Novel merosesquiterpene exerts a potent antitumor activity against breast cancer cells in vitro and in vivo

European Journal of Medicinal Chemistry

Volumn 79, Issue , 2014, Pages 1-12

  Carrasco, Esther ^a,b   Álvarez, Pablo Juan ^a   Melguizo, Consolación ^a   Prados, José ^a   Álvarez Manzaneda, Enrique ^b   Chahboun, Rachid ^b   Messouri, Ibtissam ^b   Vázquez Vázquez, María Isabel ^a   Aránega, Antonia ^a   Rodríguez Serrano, Fernando ^a  

^a Biomedical Research Center   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Allografts; Apoptosis; Cancer; Cell cycle arrest; Merosesquiterpene; Oxidative stress

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D1; HYDROXYQUINONE; MEROSESQUITERPENE; METHOXYQUINONE; NAPHTHOQUINONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P27; PROTEIN P53; TERPENE DERIVATIVE; UNCLASSIFIED DRUG; SESQUITERPENE;

ALLOGRAFT; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST TUMOR; CANCER CELL; CANCER PROGNOSIS; CANCER STAGING; CELL CYCLE ARREST; CELL STRAIN MCF 7; COLON TUMOR; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; LUNG TUMOR; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; TREATMENT OUTCOME; TUMOR PROMOTION; ANIMAL; BREAST NEOPLASMS; C57BL MOUSE; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HT 29 CELL LINE; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF 7 CELL LINE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL CULTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HT29 CELLS; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MCF-7 CELLS; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84898718371     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.071     Document Type: Article

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