Are all metabolic syndrome components responsible for penile hemodynamics impairment in patients with erectile dysfunction? The role of body fat mass assessment

Journal of Sexual Medicine

Volumn 8, Issue 3, 2011, Pages 831-839

  Tomada, Nuno ^a,b   Tomada, Inês ^b   Botelho, Francisco ^a   Cruz, Francisco ^a,b   Vendeira, Pedro ^a,b  

^a University of Porto   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Body Fat Mass; Erectile Dysfunction; Metabolic Syndrome; Obesity; Penile Duplex Doppler Ultrasound

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; ARTICLE; BODY FAT; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; CONTROLLED STUDY; DATA ANALYSIS SOFTWARE; DOPPLER ECHOGRAPHY; ERECTILE DYSFUNCTION; HEMODYNAMICS; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOGONADISM; INSULIN RESISTANCE; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; PEAK SYSTOLIC VELOCITY; PENILE DUPLEX DOPPLER ULTRASOUND; PENIS; PENIS DISEASE; PENIS ERECTION; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SMOKING; SYSTOLIC TIME INTERVAL;

EID: 79952030945     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.02122.x     Document Type: Article

References (42)

1. Grundy G. Metabolic syndrome: A multiplex cardiovascular risk factor. J Clin Endocrinol Metab 2007;92:399-404.
2. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143-421.
3. Corona G, Mannucci E, Petrone L, Schulman C, Balercia G, Fisher AD, Chiarini V, Forti G, Maggi M. A comparison of NCEP-ATPIII and IDF metabolic syndrome definitions with relation to metabolic syndrome-associated sexual dysfunction. J Sex Med 2007;4:789-96.
4. McKinlay J. The worldwide prevalence and epidemiology of erectile dysfunction. Int J Impot Res 2000;12(4 suppl):S6-11.
5. Brunner H, Cockcroft JR, Deanfield J, Donald A, Ferrannini E, Halcox J, Kiowski W, Lüscher TF, Mancia G, Natali A, Oliver JJ, Pessina AC, Rizzoni D, Rossi GP, Salvetti A, Spieker LE, Taddei S, Webb DJ, Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005;23:233-46.
6. Jackson G, Montorsi P, Adams MA, Anis T, El-Sakka A, Miner M, Vlachopoulos C, Kim E. Cardiovascular aspects of sexual medicine. J Sex Med 2010;7(4 Pt 2):1608-26.
7. Demir T. Prevalence of erectile dysfunction in patients with metabolic syndrome. Int J Urol 2006;13:385-8.
8. Esposito K, Giugliano F, Martedì E, Feola G, Marfella R, D'Armiento M, Giugliano D. High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes Care 2005;28:1201-3.
9. Gundz M, Gms B, Sekuri C. Relationship between metabolic syndrome and erectile dysfunction. Asian J Androl 2004;6:355-8.
10. Kupelian V, Shabsigh R, Araujo A, O'Donnell A, McKinlayt J. Erectile dysfunction as a predictor of the metabolic syndrome in aging men: Results from the Massachusetts Male Aging Study. J Urol 2006;176:222-6.
11. Ho J, Cannaday J, Barlow C, Mitchell T, Cooper K, Fitzgerald S. Relation of the number of metabolic syndrome risk factors with all-cause and cardiovascular mortality. Am J Cardiol 2008;102:689-92.
12. Corona G, Mannucci E, Schulman C, Petrone L, Mansani R, Cilotti A, Balercia G, Chiarini V, Forti G, Maggi M. Psychobiologic correlates of the metabolic syndrome and associated sexual dysfunction. Eur Urol 2006;50:595-604.
13. Riedner CE, Rhoden EL, Ribeiro EP, Fuchs SC. Central obesity is an independent predictor of erectile dysfunction in older men. J Urol 2006;176(4 Pt 1):1519-23.
14. Hannan JL, Maio MT, Komolova M, Adams MA. Beneficial impact of exercise and obesity interventions on erectile function and its risk factors. J Sex Med 2009;6(3 suppl):254-61.
15. Ahn TY, Park JK, Lee SW, Hong JH, Park NC, Kim JJ, Park K, Park H, Hyun JS. Prevalence and risk factors for erectile dysfunction in Korean men: Results of an epidemiological study. J Sex Med 2007;4:1269-76.
16. Mulhall J, Teloken P, Brock G, Kim E. Obesity, dyslipidemias and erectile dysfunction: A report of a subcommittee of the sexual medicine society of North America. J Sex Med 2006;3:778-86.
17. Deurenberg P, Andreoli A, Borg P, Kukkonen-Harjula K, de Lorenzo A, van Marken Lichtenbelt WD, Testolin G, Vigano R, Vollaard N. The validity of predicted body fat percentage from body mass index and from impedance in samples of five European populations. Eur J Clin Nutr 2001;55:973-9.
18. Chung WS, Shim BS, Park YY. Hemodynamic insult by vascular risk factors and pharmacologic erection in men with erectile dysfunction: Doppler sonography study. World J Urol 2000;18:427-30.
19. Demir O, Demir T, Kefi A, Secil M, Comlekci A, Yesil S, Esen AA. Penile vascular impairment in erectile dysfunction patients with metabolic syndrome: Penile Doppler ultrasound findings. Urol Int 2009;82:175-8.
20. Deveci S, O'Brien K, Ahmed A, Parker M, Guhring P, Mulhall JP. Can the International Index of Erectile Function distinguish between organic and psychogenic erectile function? BJU Int 2008;102:354-6.
21. Kendirci M, Trost L, Sikka SC, Hellstrom WJ. The effect of vascular risk factors on penile vascular status in men with erectile dysfunction. J Urol 2007;178:2516-20.
22. Traish AM, Feeley RJ, Guay A. Mechanisms of obesity and related pathologies: Androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction. FEBS J 2009;276:5755-67.
23. Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Peña BM. Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999;11:319-26.
24. Cho YG, Song HJ, Kim JM, Park KH, Paek YJ, Cho JJ, Caterson I, Kang JG. The estimation of cardiovascular risk factors by body mass index and body fat percentage in Korean male adults. Metabolism 2009;58:765-71.
25. Vega GL, Barlow CE, Grundy SM. Prevalence of the metabolic syndrome as influenced by the measure of obesity employed. Am J Cardiol 2010;105:1306-12.
26. Wang C, Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, Gooren LJ, Kaufman JM, Legros JJ, Lunenfeld B, Morales A, Morley JE, Schulman C, Thompson IM, Weidner W, Wu FC. ISA, ISSAM, EAU, EAA and ASA recommendations: Investigation, treatment and monitoring of late-onset hypogonadism in males. Int J Impot Res 2009;21:1-8.
27. Seftel AD. Diagnosis of erectile dysfunction. In: Porst H, Buvat J, eds. Standard practice in sexual medicine. Malden: Blackwell Publishing; 2006:67.
28. Barret-Conner E. Heart disease risk factors predict erectile dysfunction 25 years later (The Rancho Bernando Study). Am J Cardiol 2005;96(12B suppl):3M-7M.
29. Blumentals WA, Gomez-Caminero A, Joo S, Vannappagari V. Should erectile dysfunction be considered as a marker for acute myocardial infarction? Results from a retrospective cohort study. Int J Impot Res 2004;16:350-3.
30. Montorsi F, Briganti A, Salonia A, Rigatti P, Margonato A, Macchi A, Galli S, Ravagnani PM, Montorsi P. Erectile dysfunction prevalence, time of onset, and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 2003;44:360-5.
31. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Nour KR, Quyyumi AA. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002;106:653-8.
32. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey. JAMA 2002;287:356-9.
33. Santos AC, Barros H. Impact of metabolic syndrome definitions on prevalence estimates: A study in a Portuguese community. Diab Vasc Dis Res 2007;4:320-7.
34. Hu G, Qiao Q, Tuomilehto J, Balkau B, Borch-Johnsen K, Pyorala K, DECODE Study Group. Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med 2004;164:1066-76.
35. Corona G, Mannucci E, Forti G, Maggi M. Hypogonadism, ED, metabolic syndrome and obesity: A pathological link supporting cardiovascular diseases. Int J Androl 2009;32:587-98.
36. Borges R, Temido P, Sousa L, Azinhais P, Conceição P, Pereira B, Leão R, Retroz E, Brandão A, Cristo L, Sobral F. Metabolic syndrome and sexual (dys)function. J Sex Med 2009;6:2958-75.
37. Stehouwer CD, Henry RM, Ferreira I. Arterial stiffness in diabetes and the metabolic syndrome: A pathway to cardiovascular disease. Diabetologia 2008;51:527-39.
38. Montorsi P, Montorsi F, Schulman C. Is erectile dysfunction the tip of the iceberg of a systemic vascular disorder? Eur Urol 2003;22:352-4.
39. Corona G, Mannucci E, Fisher AD, Lotti F, Petrone L, Balercia G, Bandini E, Forti G, Maggi M. Low levels of androgens in men with erectile dysfunction and obesity. J Sex Med 2008;5:2454-63.
40. Paick JS, Yang JH, Kim SW, Ku JH. Severity of erectile dysfunction in married impotent patients: Interrelationship with anthropometry, hormones, metabolic profiles and lifestyle. Int J Urol 2007;14:48-53.
41. Chang ST, Chu CM, Hsu JT, Lin PC, Shee JJ. Surveillance of cardiovascular risk factors for outpatients in different erectile dysfunction severity. Int J Impot Res 2009;21:116-21.
42. Corona G, Mannucci E, Petrone L, Balercia G, Paggi F, Fisher AD, Lotti F, Chiarini V, Fedele D, Forti G, Maggi M. NCEP-ATPIII-defined metabolic syndrome, type 2 diabetes mellitus, and prevalence of hypogonadism in male patients with sexual dysfunction. J Sex Med 2007;4(4 Pt 1):1038-45.