메뉴 건너뛰기




Volumn 36, Issue 2, 2014, Pages 597-611

Long-term high-fat consumption leads to downregulation of Akt phosphorylation of eNOS at Ser1177 and upregulation of Sirtuin-1 expression in rat cavernous tissue

Author keywords

Aging; Cavernous tissue; Energy restriction; High fat diet; Nitric oxide synthase; Sirtuin 1

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROTEIN KINASE B; SERINE; SIRTUIN 1;

EID: 84898662208     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-013-9591-2     Document Type: Article
Times cited : (15)

References (75)
  • 1
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: A joint interim statement of the international diabetes federation task force on epidemiology and prevention; National heart, lung, and blood institute; American heart association; World heart federation; International atherosclerosis society; And international association for the study of obesity
    • 1:CAS:528:DC%2BD1MXht1OrtrrK 19805654 10.1161/CIRCULATIONAHA.109.192644
    • Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr (2009) Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation 120:1640-1645
    • (2009) Circulation , vol.120 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3    Zimmet, P.Z.4    Cleeman, J.I.5    Donato, K.A.6    Fruchart, J.C.7    James, W.P.8    Loria, C.M.9    Smith, Jr.S.C.10
  • 3
    • 74049092278 scopus 로고    scopus 로고
    • Endothelial dysfunction and erectile dysfunction in the aging man
    • 20002226 10.1111/j.1442-2042.2009.02426.x
    • Aversa A, Bruzziches R, Francomano D, Natali M, Gareri P, Spera G (2010) Endothelial dysfunction and erectile dysfunction in the aging man. Int J Urol 17:38-47
    • (2010) Int J Urol , vol.17 , pp. 38-47
    • Aversa, A.1    Bruzziches, R.2    Francomano, D.3    Natali, M.4    Gareri, P.5    Spera, G.6
  • 4
    • 1942501869 scopus 로고    scopus 로고
    • Effect of chronic ischemia on constitutive and inducible nitric oxide synthase expression in erectile tissue
    • 1:CAS:528:DC%2BD2cXjvFymu7k%3D 15064316
    • Azadzoi KM, Master TA, Siroky MB (2004) Effect of chronic ischemia on constitutive and inducible nitric oxide synthase expression in erectile tissue. J Androl 25:382-388
    • (2004) J Androl , vol.25 , pp. 382-388
    • Azadzoi, K.M.1    Master, T.A.2    Siroky, M.B.3
  • 5
  • 6
    • 0037772382 scopus 로고    scopus 로고
    • Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase
    • 1:CAS:528:DC%2BD3sXjtVCmur0%3D 12591925 10.1074/jbc.M211926200
    • Bauer PM, Fulton D, Boo YC, Sorescu GP, Kemp BE, Jo H, Sessa WC (2003) Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem 278:14841-14849
    • (2003) J Biol Chem , vol.278 , pp. 14841-14849
    • Bauer, P.M.1    Fulton, D.2    Boo, Y.C.3    Sorescu, G.P.4    Kemp, B.E.5    Jo, H.6    Sessa, W.C.7
  • 7
    • 43649083208 scopus 로고    scopus 로고
    • Erectile dysfunction as a harbinger for increased cardiometabolic risk
    • 1:STN:280:DC%2BD1czgvFajtA%3D%3D 18200018 10.1038/sj.ijir.3901634
    • Billups KL, Bank AJ, Padma-Nathan H, Katz SD, Williams RA (2008) Erectile dysfunction as a harbinger for increased cardiometabolic risk. Int J Impot Res 20:236-242
    • (2008) Int J Impot Res , vol.20 , pp. 236-242
    • Billups, K.L.1    Bank, A.J.2    Padma-Nathan, H.3    Katz, S.D.4    Williams, R.A.5
  • 8
    • 0036479305 scopus 로고    scopus 로고
    • Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: Role of protein kinase
    • 1:CAS:528:DC%2BD38XhtVaktr8%3D 10.1074/jbc.M108789200
    • Boo YC, Sorescu G, Boyd N, Shiojima I, Walsh K, Du J, Jo H (2002) Shear stress stimulates phosphorylation of endothelial nitric-oxide synthase at Ser1179 by Akt-independent mechanisms: role of protein kinase. Am J Biol Chem 277:3388-3396
    • (2002) Am J Biol Chem , vol.277 , pp. 3388-3396
    • Boo, Y.C.1    Sorescu, G.2    Boyd, N.3    Shiojima, I.4    Walsh, K.5    Du, J.6    Jo, H.7
  • 9
    • 84879161229 scopus 로고    scopus 로고
    • A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance
    • 1:CAS:528:DC%2BC3sXhtVyjtLvP 23604708 10.1152/ajpheart.00631.2012
    • Bosse JD, Lin HY, Sloan C, Zhang QJ, Abel ED, Pereira TJ, Dolinsky VW, Symons JD, Jalili T (2013) A low-carbohydrate/high-fat diet reduces blood pressure in spontaneously hypertensive rats without deleterious changes in insulin resistance. Am J Physiol Heart Circ Physiol 304:H1733-H1742
    • (2013) Am J Physiol Heart Circ Physiol , vol.304
    • Bosse, J.D.1    Lin, H.Y.2    Sloan, C.3    Zhang, Q.J.4    Abel, E.D.5    Pereira, T.J.6    Dolinsky, V.W.7    Symons, J.D.8    Jalili, T.9
  • 10
    • 34248393099 scopus 로고    scopus 로고
    • High-fat diets: Modeling the metabolic disorders of human obesity in rodents
    • 1:CAS:528:DC%2BD2sXlt12ks7s%3D 10.1038/oby.2007.608
    • Buettner R, Schölmerich J, Bollheimer LC (2007) High-fat diets: modeling the metabolic disorders of human obesity in rodents. Obesity (Silver Spring) 15:798-808
    • (2007) Obesity (Silver Spring) , vol.15 , pp. 798-808
    • Buettner, R.1    Schölmerich, J.2    Bollheimer, L.C.3
  • 11
    • 0034681455 scopus 로고    scopus 로고
    • Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases
    • 1:CAS:528:DC%2BD3cXhsVymt70%3D 10671564 10.1074/jbc.275.7.5179
    • Butt E, Bernhardt M, Smolenski A, Kotsonis P, Fröhlich LG, Sickmann A, Meyer HE, Lohmann SM, Schmidt HH (2000) Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases. J Biol Chem 275:5179-5187
    • (2000) J Biol Chem , vol.275 , pp. 5179-5187
    • Butt, E.1    Bernhardt, M.2    Smolenski, A.3    Kotsonis, P.4    Fröhlich, L.G.5    Sickmann, A.6    Meyer, H.E.7    Lohmann, S.M.8    Schmidt, H.H.9
  • 12
    • 84866346582 scopus 로고    scopus 로고
    • Differential modulation of nitric oxide synthases in aging: Therapeutic opportunities
    • 1:CAS:528:DC%2BC38XhtVCqtr%2FK 3382417 22737132
    • Cau SB, Carneiro FS, Tostes RC (2012) Differential modulation of nitric oxide synthases in aging: therapeutic opportunities. Front Physiol 3:218
    • (2012) Front Physiol , vol.3 , pp. 218
    • Cau, S.B.1    Carneiro, F.S.2    Tostes, R.C.3
  • 15
    • 84863309943 scopus 로고    scopus 로고
    • Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence
    • 1:CAS:528:DC%2BC38XpvVeisLY%3D 22744176 10.1007/s11427-012-4329-4
    • Chen H, Wan Y, Zhou S, Lu Y, Zhang Z, Zhang R, Chen F, Hao D, Zhao X, Guo Z, Liu D, Liang C (2012) Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence. Sci China Life Sci 55:467-473
    • (2012) Sci China Life Sci , vol.55 , pp. 467-473
    • Chen, H.1    Wan, Y.2    Zhou, S.3    Lu, Y.4    Zhang, Z.5    Zhang, R.6    Chen, F.7    Hao, D.8    Zhao, X.9    Guo, Z.10    Liu, D.11    Liang, C.12
  • 16
    • 74049141326 scopus 로고    scopus 로고
    • Erectile dysfunction as a predictor for subsequent atherosclerotic events: Findings from a linked-data study
    • 19912508 10.1111/j.1743-6109.2009.01576.x
    • Chew KK, Finn J, Stuckey B, Gibson N, Sanfilippo F, Bremner A, Thompson P, Hobbs M, Jamrozik K (2010) Erectile dysfunction as a predictor for subsequent atherosclerotic events: findings from a linked-data study. J Sex Med 7:192-202
    • (2010) J Sex Med , vol.7 , pp. 192-202
    • Chew, K.K.1    Finn, J.2    Stuckey, B.3    Gibson, N.4    Sanfilippo, F.5    Bremner, A.6    Thompson, P.7    Hobbs, M.8    Jamrozik, K.9
  • 17
    • 0037112204 scopus 로고    scopus 로고
    • Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction
    • 1:CAS:528:DC%2BD38XpsVWjuro%3D 12424787 10.1002/jemt.10203
    • Chung HY, Kim HJ, Kim JW, Choi JS, Yu BP (2002) Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc Res Tech 59:264-272
    • (2002) Microsc Res Tech , vol.59 , pp. 264-272
    • Chung, H.Y.1    Kim, H.J.2    Kim, J.W.3    Choi, J.S.4    Yu, B.P.5
  • 18
    • 0037076784 scopus 로고    scopus 로고
    • Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function
    • 1:CAS:528:DC%2BD38XkvV2gsLs%3D 12065318 10.1161/01.RES.0000020401.61826. EA
    • Csiszar A, Kaminski P, Wolin MS, Koller A, Kaley G (2002) Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res 90:1159-1166
    • (2002) Circ Res , vol.90 , pp. 1159-1166
    • Csiszar, A.1    Kaminski, P.2    Wolin, M.S.3    Koller, A.4    Kaley, G.5
  • 19
    • 55449136486 scopus 로고    scopus 로고
    • Inflammation and endothelial dysfunction during aging: Role of NF-kappaB
    • 1:CAS:528:DC%2BD1cXht1KqurzK 2576023 18599677 10.1152/japplphysiol.90470. 2008
    • Csiszar A, Wang M, Lakatta EG, Ungvari Z (2008) Inflammation and endothelial dysfunction during aging: role of NF-kappaB. J Appl Physiol 105:1333-1341
    • (2008) J Appl Physiol , vol.105 , pp. 1333-1341
    • Csiszar, A.1    Wang, M.2    Lakatta, E.G.3    Ungvari, Z.4
  • 20
    • 67650659852 scopus 로고    scopus 로고
    • Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
    • 1:CAS:528:DC%2BD1MXptVShtrY%3D 10.1016/j.mad.2009.06.004
    • Csiszar A, Labinskyya N, Jimeneza R, Pinto JT, Ballabh P, Losonczy G, Pearson KJ, de Cabo R, Ungvari Z (2009) Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Age Dev 130:518-527
    • (2009) Mech Age Dev , vol.130 , pp. 518-527
    • Csiszar, A.1    Labinskyya, N.2    Jimeneza, R.3    Pinto, J.T.4    Ballabh, P.5    Losonczy, G.6    Pearson, K.J.7    De Cabo, R.8    Ungvari, Z.9
  • 21
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • 1:CAS:528:DyaK1MXjvFegu7s%3D 10376603 10.1038/21224
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 22
    • 0033067451 scopus 로고    scopus 로고
    • Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model
    • 1:STN:280:DyaK1Mzjt1emsw%3D%3D 10404280 10.1038/sj.ijir.3900392
    • El-Sakka AI, Lin CS, Chui RM, Dahiya R, Lue TF (1999) Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model. Int J Impot Res 11:123-132
    • (1999) Int J Impot Res , vol.11 , pp. 123-132
    • El-Sakka, A.I.1    Lin, C.S.2    Chui, R.M.3    Dahiya, R.4    Lue, T.F.5
  • 24
    • 2342647592 scopus 로고    scopus 로고
    • Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
    • 1:CAS:528:DC%2BD2cXjvVyiu7c%3D 404101 15096581 10.1073/pnas.0308291101
    • Fontana L, Meyer TE, Klein S, Holloszy JO (2004) Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. PNAS 101:6659-6663
    • (2004) PNAS , vol.101 , pp. 6659-6663
    • Fontana, L.1    Meyer, T.E.2    Klein, S.3    Holloszy, J.O.4
  • 25
    • 77952671803 scopus 로고    scopus 로고
    • Erectile dysfunction in a Mediterranean country: Results of an epidemiological survey of a representative sample of men
    • 1:STN:280:DC%2BC3czivFensA%3D%3D 20090762 10.1038/ijir.2009.65
    • Ghalayini IF, Al-Ghazo MA, Al-Azab R, Bani-Hani I, Matani YS, Barham AE, Harfeil MN, Haddad Y (2010) Erectile dysfunction in a Mediterranean country: results of an epidemiological survey of a representative sample of men. Int J Impot Res 22:196-203
    • (2010) Int J Impot Res , vol.22 , pp. 196-203
    • Ghalayini, I.F.1    Al-Ghazo, M.A.2    Al-Azab, R.3    Bani-Hani, I.4    Matani, Y.S.5    Barham, A.E.6    Harfeil, M.N.7    Haddad, Y.8
  • 27
    • 15744381294 scopus 로고    scopus 로고
    • Hypoadiponectinemia is caused by chronic blockade of nitric oxide synthesis in rats
    • 1:CAS:528:DC%2BD2MXis1Gqs74%3D 15798955 10.1016/j.metabol.2004.10.017
    • Hattori S, Hattori Y, Kasai K (2005) Hypoadiponectinemia is caused by chronic blockade of nitric oxide synthesis in rats. Metabolism 54:482-487
    • (2005) Metabolism , vol.54 , pp. 482-487
    • Hattori, S.1    Hattori, Y.2    Kasai, K.3
  • 28
    • 68149137621 scopus 로고    scopus 로고
    • ENOS, metabolic syndrome and cardiovascular disease
    • 1:CAS:528:DC%2BD1MXps1Sqsrk%3D 2731551 19647446 10.1016/j.tem.2009.03.005
    • Huang PL (2009) eNOS, metabolic syndrome and cardiovascular disease. Trends Endocrinol Metab 20:295-302
    • (2009) Trends Endocrinol Metab , vol.20 , pp. 295-302
    • Huang, P.L.1
  • 29
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • 1:CAS:528:DyaL1cXht12hsr8%3D 299734 2827174 10.1073/pnas.84.24.9265
    • Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G (1987) Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. PNAS 84:9265-9269
    • (1987) PNAS , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1    Buga, G.M.2    Wood, K.S.3    Byrns, R.E.4    Chaudhuri, G.5
  • 33
    • 33646178955 scopus 로고    scopus 로고
    • Reciprocal relationships between insulin resistance and endothelial dysfunction: Molecular and pathophysiological mechanisms
    • 16618833 10.1161/CIRCULATIONAHA.105.563213
    • Kim JA, Montagnani M, Koh KK, Quon MJ (2006) Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 113:1888-1904
    • (2006) Circulation , vol.113 , pp. 1888-1904
    • Kim, J.A.1    Montagnani, M.2    Koh, K.K.3    Quon, M.J.4
  • 34
    • 59449094091 scopus 로고    scopus 로고
    • Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase
    • 1:CAS:528:DC%2BD1MXjtFOhsA%3D%3D 2615500 18990685 10.1074/jbc.M805301200
    • Kondo M, Shibata R, Miura R, Shimano M, Kondo K, Li P, Ohashi T, Kihara S, Maeda N, Walsh K, Ouchi N, Murohara T (2009) Caloric restriction stimulates revascularization in response to ischemia via adiponectin-mediated activation of endothelial nitric-oxide synthase. J Biol Chem 284:1718-1724
    • (2009) J Biol Chem , vol.284 , pp. 1718-1724
    • Kondo, M.1    Shibata, R.2    Miura, R.3    Shimano, M.4    Kondo, K.5    Li, P.6    Ohashi, T.7    Kihara, S.8    Maeda, N.9    Walsh, K.10    Ouchi, N.11    Murohara, T.12
  • 35
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriphage T4
    • 1:CAS:528:DC%2BD3MXlsFags7s%3D 5432063 10.1038/227680a0
    • Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriphage T4. Nature 227:680-685
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 36
    • 36549042103 scopus 로고    scopus 로고
    • Adipokines as emerging mediators of immune response and inflammation
    • 1:CAS:528:DC%2BD2sXhtlCqsr%2FF 18037931 10.1038/ncprheum0674
    • Lago F, Dieguez C, Gómez-Reino J, Gualillo O (2007) Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol 3:716-724
    • (2007) Nat Clin Pract Rheumatol , vol.3 , pp. 716-724
    • Lago, F.1    Dieguez, C.2    Gómez-Reino, J.3    Gualillo, O.4
  • 38
    • 66849111706 scopus 로고    scopus 로고
    • Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: Translational implications for atherosclerosis
    • 1:CAS:528:DC%2BD1MXnsVCltbs%3D 19351806 10.1152/ajpendo.90780.2008
    • Lovren F, Pan Y, Shukla PC, Quan A, Teoh H, Szmitko PE, Peterson MD, Gupta M, Al-Omran M, Verma S (2009) Visfatin activates eNOS via Akt and MAP kinases and improves endothelial cell function and angiogenesis in vitro and in vivo: translational implications for atherosclerosis. Am J Physiol Endocrinol Metab 296:E1440-E1449
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Lovren, F.1    Pan, Y.2    Shukla, P.C.3    Quan, A.4    Teoh, H.5    Szmitko, P.E.6    Peterson, M.D.7    Gupta, M.8    Al-Omran, M.9    Verma, S.10
  • 40
    • 35549008884 scopus 로고    scopus 로고
    • SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
    • 1:CAS:528:DC%2BD2sXhtVOnsLrL 1976244 17785417 10.1073/pnas.0704329104
    • Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, DeRicco J, Kasuno K, Irani K (2007) SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. PNAS 104:14855-14860
    • (2007) PNAS , vol.104 , pp. 14855-14860
    • Mattagajasingh, I.1    Kim, C.S.2    Naqvi, A.3    Yamamori, T.4    Hoffman, T.A.5    Jung, S.B.6    Dericco, J.7    Kasuno, K.8    Irani, K.9
  • 41
    • 0037752795 scopus 로고    scopus 로고
    • Is erectile dysfunction the "tip of iceberg" of a systemic vascular disease?
    • 12932935 10.1016/S0302-2838(03)00307-5
    • Montorsi P, Montorsi F, Schullman CC (2003) Is erectile dysfunction the "tip of iceberg" of a systemic vascular disease? Eur Urol 44:352-354
    • (2003) Eur Urol , vol.44 , pp. 352-354
    • Montorsi, P.1    Montorsi, F.2    Schullman, C.C.3
  • 42
    • 33748311881 scopus 로고    scopus 로고
    • Association between erectile dysfunction and coronary artery disease: Matching the right target with the right test in the right patient
    • 16901623 10.1016/j.eururo.2006.07.015
    • Montorsi P, Ravagnani PM, Galli S, Salonia A, Briganti A, Werba JP, Montorsi F (2006) Association between erectile dysfunction and coronary artery disease: matching the right target with the right test in the right patient. Eur Urol 50:721-731
    • (2006) Eur Urol , vol.50 , pp. 721-731
    • Montorsi, P.1    Ravagnani, P.M.2    Galli, S.3    Salonia, A.4    Briganti, A.5    Werba, J.P.6    Montorsi, F.7
  • 43
    • 84874108083 scopus 로고    scopus 로고
    • Seven sirtuins for seven deadly diseases of aging
    • 1:CAS:528:DC%2BC38Xhs1KqsrrE 23104101 10.1016/j.freeradbiomed.2012.10.525
    • Morris BJ (2013) Seven sirtuins for seven deadly diseases of aging. Free Radic Biol Med 56:133-171
    • (2013) Free Radic Biol Med , vol.56 , pp. 133-171
    • Morris, B.J.1
  • 44
    • 0842332231 scopus 로고    scopus 로고
    • Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL
    • 1:CAS:528:DC%2BD2cXps1OhsA%3D%3D 14766203 10.1016/j.bbrc.2004.01.049
    • Motoshima H, Wu X, Mahadev K, Goldstein B (2004) Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun 315:264-271
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 264-271
    • Motoshima, H.1    Wu, X.2    Mahadev, K.3    Goldstein, B.4
  • 46
    • 0034995828 scopus 로고    scopus 로고
    • Diet-induced endothelial dysfunction in the rat is independent of the degree of increase in total body weight
    • 1:STN:280:DC%2BD3M3lsVKltA%3D%3D 10.1042/CS20000279
    • Naderali EK, Pickavance LC, Wilding JP, Williams G (2001) Diet-induced endothelial dysfunction in the rat is independent of the degree of increase in total body weight. Clin Sci (Lond) 100:635-641
    • (2001) Clin Sci (Lond) , vol.100 , pp. 635-641
    • Naderali, E.K.1    Pickavance, L.C.2    Wilding, J.P.3    Williams, G.4
  • 47
    • 84942949401 scopus 로고
    • NIH consensus development panel on impotence
    • NIH Consensus Conference Impotence 10.1001/jama.1993.03510010089036
    • NIH Consensus Conference Impotence (1993) NIH consensus development panel on impotence. JAMA 270:83-90
    • (1993) JAMA , vol.270 , pp. 83-90
  • 49
    • 78149285838 scopus 로고    scopus 로고
    • Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway
    • 1:CAS:528:DC%2BC3cXhtlSqtbzP 20705918 10.1161/ATVBAHA.110.210500
    • Ota H, Eto M, Kano MR, Kahyo T, Setou M, Ogawa S, Iijima K, Akishita M, Ouchi Y (2010a) Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway. Arterioscler Thromb Vasc Biol 30:2205-2211
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 2205-2211
    • Ota, H.1    Eto, M.2    Kano, M.R.3    Kahyo, T.4    Setou, M.5    Ogawa, S.6    Iijima, K.7    Akishita, M.8    Ouchi, Y.9
  • 50
    • 77953355431 scopus 로고    scopus 로고
    • SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis
    • 1:CAS:528:DC%2BC3MXhvVertrY%3D 20215708 10.5551/jat.3525
    • Ota H, Eto M, Ogawa S, Iijima K, Akishita M, Ouchi Y (2010b) SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis. J Atheroscler Thromb 17:431-435
    • (2010) J Atheroscler Thromb , vol.17 , pp. 431-435
    • Ota, H.1    Eto, M.2    Ogawa, S.3    Iijima, K.4    Akishita, M.5    Ouchi, Y.6
  • 52
    • 84863643253 scopus 로고    scopus 로고
    • Calorie restriction with a high-fat diet effectively attenuated inflammatory response and oxidative stress-related markers of obese tissue of the high diet fed rats
    • 3388520 22778500 10.1155/2012/984643
    • Park S, Park NY, Valacchi G, Lim Y (2012) Calorie restriction with a high-fat diet effectively attenuated inflammatory response and oxidative stress-related markers of obese tissue of the high diet fed rats. Mediators Inflamm 2012:984643
    • (2012) Mediators Inflamm , vol.2012 , pp. 984643
    • Park, S.1    Park, N.Y.2    Valacchi, G.3    Lim, Y.4
  • 53
    • 47749128879 scopus 로고    scopus 로고
    • Sirt1 protects against high-fat diet-induced metabolic damage
    • 1:CAS:528:DC%2BD1cXovVKrs78%3D 2474520 18599449 10.1073/pnas.0802917105
    • Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH (2008) Sirt1 protects against high-fat diet-induced metabolic damage. PNAS 105:9793-9798
    • (2008) PNAS , vol.105 , pp. 9793-9798
    • Pfluger, P.T.1    Herranz, D.2    Velasco-Miguel, S.3    Serrano, M.4    Tschöp, M.H.5
  • 54
    • 46449084157 scopus 로고    scopus 로고
    • Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults
    • 1:CAS:528:DC%2BD1cXntVaitL0%3D 2913284 18504322 10.1161/HYPERTENSIONAHA. 108.111427
    • Pierce GL, Beske SD, Lawson BR, Southall KL, Benay FJ, Donato AJ, Seals DR (2008) Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension 52:72-79
    • (2008) Hypertension , vol.52 , pp. 72-79
    • Pierce, G.L.1    Beske, S.D.2    Lawson, B.R.3    Southall, K.L.4    Benay, F.J.5    Donato, A.J.6    Seals, D.R.7
  • 56
    • 77956701448 scopus 로고    scopus 로고
    • Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress
    • 1:CAS:528:DC%2BC3cXmvFCgtL4%3D 2894368 20121721 10.1111/j.1474-9726.2010. 00557.x
    • Rippe C, Lesniewski L, Connell M, LaRocca T, Donato A, Seals D (2010) Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress. Aging Cell 9:304-312
    • (2010) Aging Cell , vol.9 , pp. 304-312
    • Rippe, C.1    Lesniewski, L.2    Connell, M.3    Larocca, T.4    Donato, A.5    Seals, D.6
  • 58
    • 79951793045 scopus 로고    scopus 로고
    • Aging and vascular endothelial function in humans
    • 1:CAS:528:DC%2BC3MXptFShsQ%3D%3D 10.1042/CS20100476
    • Seals DR, Jablonski KL, Donato AJ (2011) Aging and vascular endothelial function in humans. Clin Sci (Lond) 120:357-375
    • (2011) Clin Sci (Lond) , vol.120 , pp. 357-375
    • Seals, D.R.1    Jablonski, K.L.2    Donato, A.J.3
  • 59
    • 78650798186 scopus 로고    scopus 로고
    • Erectile dysfunction. A disease marker for cardiovascular disease
    • 21135596 10.1097/CRD.0b013e3181fb7eb8
    • Shin D, Pregenzer G, Gardin JM (2011) Erectile dysfunction. A disease marker for cardiovascular disease. Cardiol Rev 19:5-11
    • (2011) Cardiol Rev , vol.19 , pp. 5-11
    • Shin, D.1    Pregenzer, G.2    Gardin, J.M.3
  • 60
    • 33748917958 scopus 로고    scopus 로고
    • Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age
    • 1:CAS:528:DC%2BD28XhtVagurfP 16982030 10.1016/j.abb.2006.02.017
    • Smith AR, Visioli F, Hagen TM (2006) Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age. Arch Biochem Biophys 454:100-105
    • (2006) Arch Biochem Biophys , vol.454 , pp. 100-105
    • Smith, A.R.1    Visioli, F.2    Hagen, T.M.3
  • 61
    • 33745935414 scopus 로고    scopus 로고
    • High-fat feeding reduces endothelium-dependent vasodilation in rats: Differential mechanisms for saturated and unsaturated fatty acids?
    • 1:CAS:528:DC%2BD28XotVCjt7g%3D 16895544 10.1111/j.1440-1681.2006.04422.x
    • Song G, Gao Y, Di YW, Pan LL, Zhou Y, Ye JM (2006) High-fat feeding reduces endothelium-dependent vasodilation in rats: differential mechanisms for saturated and unsaturated fatty acids? Clin Exp Pharmacol Physiol 33:708-713
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 708-713
    • Song, G.1    Gao, Y.2    Di, Y.W.3    Pan, L.L.4    Zhou, Y.5    Ye, J.M.6
  • 62
    • 33845400838 scopus 로고    scopus 로고
    • Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness
    • 1:CAS:528:DC%2BD28Xhtlent7fM 17106067 10.1152/japplphysiol.00138.2006
    • Soucy KG, Ryoo S, Benjo A, Lim HK, Gupta G, Sohi JS, Elser J, Aon MA, Nyhan D, Shoukas AA, Berkowitz DE (2006) Impaired shear stress-induced nitric oxide production through decreased NOS phosphorylation contributes to age-related vascular stiffness. J Appl Physiol 101:1751-1759
    • (2006) J Appl Physiol , vol.101 , pp. 1751-1759
    • Soucy, K.G.1    Ryoo, S.2    Benjo, A.3    Lim, H.K.4    Gupta, G.5    Sohi, J.S.6    Elser, J.7    Aon, M.A.8    Nyhan, D.9    Shoukas, A.A.10    Berkowitz, D.E.11
  • 63
    • 84874667392 scopus 로고    scopus 로고
    • Lipotoxicity contributes to endothelial dysfunction: A focus on the contribution from ceramide
    • 1:CAS:528:DC%2BC3sXjsFKqsL8%3D 23292334 10.1007/s11154-012-9235-3
    • Symons JD, Abel ED (2013) Lipotoxicity contributes to endothelial dysfunction: a focus on the contribution from ceramide. Rev Endocr Metab Disord 14:59-68
    • (2013) Rev Endocr Metab Disord , vol.14 , pp. 59-68
    • Symons, J.D.1    Abel, E.D.2
  • 64
    • 79952030945 scopus 로고    scopus 로고
    • Are all metabolic syndrome components responsible for penile hemodynamics impairment in patients with erectile dysfunction? the role of body fat mass assessment
    • 21091885 10.1111/j.1743-6109.2010.02122.x
    • Tomada N, Tomada I, Botelho F, Cruz F, Vendeira P (2011) Are all metabolic syndrome components responsible for penile hemodynamics impairment in patients with erectile dysfunction? The role of body fat mass assessment. J Sex Med 8:831-839
    • (2011) J Sex Med , vol.8 , pp. 831-839
    • Tomada, N.1    Tomada, I.2    Botelho, F.3    Cruz, F.4    Vendeira, P.5
  • 65
    • 84892580650 scopus 로고    scopus 로고
    • Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats
    • Tomada I, Fernandes D, Guimarães JT, Almeida H, Neves D (2013a) Energy restriction ameliorates metabolic syndrome-induced cavernous tissue structural modifications in aged rats. Age (Dordr) 35:1721-1739
    • (2013) Age (Dordr) , vol.35 , pp. 1721-1739
    • Tomada, I.F.1
  • 66
    • 84863672272 scopus 로고    scopus 로고
    • Energy restriction and exercise modulate angiopoietins and vascular endothelial growth factor expression in the cavernous tissue of high-fat diet-fed rats
    • 1:CAS:528:DC%2BC38Xpsl2msbY%3D 3720086 22138901 10.1038/aja.2011.131
    • Tomada I, Tomada N, Almeida H, Neves D (2012) Energy restriction and exercise modulate angiopoietins and vascular endothelial growth factor expression in the cavernous tissue of high-fat diet-fed rats. Asian J Androl 14:635-642
    • (2012) Asian J Androl , vol.14 , pp. 635-642
    • Tomada, I.1    Tomada, N.2    Almeida, H.3    Neves, D.4
  • 67
    • 84872595357 scopus 로고    scopus 로고
    • Androgen depletion in humans leads to cavernous tissue reorganization and upregulation of Sirt1-eNOS axis
    • 1:CAS:528:DC%2BC3sXptlWmtA%3D%3D 10.1007/s11357-011-9328-z
    • Tomada I, Tomada N, Almeida H, Neves D (2013b) Androgen depletion in humans leads to cavernous tissue reorganization and upregulation of Sirt1-eNOS axis. Age (Dordr) 35:35-47
    • (2013) Age (Dordr) , vol.35 , pp. 35-47
    • Tomada, I.1    Tomada, N.2    Almeida, H.3    Neves, D.4
  • 68
    • 40949142846 scopus 로고    scopus 로고
    • Mechanisms underlying caloric restriction and lifespan regulation: Implications for vascular aging
    • 1:CAS:528:DC%2BD1cXjtVeru70%3D 10.1161/CIRCRESAHA.107.168369
    • Ungvari Z, Parrado-Fernandez C, Csiszar A, de Cabo R (2008) Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Cir Res 102:519-528
    • (2008) Cir Res , vol.102 , pp. 519-528
    • Ungvari, Z.1    Parrado-Fernandez, C.2    Csiszar, A.3    De Cabo, R.4
  • 69
    • 33749986298 scopus 로고    scopus 로고
    • Free radicals and antioxidants in normal physiological functions and human disease
    • 1:CAS:528:DC%2BD28XhtVygt7%2FF 16978905 10.1016/j.biocel.2006.07.001
    • Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39:44-84
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 44-84
    • Valko, M.1    Leibfritz, D.2    Moncol, J.3    Cronin, M.T.4    Mazur, M.5    Telser, J.6
  • 71
    • 84880570871 scopus 로고    scopus 로고
    • The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: The vascular health triad
    • 1:CAS:528:DC%2BC3sXmvFWiuro%3D 10.1007/s11357-012-9402-1
    • Wadley AJ, Veldhuijzen van Zanten JJ, Aldred S (2013) The interactions of oxidative stress and inflammation with vascular dysfunction in ageing: the vascular health triad. Age (Dordr) 35:705-718
    • (2013) Age (Dordr) , vol.35 , pp. 705-718
    • Wadley, A.J.1    Veldhuijzen Van Zanten, J.J.2    Aldred, S.3
  • 72
    • 84866142927 scopus 로고    scopus 로고
    • Subclinical endothelial dysfunction and low-grade inflammation play roles in the development of erectile dysfunction in young men with low risk of coronary heart disease
    • 1:CAS:528:DC%2BC38Xhtlehsb7K 22519624 10.1111/j.1365-2605.2012.01273.x
    • Yao F, Huang Y, Zhang Y, Dong Y, Ma H, Deng C, Lin H, Liu D, Lu K (2012) Subclinical endothelial dysfunction and low-grade inflammation play roles in the development of erectile dysfunction in young men with low risk of coronary heart disease. Int J Androl 35:653-659
    • (2012) Int J Androl , vol.35 , pp. 653-659
    • Yao, F.1    Huang, Y.2    Zhang, Y.3    Dong, Y.4    Ma, H.5    Deng, C.6    Lin, H.7    Liu, D.8    Lu, K.9
  • 74
    • 77957820976 scopus 로고    scopus 로고
    • Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta
    • 1:CAS:528:DC%2BC3cXhtlWjs7nP 20637278 10.1016/j.exger.2010.07.002
    • Zanetti M, Cappellari GG, Burekovic I, Barazzoni R, Stebel M, Guarnieri G (2010) Caloric restriction improves endothelial dysfunction during vascular aging: effects on nitric oxide synthase isoforms and oxidative stress in rat aorta. Exp Gerontol 45:848-855
    • (2010) Exp Gerontol , vol.45 , pp. 848-855
    • Zanetti, M.1    Cappellari, G.G.2    Burekovic, I.3    Barazzoni, R.4    Stebel, M.5    Guarnieri, G.6
  • 75
    • 54149103338 scopus 로고    scopus 로고
    • Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
    • 1:CAS:528:DC%2BD1cXht1Knt7jI 3657473 18689793 10.1093/cvr/cvn224
    • Zhang QJ, Wang Z, Chen HZ, Zhou S, Zheng W, Liu G, Wei YS, Cai H, Liu DP, Liang CC (2008) Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res 80:191-199
    • (2008) Cardiovasc Res , vol.80 , pp. 191-199
    • Zhang, Q.J.1    Wang, Z.2    Chen, H.Z.3    Zhou, S.4    Zheng, W.5    Liu, G.6    Wei, Y.S.7    Cai, H.8    Liu, D.P.9    Liang, C.C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.