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Volumn 20, Issue 26, 2013, Pages 3226-3233

Mitochondria damage in the pathogenesis of diabetic retinopathy and in the metabolic memory associated with its continued progression

Author keywords

Diabetic retinopathy; Epigenetic modifications; Mitochondria damage; Mitochondria DNA; Oxidative stress

Indexed keywords

BENFOTIAMINE; CASPASE 3; CELL NUCLEUS DNA; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; THIOCTIC ACID;

EID: 84883246730     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/09298673113209990029     Document Type: Article
Times cited : (59)

References (99)
  • 1
    • 65449151412 scopus 로고    scopus 로고
    • Therapies for hyperglycaemia-induced diabetic complications: From animal models to clinical trials
    • Calcutt, N.A.; Cooper, M.E.; Kern, T.S.; Schmidt, A.M. Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials. Nat. Rev. Drug. Discov., 2009, 8, 417-429.
    • (2009) Nat. Rev. Drug. Discov , vol.8 , pp. 417-429
    • Calcutt, N.A.1    Cooper, M.E.2    Kern, T.S.3    Schmidt, A.M.4
  • 2
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development of long-Term complications in insulin-dependent diabetes mellitus
    • Diabetes Control and Complications Trial Research Group
    • Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development of long-Term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med., 1993, 329, 977-986.
    • (1993) N. Engl. J. Med , vol.329 , pp. 977-986
  • 3
    • 0348048874 scopus 로고    scopus 로고
    • Diabetic retinopathy
    • Frank, R.N. Diabetic Retinopathy. N. Engl. J. Med., 2004, 350, 48-358.
    • (2004) N. Engl. J. Med , vol.350 , pp. 48-358
    • Frank, R.N.1
  • 4
    • 0028944962 scopus 로고
    • Hyperglycemia and microvascular and macrovascular disease in diabetes
    • Klein, R. Hyperglycemia and microvascular and macrovascular disease in diabetes. Diabetes Care, 1995, 18, 258-268.
    • (1995) Diabetes Care , vol.18 , pp. 258-268
    • Klein, R.1
  • 5
    • 0028153935 scopus 로고
    • The relation of socioeconomic factors to the incidence of proliferative diabetic retinopathy and loss of vision
    • Klein, R.; Klein, B.E.; Jensen, S.C.; Moss, S.E. The relation of socioeconomic factors to the incidence of proliferative diabetic retinopathy and loss of vision. Ophthalmology, 1994, 101, 68-76.
    • (1994) Ophthalmology , vol.101 , pp. 68-76
    • Klein, R.1    Klein, B.E.2    Jensen, S.C.3    Moss, S.E.4
  • 7
    • 85028010773 scopus 로고    scopus 로고
    • Global prevalence of diabetic retinopathy: Pooled data from population studies from the United States, Australia, Europe and Asia
    • Abstract# 4818
    • Wong, T.Y.; Yau, J.; Rogers.; S, Kawasaki, R.; Lamoureux, E.L. Global Prevalence of Diabetic Retinopathy: Pooled Data from Population Studies from the United States, Australia, Europe and Asia. Invest. Ophtahlmol. Vis. Sci., 2011, Abstract# 4818.
    • (2011) Invest. Ophtahlmol. Vis. Sci
    • Wong, T.Y.1    Yau, J.2    Rogers, S.3    Kawasaki, R.4    Lamoureux, E.L.5
  • 9
    • 0034628425 scopus 로고    scopus 로고
    • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. N.Engl. J. Med., 2000, 42, 381-389.
    • (2000) N.Engl. J. Med , vol.42 , pp. 381-389
  • 10
    • 0037093012 scopus 로고    scopus 로고
    • Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus. JAMA., 2002, 287, 2563-2569.
    • (2002) JAMA , vol.287 , pp. 2563-2569
  • 11
    • 0021136256 scopus 로고
    • The Wisconsin epidemiologic study of diabetic retinopathy. I. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years
    • Klein, R.; Klein, B.E.; Moss, S.E.; Davis, M.D.; DeMets, D.L. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. I. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. Arch. Ophthalmol., 1984, 102, 520-526.
    • (1984) Arch. Ophthalmol , vol.102 , pp. 520-526
    • Klein, R.1    Klein, B.E.2    Moss, S.E.3    Davis, M.D.4    Demets, D.L.5
  • 12
    • 65949123780 scopus 로고    scopus 로고
    • Management of diabetic retinopathy: Could lipidlowering be a worthwhile treatment modality?
    • Dodson, P.M. Management of diabetic retinopathy: could lipidlowering be a worthwhile treatment modality? Eye (Lond). 2009, 23, 997-1003.
    • (2009) Eye (Lond) , vol.23 , pp. 997-1003
    • Dodson, P.M.1
  • 13
    • 66649114798 scopus 로고    scopus 로고
    • Diabetic retinal neurodegeneration is associated with mitochondrial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes
    • Silva, K.C.; Rosales, A.; Biswas, S.K.; Lopes de Faria, J.B.; Lopes de Faria, J.M. Diabetic retinal neurodegeneration is associated with mitochondrial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes. Diabetes, 2009, 58, 382-1390.
    • (2009) Diabetes , vol.58 , pp. 382-1390
    • Silva, K.C.1    Rosales, A.2    Biswas, S.K.3    Lopes De Faria, J.B.4    Lopes De Faria, J.M.5
  • 14
    • 0024420402 scopus 로고
    • Pathogenesis of diabetic retinopathy
    • Engerman, R.L. Pathogenesis of diabetic retinopathy. Diabetes, 1989, 38, 1203-1206.
    • (1989) Diabetes , vol.38 , pp. 1203-1206
    • Engerman, R.L.1
  • 15
    • 0032529103 scopus 로고    scopus 로고
    • Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin
    • Barber, A.J.; Lieth, E.; Khin, S.A.; Antonetti, D.A.; Buchanan, A.G.; Gardner, T.W. Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J. Clin. Invest., 1998, 102, 783-791.
    • (1998) J. Clin. Invest , vol.102 , pp. 783-791
    • Barber, A.J.1    Lieth, E.2    Khin, S.A.3    Antonetti, D.A.4    Buchanan, A.G.5    Gardner, T.W.6
  • 16
    • 0033753702 scopus 로고    scopus 로고
    • Response of capillary cell death to aminoguanidine predicts the development of retinopathy: Comparison of diabetes and galactosemia
    • Kern, T.S.; Tang, J.; Mizutani, M.; Kowluru, R.; Nagraj, R.; Lorenzi, M. Response of capillary cell death to aminoguanidine predicts the development of retinopathy: Comparison of diabetes and galactosemia. Invest. Ophthalmol. Vis. Sci., 2000, 41, 3972-3978.
    • (2000) Invest. Ophthalmol. Vis. Sci , vol.41 , pp. 3972-3978
    • Kern, T.S.1    Tang, J.2    Mizutani, M.3    Kowluru, R.4    Nagraj, R.5    Lorenzi, M.6
  • 17
    • 0031594369 scopus 로고    scopus 로고
    • Muller cell changes in human diabetic retinopathy
    • Mizutani, M.; Gerhardinger, C.; Lorenzi, M. Muller cell changes in human diabetic retinopathy. Diabetes. 1998, 47, 455-459.
    • (1998) Diabetes , vol.47 , pp. 455-459
    • Mizutani, M.1    Gerhardinger, C.2    Lorenzi, M.3
  • 18
    • 0029973474 scopus 로고    scopus 로고
    • Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy
    • Mizutani, M.; Kern, T.S.; Lorenzi, M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J. Clin. Invest., 1996, 97, 2883-2890.
    • (1996) J. Clin. Invest , vol.97 , pp. 2883-2890
    • Mizutani, M.1    Kern, T.S.2    Lorenzi, M.3
  • 20
    • 84867094327 scopus 로고    scopus 로고
    • Neurodegeneration is an early event in diabetic retinopathy: Therapeutic implications
    • Simó, R.; Hernández, C. Neurodegeneration is an early event in diabetic retinopathy: therapeutic implications. Br. J.Ophthalmol., 2012, 96, A1285-1290.
    • (2012) Br. J.Ophthalmol , vol.96
    • Simó, R.1    Hernández, C.2
  • 21
    • 34247394257 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy
    • Kowluru, R.A.; Chan, P.S. Oxidative stress and diabetic retinopathy. Exp. Diabetes. Res. 2007, 2007, 43603.
    • (2007) Exp. Diabetes. Res , vol.2007 , pp. 43603
    • Kowluru, R.A.1    Chan, P.S.2
  • 22
    • 84855411960 scopus 로고    scopus 로고
    • Beyond AREDS: Is there a place for anti-oxidant therapy in the prevention/ treatment of eye disease? Invest Ophthalmol
    • Kowluru, R.A.; Zhong, Q. Beyond AREDS: Is there a place for anti-oxidant therapy in the prevention/ treatment of eye disease? Invest Ophthalmol. Vis. Sci., 2011, 52, 8665-8671.
    • (2011) Vis. Sci , vol.52 , pp. 8665-8671
    • Kowluru, R.A.1    Zhong, Q.2
  • 23
    • 84863490715 scopus 로고    scopus 로고
    • Update on animal models of diabetic retinopathy: From molecular approaches to mice and higher mammals
    • Robinson, R.; Barathi, V.A.; Chaurasia, S.S.; Wong, T.Y.; Kern, T.S. Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals. Dis. Model. Mech., 2012, 5, 444-446.
    • (2012) Dis. Model. Mech , vol.5 , pp. 444-446
    • Robinson, R.1    Barathi, V.A.2    Chaurasia, S.S.3    Wong, T.Y.4    Kern, T.S.5
  • 24
    • 0032913309 scopus 로고    scopus 로고
    • Role of oxidative stress in diabetic complications: A new perspective on an old paradigm
    • Baynes, J.W.; Thrope, S.R. Role of oxidative stress in diabetic complications: A new perspective on an old paradigm. Diabetes, 1999, 48, 1-9.
    • (1999) Diabetes , vol.48 , pp. 1-9
    • Baynes, J.W.1    Thrope, S.R.2
  • 25
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • Brownlee, M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes, 2005, 54, 615-1625.
    • (2005) Diabetes , vol.54 , pp. 615-1625
    • Brownlee, M.1
  • 27
    • 9244250838 scopus 로고    scopus 로고
    • Mitochondrial bioenergetics, aging, and aging-related disease
    • Nicholls, D. Mitochondrial bioenergetics, aging, and aging-related disease. Sci. Aging Knowledge. Environ., 2002, 2002, pe12.
    • (2002) Sci. Aging Knowledge. Environ , vol.2002
    • Nicholls, D.1
  • 30
    • 84869051280 scopus 로고    scopus 로고
    • Mitochondrial disorders as windows into an ancient organelle
    • Vafai, S.B.; Mootha, V.K.; Mitochondrial disorders as windows into an ancient organelle. Nature, 2012, 491, 374-383.
    • (2012) Nature , vol.491 , pp. 374-383
    • Vafai, S.B.1    Mootha, V.K.2
  • 31
    • 84857116578 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
    • Ray, P.D.; Huang, B.W.; Tsuji, Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal, 2012, 24, 981-990.
    • (2012) Cell Signal , vol.24 , pp. 981-990
    • Ray, P.D.1    Huang, B.W.2    Tsuji, Y.3
  • 32
    • 28844466951 scopus 로고    scopus 로고
    • Diabetic retinopathy: Mitochondrial dysfunction and retinal capillary cell death
    • Kowluru, R.A. Diabetic retinopathy: Mitochondrial dysfunction and retinal capillary cell death. Antioxid. Redox. Sign., 2005, 7,1581-1587.
    • (2005) Antioxid. Redox. Sign , vol.7 , pp. 1581-1587
    • Kowluru, R.A.1
  • 33
    • 0142221070 scopus 로고    scopus 로고
    • Diabetes-induced mitochondrial dysfunction in the retina
    • Kowluru, R.A.; Abbas, S.N. Diabetes-induced mitochondrial dysfunction in the retina. Inves Ophthalmol. Vis. Sci., 2003, 44, 5327-5334.
    • (2003) Inves Ophthalmol. Vis. Sci , vol.44 , pp. 5327-5334
    • Kowluru, R.A.1    Abbas, S.N.2
  • 34
    • 34648825492 scopus 로고    scopus 로고
    • Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dismutase
    • Kanwar, M.; Chan, P.S.; Kern, T.S.; Kowluru, R.A. Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest. Ophthalmol. Vis. Sci., 2007, 48, 3805-3811.
    • (2007) Invest. Ophthalmol. Vis. Sci , vol.48 , pp. 3805-3811
    • Kanwar, M.1    Chan, P.S.2    Kern, T.S.3    Kowluru, R.A.4
  • 35
    • 77954617065 scopus 로고    scopus 로고
    • High glucose disrupts mitochondrial morphology in retinal endothelial cells: Implications for diabetic retinopathy
    • Trudea, K.; Molina, A.J.; Guo, W.; Roy, S. High glucose disrupts mitochondrial morphology in retinal endothelial cells: implications for diabetic retinopathy. Am. J. Path., 2010, 177, 447-455.
    • (2010) Am. J. Path , vol.177 , pp. 447-455
    • Trudea, K.1    Molina, A.J.2    Guo, W.3    Roy, S.4
  • 36
    • 0037007152 scopus 로고    scopus 로고
    • DNA damage: Air-breaks
    • Barnes, D.E. DNA damage: air-breaks. Curr. Biol., 2002, 12, R262-R264.
    • (2002) Curr. Biol , vol.12
    • Barnes, D.E.1
  • 37
    • 33644674439 scopus 로고    scopus 로고
    • The organization and inheritance of the mitochondrial genome
    • Chen, X.J.; Butow, R.A. The organization and inheritance of the mitochondrial genome. Nat. Rev. Genet., 2005, 6, 815-25.
    • (2005) Nat. Rev. Genet , vol.6 , pp. 815-825
    • Chen, X.J.1    Butow, R.A.2
  • 38
    • 46749110071 scopus 로고    scopus 로고
    • Mitochondrial nucleoids undergo remodeling in response to metabolic cues
    • Kucej, M.; Kucejova, B.; Subramanian, R.; Chen, X.J.; Butow, R.A. Mitochondrial nucleoids undergo remodeling in response to metabolic cues. J. Cell. Sci., 2008, 121,1861-1868.
    • (2008) J. Cell. Sci , vol.121 , pp. 1861-1868
    • Kucej, M.1    Kucejova, B.2    Subramanian, R.3    Chen, X.J.4    Butow, R.A.5
  • 39
    • 77953811054 scopus 로고    scopus 로고
    • The human mitochondrial replication fork in health and disease
    • Wanrooij, S.; Falkenberg, M. The human mitochondrial replication fork in health and disease. Biochim. Biophys. Acta., 2010,1797, 1378-1388.
    • (2010) Biochim. Biophys. Acta , vol.1797 , pp. 1378-1388
    • Wanrooij, S.1    Falkenberg, M.2
  • 40
    • 33644992894 scopus 로고    scopus 로고
    • Mitochondrial DNA maintenance and bioenergetics
    • Stuart, J.A.; Brown, M.F. Mitochondrial DNA maintenance and bioenergetics. Biochim Biophys. Acta., 2006, 1757,79-89.
    • (2006) Biochim Biophys. Acta , vol.1757 , pp. 79-89
    • Stuart, J.A.1    Brown, M.F.2
  • 42
    • 30344432706 scopus 로고    scopus 로고
    • Role of mitochondrial DNA in toxic responses to oxidative stress
    • Van Houten, B.; Woshner, V.; Santos, J.H. Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair, 2005, 5,145-152.
    • (2005) DNA Repair , vol.5 , pp. 145-152
    • Van Houten, B.1    Woshner, V.2    Santos, J.H.3
  • 43
    • 84867374188 scopus 로고    scopus 로고
    • A compensatory mechanism protects retinal mitochondria from initial insult in diabetic retinopathy
    • Santos, J.M.; Tewari, S.; Kowluru, R.A. A compensatory mechanism protects retinal mitochondria from initial insult in diabetic retinopathy. Free Rad. Biol. Med., 2012, 53, 1729-1737.
    • (2012) Free Rad. Biol. Med , vol.53 , pp. 1729-1737
    • Santos, J.M.1    Tewari, S.2    Kowluru, R.A.3
  • 44
    • 77954909054 scopus 로고    scopus 로고
    • Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression
    • Madsen-Bouterse, S.A.; Mohammad, G.; Kanwar, M.; Kowluru, R.A. Role of mitochondrial DNA damage in the development of diabetic retinopathy, and the metabolic memory phenomenon associated with its progression. Antioxid. Redox Signal, 2010, 13,797-805.
    • (2010) Antioxid. Redox Signal , vol.13 , pp. 797-805
    • Madsen-Bouterse, S.A.1    Mohammad, G.2    Kanwar, M.3    Kowluru, R.A.4
  • 45
    • 77249096912 scopus 로고    scopus 로고
    • Oxidative damage of mitochondrial DNA in diabetes, and its protection by manganese superoxide dismutase
    • Madsen-Bouterse, S. Zhong, Q. Mohammad, G.; Ho, Y.S.; Kowluru, R.A. Oxidative damage of mitochondrial DNA in diabetes, and its protection by manganese superoxide dismutase. Free Rad. Research., 2010, 44, 313-321.
    • (2010) Free Rad. Research , vol.44 , pp. 313-321
    • Madsen-Bouterse, S.1    Zhong, Q.2    Mohammad, G.3    Ho, Y.S.4    Kowluru, R.A.5
  • 46
    • 84055204963 scopus 로고    scopus 로고
    • Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy
    • Santos, J.M.; Kowluru, R.A. Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy. Invest. Ophthalmol. Vis. Sci., 2011, 52, 8791-8798.
    • (2011) Invest. Ophthalmol. Vis. Sci , vol.52 , pp. 8791-8798
    • Santos, J.M.1    Kowluru, R.A.2
  • 47
    • 80054717662 scopus 로고    scopus 로고
    • Mitochondria biogenesis and the development of diabetic retinopathy
    • Santos, J.M.; Tewari, S.; Goldberg, A.F.X.; Kowluru, R.A. Mitochondria biogenesis and the development of diabetic retinopathy. Free Rad. Biol. Med., 2011, 51, 1849-1860.
    • (2011) Free Rad. Biol. Med , vol.51 , pp. 1849-1860
    • Santos, J.M.1    Tewari, S.2    Goldberg, A.F.X.3    Kowluru, R.A.4
  • 48
    • 57649148823 scopus 로고    scopus 로고
    • Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator
    • Scarpulla, R.C. Nuclear control of respiratory chain expression by nuclear respiratory factors and PGC-1-related coactivator. Ann. N Y. Acad. Sci., 2008, 1147, 321-334.
    • (2008) Ann. N Y. Acad. Sci , vol.1147 , pp. 321-334
    • Scarpulla, R.C.1
  • 49
    • 42049114034 scopus 로고    scopus 로고
    • Transcriptional paradigms in mammalian mitochondrial biogenesis and function
    • Scarpulla, R.C. Transcriptional paradigms in mammalian mitochondrial biogenesis and function. Physiol. Rev., 2008, 88, 611-638.
    • (2008) Physiol. Rev , vol.88 , pp. 611-638
    • Scarpulla, R.C.1
  • 50
    • 84862233042 scopus 로고    scopus 로고
    • Damaged mitochondrial DNA replication system and the development of diabetic retinopathy
    • Tewari, S.; Santos, J.M.; Kowluru, R.A. Damaged mitochondrial DNA replication system and the development of diabetic retinopathy. Antioxid. Redox. Signal., 2012, 17, 492-504.
    • (2012) Antioxid. Redox. Signal , vol.17 , pp. 492-504
    • Tewari, S.1    Santos, J.M.2    Kowluru, R.A.3
  • 51
    • 84867320438 scopus 로고    scopus 로고
    • Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy
    • Tewari, S.; Zhong, Q.; Santos, J.M.; Kowluru, R.A. Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy. Inves Ophthalmol. Vis. Sci., 2012, 53, 4881-4888.
    • (2012) Inves Ophthalmol. Vis. Sci , vol.53 , pp. 4881-4888
    • Tewari, S.1    Zhong, Q.2    Santos, J.M.3    Kowluru, R.A.4
  • 52
    • 0033646639 scopus 로고    scopus 로고
    • Transcription and replication of mitochondrial DNA
    • Clayton, D.A. Transcription and replication of mitochondrial DNA. Hum, Reprod., 2000, 15, 11-17.
    • (2000) Hum, Reprod , vol.15 , pp. 11-17
    • Clayton, D.A.1
  • 53
    • 77951186338 scopus 로고    scopus 로고
    • Analysis of differential DNA damage in the mitochondrial genome employing a semi-long run real-Time PCR approach
    • Rothfuss, O.; Gasser, T.; Patenge, N. Analysis of differential DNA damage in the mitochondrial genome employing a semi-long run real-Time PCR approach. Nucleic Acids Res., 2010, 38, e24.
    • (2010) Nucleic Acids Res , vol.38
    • Rothfuss, O.1    Gasser, T.2    Patenge, N.3
  • 55
    • 29544450016 scopus 로고    scopus 로고
    • Mutations in the mitochondrial DNA D-loop region are frequent in cervical cancer
    • Sharma, H.; Singh, A.; Sharma, C.; Jain, S.K.; Singh, N. Mutations in the mitochondrial DNA D-loop region are frequent in cervical cancer. Cancer. Cell. Int., 2005, 5, 34.
    • (2005) Cancer. Cell. Int , vol.5 , pp. 34
    • Sharma, H.1    Singh, A.2    Sharma, C.3    Jain, S.K.4    Singh, N.5
  • 57
    • 3242739284 scopus 로고    scopus 로고
    • Reconstitution of a minimal mtDNA replisome in vitro
    • Korhonen, J.A.; Pham, X.H.; Pellegrini, M.; Falkenberg, M. Reconstitution of a minimal mtDNA replisome in vitro. EMBO J., 2004, 23, 2423-2429.
    • (2004) EMBO J , vol.23 , pp. 2423-2429
    • Korhonen, J.A.1    Pham, X.H.2    Pellegrini, M.3    Falkenberg, M.4
  • 58
    • 0031729874 scopus 로고    scopus 로고
    • Early worsening of diabetic retinopathy in the diabetes control and complication trial
    • Diabetes Control and Complications Trial Research Group
    • Diabetes Control and Complications Trial Research Group. Early worsening of diabetic retinopathy in the diabetes control and complication trial. Arch. Ophthalm., 1998, 116, 874-886.
    • (1998) Arch. Ophthalm , vol.116 , pp. 874-886
  • 59
    • 58149252632 scopus 로고    scopus 로고
    • Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial
    • White, N.H.; Sun, W.; Cleary, P.A.; Danis, R.P.; Davis, M.D.; Hainsworth, D.P. Hubbard, L.D.; Lachin, J.M.; Nathan, D.M. Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Arch. Ophthalmol., 2008, 126,1707-1715.
    • (2008) Arch. Ophthalmol , vol.126 , pp. 1707-1715
    • White, N.H.1    Sun, W.2    Cleary, P.A.3    Danis, R.P.4    Davis, M.D.5    Hainsworth, D.P.6    Hubbard, L.D.7    Lachin, J.M.8    Nathan, D.M.9
  • 60
    • 77951843664 scopus 로고    scopus 로고
    • Effect of prior intensive therapy in type 1 diabetes on 10-year progression of retinopathy in the DCCT/EDIC: Comparison of adults and adolescents
    • DCCT-EDIC Research Group
    • White, N.H.; Sun, W.; Cleary, P.A.; Tamborlane, W.W.; Danis, R.P.; Hainsworth, D.P. Davis, M.D.; DCCT-EDIC Research Group. Effect of prior intensive therapy in type 1 diabetes on 10-year progression of retinopathy in the DCCT/EDIC: comparison of adults and adolescents. Diabetes, 2010, 59,1244-1253.
    • (2010) Diabetes , vol.59 , pp. 1244-1253
    • White, N.H.1    Sun, W.2    Cleary, P.A.3    Tamborlane, W.W.4    Danis, R.P.5    Hainsworth, D.P.6    Davis, M.D.7
  • 61
    • 0032511583 scopus 로고    scopus 로고
    • Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes
    • UKPDS
    • UKPDS. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet, 1998, 352, 837-853.
    • (1998) Lancet , vol.352 , pp. 837-853
  • 62
    • 0023641117 scopus 로고
    • Progression of incipient diabetic retinopathy during good glycemic control
    • Engerman, R.L.; Kern, T.S. Progression of incipient diabetic retinopathy during good glycemic control. Diabetes, 1987, 36, 808-812.
    • (1987) Diabetes , vol.36 , pp. 808-812
    • Engerman, R.L.1    Kern, T.S.2
  • 64
    • 0037342855 scopus 로고    scopus 로고
    • Effect of re-institution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats
    • Kowluru, R.A. Effect of re-institution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes, 2003, 52, 818-823.
    • (2003) Diabetes , vol.52 , pp. 818-823
    • Kowluru, R.A.1
  • 65
    • 84883213667 scopus 로고    scopus 로고
    • Effect of re-institution of good metabolic control on oxidative stress in the kidney of diabetic rats
    • Kowluru, R.A.; Abbas, S.N.; Odenbach, S. Effect of re-institution of good metabolic control on oxidative stress in the kidney of diabetic rats. J. Diabetes & its Complications, 2004, 18, 82-288.
    • (2004) J. Diabetes & Its Complications , vol.18 , pp. 82-288
    • Kowluru, R.A.1    Abbas, S.N.2    Odenbach, S.3
  • 66
    • 73149121384 scopus 로고    scopus 로고
    • Metabolic memory in diabetes-from in vitro oddity to in vivo problem: Role of Apoptosis
    • Kowluru, R.A.; Chan, P.S. Metabolic memory in diabetes-from in vitro oddity to in vivo problem: Role of Apoptosis. Brain. Res. Bull., 2010, 87, 297-302.
    • (2010) Brain. Res. Bull , vol.87 , pp. 297-302
    • Kowluru, R.A.1    Chan, P.S.2
  • 67
    • 77955498700 scopus 로고    scopus 로고
    • Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon
    • Zhong, Q.; Kowluru, R.A. Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon. J. Cell. Biochem., 2010, 110,1306-1313.
    • (2010) J. Cell. Biochem , vol.110 , pp. 1306-1313
    • Zhong, Q.1    Kowluru, R.A.2
  • 68
    • 79953183375 scopus 로고    scopus 로고
    • Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy
    • Zhong, Q.; Kowluru, R.A. Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy. Diabetes, 2011, 60,1304-1313.
    • (2011) Diabetes , vol.60 , pp. 1304-1313
    • Zhong, Q.1    Kowluru, R.A.2
  • 69
    • 84855389514 scopus 로고    scopus 로고
    • Diabetic retinopathy and damage to mitochondrial structure and transport machinery
    • Zhong, Q.; Kowluru R.A. Diabetic retinopathy and damage to mitochondrial structure and transport machinery. Inves Ophthalmol. Vis. Sci., 2011, 52, 8739-8746.
    • (2011) Inves Ophthalmol. Vis. Sci , vol.52 , pp. 8739-8746
    • Zhong, Q.1    Kowluru, R.A.2
  • 70
    • 0028954710 scopus 로고
    • Retinopathy in galactose-fed dogs continues to progress after cessation of galactosemia
    • Engerman, R.L.; Kern, T.S. Retinopathy in galactose-fed dogs continues to progress after cessation of galactosemia. Arch. Ophthalmol., 1995, 113, 355-358.
    • (1995) Arch. Ophthalmol , vol.113 , pp. 355-358
    • Engerman, R.L.1    Kern, T.S.2
  • 71
    • 0025067393 scopus 로고
    • Overexpression of fibronectin induced by diabetes or high glucose: Phenomenon with a memory
    • Roy, S.; Sala, R.; Cagliero, E.; Lorenzi, M. Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory. Proc. Natl. Acad. Sci. USA., 1990, 87, 404-408.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 404-408
    • Roy, S.1    Sala, R.2    Cagliero, E.3    Lorenzi, M.4
  • 72
    • 77951224619 scopus 로고    scopus 로고
    • Metabolic memory and diabetic retinopathy: Role of inflammatory mediators in retinal pericytes
    • Kowluru, R.A.; Zhong, Q.; Kanwar, M. Metabolic memory and diabetic retinopathy: role of inflammatory mediators in retinal pericytes. Exp. Eye Res., 2010, 90, 617-623.
    • (2010) Exp. Eye Res , vol.90 , pp. 617-623
    • Kowluru, R.A.1    Zhong, Q.2    Kanwar, M.3
  • 73
    • 54949157448 scopus 로고    scopus 로고
    • Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives
    • Madsen-Bouterse, S.A.; Kowluru, R.A. Oxidative stress and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives. Rev. Endocr. Metab. Disord., 2008, 9, 315-327.
    • (2008) Rev. Endocr. Metab. Disord , vol.9 , pp. 315-327
    • Madsen-Bouterse, S.A.1    Kowluru, R.A.2
  • 74
    • 84874534208 scopus 로고    scopus 로고
    • Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: Role of histone methylation
    • Zhong, Q.; Kowluru, R.A. Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: Role of histone methylation. Invest. Ophthalmol. Vis. Sci., 2013, 54, 244-250.
    • (2013) Invest. Ophthalmol. Vis. Sci , vol.54 , pp. 244-250
    • Zhong, Q.1    Kowluru, R.A.2
  • 75
    • 84878774334 scopus 로고    scopus 로고
    • Regulation of matrix metallopeptidase-9 by epigenetic modifications, and the development of diabetic retinopathy
    • Zhong, Q.; Kowluru, R.A. Regulation of matrix metallopeptidase-9 by epigenetic modifications, and the development of diabetic retinopathy. Diabetes, 2013, 62, 2559-2568.
    • (2013) Diabetes , vol.62 , pp. 2559-2568
    • Zhong, Q.1    Kowluru, R.A.2
  • 76
    • 33644698951 scopus 로고    scopus 로고
    • Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications participants with type 1 diabetes
    • DCCT Skin Collagen Ancillary Study Group
    • Genuth, S.; Sun, W.; Cleary, P.; Sell, D.R.; Dahms, W.; Malone, J.; Sivitz, W.; Monnier, V.M.; DCCT Skin Collagen Ancillary Study Group. Glycation and carboxymethyllysine levels in skin collagen predict the risk of future 10-year progression of diabetic retinopathy and nephropathy in the diabetes control and complications trial and epidemiology of diabetes interventions and complications participants with type 1 diabetes. Diabetes, 2005, 54, 3103-3111.
    • (2005) Diabetes , vol.54 , pp. 3103-3111
    • Genuth, S.1    Sun, W.2    Cleary, P.3    Sell, D.R.4    Dahms, W.5    Malone, J.6    Sivitz, W.7    Monnier, V.M.8
  • 77
    • 12944302088 scopus 로고    scopus 로고
    • Re-Institution of good metabolic control in diabetic rats on the activation of caspase-3 and nuclear transcriptional factor (NF-kB) in the retina
    • Kowluru, R.A.; Chakrabarti, S.; Chen, S. Re-Institution of good metabolic control in diabetic rats on the activation of caspase-3 and nuclear transcriptional factor (NF-kB) in the retina. Acta Diabetologica, 2004, 44, 194-199.
    • (2004) Acta Diabetologica , vol.44 , pp. 194-199
    • Kowluru, R.A.1    Chakrabarti, S.2    Chen, S.3
  • 78
    • 78649842470 scopus 로고    scopus 로고
    • The diverse functions of GAPDH: Views from different subcellular compartments
    • Tristan, C.; Shahani, N.; Sedlak, T.W.; Sawa, A. The diverse functions of GAPDH: views from different subcellular compartments. Cell Signal, 2011, 23, 317-323.
    • (2011) Cell Signal , vol.23 , pp. 317-323
    • Tristan, C.1    Shahani, N.2    Sedlak, T.W.3    Sawa, A.4
  • 79
    • 85047691537 scopus 로고    scopus 로고
    • Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
    • Du, X.; Matsumura, T.; Edelstein, D.; Rossetti, L.; Zsengeller, Z.; Szabo, C.; Brownlee, M. Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J. Clin. Invest., 2003, 112, 1049-1057.
    • (2003) J. Clin. Invest , vol.112 , pp. 1049-1057
    • Du, X.1    Matsumura, T.2    Edelstein, D.3    Rossetti, L.4    Zsengeller, Z.5    Szabo, C.6    Brownlee, M.7
  • 80
    • 63249102297 scopus 로고    scopus 로고
    • Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy
    • Kanwar, M.; Kowluru, R. Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. Diabetes, 2009, 58, 227-234.
    • (2009) Diabetes , vol.58 , pp. 227-234
    • Kanwar, M.1    Kowluru, R.2
  • 81
    • 40349089627 scopus 로고    scopus 로고
    • Epigenetic modulation and cancer: Effect of metabolic syndrome?
    • Ross, S.A.; Milner, J.A. Epigenetic modulation and cancer: effect of metabolic syndrome? Am. J. Clin. Nutr., 2007, 86, 872-877.
    • (2007) Am. J. Clin. Nutr , vol.86 , pp. 872-877
    • Ross, S.A.1    Milner, J.A.2
  • 82
    • 77449083293 scopus 로고    scopus 로고
    • Epigenetics and the environmental regulation of the genome and its function
    • Zhang, T.Y.; Meaney, M.J. Epigenetics and the environmental regulation of the genome and its function. Annu. Rev. Psychol., 2010, 61, 439-466.
    • (2010) Annu. Rev. Psychol , vol.61 , pp. 439-466
    • Zhang, T.Y.1    Meaney, M.J.2
  • 83
    • 84855956247 scopus 로고    scopus 로고
    • Epigenetics and the environment: Emerging patterns and implications
    • Feil, R.; Fraga, M.F. Epigenetics and the environment: emerging patterns and implications. Nat. Rev. Genet., 2012, 13, 97-109.
    • (2012) Nat. Rev. Genet , vol.13 , pp. 97-109
    • Feil, R.1    Fraga, M.F.2
  • 84
    • 84863706772 scopus 로고    scopus 로고
    • Redefining the impact of nutrition on breast cancer incidence: Is epigenetics involved? Nut
    • Teegarden, D.; Romieu, I.; Lelièvre, S.A. Redefining the impact of nutrition on breast cancer incidence: is epigenetics involved? Nut. Res. Rev., 2012, 25, 68-95.
    • (2012) Res. Rev , vol.25 , pp. 68-95
    • Teegarden, D.1    Romieu, I.2    Lelièvre, S.A.3
  • 85
    • 84861420089 scopus 로고    scopus 로고
    • The role of diet in prevention and management of type 2 diabetes: Implications for public health
    • Lazarou, C.; Panagiotakos, D.; Matalas, A.L. The role of diet in prevention and management of type 2 diabetes: implications for public health. Crit. Rev. Food. Sci. Nutr., 2012, 52, 382-389.
    • (2012) Crit. Rev. Food. Sci. Nutr , vol.52 , pp. 382-389
    • Lazarou, C.1    Panagiotakos, D.2    Matalas, A.L.3
  • 86
    • 65549170303 scopus 로고    scopus 로고
    • Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with geneactivating epigenetic marks that coexist on the lysine tail
    • Brasacchio, D.; Okabe, J.; Tikellis, C.; Balcerczyk, A.; George, O.; Baker, E.K.; Calkin, A.C.; Brownlee, M.; Cooper, M.E.; El-Osta, A. Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with geneactivating epigenetic marks that coexist on the lysine tail. Diabetes, 2009, 58, 1229-1236.
    • (2009) Diabetes , vol.58 , pp. 1229-1236
    • Brasacchio, D.1    Okabe, J.2    Tikellis, C.3    Balcerczyk, A.4    George, O.5    Baker, E.K.6    Calkin, A.C.7    Brownlee, M.8    Cooper, M.E.9    El-Osta, A.10
  • 87
    • 53349101264 scopus 로고    scopus 로고
    • Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
    • El-Osta, A.; Brasacchio, D.; Yao, D.; Pocai, A.; Jones, P.L.; Roeder, R.G. Cooper, M.E.; Brownlee, M. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J. Exp. Med., 2008, 205, 2409-2417.
    • (2008) J. Exp. Med , vol.205 , pp. 2409-2417
    • El-Osta, A.1    Brasacchio, D.2    Yao, D.3    Pocai, A.4    Jones, P.L.5    Roeder, R.G.6    Cooper, M.E.7    Brownlee, M.8
  • 88
    • 78650694320 scopus 로고    scopus 로고
    • Epigenetics: Mechanisms and implications for diabetic complications
    • Cooper, M.E.; El-Osta, A. Epigenetics: mechanisms and implications for diabetic complications. Circ. Res., 2010, 107,1403-1413.
    • (2010) Circ. Res , vol.107 , pp. 1403-1413
    • Cooper, M.E.1    El-Osta, A.2
  • 89
    • 79959730772 scopus 로고    scopus 로고
    • Epigenetics: Deciphering its role in diabetes and its chronic complications
    • Villeneuve, L.M.; Reddy, M.A.; Natarajan, R. Epigenetics: deciphering its role in diabetes and its chronic complications. Clin. Exp. Pharmacol. Physiol., 2011, 38, 401-409.
    • (2011) Clin. Exp. Pharmacol. Physiol , vol.38 , pp. 401-409
    • Villeneuve, L.M.1    Reddy, M.A.2    Natarajan, R.3
  • 91
    • 0035839057 scopus 로고    scopus 로고
    • The role of DNA methylation in mammalian epigenetics
    • Jones, P.A.; Takai, D. The role of DNA methylation in mammalian epigenetics. Science, 2001, 293, 1068-1070.
    • (2001) Science , vol.293 , pp. 1068-1070
    • Jones, P.A.1    Takai, D.2
  • 92
    • 84856558597 scopus 로고    scopus 로고
    • Heritable transmission of diabetic metabolic memory in Zebrafish correlates with DNA hypomethylation and aberrant gene expression
    • Olsen, A.S.; Sarras, M.P.; Leontovich, A.; Intine, R.V. Heritable transmission of diabetic metabolic memory in Zebrafish correlates with DNA hypomethylation and aberrant gene expression. Diabetes, 2012, 61, 485-491.
    • (2012) Diabetes , vol.61 , pp. 485-491
    • Olsen, A.S.1    Sarras, M.P.2    Leontovich, A.3    Intine, R.V.4
  • 93
  • 94
    • 80055041172 scopus 로고    scopus 로고
    • Targeting mitochondria as a therapeutic target in cancer
    • Wenner, C.E. Targeting mitochondria as a therapeutic target in cancer. J. Cell. Physiol., 2012, 227, 450-456.
    • (2012) J. Cell. Physiol , vol.227 , pp. 450-456
    • Wenner, C.E.1
  • 96
    • 9444224415 scopus 로고    scopus 로고
    • Effect of long-Term administration of alpha lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats
    • Kowluru, R.A.; Odenbach, S. Effect of long-Term administration of alpha lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes, 2004, 53, 3233-3238.
    • (2004) Diabetes , vol.53 , pp. 3233-3238
    • Kowluru, R.A.1    Odenbach, S.2
  • 98
    • 84861715426 scopus 로고    scopus 로고
    • Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells
    • Zhu, Q.; Huang, Y.; Marton, L.J.; Woster, P.M.; Davidson, N.E.; Casero, R.A.J. Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino Acids, 2012, 42, 887-898.
    • (2012) Amino Acids , vol.42 , pp. 887-898
    • Zhu, Q.1    Huang, Y.2    Marton, L.J.3    Woster, P.M.4    Davidson, N.E.5    Casero, R.A.J.6


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