Purinergic signaling via P2X7 receptor mediates IL-1β production in Kupffer cells exposed to silica nanoparticle

Toxicology

Volumn 321, Issue 1, 2014, Pages 13-20

  Kojima, Shuji ^a   Negishi, Yusuke ^a   Tsukimoto, Mitsutoshi ^a   Takenouchi, Takato ^b   Kitani, Hiroshi ^b   Takeda, Ken ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

Author keywords

ATP; IL 1 ; Inflammasome; Kupffer cell; Silica nanoparticle

Indexed keywords

3 [[5 (2,3 DICHLOROPHENYL) 1H TETRAZOL 1 YL]METHYL]PYRIDINE; ADENOSINE TRIPHOSPHATE; APYRASE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NANOPARTICLE; PURINERGIC P2X7 RECEPTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SILICA NANOPARTICLE; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CELL MEMBRANE; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; KUPFFER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ATP; IL-1Β; INFLAMMASOME; KUPFFER CELL; P2X(7) RECEPTOR; SILICA NANOPARTICLE;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-1BETA; KUPFFER CELLS; LIPOPOLYSACCHARIDES; MICE; NANOPARTICLES; POLYMORPHISM, SINGLE NUCLEOTIDE; PRIMARY CELL CULTURE; REACTIVE OXYGEN SPECIES; RECEPTORS, PURINERGIC P2X7; SILICON DIOXIDE;

EID: 84898681803     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.03.008     Document Type: Article

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