Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice

Journal of Molecular and Cellular Cardiology

Volumn 51, Issue 6, 2011, Pages 1026-1036

  Kawashima, Tsuneaki ^a   Inuzuka, Yasutaka ^a   Okuda, Junji ^a   Kato, Takao ^a   Niizuma, Shinichiro ^a   Tamaki, Yodo ^a   Iwanaga, Yoshitaka ^a   Kawamoto, Akira ^a   Narazaki, Michiko ^a   Matsuda, Tetsuya ^a   Adachi, Souichi ^a   Takemura, Genzou ^b   Kita, Toru ^a   Kimura, Takeshi ^a   Shioi, Tetsuo ^a  

^a KYOTO UNIVERSITY   (Japan)

^b GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Heart failure; Metabolism; Mitochondria; SIRT1

Indexed keywords

FATTY ACID; REACTIVE OXYGEN METABOLITE; SIRTUIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; CELL ENERGY; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ECHOCARDIOGRAPHY; ENERGY METABOLISM; FATTY ACID TRANSPORT; GENE EXPRESSION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE OVERLOAD; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ANIMALS; AUTOPHAGY; BLOOD GLUCOSE; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ENERGY METABOLISM; FATTY ACIDS; GENE DOSAGE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEART FAILURE, DIASTOLIC; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOCARDIUM; NAD; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; REACTIVE OXYGEN SPECIES; SIRTUIN 1;

MUS; MUS MUSCULUS;

EID: 80055108043     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.09.013     Document Type: Article

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