Activation, dysfunction and retention of T cells in vaccine sites after injection of incomplete Freund's adjuvant, with or without peptide
    • Salerno EP, Shea SM, Olson WC, et al. Activation, dysfunction and retention of T cells in vaccine sites after injection of incomplete Freund's adjuvant, with or without peptide. Cancer Immunol Immunother 2013;62:1149-59
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1149-1159
    • Salerno, E.P.1    Shea, S.M.2    Olson, W.C.3
  • 128
    • 84878469107 scopus 로고    scopus 로고
    • Persistent antigen at vaccination sites induces tumor-specific CD8(+) T cell sequestration, dysfunction and deletion
    • Hailemichael Y, Dai Z, Jaffarzad N, et al. Persistent antigen at vaccination sites induces tumor-specific CD8(+) T cell sequestration, dysfunction and deletion. Nat Med 2013;19:465-72
    • (2013) Nat Med , vol.19 , pp. 465-472
    • Hailemichael, Y.1    Dai, Z.2    Jaffarzad, N.3
  • 129
    • 84887017053 scopus 로고    scopus 로고
    • CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2
    • Bedognetti D, Spivey TL, Zhao Y, et al. CXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2. Br J Cancer 2013;109:2412-23
    • (2013) Br J Cancer , vol.109 , pp. 2412-2423
    • Bedognetti, D.1    Spivey, T.L.2    Zhao, Y.3
  • 130
    • 80053997259 scopus 로고    scopus 로고
    • A human memory T cell subset with stem cell-like properties
    • Gattinoni L, Lugli E, Ji Y, et al. A human memory T cell subset with stem cell-like properties. Nat Med 2011;17:1290-7
    • (2011) Nat Med , vol.17 , pp. 1290-1297
    • Gattinoni, L.1    Lugli, E.2    Ji, Y.3
  • 132
    • 84864487810 scopus 로고    scopus 로고
    • A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon
    • Wang E, Zhao Y, Monaco A, et al. A multi-factorial genetic model for prognostic assessment of high risk melanoma patients receiving adjuvant interferon. PLoS One 2012;7:e40805
    • (2012) PLoS One , vol.7
    • Wang, E.1    Zhao, Y.2    Monaco, A.3
  • 133
    • 84886038035 scopus 로고    scopus 로고
    • Increasing immunogenicity of cancer vaccines to improve their clinical outcome
    • Parmiani G, Cimminiello C, Maccalli C. Increasing immunogenicity of cancer vaccines to improve their clinical outcome. Expert Rev Vaccines 2013;12:1111-13
    • (2013) Expert Rev Vaccines , vol.12 , pp. 1111-1113
    • Parmiani, G.1    Cimminiello, C.2    Maccalli, C.3
  • 134
    • 79957831345 scopus 로고    scopus 로고
    • Gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
    • Schwartzentruber DJ, Lawson DH, Richards JM, et al. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med 2011;364:2119-27
    • (2011) N Engl J Med , vol.364 , pp. 2119-2127
    • Schwartzentruber, D.J.1    Lawson, D.H.2    Richards, J.M.3
  • 135
    • 84880730418 scopus 로고    scopus 로고
    • Selection of immunostimulant AS15 for active immunization with MAGE-A3 protein: Results of a randomized phase II study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma
    • Kruit WH, Suciu S, Dreno B, et al. Selection of immunostimulant AS15 for active immunization with MAGE-A3 protein: Results of a randomized phase II study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma. J Clin Oncol 2013;31:2413-20
    • (2013) J Clin Oncol , vol.31 , pp. 2413-2420
    • Kruit, W.H.1    Suciu, S.2    Dreno, B.3
  • 136
    • 84880720167 scopus 로고    scopus 로고
    • Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy
    • Ulloa-Montoya F, Louahed J, Dizier B, et al. Predictive gene signature in MAGE-A3 antigen-specific cancer immunotherapy. J Clin Oncol 2013;31:2388-95
    • (2013) J Clin Oncol , vol.31 , pp. 2388-2395
    • Ulloa-Montoya, F.1    Louahed, J.2    Dizier, B.3
  • 138
    • 84861133191 scopus 로고    scopus 로고
    • Vaccines for melanoma and renal cell carcinoma
    • Kaufman HL. Vaccines for melanoma and renal cell carcinoma. Semin Oncol 2012;39:263-75
    • (2012) Semin Oncol , vol.39 , pp. 263-275
    • Kaufman, H.L.1
  • 139
    • 84884594361 scopus 로고    scopus 로고
    • OPTiM: A randomized phase III trial of talimogene laherparepvec (T-VEC) versus subcutaneous (SC) granulocyte-macrophage colonystimulating factor (GM-CSF) for the treatment (tx) of unresected stage IIIB/C and IV melanoma
    • Suppl):abstract LBA9008
    • Andtbacka R, Collichio FA, Amatruda T, et al. OPTiM: A randomized phase III trial of talimogene laherparepvec (T-VEC) versus subcutaneous (SC) granulocyte-macrophage colonystimulating factor (GM-CSF) for the treatment (tx) of unresected stage IIIB/C and IV melanoma. J Clin Oncol 2013;31(Suppl):abstract LBA9008
    • (2013) J Clin Oncol , vol.31
    • Andtbacka, R.1    Collichio, F.A.2    Amatruda, T.3
  • 140
    • 78650555335 scopus 로고    scopus 로고
    • Immunologic therapy targeting metastatic melanoma: Allovectin-7
    • Chowdhery R, Gonzalez R. Immunologic therapy targeting metastatic melanoma: Allovectin-7. Immunotherapy 2011;3:17-21
    • (2011) Immunotherapy , vol.3 , pp. 17-21
    • Chowdhery, R.1    Gonzalez, R.2
  • 141
    • 1342294725 scopus 로고    scopus 로고
    • Immunopharmacologic analysis of an autologous, hapten-modified human melanoma vaccine
    • Berd D, Sato T, Maguire HC Jr, et al. Immunopharmacologic analysis of an autologous, hapten-modified human melanoma vaccine. J Clin Oncol 2004;22:403-15
    • (2004) J Clin Oncol , vol.22 , pp. 403-415
    • Berd, D.1    Sato, T.2    Maguire Jr., H.C.3
  • 142
    • 84883617163 scopus 로고    scopus 로고
    • Carbon nanotubes as a novel tool for vaccination against infectious diseases and cancer
    • Gottardi R, Douradinha B. Carbon nanotubes as a novel tool for vaccination against infectious diseases and cancer. J Nanobiotechnology 2013;11:30
    • (2013) J Nanobiotechnology , vol.11 , pp. 30
    • Gottardi, R.1    Douradinha, B.2
  • 143
    • 84875581095 scopus 로고    scopus 로고
    • Functionalized carbon nanotubes as immunomodulator systems
    • Pescatori M, Bedognetti D, Venturelli E, et al. Functionalized carbon nanotubes as immunomodulator systems. Biomaterials 2013;34:4395-403
    • (2013) Biomaterials , vol.34 , pp. 4395-4403
    • Pescatori, M.1    Bedognetti, D.2    Venturelli, E.3
  • 144
    • 84867363425 scopus 로고    scopus 로고
    • Functionalized multiwalled carbon nanotubes as ultrasound contrast agents
    • Delogu LG, Vidili G, Venturelli E, et al. Functionalized multiwalled carbon nanotubes as ultrasound contrast agents. Proc Natl Acad Sci USA 2012;109:16612-17
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 16612-16617
    • Delogu, L.G.1    Vidili, G.2    Venturelli, E.3
  • 145
    • 84858758766 scopus 로고    scopus 로고
    • Adoptive immunotherapy for cancer: Harnessing the T cell response
    • Restifo NP, Dudley ME, Rosenberg SA. Adoptive immunotherapy for cancer: Harnessing the T cell response. Nat Rev Immunol 2012;12:269-81
    • (2012) Nat Rev Immunol , vol.12 , pp. 269-281
    • Restifo, N.P.1    Dudley, M.E.2    Rosenberg, S.A.3
  • 146
    • 84887474711 scopus 로고    scopus 로고
    • Reassessing target antigens for adoptive T-cell therapy
    • Hinrichs CS, Restifo NP. Reassessing target antigens for adoptive T-cell therapy. Nat Biotechnol 2013;31:999-1008
    • (2013) Nat Biotechnol , vol.31 , pp. 999-1008
    • Hinrichs, C.S.1    Restifo, N.P.2
  • 147
    • 81255188604 scopus 로고    scopus 로고
    • Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma
    • Wang XY, Zuo D, Sarkar D, Fisher PB. Blockade of cytotoxic T-lymphocyte antigen-4 as a new therapeutic approach for advanced melanoma. Expert Opin Pharmacother 2011;12:2695-706
    • (2011) Expert Opin Pharmacother , vol.12 , pp. 2695-2706
    • Wang, X.Y.1    Zuo, D.2    Sarkar, D.3    Fisher, P.B.4
  • 148
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12:252-64
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 149
    • 0028841784 scopus 로고
    • The Yin and Yang of T cell costimulation
    • Allison JP, Krummel MF. The Yin and Yang of T cell costimulation. Science 1995;270:932-3
    • (1995) Science , vol.270 , pp. 932-933
    • Allison, J.P.1    Krummel, M.F.2
  • 150
    • 0029120245 scopus 로고
    • CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
    • Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med 1995;182:459-65
    • (1995) J Exp Med , vol.182 , pp. 459-465
    • Krummel, M.F.1    Allison, J.P.2
  • 151
    • 84880512712 scopus 로고    scopus 로고
    • Four-year survival update for metastatic melanoma (MM) patients (pts) treated with ipilimumab (IPI) + dacarbazine (DTIC) on Phase 3 study CA184-024
    • 9s Suppl): Abstract 1127P
    • Maio M, Bondarenko I, Robert C, et al. Four-year survival update for metastatic melanoma (MM) patients (pts) treated with ipilimumab (IPI) + dacarbazine (DTIC) on Phase 3 study CA184-024. Ann Oncol 23(9s Suppl): Abstract 1127P
    • Ann Oncol , vol.23
    • Maio, M.1    Bondarenko, I.2    Robert, C.3
  • 152
    • 84880310548 scopus 로고    scopus 로고
    • Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials
    • Wolchok JD, Weber JS, Maio M, et al. Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials. Ann Oncol 2013;24:2174-80
    • (2013) Ann Oncol , vol.24 , pp. 2174-2180
    • Wolchok, J.D.1    Weber, J.S.2    Maio, M.3
  • 153
    • 84873714872 scopus 로고    scopus 로고
    • Update on the role of ipilimumab in melanoma and first data on new combination therapies
    • Maio M, Di Giacomo AM, Robert C, Eggermont AM. Update on the role of ipilimumab in melanoma and first data on new combination therapies. Curr Opin Oncol 2013;25:166-72
    • (2013) Curr Opin Oncol , vol.25 , pp. 166-172
    • Maio, M.1    Di Giacomo, A.M.2    Robert, C.3    Eggermont, A.M.4
  • 154
    • 84892808887 scopus 로고    scopus 로고
    • Ipilimumab (Ipi) expanded access program (EAP) for patients (pts) with stage III/IV melanoma: 10 mg/kg cohort interim results
    • Suppl):abstract 8508
    • Hamid O, Hwu W, Richards J, et al. Ipilimumab (Ipi) expanded access program (EAP) for patients (pts) with stage III/IV melanoma: 10 mg/kg cohort interim results. J Clin Oncol 2012;30(Suppl):abstract 8508
    • (2012) J Clin Oncol , vol.30
    • Hamid, O.1    Hwu, W.2    Richards, J.3
  • 155
    • 84865567547 scopus 로고    scopus 로고
    • Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): An open-label, single-Arm phase 2 trial
    • Di Giacomo AM, Ascierto PA, Pilla L, et al. Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): An open-label, single-Arm phase 2 trial. Lancet Oncol 2012;13:879-86
    • (2012) Lancet Oncol , vol.13 , pp. 879-886
    • Di Giacomo, A.M.1    Ascierto, P.A.2    Pilla, L.3
  • 156
    • 84873723177 scopus 로고    scopus 로고
    • Phase II study of the frontline combination of ipilimumab and temozolomide in patients with metastatic melanoma
    • Suppl): Abstract 8514
    • Patel SP, Hwu W, Kim KB, et al. Phase II study of the frontline combination of ipilimumab and temozolomide in patients with metastatic melanoma. J Clin Oncol 2012;30(Suppl): Abstract 8514
    • (2012) J Clin Oncol , vol.30
    • Patel, S.P.1    Hwu, W.2    Kim, K.B.3
  • 157
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok JD, Hoos A, O'Day S, et al. Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria. Clin Cancer Res 2009;15:7412-20
    • (2009) Clin Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3
  • 158
    • 84874605864 scopus 로고    scopus 로고
    • Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
    • Ribas A, Kefford R, Marshall MA, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol 2013;31:616-22
    • (2013) J Clin Oncol , vol.31 , pp. 616-622
    • Ribas, A.1    Kefford, R.2    Marshall, M.A.3
  • 159
    • 78449250123 scopus 로고    scopus 로고
    • Clinical development of the anti-CTLA-4 antibody tremelimumab
    • Ribas A. Clinical development of the anti-CTLA-4 antibody tremelimumab. Semin Oncol 2010;37:450-4
    • (2010) Semin Oncol , vol.37 , pp. 450-454
    • Ribas, A.1
  • 160
    • 84856069688 scopus 로고    scopus 로고
    • Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma
    • Tarhini AA, Cherian J, Moschos SJ, et al. Safety and efficacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma. J Clin Oncol 2012;30:322-8
    • (2012) J Clin Oncol , vol.30 , pp. 322-328
    • Tarhini, A.A.1    Cherian, J.2    Moschos, S.J.3
  • 161
    • 84884703526 scopus 로고    scopus 로고
    • Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: An open-label, single-Arm, phase 2 trial
    • Calabro L, Morra A, Fonsatti E, et al. Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: An open-label, single-Arm, phase 2 trial. Lancet Oncol 2013;14:1104-11
    • (2013) Lancet Oncol , vol.14 , pp. 1104-1111
    • Calabro, L.1    Morra, A.2    Fonsatti, E.3
  • 162
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • Freeman GJ, Long AJ, Iwai Y, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 2000;192:1027-34
    • (2000) J Exp Med , vol.192 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3
  • 163
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Latchman Y, Wood CR, Chernova T, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001;2:261-8
    • (2001) Nat Immunol , vol.2 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3
  • 164
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 2012;366:2455-65
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 165
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 166
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013;369:134-44
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 167
    • 84880732199 scopus 로고    scopus 로고
    • Survival and long-Term follow-up of safety and response in patients (pts) with advanced melanoma (MEL) in a phase I trial of nivolumab (anti-PD-1; BMS-936558; ONO-4538)
    • Suppl):abstract CRA9006
    • Sznol M, Kluger H, Hodi FS, et al. Survival and long-Term follow-up of safety and response in patients (pts) with advanced melanoma (MEL) in a phase I trial of nivolumab (anti-PD-1; BMS-936558; ONO-4538). J Clin Oncol 2013;31(Suppl):abstract CRA9006
    • (2013) J Clin Oncol , vol.31
    • Sznol, M.1    Kluger, H.2    Hodi, F.S.3
  • 168
    • 84880277245 scopus 로고    scopus 로고
    • Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic melanoma (mM)
    • Suppl): Abstract 9010
    • Hamid O, Sosman J, Lawrence D, et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic melanoma (mM). J Clin Oncol 2013;31(Suppl): Abstract 9010
    • (2013) J Clin Oncol , vol.31
    • Hamid, O.1    Sosman, J.2    Lawrence, D.3
  • 169
    • 84874889330 scopus 로고    scopus 로고
    • Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination
    • Melero I, Grimaldi AM, Perez-Gracia JL, Ascierto PA. Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination. Clin Cancer Res 2013;19:997-1008
    • (2013) Clin Cancer Res , vol.19 , pp. 997-1008
    • Melero, I.1    Grimaldi, A.M.2    Perez-Gracia, J.L.3    Ascierto, P.A.4
  • 170
    • 2942592429 scopus 로고    scopus 로고
    • Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40
    • Sugamura K, Ishii N, Weinberg AD. Therapeutic targeting of the effector T-cell co-stimulatory molecule OX40. Nat Rev Immunol 2004;4:420-31
    • (2004) Nat Rev Immunol , vol.4 , pp. 420-431
    • Sugamura, K.1    Ishii, N.2    Weinberg, A.D.3
  • 171
    • 38049037266 scopus 로고    scopus 로고
    • Targeting OX40 and OX40L for the treatment of autoimmunity and cancer
    • Redmond WL, Weinberg AD. Targeting OX40 and OX40L for the treatment of autoimmunity and cancer. Crit Rev Immunol 2007;27:415-36
    • (2007) Crit Rev Immunol , vol.27 , pp. 415-436
    • Redmond, W.L.1    Weinberg, A.D.2
  • 172
    • 17644389199 scopus 로고    scopus 로고
    • TNF/TNFR family members in costimulation of T cell responses
    • Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005;23:23-68
    • (2005) Annu Rev Immunol , vol.23 , pp. 23-68
    • Watts, T.H.1
  • 173
    • 77952311199 scopus 로고    scopus 로고
    • Control of immunity by the TNFR-related molecule OX40 (CD134)
    • Croft M. Control of immunity by the TNFR-related molecule OX40 (CD134). Annu Rev Immunol 2010;28:57-78
    • (2010) Annu Rev Immunol , vol.28 , pp. 57-78
    • Croft, M.1
  • 174
    • 84891275907 scopus 로고    scopus 로고
    • OX40 is a potent immune-stimulating target in late-stage cancer patients
    • Curti BD, Kovacsovics-Bankowski M, Morris N, et al. OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients. Cancer Res 2013;73:7189-98
    • (2013) Cancer Res , vol.73 , pp. 7189-7198
    • Curti, B.D.1    Kovacsovics-Bankowski, M.2    Morris, N.3
  • 175
    • 84859354954 scopus 로고    scopus 로고
    • Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression
    • Redmond WL, Triplett T, Floyd K, Weinberg AD. Dual anti-OX40/IL-2 therapy augments tumor immunotherapy via IL-2R-mediated regulation of OX40 expression. PLoS One 2012;7:e34467
    • (2012) PLoS One , vol.7
    • Redmond, W.L.1    Triplett, T.2    Floyd, K.3    Weinberg, A.D.4
  • 176
    • 0032896709 scopus 로고    scopus 로고
    • CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help
    • French RR, Chan HT, Tutt AL, Glennie MJ. CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help. Nat Med 1999;5:548-53
    • (1999) Nat Med , vol.5 , pp. 548-553
    • French, R.R.1    Chan, H.T.2    Tutt, A.L.3    Glennie, M.J.4
  • 177
    • 0032984496 scopus 로고    scopus 로고
    • CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-Tumor vaccine efficacy
    • Diehl L, den Boer AT, Schoenberger SP, et al. CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-Tumor vaccine efficacy. Nat Med 1999;5:774-9
    • (1999) Nat Med , vol.5 , pp. 774-779
    • Diehl, L.1    Den Boer, A.T.2    Schoenberger, S.P.3
  • 178
    • 0032984347 scopus 로고    scopus 로고
    • Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40
    • Sotomayor EM, Borrello I, Tubb E, et al. Conversion of tumor-specific CD4+ T-cell tolerance to T-cell priming through in vivo ligation of CD40. Nat Med 1999;5:780-7
    • (1999) Nat Med , vol.5 , pp. 780-787
    • Sotomayor, E.M.1    Borrello, I.2    Tubb, E.3
  • 179
    • 84874845333 scopus 로고    scopus 로고
    • Agonistic CD40 antibodies and cancer therapy
    • Vonderheide RH, Glennie MJ. Agonistic CD40 antibodies and cancer therapy. Clin Cancer Res 2013;19:1035-43
    • (2013) Clin Cancer Res , vol.19 , pp. 1035-1043
    • Vonderheide, R.H.1    Glennie, M.J.2
  • 180
    • 33947506186 scopus 로고    scopus 로고
    • Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody
    • Vonderheide RH, Flaherty KT, Khalil M, et al. Clinical activity and immune modulation in cancer patients treated with CP-870,893, a novel CD40 agonist monoclonal antibody. J Clin Oncol 2007;25:876-83
    • (2007) J Clin Oncol , vol.25 , pp. 876-883
    • Vonderheide, R.H.1    Flaherty, K.T.2    Khalil, M.3
  • 181
    • 84898761363 scopus 로고    scopus 로고
    • Therapeutic efficacy of combined blockade of CTLA-4 +/-PD-L1 +/-IDO is associated with re-Activation of T cells directly within the tumor microenvironment
    • Spranger S, Gajewski T. Therapeutic efficacy of combined blockade of CTLA-4 +/-PD-L1 +/-IDO is associated with re-Activation of T cells directly within the tumor microenvironment. J Immuno Ther Cancer 2013;1(Suppl 1):O8
    • (2013) J Immuno Ther Cancer , vol.1 , Issue.SUPPL. 1
    • Spranger, S.1    Gajewski, T.2
  • 182
    • 77955487541 scopus 로고    scopus 로고
    • First-line chemoimmunotherapy in metastatic breast carcinoma: Combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity
    • Brignone C, Gutierrez M, Mefti F, et al. First-line chemoimmunotherapy in metastatic breast carcinoma: Combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity. J Transl Med 2010;8:71
    • (2010) J Transl Med , vol.8 , pp. 71
    • Brignone, C.1    Gutierrez, M.2    Mefti, F.3
  • 183
    • 79953768104 scopus 로고    scopus 로고
    • Antibody-mediated depletion of lymphocyte-Activation gene-3 (LAG-3(+))-Activated T lymphocytes prevents delayed-Type hypersensitivity in nonhuman primates
    • Poirier N, Haudebourg T, Brignone C, et al. Antibody-mediated depletion of lymphocyte-Activation gene-3 (LAG-3(+))-Activated T lymphocytes prevents delayed-Type hypersensitivity in nonhuman primates. Clin Exp Immunol 2011;164:265-74
    • (2011) Clin Exp Immunol , vol.164 , pp. 265-274
    • Poirier, N.1    Haudebourg, T.2    Brignone, C.3
  • 184
    • 84879685794 scopus 로고    scopus 로고
    • BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis
    • Roychoudhuri R, Hirahara K, Mousavi K, et al. BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis. Nature 2013;498:506-10
    • (2013) Nature , vol.498 , pp. 506-510
    • Roychoudhuri, R.1    Hirahara, K.2    Mousavi, K.3
  • 185
    • 79960299888 scopus 로고    scopus 로고
    • Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy
    • Rosenberg SA, Yang JC, Sherry RM, et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin Cancer Res 2011;17:4550-7
    • (2011) Clin Cancer Res , vol.17 , pp. 4550-4557
    • Rosenberg, S.A.1    Yang, J.C.2    Sherry, R.M.3
  • 186
    • 84871207055 scopus 로고    scopus 로고
    • Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients
    • Radvanyi LG, Bernatchez C, Zhang M, et al. Specific lymphocyte subsets predict response to adoptive cell therapy using expanded autologous tumor-infiltrating lymphocytes in metastatic melanoma patients. Clin Cancer Res 2012;18:6758-70
    • (2012) Clin Cancer Res , vol.18 , pp. 6758-6770
    • Radvanyi, L.G.1    Bernatchez, C.2    Zhang, M.3
  • 187
    • 84883472041 scopus 로고    scopus 로고
    • Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: Intent-To-Treat analysis and efficacy after failure to prior immunotherapies
    • Besser MJ, Shapira-Frommer R, Itzhaki O, et al. Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: Intent-To-Treat analysis and efficacy after failure to prior immunotherapies. Clin Cancer Res 2013;19:4792-800
    • (2013) Clin Cancer Res , vol.19 , pp. 4792-4800
    • Besser, M.J.1    Shapira-Frommer, R.2    Itzhaki, O.3
  • 188
    • 84887991307 scopus 로고    scopus 로고
    • Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma
    • Dudley ME, Gross CA, Somerville RP, et al. Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma. J Clin Oncol 2013;31:2152-9
    • (2013) J Clin Oncol , vol.31 , pp. 2152-2159
    • Dudley, M.E.1    Gross, C.A.2    Somerville, R.P.3
  • 189
    • 84884745916 scopus 로고    scopus 로고
    • Adoptive cell transfer for patients with metastatic melanoma: The potential and promise of cancer immunotherapy
    • Phan GQ, Rosenberg SA. Adoptive cell transfer for patients with metastatic melanoma: The potential and promise of cancer immunotherapy. Cancer Control 2013;20:289-97
    • (2013) Cancer Control , vol.20 , pp. 289-297
    • Phan, G.Q.1    Rosenberg, S.A.2
  • 190
    • 84902216759 scopus 로고    scopus 로고
    • In: Prendergsat GC, Jaffee EM, editors, Cancer immunotherapy, immune suppression and tumor growth. 2nd edition. Elsevier
    • Bedognetti D, Wang E, Sato-Matsushita M, et al. Molecular profiling of immunotherapeutic resistance. In: Prendergsat GC, Jaffee EM, editors, Cancer immunotherapy, immune suppression and tumor growth. 2nd edition. Elsevier, 2013.
    • (2013) Molecular profiling of immunotherapeutic resistance
    • Bedognetti, D.1    Wang, E.2    Sato-Matsushita, M.3
  • 191
    • 0024580003 scopus 로고
    • Tumor localization of adoptively transferred indium-111 labeled tumor infiltrating lymphocytes in patients with metastatic melanoma
    • Fisher B, Packard BS, Read EJ, et al. Tumor localization of adoptively transferred indium-111 labeled tumor infiltrating lymphocytes in patients with metastatic melanoma. J Clin Oncol 1989;7:250-61
    • (1989) J Clin Oncol , vol.7 , pp. 250-261
    • Fisher, B.1    Packard, B.S.2    Read, E.J.3
  • 192
    • 80053896382 scopus 로고    scopus 로고
    • Gene expression profiling in acute allograft rejection: Challenging the immunologic constant of rejection hypothesis
    • Spivey TL, Uccellini L, Ascierto ML, et al. Gene expression profiling in acute allograft rejection: Challenging the immunologic constant of rejection hypothesis. J Transl Med 2011;9:174
    • (2011) J Transl Med , vol.9 , pp. 174
    • Spivey, T.L.1    Uccellini, L.2    Ascierto, M.L.3
  • 193
    • 79960564054 scopus 로고    scopus 로고
    • Combination therapy: The next opportunity and challenge of medicine
    • Ascierto PA, Marincola FM. Combination therapy: The next opportunity and challenge of medicine. J Transl Med 2011;9:115
    • (2011) J Transl Med , vol.9 , pp. 115
    • Ascierto, P.A.1    Marincola, F.M.2
  • 194
    • 0029027251 scopus 로고
    • Combination therapy with interferon alfa-2a and interleukin-2 for the treatment of metastatic cancer
    • Marincola FM, White DE, Wise AP, Rosenberg SA. Combination therapy with interferon alfa-2a and interleukin-2 for the treatment of metastatic cancer. J Clin Oncol 1995;13:1110-22
    • (1995) J Clin Oncol , vol.13 , pp. 1110-1122
    • Marincola, F.M.1    White, D.E.2    Wise, A.P.3    Rosenberg, S.A.4
  • 195
    • 84874721742 scopus 로고    scopus 로고
    • Phase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferonalpha in advanced malignant melanoma
    • Daponte A, Signoriello S, Maiorino L, et al. Phase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferonalpha in advanced malignant melanoma. J Transl Med 2013;11:38
    • (2013) J Transl Med , vol.11 , pp. 38
    • Daponte, A.1    Signoriello, S.2    Maiorino, L.3
  • 196
    • 84880263903 scopus 로고    scopus 로고
    • Multicenter, randomized phase II trial of GM-CSF plus ipilimumab versus ipi alone in metastatic melanoma
    • Suppl): Abstract CRA9007
    • Hodi FS, Lee SJ, McDermott DF, et al. Multicenter, randomized phase II trial of GM-CSF plus ipilimumab versus ipi alone in metastatic melanoma. J Clin Oncol 2013;31(Suppl): Abstract CRA9007
    • (2013) J Clin Oncol , vol.31
    • Hodi, F.S.1    Lee, S.J.2    McDermott, D.F.3
  • 197
    • 84859393995 scopus 로고    scopus 로고
    • CTLA-4 blockade with ipilimumab: Long-Term follow-up of 177 patients with metastatic melanoma
    • Prieto PA, Yang JC, Sherry RM, et al. CTLA-4 blockade with ipilimumab: Long-Term follow-up of 177 patients with metastatic melanoma. Clin Cancer Res 2012;18:2039-47
    • (2012) Clin Cancer Res , vol.18 , pp. 2039-2047
    • Prieto, P.A.1    Yang, J.C.2    Sherry, R.M.3
  • 198
    • 79960260495 scopus 로고    scopus 로고
    • The trouble with translational medicine
    • Marincola FM. The trouble with translational medicine. J Intern Med 2011;270:123-7
    • (2011) J Intern Med , vol.270 , pp. 123-127
    • Marincola, F.M.1
  • 200
    • 84886945241 scopus 로고    scopus 로고
    • Strong emerging rationale for combining oncogene-Targeted agents with immunotherapy
    • Yang Y, Lizee G, Hwu P. Strong emerging rationale for combining oncogene-Targeted agents with immunotherapy. Oncoimmunology 2013;2:e22730
    • (2013) Oncoimmunology , vol.2
    • Yang, Y.1    Lizee, G.2    Hwu, P.3
  • 201
    • 84856021675 scopus 로고    scopus 로고
    • New challenges in endpoints for drug development in advanced melanoma
    • Ribas A, Hersey P, Middleton MR, et al. New challenges in endpoints for drug development in advanced melanoma. Clin Cancer Res 2012;18:336-41
    • (2012) Clin Cancer Res , vol.18 , pp. 336-341
    • Ribas, A.1    Hersey, P.2    Middleton, M.R.3
  • 202
    • 84880747672 scopus 로고    scopus 로고
    • Mechanism of action of conventional and targeted anticancer therapies: Reinstating immunosurveillance
    • Zitvogel L, Galluzzi L, Smyth MJ, Kroemer G. Mechanism of action of conventional and targeted anticancer therapies: Reinstating immunosurveillance. Immunity 2013;39:74-88
    • (2013) Immunity , vol.39 , pp. 74-88
    • Zitvogel, L.1    Galluzzi, L.2    Smyth, M.J.3    Kroemer, G.4
  • 203
    • 84877051042 scopus 로고    scopus 로고
    • Combining cancer immunotherapy and targeted therapy
    • Ribas A, Wolchok JD. Combining cancer immunotherapy and targeted therapy. Curr Opin Immunol 2013;25:291-6
    • (2013) Curr Opin Immunol , vol.25 , pp. 291-296
    • Ribas, A.1    Wolchok, J.D.2
  • 204
    • 0028169370 scopus 로고
    • Expression of interleukin 1 alpha, interleukin 6, and tumor necrosis factor alpha genes in human melanoma clones is associated with that of mutated N-RAS oncogene
    • Castelli C, Sensi M, Lupetti R, et al. Expression of interleukin 1 alpha, interleukin 6, and tumor necrosis factor alpha genes in human melanoma clones is associated with that of mutated N-RAS oncogene. Cancer Res 1994;54:4785-90
    • (1994) Cancer Res , vol.54 , pp. 4785-4790
    • Castelli, C.1    Sensi, M.2    Lupetti, R.3
  • 205
    • 33745859743 scopus 로고    scopus 로고
    • The BRAF-MAPK signaling pathway is essential for cancerimmune evasion in human melanoma cells
    • Sumimoto H, Imabayashi F, Iwata T, Kawakami Y. The BRAF-MAPK signaling pathway is essential for cancerimmune evasion in human melanoma cells. J Exp Med 2006;203:1651-6
    • (2006) J Exp Med , vol.203 , pp. 1651-1656
    • Sumimoto, H.1    Imabayashi, F.2    Iwata, T.3    Kawakami, Y.4
  • 206
    • 84866918738 scopus 로고    scopus 로고
    • Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma
    • Khalili JS, Liu S, Rodriguez-Cruz TG, et al. Oncogenic BRAF(V600E) promotes stromal cell-mediated immunosuppression via induction of interleukin-1 in melanoma. Clin Cancer Res 2012;18:5329-40
    • (2012) Clin Cancer Res , vol.18 , pp. 5329-5340
    • Khalili, J.S.1    Liu, S.2    Rodriguez-Cruz, T.G.3
  • 207
    • 84874872137 scopus 로고    scopus 로고
    • BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
    • Frederick DT, Piris A, Cogdill AP, et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res 2013;19:1225-31
    • (2013) Clin Cancer Res , vol.19 , pp. 1225-1231
    • Frederick, D.T.1    Piris, A.2    Cogdill, A.P.3
  • 208
    • 84872514398 scopus 로고    scopus 로고
    • BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice
    • Liu C, Peng W, Xu C, et al. BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice. Clin Cancer Res 2013;19:393-403
    • (2013) Clin Cancer Res , vol.19 , pp. 393-403
    • Liu, C.1    Peng, W.2    Xu, C.3
  • 209
    • 77954373338 scopus 로고    scopus 로고
    • Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function
    • Boni A, Cogdill AP, Dang P, et al. Selective BRAFV600E inhibition enhances T-cell recognition of melanoma without affecting lymphocyte function. Cancer Res 2010;70:5213-19
    • (2010) Cancer Res , vol.70 , pp. 5213-5219
    • Boni, A.1    Cogdill, A.P.2    Dang, P.3
  • 210
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • Ribas A, Hodi FS, Callahan M, et al. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med 2013;368:1365-6
    • (2013) N Engl J Med , vol.368 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3
  • 211
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012;367:1694-703
    • (2012) N Engl J Med , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 212
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013;369:122-33
    • (2013) N Engl J Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 213
    • 84880253427 scopus 로고    scopus 로고
    • IRF-1 responsiveness to IFN-gamma predicts different cancer immune phenotypes
    • Murtas D, Maric D, De Giorgi V, et al. IRF-1 responsiveness to IFN-gamma predicts different cancer immune phenotypes. Br J Cancer 2013;109:76-82
    • (2013) Br J Cancer , vol.109 , pp. 76-82
    • Murtas, D.1    Maric, D.2    De Giorgi, V.3
  • 214
    • 82155168544 scopus 로고    scopus 로고
    • A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
    • Hamid O, Schmidt H, Nissan A, et al. A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med 2011;9:204
    • (2011) J Transl Med , vol.9 , pp. 204
    • Hamid, O.1    Schmidt, H.2    Nissan, A.3
  • 215
    • 84862769116 scopus 로고    scopus 로고
    • An immune-Active tumor microenvironment favors clinical response to ipilimumab
    • Ji RR, Chasalow SD, Wang L, et al. An immune-Active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother 2012;61:1019-31
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1019-1031
    • Ji, R.R.1    Chasalow, S.D.2    Wang, L.3
  • 216
    • 84861651644 scopus 로고    scopus 로고
    • Regression of melanoma metastases after immunotherapy is associated with activation of antigen presentation and interferon-mediated rejection genes
    • Carretero R, Wang E, Rodriguez AI, et al. Regression of melanoma metastases after immunotherapy is associated with activation of antigen presentation and interferon-mediated rejection genes. Int J Cancer 2012;131:387-95
    • (2012) Int J Cancer , vol.131 , pp. 387-395
    • Carretero, R.1    Wang, E.2    Rodriguez, A.I.3
  • 217
    • 33847646901 scopus 로고    scopus 로고
    • Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection
    • Panelli MC, Stashower ME, Slade HB, et al. Sequential gene profiling of basal cell carcinomas treated with imiquimod in a placebo-controlled study defines the requirements for tissue rejection. Genome Biol 2007;8:R8
    • (2007) Genome Biol , vol.8
    • Panelli, M.C.1    Stashower, M.E.2    Slade, H.B.3
  • 218
    • 84862315687 scopus 로고    scopus 로고
    • A genetic inference on cancer immune responsiveness
    • Wang E, Uccellini L, Marincola FM. A genetic inference on cancer immune responsiveness. Oncoimmunology 2012;1:520-5
    • (2012) Oncoimmunology , vol.1 , pp. 520-525
    • Wang, E.1    Uccellini, L.2    Marincola, F.M.3


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