Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 8, 2012, Pages 4881-4888

  Tewari, Shikha ^a   Zhong, Qing ^a   Santos, Julia M ^a   Kowluru, Renu A ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE GAMMA; DNA METHYLTRANSFERASE; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; TWINKLE PROTEIN; UNCLASSIFIED DRUG; DNA DIRECTED DNA POLYMERASE; POLG PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE COURSE; DNA DAMAGE; DNA ISOLATION; DNA METHYLATION; DNA REPLICATION; GENE EXPRESSION; GLYCEMIC CONTROL; HYPERGLYCEMIA; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETINA CELL; ANIMAL; DISEASE MODEL; ENDOTHELIUM CELL; ENZYMOLOGY; GENETICS; METABOLISM; RETINA; WISTAR RAT;

ANIMALS; DIABETIC RETINOPATHY; DISEASE MODELS, ANIMAL; DNA METHYLATION; DNA, MITOCHONDRIAL; DNA-DIRECTED DNA POLYMERASE; ENDOTHELIAL CELLS; HYPERGLYCEMIA; MALE; MITOCHONDRIA; RATS; RATS, WISTAR; RETINA;

EID: 84867320438     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-9732     Document Type: Article

References (28)

1. Engerman RL, Kern TS. Progression of incipient diabetic retinopathy during good glycemic control. Diabetes. 1987;36: 808-812.
2. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977-986.
3. Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N Engl J Med. 2000; 342:381-389.
4. Kowluru RA. Effect of re-institution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes. 2003;52:818-823.
5. Kowluru RA, Kanwar M, Kennedy A. Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries. Exp Diabetes Res. 2007;2007:2196.
6. Durham JT, Herman IM. Microvascular modifications in diabetic retinopathy. Curr Diab Rep. 2011;4:253-264.
7. Kowluru RA, Abbas SN. Diabetes-induced mitochondrial dysfunction in the retina. Invest Ophthalmol Vis Sci. 2003; 44:5327-5334.
8. Madsen-Bouterse SA, Mohammad G, Kanwar M, Kowluru RA. Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression. Antioxid Redox Signal. 2010; 13:797-805.
9. Santos JM, Kowluru RA. Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2011;52: 8791-8798.
10. Mohammad G, Kowluru RA. Novel role of mitochondrial matrix metalloproteinase-2 in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2011;52:3832-3841.
11. Tewari S, Santos JM, Kowluru RA. Damaged mitochondrial DNA replication system and the development of diabetic retinopathy. Antioxid Redox Signal. 2012;17: 492-504.
12. Madsen-Bouterse S, Zhong Q, Mohammad G, Ho YS, Kowluru RA. Oxidative damage of mitochondrial DNA in diabetes, and its protection by manganese superoxide dismutase. Free Rad Research. 2010;44:313-321.
13. Zhong Q, Kowluru RA. Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy. Diabetes. 2011;60:1304-1313.
14. Schinke C, Mo Y, Yu Y, et al. Aberrant DNA methylation in malignant melanoma. Melanoma Res. 2010;20:253-265.
15. Akçay T, Dinçer Y, Celebi N, Ilkova H. O(6)-methylguanine DNA methyltransferase activity in diabetic patients. Diabetes Res Clin Pract. 2003;61:1-6.
16. Williams KT, Garrow TA, Schalinske KL. Type I diabetes leads to tissue-specific DNA hypomethylation in male rats. J Nutr. 2008;138:2064-2069.
17. Ling C, Del GS, Lupi R, et al. Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia. 2008;51:1992-2000.
18. Korhonen JA, Pham XH, Pellegrini M, Falkenberg M. Reconstitution of a minimal mtDNA replisome in vitro. EMBO J. 2004;23:2423-2429.
19. Kowluru RA. Effect of re-institution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes. 2003;52:818-823.
20. Zhong Q, Kowluru RA. Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon. J Cell Biochem. 2010;110:1306-1313.
21. Santos JM, Tewari S, Goldberg AFX, Kowluru RA. Mitochondria biogenesis and the development of diabetic retinopathy. Free Rad Biol Med. 2011;51:1849-1860.
22. Kumar M, Tanwar M, Saxena R, Sharma P, Dada R. Identification of novel mitochondrial mutations in Leber's hereditary optic neuropathy. Mol Vis. 2010;16:782-792.
23. Cai FF, Kohler C, Zhang B, et al. Mutations of mitochondrialDNA as potential biomarkers in breast cancer. Anticancer Res. 2011;31:4267-4271.
24. Rakyan VK, Down TA, Balding DJ, Beck S. Epigenome-wide association studies for common human diseases. Nat Rev Genet. 2011;12:529-41.
25. El-Osta A, Brasacchio D, Yao D, et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med. 2008;205:2409-2417.
26. Villeneuve LM, Reddy MA, Lanting LL, Wang M, Meng L, Natarajan R. Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci U S A. 2008;105:9047-9052.
27. Villeneuve LM, Reddy MA, Natarajan R. Epigenetics: deciphering its role in diabetes and its chronic complications. Clin Exp Pharmacol Physiol. 2011;38:401-409.
28. Roy S, Sala R, Cagliero E, Lorenzi M. Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory. Proc Natl Acad Sci U.S.A. 1990;87:404-408.