-
1
-
-
0035095973
-
Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks
-
Adams PD. (2001). Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim Biophys Acta 1471: M123-M133.
-
(2001)
Biochim Biophys Acta
, vol.1471
-
-
Adams, P.D.1
-
2
-
-
0032929012
-
Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes
-
Adams PD, Li X, Sellers WR, Baker KB, Leng X, Harper JW et al. (1999). Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes. Mol Cell Biol 19: 1068-1080.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1068-1080
-
-
Adams, P.D.1
Li, X.2
Sellers, W.R.3
Baker, K.B.4
Leng, X.5
Harper, J.W.6
-
3
-
-
58149295717
-
Protein arginine methylation in mammals: Who, what, and why
-
Bedford MT, Clarke SG. (2009). Protein arginine methylation in mammals: who, what, and why. Mol Cell 33: 1-13.
-
(2009)
Mol Cell
, vol.33
, pp. 1-13
-
-
Bedford, M.T.1
Clarke, S.G.2
-
4
-
-
0032939925
-
Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
-
Blattner C, Sparks A, Lane D. (1999). Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol Cell Biol 19: 3704-3713.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3704-3713
-
-
Blattner, C.1
Sparks, A.2
Lane, D.3
-
6
-
-
33746832077
-
Identification and characterization of Smyd2: A split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex
-
Brown MA, Sims 3rd RJ, Gottlieb PD, Tucker PW. (2006). Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol Cancer 5: 26.
-
(2006)
Mol Cancer
, vol.5
, pp. 26
-
-
Brown, M.A.1
Sims Iii., R.J.2
Gottlieb, P.D.3
Tucker, P.W.4
-
7
-
-
0030903750
-
Regulation of E2F through ubiquitin-proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein
-
Campanero MR, Flemington EK. (1997). Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein. Proc Natl Acad Sci USA 94: 2221-2226.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2221-2226
-
-
Campanero, M.R.1
Flemington, E.K.2
-
8
-
-
78751629039
-
Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein
-
Carr SM, Munro S, Kessler B, Oppermann U, La Thangue NB. (2011). Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein. EMBO J 30: 317-327.
-
(2011)
EMBO J
, vol.30
, pp. 317-327
-
-
Carr, S.M.1
Munro, S.2
Kessler, B.3
Oppermann, U.4
La Thangue, N.B.5
-
9
-
-
0034944423
-
Acetylation control of the retinoblastoma tumour-suppressor protein
-
Chan HM, Krstic-Demonacos M, Smith L, Demonacos C, La Thangue NB. (2001a). Acetylation control of the retinoblastoma tumour-suppressor protein. Nat Cell Biol 3: 667-674.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 667-674
-
-
Chan, H.M.1
Krstic-Demonacos, M.2
Smith, L.3
Demonacos, C.4
La Thangue, N.B.5
-
10
-
-
0035959853
-
Role of LXCXE motifdependent interactions in the activity of the retinoblastoma protein
-
Chan HM, Smith L, La Thangue NB. (2001b). Role of LXCXE motifdependent interactions in the activity of the retinoblastoma protein. Oncogene 20: 6152-6163.
-
(2001)
Oncogene
, vol.20
, pp. 6152-6163
-
-
Chan, H.M.1
Smith, L.2
La Thangue, N.B.3
-
11
-
-
68949212379
-
Lysine acetylation targets protein complexes and co-regulates major cellular functions
-
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC et al. (2009). Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 325: 834-840.
-
(2009)
Science
, vol.325
, pp. 834-840
-
-
Choudhary, C.1
Kumar, C.2
Gnad, F.3
Nielsen, M.L.4
Rehman, M.5
Walther, T.C.6
-
12
-
-
0026760426
-
Requirement for a functional Rb-1 gene in murine development
-
Clarke AR, Maandag ER, van Roon M, van der Lugt NM, van der Valk M, Hooper ML et al. (1992). Requirement for a functional Rb-1 gene in murine development. Nature 359: 328-330.
-
(1992)
Nature
, vol.359
, pp. 328-330
-
-
Clarke, A.R.1
Maandag, E.R.2
Van Roon, M.3
Van Der Lugt, N.M.4
Van Der Valk, M.5
Hooper, M.L.6
-
13
-
-
0036884829
-
The retinoblastoma tumour suppressor in development and cancer
-
Classon M, Harlow E. (2002). The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer 2: 910-917.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 910-917
-
-
Classon, M.1
Harlow, E.2
-
14
-
-
18344383345
-
Pocket proteins and cell cycle control
-
Cobrinik D. (2005). Pocket proteins and cell cycle control. Oncogene 24: 2796-2809.
-
(2005)
Oncogene
, vol.24
, pp. 2796-2809
-
-
Cobrinik, D.1
-
15
-
-
0031019197
-
Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation
-
Connell-Crowley L, Harper JW, Goodrich DW. (1997). Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell 8: 287-301.
-
(1997)
Mol Biol Cell
, vol.8
, pp. 287-301
-
-
Connell-Crowley, L.1
Harper, J.W.2
Goodrich, D.W.3
-
16
-
-
78049302116
-
P53 post-translational modification: Deregulated in tumorigenesis
-
Dai C, Gu W. (2010). p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med 16: 528-536.
-
(2010)
Trends Mol Med
, vol.16
, pp. 528-536
-
-
Dai, C.1
Gu, W.2
-
17
-
-
79551622682
-
P38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
-
Delston RB, Matatall KA, Sun Y, Onken MD, Harbour JW. (2011). p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis. Oncogene 30: 588-599.
-
(2011)
Oncogene
, vol.30
, pp. 588-599
-
-
Delston, R.B.1
Matatall, K.A.2
Sun, Y.3
Onken, M.D.4
Harbour, J.W.5
-
18
-
-
0141927097
-
PRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities
-
Dick FA, Dyson N. (2003). pRB contains an E2F1-specific binding domain that allows E2F1-induced apoptosis to be regulated separately from other E2F activities. Mol Cell 12: 639-649.
-
(2003)
Mol Cell
, vol.12
, pp. 639-649
-
-
Dick, F.A.1
Dyson, N.2
-
19
-
-
0032146274
-
The regulation of E2F by pRB-family proteins
-
Dyson N. (1998). The regulation of E2F by pRB-family proteins. Genes Dev 12: 2245-2262.
-
(1998)
Genes Dev
, vol.12
, pp. 2245-2262
-
-
Dyson, N.1
-
20
-
-
0027936238
-
Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein
-
Fagan R, Flint KJ, Jones N. (1994). Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein. Cell 78: 799-811.
-
(1994)
Cell
, vol.78
, pp. 799-811
-
-
Fagan, R.1
Flint, K.J.2
Jones, N.3
-
21
-
-
79955469653
-
Sirtuin 1 in malignant transformation: Friend or foe?
-
Fang Y, Nicholl MB. (2011). Sirtuin 1 in malignant transformation: friend or foe? Cancer Lett 306: 10-14.
-
(2011)
Cancer Lett
, vol.306
, pp. 10-14
-
-
Fang, Y.1
Nicholl, M.B.2
-
22
-
-
0141929385
-
Binary switches and modification cassettes in histone biology and beyond
-
Fischle W, Wang Y, Allis CD. (2003). Binary switches and modification cassettes in histone biology and beyond. Nature 425: 475-479.
-
(2003)
Nature
, vol.425
, pp. 475-479
-
-
Fischle, W.1
Wang, Y.2
Allis, C.D.3
-
23
-
-
20244376464
-
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
-
Gonzalo S, Garcia-Cao M, Fraga MF, Schotta G, Peters AH, Cotter SE et al. (2005). Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol 7: 420-428.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 420-428
-
-
Gonzalo, S.1
Garcia-Cao, M.2
Fraga, M.F.3
Schotta, G.4
Peters, A.H.5
Cotter, S.E.6
-
24
-
-
57349172673
-
The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F
-
Gorges LL, Lents NH, Baldassare JJ. (2008). The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F. Am J Physiol Cell Physiol 295: C1151-C1160.
-
(2008)
Am J Physiol Cell Physiol
, vol.295
-
-
Gorges, L.L.1
Lents, N.H.2
Baldassare, J.J.3
-
25
-
-
0027499060
-
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
-
Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal-Ginard B. (1993). Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 72: 309-324.
-
(1993)
Cell
, vol.72
, pp. 309-324
-
-
Gu, W.1
Schneider, J.W.2
Condorelli, G.3
Kaushal, S.4
Mahdavi, V.5
Nadal-Ginard, B.6
-
26
-
-
0034306996
-
The Rb/E2F pathway: Expanding roles and emerging paradigms
-
Harbour JW, Dean DC. (2000). The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev 14: 2393-2409.
-
(2000)
Genes Dev
, vol.14
, pp. 2393-2409
-
-
Harbour, J.W.1
Dean, D.C.2
-
27
-
-
0033578816
-
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
-
Harbour JW, Luo RX, Dei Santi A, Postigo AA, Dean DC. (1999). Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98: 859-869.
-
(1999)
Cell
, vol.98
, pp. 859-869
-
-
Harbour, J.W.1
Luo, R.X.2
Dei Santi, A.3
Postigo, A.A.4
Dean, D.C.5
-
28
-
-
33644850958
-
Heterochromatin protein 1: Don't judge the book by its cover!
-
Hediger F, Gasser SM. (2006). Heterochromatin protein 1: don't judge the book by its cover!. Curr Opin Genet Dev 16: 143-150.
-
(2006)
Curr Opin Genet Dev
, vol.16
, pp. 143-150
-
-
Hediger, F.1
Gasser, S.M.2
-
29
-
-
0029909105
-
Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts
-
Herrera RE, Chen F, Weinberg RA. (1996). Increased histone H1 phosphorylation and relaxed chromatin structure in Rb-deficient fibroblasts. Proc Natl Acad Sci USA 93: 11510-11515.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 11510-11515
-
-
Herrera, R.E.1
Chen, F.2
Weinberg, R.A.3
-
30
-
-
77956340499
-
An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein
-
Hirschi A, Cecchini M, Steinhardt RC, Schamber MR, Dick FA, Rubin SM. (2010). An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein. Nat Struct Mol Biol 17: 1051-1057.
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 1051-1057
-
-
Hirschi, A.1
Cecchini, M.2
Steinhardt, R.C.3
Schamber, M.R.4
Dick, F.A.5
Rubin, S.M.6
-
31
-
-
34247199852
-
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage
-
Inoue Y, Kitagawa M, Taya Y. (2007). Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage. EMBO J 26: 2083-2093.
-
(2007)
EMBO J
, vol.26
, pp. 2083-2093
-
-
Inoue, Y.1
Kitagawa, M.2
Taya, Y.3
-
32
-
-
58149359240
-
Phosphorylation by p38 MAP kinase is required for E2F1 degradation and keratinocyte differentiation
-
Ivanova IA, Nakrieko KA, Dagnino L. (2009). Phosphorylation by p38 MAP kinase is required for E2F1 degradation and keratinocyte differentiation. Oncogene 28: 52-62.
-
(2009)
Oncogene
, vol.28
, pp. 52-62
-
-
Ivanova, I.A.1
Nakrieko, K.A.2
Dagnino, L.3
-
33
-
-
0026702996
-
Effects of an Rb mutation in the mouse
-
Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA. (1992). Effects of an Rb mutation in the mouse. Nature 359: 295-300.
-
(1992)
Nature
, vol.359
, pp. 295-300
-
-
Jacks, T.1
Fazeli, A.2
Schmitt, E.M.3
Bronson, R.T.4
Goodell, M.A.5
Weinberg, R.A.6
-
34
-
-
0036282703
-
The SCF ubiquitin ligase: An extended look
-
Jackson PK, Eldridge AG. (2002). The SCF ubiquitin ligase: an extended look. Mol Cell 9: 923-925.
-
(2002)
Mol Cell
, vol.9
, pp. 923-925
-
-
Jackson, P.K.1
Eldridge, A.G.2
-
35
-
-
0035839136
-
Translating the histone code
-
Jenuwein T, Allis CD. (2001). Translating the histone code. Science 293: 1074-1080.
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
36
-
-
33748065310
-
RB, the conductor that orchestrates life, death and differentiation
-
Khidr L, Chen PL. (2006). RB, the conductor that orchestrates life, death and differentiation. Oncogene 25: 5210-5219.
-
(2006)
Oncogene
, vol.25
, pp. 5210-5219
-
-
Khidr, L.1
Chen, P.L.2
-
37
-
-
0029924241
-
Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites
-
Knudsen ES, Wang JY. (1996). Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J Biol Chem 271: 8313-8320.
-
(1996)
J Biol Chem
, vol.271
, pp. 8313-8320
-
-
Knudsen, E.S.1
Wang, J.Y.2
-
38
-
-
0033796320
-
RB-dependent S-phase response to DNA damage
-
Knudsen KE, Booth D, Naderi S, Sever-Chroneos Z, Fribourg AF, Hunton IC et al. (2000). RB-dependent S-phase response to DNA damage. Mol Cell Biol 20: 7751-7763.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 7751-7763
-
-
Knudsen, K.E.1
Booth, D.2
Naderi, S.3
Sever-Chroneos, Z.4
Fribourg, A.F.5
Hunton, I.C.6
-
39
-
-
77954274181
-
Lysine methylation regulates E2F1-induced cell death
-
Kontaki H, Talianidis I. (2010). Lysine methylation regulates E2F1-induced cell death. Mol Cell 39: 152-160.
-
(2010)
Mol Cell
, vol.39
, pp. 152-160
-
-
Kontaki, H.1
Talianidis, I.2
-
40
-
-
19844383887
-
Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor
-
Ledl A, Schmidt D, Muller S. (2005). Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor. Oncogene 24: 3810-3818.
-
(2005)
Oncogene
, vol.24
, pp. 3810-3818
-
-
Ledl, A.1
Schmidt, D.2
Muller, S.3
-
41
-
-
33746035661
-
P14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation
-
Leduc C, Claverie P, Eymin B, Col E, Khochbin S, Brambilla E et al. (2006). p14ARF promotes RB accumulation through inhibition of its Tip60-dependent acetylation. Oncogene 25: 4147-4154.
-
(2006)
Oncogene
, vol.25
, pp. 4147-4154
-
-
Leduc, C.1
Claverie, P.2
Eymin, B.3
Col, E.4
Khochbin, S.5
Brambilla, E.6
-
42
-
-
33747824464
-
Reverse mutational analysis reveals threonine-373 as a potentially sufficient phosphorylation site for inactivation of the retinoblastoma tumor suppressor protein (pRB)
-
Lents NH, Gorges LL, Baldassare JJ. (2006). Reverse mutational analysis reveals threonine-373 as a potentially sufficient phosphorylation site for inactivation of the retinoblastoma tumor suppressor protein (pRB). Cell Cycle 5: 1699-1707.
-
(2006)
Cell Cycle
, vol.5
, pp. 1699-1707
-
-
Lents, N.H.1
Gorges, L.L.2
Baldassare, J.J.3
-
43
-
-
0035878122
-
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
-
Lin WC, Lin FT, Nevins JR. (2001). Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev 15: 1833-1844.
-
(2001)
Genes Dev
, vol.15
, pp. 1833-1844
-
-
Lin, W.C.1
Lin, F.T.2
Nevins, J.R.3
-
44
-
-
0345352653
-
Regulation of E2F1 by BRCT domain-containing protein TopBP1
-
Liu K, Lin FT, Ruppert JM, Lin WC. (2003). Regulation of E2F1 by BRCT domain-containing protein TopBP1. Mol Cell Biol 23: 3287-3304.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 3287-3304
-
-
Liu, K.1
Lin, F.T.2
Ruppert, J.M.3
Lin, W.C.4
-
45
-
-
1842831271
-
TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival
-
Liu K, Luo Y, Lin FT, Lin WC. (2004). TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Genes Dev 18: 673-686.
-
(2004)
Genes Dev
, vol.18
, pp. 673-686
-
-
Liu, K.1
Luo, Y.2
Lin, F.T.3
Lin, W.C.4
-
46
-
-
74149083175
-
PRb, a local chromatin organizer with global possibilities
-
Longworth MS, Dyson NJ. (2010). pRb, a local chromatin organizer with global possibilities. Chromosoma 119: 1-11.
-
(2010)
Chromosoma
, vol.119
, pp. 1-11
-
-
Longworth, M.S.1
Dyson, N.J.2
-
47
-
-
0347520938
-
Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A
-
Lowe ED, Tews I, Cheng KY, Brown NR, Gul S, Noble ME et al. (2002). Specificity determinants of recruitment peptides bound to phospho-CDK2/cyclin A. Biochemistry 41: 15625-15634.
-
(2002)
Biochemistry
, vol.41
, pp. 15625-15634
-
-
Lowe, E.D.1
Tews, I.2
Cheng, K.Y.3
Brown, N.R.4
Gul, S.5
Noble, M.E.6
-
50
-
-
33645830066
-
DNA-damage-responsive acetylation of pRb regulates binding to E2F-1
-
Markham D, Munro S, Soloway J, O'Connor DP, La Thangue NB. (2006). DNA-damage-responsive acetylation of pRb regulates binding to E2F-1. EMBO Rep 7: 192-198.
-
(2006)
EMBO Rep
, vol.7
, pp. 192-198
-
-
Markham, D.1
Munro, S.2
Soloway, J.3
O'Connor, D.P.4
La Thangue, N.B.5
-
51
-
-
0035836772
-
P19ARF targets certain E2F species for degradation
-
Martelli F, Hamilton T, Silver DP, Sharpless NE, Bardeesy N, Rokas M et al. (2001). p19ARF targets certain E2F species for degradation. Proc Natl Acad Sci USA 98: 4455-4460.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4455-4460
-
-
Martelli, F.1
Hamilton, T.2
Silver, D.P.3
Sharpless, N.E.4
Bardeesy, N.5
Rokas, M.6
-
52
-
-
0033130137
-
Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation
-
Marti A, Wirbelauer C, Scheffner M, Krek W. (1999). Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation. Nat Cell Biol 1: 14-19.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 14-19
-
-
Marti, A.1
Wirbelauer, C.2
Scheffner, M.3
Krek, W.4
-
53
-
-
27644589675
-
The diverse functions of histone lysine methylation
-
Martin C, Zhang Y. (2005). The diverse functions of histone lysine methylation. Nat Rev Mol Cell Biol 6: 838-849.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 838-849
-
-
Martin, C.1
Zhang, Y.2
-
54
-
-
0343484254
-
Regulation of E2F1 activity by acetylation
-
Martinez-Balbas MA, Bauer UM, Nielsen SJ, Brehm A, Kouzarides T. (2000). Regulation of E2F1 activity by acetylation. EMBO J 19: 662-671.
-
(2000)
EMBO J
, vol.19
, pp. 662-671
-
-
Martinez-Balbas, M.A.1
Bauer, U.M.2
Nielsen, S.J.3
Brehm, A.4
Kouzarides, T.5
-
55
-
-
0034646630
-
E2F family members are differentially regulated by reversible acetylation
-
Marzio G, Wagener C, Gutierrez MI, Cartwright P, Helin K, Giacca M. (2000). E2F family members are differentially regulated by reversible acetylation. J Biol Chem 275: 10887-10892.
-
(2000)
J Biol Chem
, vol.275
, pp. 10887-10892
-
-
Marzio, G.1
Wagener, C.2
Gutierrez, M.I.3
Cartwright, P.4
Helin, K.5
Giacca, M.6
-
56
-
-
77955858336
-
Posttranslational modification of p53: Cooperative integrators of function
-
Meek DW, Anderson CW. (2009). Posttranslational modification of p53: cooperative integrators of function. Cold Spring Harb Perspect Biol 1: a000950.
-
(2009)
Cold Spring Harb Perspect Biol
, vol.1
-
-
Meek, D.W.1
Anderson, C.W.2
-
57
-
-
36849095082
-
L3MBTL1 recognition of mono-and dimethylated histones
-
Min J, Allali-Hassani A, Nady N, Qi C, Ouyang H, Liu Y et al. (2007). L3MBTL1 recognition of mono-and dimethylated histones. Nat Struct Mol Biol 14: 1229-1230.
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 1229-1230
-
-
Min, J.1
Allali-Hassani, A.2
Nady, N.3
Qi, C.4
Ouyang, H.5
Liu, Y.6
-
58
-
-
0031935648
-
Control of pRB phosphorylation
-
Mittnacht S. (1998). Control of pRB phosphorylation. Curr Opin Genet Dev 8: 21-27.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 21-27
-
-
Mittnacht, S.1
-
59
-
-
0034458872
-
Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle
-
Miyake S, Sellers WR, Safran M, Li X, Zhao W, Grossman SR et al. (2000). Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle. Mol Cell Biol 20: 8889-8902.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8889-8902
-
-
Miyake, S.1
Sellers, W.R.2
Safran, M.3
Li, X.4
Zhao, W.5
Grossman, S.R.6
-
60
-
-
0035286622
-
SUMO, ubiquitin's mysterious cousin
-
Muller S, Hoege C, Pyrowolakis G, Jentsch S. (2001). SUMO, ubiquitin's mysterious cousin. Nat Rev Mol Cell Biol 2: 202-210.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 202-210
-
-
Muller, S.1
Hoege, C.2
Pyrowolakis, G.3
Jentsch, S.4
-
61
-
-
1942437991
-
SUMO: A regulator of gene expression and genome integrity
-
Muller S, Ledl A, Schmidt D. (2004). SUMO: a regulator of gene expression and genome integrity. Oncogene 23: 1998-2008.
-
(2004)
Oncogene
, vol.23
, pp. 1998-2008
-
-
Muller, S.1
Ledl, A.2
Schmidt, D.3
-
62
-
-
77951623834
-
Lysine methylation regulates the pRb tumour suppressor protein
-
Munro S, Khaire N, Inche A, Carr S, La Thangue NB. (2010). Lysine methylation regulates the pRb tumour suppressor protein. Oncogene 29: 2357-2367.
-
(2010)
Oncogene
, vol.29
, pp. 2357-2367
-
-
Munro, S.1
Khaire, N.2
Inche, A.3
Carr, S.4
La Thangue, N.B.5
-
63
-
-
0141841682
-
Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of p38 and cyclin-dependent kinases
-
Nath N, Wang S, Betts V, Knudsen E, Chellappan S. (2003). Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of p38 and cyclin-dependent kinases. Oncogene 22: 5986-5994.
-
(2003)
Oncogene
, vol.22
, pp. 5986-5994
-
-
Nath, N.1
Wang, S.2
Betts, V.3
Knudsen, E.4
Chellappan, S.5
-
64
-
-
2342569733
-
Acetylation regulates the differentiation-specific functions of the retinoblastoma protein
-
Nguyen DX, Baglia LA, Huang SM, Baker CM, McCance DJ. (2004). Acetylation regulates the differentiation-specific functions of the retinoblastoma protein. EMBO J 23: 1609-1618.
-
(2004)
EMBO J
, vol.23
, pp. 1609-1618
-
-
Nguyen, D.X.1
Baglia, L.A.2
Huang, S.M.3
Baker, C.M.4
McCance, D.J.5
-
65
-
-
0038142184
-
Differential regulation of E2F1 apoptotic target genes in response to DNA damage
-
Pediconi N, Ianari A, Costanzo A, Belloni L, Gallo R, Cimino L et al. (2003). Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat Cell Biol 5: 552-558.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 552-558
-
-
Pediconi, N.1
Ianari, A.2
Costanzo, A.3
Belloni, L.4
Gallo, R.5
Cimino, L.6
-
66
-
-
78149304022
-
Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation
-
Pickard A, Wong PP, McCance DJ. (2010). Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. J Cell Sci 123: 3718-3726.
-
(2010)
J Cell Sci
, vol.123
, pp. 3718-3726
-
-
Pickard, A.1
Wong, P.P.2
McCance, D.J.3
-
67
-
-
9744227183
-
Ubiquitin: Structures, functions, mechanisms
-
Pickart CM, Eddins MJ. (2004). Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta 1695: 55-72.
-
(2004)
Biochim Biophys Acta
, vol.1695
, pp. 55-72
-
-
Pickart, C.M.1
Eddins, M.J.2
-
68
-
-
54049120956
-
E2F-at the crossroads of life and death
-
Polager S, Ginsberg D. (2008). E2F-at the crossroads of life and death. Trends Cell Biol 18: 528-535.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 528-535
-
-
Polager, S.1
Ginsberg, D.2
-
69
-
-
0031310741
-
Differential roles of p300 and PCAF acetyltransferases in muscle differentiation
-
Puri PL, Sartorelli V, Yang XJ, Hamamori Y, Ogryzko VV, Howard BH et al. (1997). Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol Cell 1: 35-45.
-
(1997)
Mol Cell
, vol.1
, pp. 35-45
-
-
Puri, P.L.1
Sartorelli, V.2
Yang, X.J.3
Hamamori, Y.4
Ogryzko, V.V.5
Howard, B.H.6
-
70
-
-
28944437358
-
Structure of the Rb C-terminal domain bound to E2F1-DP1: A mechanism for phosphorylation-induced E2F release
-
Rubin SM, Gall AL, Zheng N, Pavletich NP. (2005). Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell 123: 1093-1106.
-
(2005)
Cell
, vol.123
, pp. 1093-1106
-
-
Rubin, S.M.1
Gall, A.L.2
Zheng, N.3
Pavletich, N.P.4
-
71
-
-
78349236076
-
Methylation of the retinoblastoma tumor suppressor by SMYD2
-
Saddic LA, West LE, Aslanian A, Yates 3rd JR, Rubin SM, Gozani O et al. (2010). Methylation of the retinoblastoma tumor suppressor by SMYD2. J Biol Chem 285: 37733-37740.
-
(2010)
J Biol Chem
, vol.285
, pp. 37733-37740
-
-
Saddic, L.A.1
West, L.E.2
Aslanian, A.3
Yates Iii., J.R.4
Rubin, S.M.5
Gozani, O.6
-
72
-
-
77954644399
-
E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity
-
Sahin F, Sladek TL. (2010). E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity. Int J Biol Sci 6: 382-395.
-
(2010)
Int J Biol Sci
, vol.6
, pp. 382-395
-
-
Sahin, F.1
Sladek, T.L.2
-
73
-
-
0032167631
-
Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A
-
Schulman BA, Lindstrom DL, Harlow E. (1998). Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci USA 95: 10453-10458.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 10453-10458
-
-
Schulman, B.A.1
Lindstrom, D.L.2
Harlow, E.3
-
74
-
-
0034660892
-
The Pezcoller lecture: Cancer cell cycles revisited
-
Sherr CJ. (2000). The Pezcoller lecture: cancer cell cycles revisited. Cancer Res 60: 3689-3695.
-
(2000)
Cancer Res
, vol.60
, pp. 3689-3695
-
-
Sherr, C.J.1
-
75
-
-
8644219655
-
Living with or without cyclins and cyclin-dependent kinases
-
Sherr CJ, Roberts JM. (2004). Living with or without cyclins and cyclin-dependent kinases. Genes Dev 18: 2699-2711.
-
(2004)
Genes Dev
, vol.18
, pp. 2699-2711
-
-
Sherr, C.J.1
Roberts, J.M.2
-
76
-
-
52449132322
-
Is there a code embedded in proteins that is based on post-translational modifications?
-
Sims 3rd RJ, Reinberg D. (2008). Is there a code embedded in proteins that is based on post-translational modifications? Nat Rev Mol Cell Biol 9: 815-820.
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 815-820
-
-
Sims Iii., R.J.1
Reinberg, D.2
-
77
-
-
0037445901
-
E2F and cell cycle control: A double-edged sword
-
Stevens C, La Thangue NB. (2003). E2F and cell cycle control: a double-edged sword. Arch Biochem Biophys 412: 157-169.
-
(2003)
Arch Biochem Biophys
, vol.412
, pp. 157-169
-
-
Stevens, C.1
La Thangue, N.B.2
-
79
-
-
0026329868
-
Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering
-
Templeton DJ, Park SH, Lanier L, Weinberg RA. (1991). Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering. Proc Natl Acad Sci USA 88: 3033-3037.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 3033-3037
-
-
Templeton, D.J.1
Park, S.H.2
Lanier, L.3
Weinberg, R.A.4
-
81
-
-
0029997146
-
The CBP co-activator stimulates E2F1/DP1 activity
-
Trouche D, Cook A, Kouzarides T. (1996). The CBP co-activator stimulates E2F1/DP1 activity. Nucleic Acids Res 24: 4139-4145.
-
(1996)
Nucleic Acids Res
, vol.24
, pp. 4139-4145
-
-
Trouche, D.1
Cook, A.2
Kouzarides, T.3
-
82
-
-
19944431662
-
Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation
-
Uchida C, Miwa S, Kitagawa K, Hattori T, Isobe T, Otani S et al. (2005). Enhanced Mdm2 activity inhibits pRB function via ubiquitin-dependent degradation. EMBO J 24: 160-169.
-
(2005)
EMBO J
, vol.24
, pp. 160-169
-
-
Uchida, C.1
Miwa, S.2
Kitagawa, K.3
Hattori, T.4
Isobe, T.5
Otani, S.6
-
83
-
-
11144241301
-
A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis
-
Wang B, Liu K, Lin FT, Lin WC. (2004). A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem 279: 54140-54152.
-
(2004)
J Biol Chem
, vol.279
, pp. 54140-54152
-
-
Wang, B.1
Liu, K.2
Lin, F.T.3
Lin, W.C.4
-
84
-
-
0033559703
-
Regulation of Rb and E2F by signal transduction cascades: Divergent effects of JNK1 and p38 kinases
-
Wang S, Nath N, Minden A, Chellappan S. (1999). Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases. EMBO J 18: 1559-1570.
-
(1999)
EMBO J
, vol.18
, pp. 1559-1570
-
-
Wang, S.1
Nath, N.2
Minden, A.3
Chellappan, S.4
-
85
-
-
0029033861
-
The retinoblastoma protein and cell cycle control
-
Weinberg RA. (1995). The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
-
(1995)
Cell
, vol.81
, pp. 323-330
-
-
Weinberg, R.A.1
-
86
-
-
77952566949
-
Mechanisms, regulation and consequences of protein SUMOylation
-
Wilkinson KA, Henley JM. (2010). Mechanisms, regulation and consequences of protein SUMOylation. Biochem J 428: 133-145.
-
(2010)
Biochem J
, vol.428
, pp. 133-145
-
-
Wilkinson, K.A.1
Henley, J.M.2
-
87
-
-
35748949600
-
Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1
-
Wong S, Weber JD. (2007). Deacetylation of the retinoblastoma tumour suppressor protein by SIRT1. Biochem J 407: 451-460.
-
(2007)
Biochem J
, vol.407
, pp. 451-460
-
-
Wong, S.1
Weber, J.D.2
-
88
-
-
0029028354
-
Interaction between the retinoblastoma protein and the oncoprotein MDM2
-
Xiao ZX, Chen J, Levine AJ, Modjtahedi N, Xing J, Sellers WR et al. (1995). Interaction between the retinoblastoma protein and the oncoprotein MDM2. Nature 375: 694-698.
-
(1995)
Nature
, vol.375
, pp. 694-698
-
-
Xiao, Z.X.1
Chen, J.2
Levine, A.J.3
Modjtahedi, N.4
Xing, J.5
Sellers, W.R.6
-
89
-
-
0028019279
-
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNAbinding activity of E2F-1/DP-1 by phosphorylation
-
Xu M, Sheppard KA, Peng CY, Yee AS, Piwnica-Worms H. (1994). Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNAbinding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol 14: 8420-8431.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 8420-8431
-
-
Xu, M.1
Sheppard, K.A.2
Peng, C.Y.3
Yee, A.S.4
Piwnica-Worms, H.5
-
90
-
-
7044250740
-
Lysine acetylation and the bromodomain: A new partnership for signaling
-
Yang XJ. (2004). Lysine acetylation and the bromodomain: a new partnership for signaling. Bioessays 26: 1076-1087.
-
(2004)
Bioessays
, vol.26
, pp. 1076-1087
-
-
Yang, X.J.1
-
91
-
-
60549094272
-
The p38(MAPK) signaling pathway regulates neuronal apoptosis through the phosphorylation of the retinoblastoma protein
-
Yeste-Velasco M, Folch J, Pallas M, Camins A. (2009). The p38(MAPK) signaling pathway regulates neuronal apoptosis through the phosphorylation of the retinoblastoma protein. Neurochem Int 54: 99-105.
-
(2009)
Neurochem Int
, vol.54
, pp. 99-105
-
-
Yeste-Velasco, M.1
Folch, J.2
Pallas, M.3
Camins, A.4
-
92
-
-
0030918714
-
Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases
-
Zarkowska T, Mittnacht S. (1997). Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J Biol Chem 272: 12738-12746.
-
(1997)
J Biol Chem
, vol.272
, pp. 12738-12746
-
-
Zarkowska, T.1
Mittnacht, S.2
-
93
-
-
0035883954
-
Transcription regulation by histone methylation: Interplay between different covalent modifications of the core histone tails
-
Zhang Y, Reinberg D. (2001). Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev 15: 2343-2360.
-
(2001)
Genes Dev
, vol.15
, pp. 2343-2360
-
-
Zhang, Y.1
Reinberg, D.2
-
94
-
-
27944478688
-
Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway
-
Zhang Z, Wang H, Li M, Rayburn ER, Agrawal S, Zhang R. (2005). Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway. Oncogene 24: 7238-7247.
-
(2005)
Oncogene
, vol.24
, pp. 7238-7247
-
-
Zhang, Z.1
Wang, H.2
Li, M.3
Rayburn, E.R.4
Agrawal, S.5
Zhang, R.6
|