메뉴 건너뛰기




Volumn 20, Issue 14, 2014, Pages 3858-3874

Predictive and prognostic biomarkers with therapeutic targets in advanced colorectal cancer

Author keywords

Advanced colorectal cancer; Biomarker; Predictive; Prognostic; Target therapy

Indexed keywords

AMPHIREGULIN; B RAF KINASE; BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIREGULIN; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4, 5 BISPHOSPHATE 3 KINASE; PROTEIN P53; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; BEVACIZUMAB; BRAF PROTEIN, HUMAN; CETUXIMAB; MONOCLONAL ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIK3CA PROTEIN, HUMAN; PTEN PROTEIN, HUMAN; RAS PROTEIN; TP53 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84898426145     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i14.3858     Document Type: Article
Times cited : (49)

References (145)
  • 1
    • 84909985319 scopus 로고    scopus 로고
    • An Analysis of Incidence and Mortality of Colorectal Cancer in China, 2009
    • Wang N, Sun TT, Zheng RS, Zhang SW, Chen WQ. An Analysis of Incidence and Mortality of Colorectal Cancer in China, 2009. Zhongguo Zhongliu 2013; 22: 516-520
    • (2013) Zhongguo Zhongliu , vol.22 , pp. 516-520
    • Wang, N.1    Sun, T.T.2    Zheng, R.S.3    Zhang, S.W.4    Chen, W.Q.5
  • 2
    • 77955635233 scopus 로고    scopus 로고
    • Cancer statistics, 2010
    • [PMID: 20610543 DOI: 10.3322/ caac.20073]
    • Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60: 277-300 [PMID: 20610543 DOI: 10.3322/ caac.20073]
    • (2010) CA Cancer J Clin , vol.60 , pp. 277-300
    • Jemal, A.1    Siegel, R.2    Xu, J.3    Ward, E.4
  • 3
    • 84855944905 scopus 로고    scopus 로고
    • Development of molecular biomarkers in individualized treatment of colorectal cancer
    • [PMID: 21729679 DOI: 10.1016/j.clcc.2011.03.030]
    • De Mattos-Arruda L, Dienstmann R, Tabernero J. Development of molecular biomarkers in individualized treatment of colorectal cancer. Clin Colorectal Cancer 2011; 10: 279-289 [PMID: 21729679 DOI: 10.1016/j.clcc.2011.03.030]
    • (2011) Clin Colorectal Cancer , vol.10 , pp. 279-289
    • De Mattos-Arruda, L.1    Dienstmann, R.2    Tabernero, J.3
  • 4
    • 42949142609 scopus 로고    scopus 로고
    • Systemic treatment of colorectal cancer
    • [PMID: 18471507 DOI: 10.1053/j.gastro.2008.02.098]
    • Wolpin BM, Mayer RJ. Systemic treatment of colorectal cancer. Gastroenterology 2008; 134: 1296-1310 [PMID: 18471507 DOI: 10.1053/j.gastro.2008.02.098]
    • (2008) Gastroenterology , vol.134 , pp. 1296-1310
    • Wolpin, B.M.1    Mayer, R.J.2
  • 6
    • 33749316418 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway: A model for targeted therapy
    • [PMID: 17000658 DOI: 10.1158/1078-0432. CCR-05-1554]
    • Scaltriti M, Baselga J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin Cancer Res 2006; 12: 5268-5272 [PMID: 17000658 DOI: 10.1158/1078-0432. CCR-05-1554]
    • (2006) Clin Cancer Res , vol.12 , pp. 5268-5272
    • Scaltriti, M.1    Baselga, J.2
  • 7
    • 16244400108 scopus 로고    scopus 로고
    • Cetuximab: An epidermal growth factor receptor chemeric human-murine monoclonal antibody
    • [PMID: 15821783 DOI: 10.1358/dot.2005.41.2.882662]
    • Harding J, Burtness B. Cetuximab: an epidermal growth factor receptor chemeric human-murine monoclonal antibody. Drugs Today (Barc) 2005; 41: 107-127 [PMID: 15821783 DOI: 10.1358/dot.2005.41.2.882662]
    • (2005) Drugs Today (Barc) , vol.41 , pp. 107-127
    • Harding, J.1    Burtness, B.2
  • 8
    • 13844250537 scopus 로고    scopus 로고
    • The epidermal growth factor receptor as a target for colorectal cancer therapy
    • [PMID: 15726506 DOI: 10.1053/j.seminoncol.2004.09.036]
    • Lockhart AC, Berlin JD. The epidermal growth factor receptor as a target for colorectal cancer therapy. Semin Oncol 2005; 32: 52-60 [PMID: 15726506 DOI: 10.1053/j.seminoncol.2004.09.036]
    • (2005) Semin Oncol , vol.32 , pp. 52-60
    • Lockhart, A.C.1    Berlin, J.D.2
  • 9
    • 36749086904 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor in metastatic colorectal cancer
    • [PMID: 18006328 DOI: 10.1016/j.critrevonc.200 7.09.006]
    • Ng K, Zhu AX. Targeting the epidermal growth factor receptor in metastatic colorectal cancer. Crit Rev Oncol Hematol 2008; 65: 8-20 [PMID: 18006328 DOI: 10.1016/j.critrevonc.200 7.09.006]
    • (2008) Crit Rev Oncol Hematol , vol.65 , pp. 8-20
    • Ng, K.1    Zhu, A.X.2
  • 10
    • 77955860591 scopus 로고    scopus 로고
    • EGFR and KRAS in colorectal cancer
    • [PMID: 20857619 DOI: 10.1016/S0065-2423(10)51004-7]
    • Markman B, Javier Ramos F, Capdevila J, Tabernero J. EGFR and KRAS in colorectal cancer. Adv Clin Chem 2010; 51: 71-119 [PMID: 20857619 DOI: 10.1016/S0065-2423(10)51004-7]
    • (2010) Adv Clin Chem , vol.51 , pp. 71-119
    • Markman, B.1    Ramos, J.F.2    Capdevila, J.3    Tabernero, J.4
  • 12
    • 63849085124 scopus 로고    scopus 로고
    • FDA review of a panitumumab (Vectibix) clinical trial for first-line treatment of metastatic colorectal cancer
    • [PMID: 19282350 DOI: 10.1634/theoncologist.2008-0254]
    • Giusti RM, Cohen MH, Keegan P, Pazdur R. FDA review of a panitumumab (Vectibix) clinical trial for first-line treatment of metastatic colorectal cancer. Oncologist 2009; 14: 284-290 [PMID: 19282350 DOI: 10.1634/theoncologist.2008-0254]
    • (2009) Oncologist , vol.14 , pp. 284-290
    • Giusti, R.M.1    Cohen, M.H.2    Keegan, P.3    Pazdur, R.4
  • 13
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • [PMID: 17363584 DOI: 10.1158/0008-5472.CAN-06-4158]
    • Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, Zanon C, Moroni M, Veronese S, Siena S, Bardelli A. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 2007; 67: 2643-2648 [PMID: 17363584 DOI: 10.1158/0008-5472.CAN-06-4158]
    • (2007) Cancer Res , vol.67 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Zanon, C.4    Moroni, M.5    Veronese, S.6    Siena, S.7    Bardelli, A.8
  • 16
    • 27744525441 scopus 로고    scopus 로고
    • Somatic mutation of EGFR catalytic domain and treatment with gefitinib in colorectal cancer
    • [PMID: 16012179 DOI: 10.1093/annonc/ mdi356]
    • Moroni M, Sartore-Bianchi A, Benvenuti S, Artale S, Bardelli A, Siena S. Somatic mutation of EGFR catalytic domain and treatment with gefitinib in colorectal cancer. Ann Oncol 2005; 16: 1848-1849 [PMID: 16012179 DOI: 10.1093/annonc/ mdi356]
    • (2005) Ann Oncol , vol.16 , pp. 1848-1849
    • Moroni, M.1    Sartore-Bianchi, A.2    Benvenuti, S.3    Artale, S.4    Bardelli, A.5    Siena, S.6
  • 18
    • 70349939382 scopus 로고    scopus 로고
    • Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
    • [PMID: 19738166 DOI: 10.1093/jnci/djp280]
    • Siena S, Sartore-Bianchi A, Di Nicolantonio F, Balfour J, Bardelli A. Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J Natl Cancer Inst 2009; 101: 1308-1324 [PMID: 19738166 DOI: 10.1093/jnci/djp280]
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1308-1324
    • Siena, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Balfour, J.4    Bardelli, A.5
  • 20
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • [PMID: 17470858 DOI: 10.1200/JCO.2006.08.1620]
    • Van Cutsem E, Peeters M, Siena S, Humblet Y, Hendlisz A, Neyns B, Canon JL, Van Laethem JL, Maurel J, Richardson G, Wolf M, Amado RG. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007; 25: 1658-1664 [PMID: 17470858 DOI: 10.1200/JCO.2006.08.1620]
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • van Cutsem, E.1    Peeters, M.2    Siena, S.3    Humblet, Y.4    Hendlisz, A.5    Neyns, B.6    Canon, J.L.7    van Laethem, J.L.8    Maurel, J.9    Richardson, G.10    Wolf, M.11    Amado, R.G.12
  • 21
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • [PMID: 14993230 DOI: 10.1200/JCO.2004.10.182]
    • Saltz LB, Meropol NJ, Loehrer PJ, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22: 1201-1208 [PMID: 14993230 DOI: 10.1200/JCO.2004.10.182]
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer, P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 24
    • 0035447953 scopus 로고    scopus 로고
    • Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: Implications for a standardized scoring system
    • [PMID: 11571750 DOI: 10.1002/1097-0142(2001 0901)]
    • Goldstein NS, Armin M. Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system. Cancer 2001; 92: 1331-1346 [PMID: 11571750 DOI: 10.1002/1097-0142(2001 0901)]
    • (2001) Cancer , vol.92 , pp. 1331-1346
    • Goldstein, N.S.1    Armin, M.2
  • 26
    • 19944422060 scopus 로고    scopus 로고
    • Somatic mutations of EGFR in colorectal cancers and glioblastomas
    • [PMID: 15625347 DOI: 10.1056/ NEJM200412303512724]
    • Barber TD, Vogelstein B, Kinzler KW, Velculescu VE. Somatic mutations of EGFR in colorectal cancers and glioblastomas. N Engl J Med 2004; 351: 2883 [PMID: 15625347 DOI: 10.1056/ NEJM200412303512724]
    • N Engl J Med , vol.2004 , pp. 351
    • Barber, T.D.1    Vogelstein, B.2    Kinzler, K.W.3    Velculescu, V.E.4
  • 27
    • 22044446497 scopus 로고    scopus 로고
    • Responsiveness to cetuximab without mutations in EGFR
    • [PMID: 16014894 DOI: 10.1056/ NEJM200507143530218]
    • Tsuchihashi Z, Khambata-Ford S, Hanna N, Jänne PA. Responsiveness to cetuximab without mutations in EGFR. N Engl J Med 2005; 353: 208-209 [PMID: 16014894 DOI: 10.1056/ NEJM200507143530218]
    • (2005) N Engl J Med , vol.353 , pp. 208-209
    • Tsuchihashi, Z.1    Khambata-Ford, S.2    Hanna, N.3    Jänne, P.A.4
  • 30
    • 84864916835 scopus 로고    scopus 로고
    • EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: A meta-analysis
    • [PMID: 22897982]
    • Yang ZY, Shen WX, Hu XF, Zheng DY, Wu XY, Huang YF, Chen JZ, Mao C, Tang JL. EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: a meta-analysis. J Hematol Oncol 2012; 5: 52 [PMID: 22897982]
    • (2012) J Hematol Oncol , vol.5 , pp. 52
    • Yang, Z.Y.1    Shen, W.X.2    Hu, X.F.3    Zheng, D.Y.4    Wu, X.Y.5    Huang, Y.F.6    Chen, J.Z.7    Mao, C.8    Tang, J.L.9
  • 31
    • 84874167463 scopus 로고    scopus 로고
    • EGFR gene copy number as a prognostic marker in colorectal cancer patients treated with cetuximab or panitumumab: A systematic review and meta analysis
    • [PMID: 23441167]
    • Jiang Z, Li C, Li F, Wang X. EGFR gene copy number as a prognostic marker in colorectal cancer patients treated with cetuximab or panitumumab: a systematic review and meta analysis. PLoS One 2013; 8: e56205 [PMID: 23441167]
    • (2013) PLoS One , vol.8
    • Jiang, Z.1    Li, C.2    Li, F.3    Wang, X.4
  • 32
    • 3343024502 scopus 로고    scopus 로고
    • Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers: An immunohistochemical and fluorescent in situ hybridization study
    • [PMID: 15143334 DOI: 10.1038/modpathol.3800137]
    • Ooi A, Takehana T, Li X, Suzuki S, Kunitomo K, Iino H, Fujii H, Takeda Y, Dobashi Y. Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers: an immunohistochemical and fluorescent in situ hybridization study. Mod Pathol 2004; 17: 895-904 [PMID: 15143334 DOI: 10.1038/modpathol.3800137]
    • (2004) Mod Pathol , vol.17 , pp. 895-904
    • Ooi, A.1    Takehana, T.2    Li, X.3    Suzuki, S.4    Kunitomo, K.5    Iino, H.6    Fujii, H.7    Takeda, Y.8    Dobashi, Y.9
  • 33
    • 84867080684 scopus 로고    scopus 로고
    • Use of epiregulin (EREG) and amphiregulin (AREG) gene expression to predict response to cetuximab therapy in combination with oxaliplatin (Ox) and 5FU in first-line treatment of advanced colorectal cancer (aCRC)
    • May 30-June 3; McCormick Place, Chicago, Illinois. J Clin Oncol 2012: Abstract 3516
    • Adams R, Fisher D, Farragher S, Scott A, Smith C, James M, Cheadle J, Nichols L, Meade AM, Kaplan RS, Wilson RH, Wasan H, Maughan T. Use of epiregulin (EREG) and amphiregulin (AREG) gene expression to predict response to cetuximab therapy in combination with oxaliplatin (Ox) and 5FU in first-line treatment of advanced colorectal cancer (aCRC). Proceedings of ASCO Annual Meeting; 2012 May 30-June 3; McCormick Place, Chicago, Illinois. J Clin Oncol 2012: Abstract 3516
    • (2012) Proceedings of ASCO Annual Meeting
    • Adams, R.1    Fisher, D.2    Farragher, S.3    Scott, A.4    Smith, C.5    James, M.6    Cheadle, J.7    Nichols, L.8    Meade, A.M.9    Kaplan, R.S.10    Wilson, R.H.11    Wasan, H.12    Maughan, T.13
  • 36
    • 43749088703 scopus 로고    scopus 로고
    • KRAS mutation signature in colorectal tumors significantly overlaps with the cetuximab response signature
    • author reply 2230-2231 [PMID: 18445856 DOI: 10.1200/JCO.2007.15.9186]
    • de Reyniès A, Boige V, Milano G, Faivre J, Laurent-Puig P. KRAS mutation signature in colorectal tumors significantly overlaps with the cetuximab response signature. J Clin Oncol 2008; 26: 2228-2230; author reply 2230-2231 [PMID: 18445856 DOI: 10.1200/JCO.2007.15.9186]
    • (2008) J Clin Oncol , vol.26 , pp. 2228-2230
    • de Reyniès, A.1    Boige, V.2    Milano, G.3    Faivre, J.4    Laurent-Puig, P.5
  • 39
    • 84898476784 scopus 로고    scopus 로고
    • Amphiregulin and epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases. Proceedings of ASCO Annual Meeting; 2011 Jun 9; McCormick Place, Chicago, Illinois
    • Kuramochi H, Nakajima G, Kaneko Y, Nakamura A, Inoue Y, Okuyama R, Kondo Y, Kanemura T, Hayashi K, Yamamoto M. Amphiregulin and epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases. Proceedings of ASCO Annual Meeting; 2011 Jun 9; McCormick Place, Chicago, Illinois. J Clin Oncol 2011: e14023
    • (2011) J Clin Oncol
    • Kuramochi, H.1    Nakajima, G.2    Kaneko, Y.3    Nakamura, A.4    Inoue, Y.5    Okuyama, R.6    Kondo, Y.7    Kanemura, T.8    Hayashi, K.9    Yamamoto, M.10
  • 41
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • [PMID: 2188735]
    • Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 61: 759-767 [PMID: 2188735]
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 43
    • 0038648571 scopus 로고    scopus 로고
    • Molecular changes in the Ki-ras and APC genes in primary colorectal carcinoma and synchronous metastases compared with the findings in accompanying adenomas
    • [PMID: 12782759 DOI: 10.1136/mp.56.3.137]
    • Zauber P, Sabbath-Solitare M, Marotta SP, Bishop DT. Molecular changes in the Ki-ras and APC genes in primary colorectal carcinoma and synchronous metastases compared with the findings in accompanying adenomas. Mol Pathol 2003; 56: 137-140 [PMID: 12782759 DOI: 10.1136/mp.56.3.137]
    • (2003) Mol Pathol , vol.56 , pp. 137-140
    • Zauber, P.1    Sabbath-Solitare, M.2    Marotta, S.P.3    Bishop, D.T.4
  • 44
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • [PMID: 2547513]
    • Bos JL. Ras oncogenes in human cancer: a review. Cancer Res 1989; 49: 4682-4689 [PMID: 2547513]
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 46
    • 0032490124 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: The multicenter "RASCAL" study
    • [PMID: 9586664 DOI: 10.1093/jnci/90.9.675]
    • Andreyev HJ, Norman AR, Cunningham D, Oates JR, Clarke PA. Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study. J Natl Cancer Inst 1998; 90: 675-684 [PMID: 9586664 DOI: 10.1093/jnci/90.9.675]
    • (1998) J Natl Cancer Inst , vol.90 , pp. 675-684
    • Andreyev, H.J.1    Norman, A.R.2    Cunningham, D.3    Oates, J.R.4    Clarke, P.A.5
  • 49
    • 0028596162 scopus 로고
    • The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival
    • [PMID: 7989112 DOI: 10.1002/ijc.2910590606]
    • Dix BR, Robbins P, Soong R, Jenner D, House AK, Iacopetta BJ. The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival. Int J Cancer 1994; 59: 747-751 [PMID: 7989112 DOI: 10.1002/ijc.2910590606]
    • (1994) Int J Cancer , vol.59 , pp. 747-751
    • Dix, B.R.1    Robbins, P.2    Soong, R.3    Jenner, D.4    House, A.K.5    Iacopetta, B.J.6
  • 51
    • 79958076574 scopus 로고    scopus 로고
    • Adjuvant mFOLFOX6 with or without cetuxiumab (Cmab) in KRAS wild-type (WT) patients (pts) with resected stage III co-lon cancer (CC): Results from NCCTG Intergroup Phase III Trial N0147
    • 2010 June 22; McCormick Place, Chicago, Illinois. J Clin Oncol 2010: CRA3507
    • Alberts SR, Sargent DJ, Smyrk TC, Shields AF, Chan E, Goldberg RM, Gill S, Kahlenberg MS, Thibodeau SN, Nair S. Adjuvant mFOLFOX6 with or without cetuxiumab (Cmab) in KRAS wild-type (WT) patients (pts) with resected stage III co-lon cancer (CC): Results from NCCTG Intergroup Phase III Trial N0147. Proceedings of ASCO Annual Meeting; 2010 June 22; McCormick Place, Chicago, Illinois. J Clin Oncol 2010: CRA3507
    • Proceedings of ASCO Annual Meeting
    • Alberts, S.R.1    Sargent, D.J.2    Smyrk, T.C.3    Shields, A.F.4    Chan, E.5    Goldberg, R.M.6    Gill, S.7    Kahlenberg, M.S.8    Thibodeau, S.N.9    Nair, S.10
  • 58
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • [PMID: 19114685 DOI: 10.1200/JCO.2008.19.8135]
    • Hecht JR, Mitchell E, Chidiac T, Scroggin C, Hagenstad C, Spigel D, Marshall J, Cohn A, McCollum D, Stella P, Deeter R, Shahin S, Amado RG. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009; 27: 672-680 [PMID: 19114685 DOI: 10.1200/JCO.2008.19.8135]
    • (2009) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3    Scroggin, C.4    Hagenstad, C.5    Spigel, D.6    Marshall, J.7    Cohn, A.8    McCollum, D.9    Stella, P.10    Deeter, R.11    Shahin, S.12    Amado, R.G.13
  • 64
    • 79956310674 scopus 로고    scopus 로고
    • Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: The OPUS study
    • [PMID: 21228335 DOI: 10.1093/annonc/mdq632]
    • Bokemeyer C, Bondarenko I, Hartmann JT, de Braud F, Schuch G, Zubel A, Celik I, Schlichting M, Koralewski P. Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol 2011; 22: 1535-1546 [PMID: 21228335 DOI: 10.1093/annonc/mdq632]
    • (2011) Ann Oncol , vol.22 , pp. 1535-1546
    • Bokemeyer, C.1    Bondarenko, I.2    Hartmann, J.T.3    de Braud, F.4    Schuch, G.5    Zubel, A.6    Celik, I.7    Schlichting, M.8    Koralewski, P.9
  • 67
    • 77949885180 scopus 로고    scopus 로고
    • Favorable response to erlotinib in a lung adenocarcinoma with both epidermal growth factor receptor exon 19 deletion and K-ras G13D mutations
    • [PMID: 20008635 DOI: 10.1200/ JCO.2009.24.0747]
    • Lee CN, Chen HY, Liu HE. Favorable response to erlotinib in a lung adenocarcinoma with both epidermal growth factor receptor exon 19 deletion and K-ras G13D mutations. J Clin Oncol 2010; 28: e111-e112 [PMID: 20008635 DOI: 10.1200/ JCO.2009.24.0747]
    • (2010) J Clin Oncol , vol.28
    • Lee, C.N.1    Chen, H.Y.2    Liu, H.E.3
  • 69
    • 0034548712 scopus 로고    scopus 로고
    • K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorageindependent growth than codon 13 mutation or proto-oncogene overexpression
    • [PMID: 11118062]
    • Guerrero S, Casanova I, Farré L, Mazo A, Capellà G, Mangues R. K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorageindependent growth than codon 13 mutation or proto-oncogene overexpression. Cancer Res 2000; 60: 6750-6756 [PMID: 11118062]
    • (2000) Cancer Res , vol.60 , pp. 6750-6756
    • Guerrero, S.1    Casanova, I.2    Farré, L.3    Mazo, A.4    Capellà, G.5    Mangues, R.6
  • 71
    • 84867117207 scopus 로고    scopus 로고
    • Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab
    • [PMID: 22734028 DOI: 10.1200/JCO.2012.42.2592]
    • Tejpar S, Celik I, Schlichting M, Sartorius U, Bokemeyer C, Van Cutsem E. Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab. J Clin Oncol 2012; 30: 3570-3577 [PMID: 22734028 DOI: 10.1200/JCO.2012.42.2592]
    • (2012) J Clin Oncol , vol.30 , pp. 3570-3577
    • Tejpar, S.1    Celik, I.2    Schlichting, M.3    Sartorius, U.4    Bokemeyer, C.5    van Cutsem, E.6
  • 75
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer
    • [PMID: 20100961 DOI: 10.1200/ JCO.2009.24.6116]
    • Bardelli A, Siena S. Molecular mechanisms of resistance to cetuximab and panitumumab in colorectal cancer. J Clin Oncol 2010; 28: 1254-1261 [PMID: 20100961 DOI: 10.1200/ JCO.2009.24.6116]
    • (2010) J Clin Oncol , vol.28 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2
  • 76
    • 83055162010 scopus 로고    scopus 로고
    • Strategies for overcoming inherent and acquired resistance to EGFR inhibitors by targeting downstream effectors in the RAS/PI3K pathway
    • [PMID: 20718704 DOI: 10.2174/156800910793357961]
    • Weickhardt AJ, Tebbutt NC, Mariadason JM. Strategies for overcoming inherent and acquired resistance to EGFR inhibitors by targeting downstream effectors in the RAS/PI3K pathway. Curr Cancer Drug Targets 2010; 10: 824-833 [PMID: 20718704 DOI: 10.2174/156800910793357961]
    • (2010) Curr Cancer Drug Targets , vol.10 , pp. 824-833
    • Weickhardt, A.J.1    Tebbutt, N.C.2    Mariadason, J.M.3
  • 78
    • 73349114941 scopus 로고    scopus 로고
    • KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial
    • [PMID: 19884549 DOI: 10.1200/ JCO.2009.22.4295]
    • Richman SD, Seymour MT, Chambers P, Elliott F, Daly CL, Meade AM, Taylor G, Barrett JH, Quirke P. KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J Clin Oncol 2009; 27: 5931-5937 [PMID: 19884549 DOI: 10.1200/ JCO.2009.22.4295]
    • (2009) J Clin Oncol , vol.27 , pp. 5931-5937
    • Richman, S.D.1    Seymour, M.T.2    Chambers, P.3    Elliott, F.4    Daly, C.L.5    Meade, A.M.6    Taylor, G.7    Barrett, J.H.8    Quirke, P.9
  • 79
    • 60849109516 scopus 로고    scopus 로고
    • Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel
    • [PMID: 19127559 DOI: 10.1002/cncr.24019]
    • Vilkin A, Niv Y, Nagasaka T, Morgenstern S, Levi Z, Fireman Z, Fuerst F, Goel A, Boland CR. Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel. Cancer 2009; 115: 760-769 [PMID: 19127559 DOI: 10.1002/cncr.24019]
    • (2009) Cancer , vol.115 , pp. 760-769
    • Vilkin, A.1    Niv, Y.2    Nagasaka, T.3    Morgenstern, S.4    Levi, Z.5    Fireman, Z.6    Fuerst, F.7    Goel, A.8    Boland, C.R.9
  • 80
    • 78649744892 scopus 로고    scopus 로고
    • Prognostic vs predictive molecular biomarkers in colorectal cancer: Is KRAS and BRAF wild type status required for anti-EGFR therapy?
    • [PMID: 21129611 DOI: 10.1016/S0305-7372(10)70021-9]
    • Rizzo S, Bronte G, Fanale D, Corsini L, Silvestris N, Santini D, Gulotta G, Bazan V, Gebbia N, Fulfaro F, Russo A. Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy? Cancer Treat Rev 2010; 36 Suppl 3: S56-S61 [PMID: 21129611 DOI: 10.1016/S0305-7372(10)70021-9]
    • (2010) Cancer Treat Rev , vol.3 , Issue.SUPPL. 3
    • Rizzo, S.1    Bronte, G.2    Fanale, D.3    Corsini, L.4    Silvestris, N.5    Santini, D.6    Gulotta, G.7    Bazan, V.8    Gebbia, N.9    Fulfaro, F.10    Russo, A.11
  • 82
    • 78649473910 scopus 로고    scopus 로고
    • The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients
    • [PMID: 20501503 DOI: 10.1093/annonc/ mdq258]
    • Fariña-Sarasqueta A, van Lijnschoten G, Moerland E, Creemers GJ, Lemmens VE, Rutten HJ, van den Brule AJ. The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients. Ann Oncol 2010; 21: 2396-2402 [PMID: 20501503 DOI: 10.1093/annonc/ mdq258]
    • (2010) Ann Oncol , vol.21 , pp. 2396-2402
    • Fariña-Sarasqueta, A.1    van Lijnschoten, G.2    Moerland, E.3    Creemers, G.J.4    Lemmens, V.E.5    Rutten, H.J.6    van den Brule, A.J.7
  • 83
    • 58249089525 scopus 로고    scopus 로고
    • CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    • [PMID: 18832519 DOI: 10.1136/gut.2008.155473]
    • Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Meyerhardt JA, Loda M, Giovannucci EL, Fuchs CS. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 2009; 58: 90-96 [PMID: 18832519 DOI: 10.1136/gut.2008.155473]
    • (2009) Gut , vol.58 , pp. 90-96
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3    Kawasaki, T.4    Meyerhardt, J.A.5    Loda, M.6    Giovannucci, E.L.7    Fuchs, C.S.8
  • 84
    • 84862026304 scopus 로고    scopus 로고
    • Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials
    • [PMID: 22446022 DOI: 10.1016/j.ejca.2012.02.057]
    • Bokemeyer C, Van Cutsem E, Rougier P, Ciardiello F, Heeger S, Schlichting M, Celik I, Köhne CH. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur J Cancer 2012; 48: 1466-1475 [PMID: 22446022 DOI: 10.1016/j.ejca.2012.02.057]
    • (2012) Eur J Cancer , vol.48 , pp. 1466-1475
    • Bokemeyer, C.1    van Cutsem, E.2    Rougier, P.3    Ciardiello, F.4    Heeger, S.5    Schlichting, M.6    Celik, I.7    Köhne, C.H.8
  • 85
    • 77954215850 scopus 로고    scopus 로고
    • Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
    • [PMID: 20413299 DOI: 10.1016/j.ejca.2010.03.036]
    • Tol J, Dijkstra JR, Klomp M, Teerenstra S, Dommerholt M, Vink-Börger ME, van Cleef PH, van Krieken JH, Punt CJ, Nagtegaal ID. Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. Eur J Cancer 2010; 46: 1997-2009 [PMID: 20413299 DOI: 10.1016/j.ejca.2010.03.036]
    • (2010) Eur J Cancer , vol.46 , pp. 1997-2009
    • Tol, J.1    Dijkstra, J.R.2    Klomp, M.3    Teerenstra, S.4    Dommerholt, M.5    Vink-Börger, M.E.6    van Cleef, P.H.7    van Krieken, J.H.8    Punt, C.J.9    Nagtegaal, I.D.10
  • 90
    • 65649086786 scopus 로고    scopus 로고
    • PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer
    • [PMID: 19366826 DOI: 10.1158/1078-0432.CCR-08-2961]
    • Prenen H, De Schutter J, Jacobs B, De Roock W, Biesmans B, Claes B, Lambrechts D, Van Cutsem E, Tejpar S. PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer. Clin Cancer Res 2009; 15: 3184-3188 [PMID: 19366826 DOI: 10.1158/1078-0432.CCR-08-2961]
    • (2009) Clin Cancer Res , vol.15 , pp. 3184-3188
    • Prenen, H.1    de Schutter, J.2    Jacobs, B.3    de Roock, W.4    Biesmans, B.5    Claes, B.6    Lambrechts, D.7    van Cutsem, E.8    Tejpar, S.9
  • 92
    • 84876290460 scopus 로고    scopus 로고
    • PIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: A meta-analysis
    • [PMID: 23435830 DOI: 10.1007/s00432-013-1400-x]
    • Wu S, Gan Y, Wang X, Liu J, Li M, Tang Y. PIK3CA mutation is associated with poor survival among patients with metastatic colorectal cancer following anti-EGFR monoclonal antibody therapy: a meta-analysis. J Cancer Res Clin Oncol 2013; 139: 891-900 [PMID: 23435830 DOI: 10.1007/s00432-013-1400-x]
    • (2013) J Cancer Res Clin Oncol , vol.139 , pp. 891-900
    • Wu, S.1    Gan, Y.2    Wang, X.3    Liu, J.4    Li, M.5    Tang, Y.6
  • 93
    • 84860634396 scopus 로고    scopus 로고
    • PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: A systematic review and meta-analysis
    • [PMID: 22039088 DOI: 10.1093/annonc/ mdr464]
    • Mao C, Yang ZY, Hu XF, Chen Q, Tang JL. PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis. Ann Oncol 2012; 23: 1518-1525 [PMID: 22039088 DOI: 10.1093/annonc/ mdr464]
    • (2012) Ann Oncol , vol.23 , pp. 1518-1525
    • Mao, C.1    Yang, Z.Y.2    Hu, X.F.3    Chen, Q.4    Tang, J.L.5
  • 97
    • 34548676803 scopus 로고    scopus 로고
    • PIK3CA mutation is predictive of poor survival in patients with colorectal cancer
    • [PMID: 17590872 DOI: 10.1002/ ijc.22890]
    • Kato S, Iida S, Higuchi T, Ishikawa T, Takagi Y, Yasuno M, Enomoto M, Uetake H, Sugihara K. PIK3CA mutation is predictive of poor survival in patients with colorectal cancer. Int J Cancer 2007; 121: 1771-1778 [PMID: 17590872 DOI: 10.1002/ ijc.22890]
    • (2007) Int J Cancer , vol.121 , pp. 1771-1778
    • Kato, S.1    Iida, S.2    Higuchi, T.3    Ishikawa, T.4    Takagi, Y.5    Yasuno, M.6    Enomoto, M.7    Uetake, H.8    Sugihara, K.9
  • 101
    • 63949084084 scopus 로고    scopus 로고
    • Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant
    • [PMID: 19293803 DOI: 10.1038/sj.bjc.6604848]
    • Molinari F, Martin V, Saletti P, De Dosso S, Spitale A, Camponovo A, Bordoni A, Crippa S, Mazzucchelli L, Frattini M. Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant. Br J Cancer 2009; 100: 1087-1094 [PMID: 19293803 DOI: 10.1038/sj.bjc.6604848]
    • (2009) Br J Cancer , vol.100 , pp. 1087-1094
    • Molinari, F.1    Martin, V.2    Saletti, P.3    De Dosso, S.4    Spitale, A.5    Camponovo, A.6    Bordoni, A.7    Crippa, S.8    Mazzucchelli, L.9    Frattini, M.10
  • 102
    • 84863799886 scopus 로고    scopus 로고
    • Loss of PTEN expression as a predictor of resistance to anti-EGFR monoclonal therapy in metastatic colorectal cancer: Evidence from retrospective studies
    • [PMID: 22610356 DOI: 10.1007/s00280-012-1886-y]
    • Wang ZH, Gao QY, Fang JY. Loss of PTEN expression as a predictor of resistance to anti-EGFR monoclonal therapy in metastatic colorectal cancer: evidence from retrospective studies. Cancer Chemother Pharmacol 2012; 69: 1647-1655 [PMID: 22610356 DOI: 10.1007/s00280-012-1886-y]
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 1647-1655
    • Wang, Z.H.1    Gao, Q.Y.2    Fang, J.Y.3
  • 106
    • 84870786128 scopus 로고    scopus 로고
    • An International Consortium in chemorefractory metastatic colorectal cancer patients shows cetuximab efficacy in patients harboring HER2 gene copy number. European Multidisciplinary Cancer Congress
    • Sep 23-27; Stockholm, Sweden, [abstr 6015]
    • Martin V, Sacconi A, Landi L, Riva A, Saletti P, Geva R, Tejpar S, Kalogeras K, Frattini M, Cappuzzo F. An International Consortium in chemorefractory metastatic colorectal cancer patients shows cetuximab efficacy in patients harboring HER2 gene copy number. European Multidisciplinary Cancer Congress; 2011 Sep 23-27; Stockholm, Sweden. Eur J Cancer 2011: S392 [abstr 6015]
    • (2011) Eur J Cancer 2011
    • Martin, V.1    Sacconi, A.2    Landi, L.3    Riva, A.4    Saletti, P.5    Geva, R.6    Tejpar, S.7    Kalogeras, K.8    Frattini, M.9    Cappuzzo, F.10
  • 107
    • 84872197534 scopus 로고    scopus 로고
    • Optimizing treatment of metastatic colorectal cancer patients with anti-EGFR antibodies: Overcoming the mechanisms of cancer cell resistance
    • [PMID: 23281932 DOI: 10.1517/147 12598.2012.756469]
    • Troiani T, Zappavigna S, Martinelli E, Addeo SR, Stiuso P, Ciardiello F, Caraglia M. Optimizing treatment of metastatic colorectal cancer patients with anti-EGFR antibodies: overcoming the mechanisms of cancer cell resistance. Expert Opin Biol Ther 2013; 13: 241-255 [PMID: 23281932 DOI: 10.1517/147 12598.2012.756469]
    • (2013) Expert Opin Biol Ther , vol.13 , pp. 241-255
    • Troiani, T.1    Zappavigna, S.2    Martinelli, E.3    Addeo, S.R.4    Stiuso, P.5    Ciardiello, F.6    Caraglia, M.7
  • 108
    • 0032946931 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer
    • [PMID: 10226727]
    • Jiang W, Hiscox S, Matsumoto K, Nakamura T. Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer. Crit Rev Oncol Hematol 1999; 29: 209-248 [PMID: 10226727]
    • (1999) Crit Rev Oncol Hematol , vol.29 , pp. 209-248
    • Jiang, W.1    Hiscox, S.2    Matsumoto, K.3    Nakamura, T.4
  • 110
    • 15044352178 scopus 로고    scopus 로고
    • Expression of the insulin-like growth factor-I receptor and proapoptotic Bax and Bak proteins in human colorectal cancer
    • [PMID: 15659820]
    • Koda M, Reszec J, Sulkowska M, Kanczuga-Koda L, Sulkowski S. Expression of the insulin-like growth factor-I receptor and proapoptotic Bax and Bak proteins in human colorectal cancer. Ann N Y Acad Sci 2004; 1030: 377-383 [PMID: 15659820]
    • (2004) Ann N Y Acad Sci , vol.1030 , pp. 377-383
    • Koda, M.1    Reszec, J.2    Sulkowska, M.3    Kanczuga-Koda, L.4    Sulkowski, S.5
  • 111
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • [PMID: 11782378]
    • Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 2002; 62: 200-207 [PMID: 11782378]
    • (2002) Cancer Res , vol.62 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3
  • 114
    • 84867047384 scopus 로고    scopus 로고
    • Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
    • [PMID: 22949147 DOI: 10.1200/JCO.2012.42.8201]
    • Van Cutsem E, Tabernero J, Lakomy R, Prenen H, Prausová J, Macarulla T, Ruff P, van Hazel GA, Moiseyenko V, Ferry D, McKendrick J, Polikoff J, Tellier A, Castan R, Allegra C. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 2012; 30: 3499-3506 [PMID: 22949147 DOI: 10.1200/JCO.2012.42.8201]
    • (2012) J Clin Oncol , vol.30 , pp. 3499-3506
    • Van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3    Prenen, H.4    Prausová, J.5    Macarulla, T.6    Ruff, P.7    van Hazel, G.A.8    Moiseyenko, V.9    Ferry, D.10    McKendrick, J.11    Polikoff, J.12    Tellier, A.13    Castan, R.14    Allegra, C.15
  • 115
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • [PMID: 19111878 DOI: 10.1016/j.ccr.2008.12.004]
    • Crawford Y, Kasman I, Yu L, Zhong C, Wu X, Modrusan Z, Kaminker J, Ferrara N. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 2009; 15: 21-34 [PMID: 19111878 DOI: 10.1016/j.ccr.2008.12.004]
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3    Zhong, C.4    Wu, X.5    Modrusan, Z.6    Kaminker, J.7    Ferrara, N.8
  • 116
    • 37049012486 scopus 로고    scopus 로고
    • Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo
    • [PMID: 18056450 DOI: 10.1158/0008-5472.CAN-07-0969]
    • Li JL, Sainson RC, Shi W, Leek R, Harrington LS, Preusser M, Biswas S, Turley H, Heikamp E, Hainfellner JA, Harris AL. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Res 2007; 67: 11244-11253 [PMID: 18056450 DOI: 10.1158/0008-5472.CAN-07-0969]
    • (2007) Cancer Res , vol.67 , pp. 11244-11253
    • Li, J.L.1    Sainson, R.C.2    Shi, W.3    Leek, R.4    Harrington, L.S.5    Preusser, M.6    Biswas, S.7    Turley, H.8    Heikamp, E.9    Hainfellner, J.A.10    Harris, A.L.11
  • 118
    • 79960149283 scopus 로고    scopus 로고
    • Impact of KRAS and BRAF Gene Mutation Status on Outcomes From the Phase III AGITG MAX Trial of Capecitabine Alone or in Combination With Bevacizumab and Mitomycin in Advanced Colorectal Cancer
    • [PMID: 21646616 DOI: 10.1200/ JCO.2010.34.5520]
    • Price TJ, Hardingham JE, Lee CK, Weickhardt A, Townsend AR, Wrin JW, Chua A, Shivasami A, Cummins MM, Murone C, Tebbutt NC. Impact of KRAS and BRAF Gene Mutation Status on Outcomes From the Phase III AGITG MAX Trial of Capecitabine Alone or in Combination With Bevacizumab and Mitomycin in Advanced Colorectal Cancer. J Clin Oncol 2011; 29: 2675-2682 [PMID: 21646616 DOI: 10.1200/ JCO.2010.34.5520]
    • (2011) J Clin Oncol , vol.29 , pp. 2675-2682
    • Price, T.J.1    Hardingham, J.E.2    Lee, C.K.3    Weickhardt, A.4    Townsend, A.R.5    Wrin, J.W.6    Chua, A.7    Shivasami, A.8    Cummins, M.M.9    Murone, C.10    Tebbutt, N.C.11
  • 119
    • 84867607464 scopus 로고    scopus 로고
    • Tumor tissue based biomarker analysis in NO16966: A randomized phase III study of first-line bevacizumab in combination with oxaliplatin-based chemotherapy in patients with mCRC
    • [abstract 374], 2010 Jan 22-24; Orlando, FL
    • Foernzler D, Delmar P, Kockx M, Cassidy J, Saltz L, Scherer S. Tumor tissue based biomarker analysis in NO16966: A randomized phase III study of first-line bevacizumab in combination with oxaliplatin-based chemotherapy in patients with mCRC [abstract 374]. Presented at the 2010 Gastrointestinal Cancers Symposium; 2010 Jan 22-24; Orlando, FL
    • 2010 Gastrointestinal Cancers Symposium
    • Foernzler, D.1    Delmar, P.2    Kockx, M.3    Cassidy, J.4    Saltz, L.5    Scherer, S.6
  • 120
    • 85081805700 scopus 로고    scopus 로고
    • Vascular endothelial growth factors (VEGF) and VEGF receptor expression as predictive biomarkers for benefit with bevacizumab in metastatic colorectal cancer (mCRC): Analysis of the phase III MAX study
    • Jun 9; Chicago, Illinois. J Clin Oncol 2011: Abst3531
    • Weickhardt AJ, Williams D, Lee C, Simes C, Murone C, Wilson K, Cummins M, Asadi K, Price TJ, Mariadason J, Tebbutt NC. Vascular endothelial growth factors (VEGF) and VEGF receptor expression as predictive biomarkers for benefit with bevacizumab in metastatic colorectal cancer (mCRC): Analysis of the phase III MAX study. Proceedings of 2011 ASCO Annual Meeting; Jun 9; Chicago, Illinois. J Clin Oncol 2011: Abst3531
    • Proceedings of 2011 ASCO Annual Meeting
    • Weickhardt, A.J.1    Williams, D.2    Lee, C.3    Simes, C.4    Murone, C.5    Wilson, K.6    Cummins, M.7    Asadi, K.8    Price, T.J.9    Mariadason, J.10    Tebbutt, N.C.11
  • 121
    • 78649537524 scopus 로고    scopus 로고
    • Biomarkers to predict the clinical efficacy of bevacizumab in cancer
    • [PMID: 21126687 DOI: 10.1016/S1470-2045(10)70232-1]
    • Jubb AM, Harris AL. Biomarkers to predict the clinical efficacy of bevacizumab in cancer. Lancet Oncol 2010; 11: 1172-1183 [PMID: 21126687 DOI: 10.1016/S1470-2045(10)70232-1]
    • (2010) Lancet Oncol , vol.11 , pp. 1172-1183
    • Jubb, A.M.1    Harris, A.L.2
  • 123
    • 85081806579 scopus 로고    scopus 로고
    • Circulating vascular endothelial growth factor (VEGF) as a biomarker for bevacizumab-based therapy in meta-static colorectal, non-small cell lung, and renal cell cancers: Analysis of phase III studies
    • Jun 14; Chicago, Illinois. J Clin Oncol 2010: Abst10519
    • Bernaards C, Hegde P, Chen D, Holmgren E, Zheng M, Jubb AM, Koeppen H, Scherer SJ, Chen DS. Circulating vascular endothelial growth factor (VEGF) as a biomarker for bevacizumab-based therapy in meta-static colorectal, non-small cell lung, and renal cell cancers: Analysis of phase III studies. Proceedings of 2010 ASCO Annual Meeting; Jun 14; Chicago, Illinois. J Clin Oncol 2010: Abst10519
    • Proceedings of 2010 ASCO Annual Meeting
    • Bernaards, C.1    Hegde, P.2    Chen, D.3    Holmgren, E.4    Zheng, M.5    Jubb, A.M.6    Koeppen, H.7    Scherer, S.J.8    Chen, D.S.9
  • 124
    • 80052564414 scopus 로고    scopus 로고
    • Plasma biomarker analyses in the AVADO phase III randomized study of first-line bevacizumab docetaxel in patients with human epidermal growth factor receptor (HER) 2-negative metastatic breast cancer
    • Abstract nr P2-16-04 [DOI: 10.1158/0008-5472.SABCS10-P2-16-04]
    • Miles DW, de Haas SL, Dirix L, Chan A, Pivot X, Tomczak P, Provencher L, Delmar P, Scherer S. Plasma biomarker analyses in the AVADO phase III randomized study of first-line bevacizumab docetaxel in patients with human epidermal growth factor receptor (HER) 2-negative metastatic breast cancer. Cancer Res 2010; 70 (24 Suppl 2): Abstract nr P2-16-04 [DOI: 10.1158/0008-5472.SABCS10-P2-16-04]
    • (2010) Cancer Res , vol.70 , Issue.24 SUPPL. 2
    • Miles, D.W.1    de Haas, S.L.2    Dirix, L.3    Chan, A.4    Pivot, X.5    Tomczak, P.6    Provencher, L.7    Delmar, P.8    Scherer, S.9
  • 126
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • [PMID: 11001068 DOI: 10.1038/35025220]
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249-257 [PMID: 11001068 DOI: 10.1038/35025220]
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 127
    • 57049132745 scopus 로고    scopus 로고
    • Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy
    • [PMID: 18696232 DOI: 10.1007/s10585-008-9200-4]
    • Thomson S, Petti F, Sujka-Kwok I, Epstein D, Haley JD. Kinase switching in mesenchymal-like non-small cell lung cancer lines contributes to EGFR inhibitor resistance through pathway redundancy. Clin Exp Metastasis 2008; 25: 843-854 [PMID: 18696232 DOI: 10.1007/s10585-008-9200-4]
    • (2008) Clin Exp Metastasis , vol.25 , pp. 843-854
    • Thomson, S.1    Petti, F.2    Sujka-Kwok, I.3    Epstein, D.4    Haley, J.D.5
  • 129
    • 77649237043 scopus 로고    scopus 로고
    • K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer
    • [PMID: 19936766 DOI: 10.1007/ s00384-009-0843-7]
    • Schimanski CC, Zimmermann T, Schmidtmann I, Gockel I, Lang H, Galle PR, Moehler M, Berger MR. K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer. Int J Colorectal Dis 2010; 25: 181-186 [PMID: 19936766 DOI: 10.1007/ s00384-009-0843-7]
    • (2010) Int J Colorectal Dis , vol.25 , pp. 181-186
    • Schimanski, C.C.1    Zimmermann, T.2    Schmidtmann, I.3    Gockel, I.4    Lang, H.5    Galle, P.R.6    Moehler, M.7    Berger, M.R.8
  • 130
    • 48149096720 scopus 로고    scopus 로고
    • PDGF-BB is a novel prognostic factor in colorectal cancer
    • [PMID: 18478301 DOI: 10.1245/s10434-008-9943-9]
    • Nakamura Y, Tanaka F, Yoshikawa Y, Mimori K, Inoue H, Yanaga K, Mori M. PDGF-BB is a novel prognostic factor in colorectal cancer. Ann Surg Oncol 2008; 15: 2129-2136 [PMID: 18478301 DOI: 10.1245/s10434-008-9943-9]
    • (2008) Ann Surg Oncol , vol.15 , pp. 2129-2136
    • Nakamura, Y.1    Tanaka, F.2    Yoshikawa, Y.3    Mimori, K.4    Inoue, H.5    Yanaga, K.6    Mori, M.7
  • 132
    • 79960845455 scopus 로고    scopus 로고
    • Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: A potential therapeutic target in colorectal cancer
    • [PMID: 21745712 DOI: 10.1016/j.canlet.2011.06.009]
    • Matsuda Y, Ishiwata T, Yamahatsu K, Kawahara K, Hagio M, Peng WX, Yamamoto T, Nakazawa N, Seya T, Ohaki Y, Naito Z. Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: a potential therapeutic target in colorectal cancer. Cancer Lett 2011; 309: 209-219 [PMID: 21745712 DOI: 10.1016/j.canlet.2011.06.009]
    • (2011) Cancer Lett , vol.309 , pp. 209-219
    • Matsuda, Y.1    Ishiwata, T.2    Yamahatsu, K.3    Kawahara, K.4    Hagio, M.5    Peng, W.X.6    Yamamoto, T.7    Nakazawa, N.8    Seya, T.9    Ohaki, Y.10    Naito, Z.11
  • 133
    • 16244416568 scopus 로고    scopus 로고
    • Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer
    • [PMID: 15643506]
    • Yoshino M, Ishiwata T, Watanabe M, Komine O, Shibuya T, Tokunaga A, Naito Z. Keratinocyte growth factor receptor expression in normal colorectal epithelial cells and differentiated type of colorectal cancer. Oncol Rep 2005; 13: 247-252 [PMID: 15643506]
    • (2005) Oncol Rep , vol.13 , pp. 247-252
    • Yoshino, M.1    Ishiwata, T.2    Watanabe, M.3    Komine, O.4    Shibuya, T.5    Tokunaga, A.6    Naito, Z.7
  • 134
    • 84866095723 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2 IIIc as a therapeutic target for colorectal cancer cells
    • [PMID: 22778155 DOI: 10.1158/1535-7163.MCT-12-0243]
    • Matsuda Y, Hagio M, Seya T, Ishiwata T. Fibroblast growth factor receptor 2 IIIc as a therapeutic target for colorectal cancer cells. Mol Cancer Ther 2012; 11: 2010-2020 [PMID: 22778155 DOI: 10.1158/1535-7163.MCT-12-0243]
    • (2012) Mol Cancer Ther , vol.11 , pp. 2010-2020
    • Matsuda, Y.1    Hagio, M.2    Seya, T.3    Ishiwata, T.4
  • 135
    • 84861460201 scopus 로고    scopus 로고
    • Correlation of bevacizumab-induced hypertension and outcome in the BOXER study, a phase II study of capecitabine, oxaliplatin (CAPOX) plus bevacizumab as peri-operative treatment in 45 patients with poor-risk colorectal liver-only metastases unsuitable for upfront resection
    • [PMID: 22531628 DOI: 10.1038/bjc.2012.152]
    • Dewdney A, Cunningham D, Barbachano Y, Chau I. Correlation of bevacizumab-induced hypertension and outcome in the BOXER study, a phase II study of capecitabine, oxaliplatin (CAPOX) plus bevacizumab as peri-operative treatment in 45 patients with poor-risk colorectal liver-only metastases unsuitable for upfront resection. Br J Cancer 2012; 106: 1718-1721 [PMID: 22531628 DOI: 10.1038/bjc.2012.152]
    • (2012) Br J Cancer , vol.106 , pp. 1718-1721
    • Dewdney, A.1    Cunningham, D.2    Barbachano, Y.3    Chau, I.4
  • 136
    • 79957793636 scopus 로고    scopus 로고
    • Bevacizumab-induced hypertension: Pathogenesis and management
    • [PMID: 21627340 DOI: 10.2165/11590180-000000000-00000]
    • Syrigos KN, Karapanagiotou E, Boura P, Manegold C, Harrington K. Bevacizumab-induced hypertension: pathogenesis and management. BioDrugs 2011; 25: 159-169 [PMID: 21627340 DOI: 10.2165/11590180-000000000-00000]
    • (2011) BioDrugs , vol.25 , pp. 159-169
    • Syrigos, K.N.1    Karapanagiotou, E.2    Boura, P.3    Manegold, C.4    Harrington, K.5
  • 137
    • 79954435158 scopus 로고    scopus 로고
    • Colorectal cancer epigenetics: Complex simplicity
    • [PMID: 21220596 DOI: 10.1200/ JCO.2010.28.2319]
    • van Engeland M, Derks S, Smits KM, Meijer GA, Herman JG. Colorectal cancer epigenetics: complex simplicity. J Clin Oncol 2011; 29: 1382-1391 [PMID: 21220596 DOI: 10.1200/ JCO.2010.28.2319]
    • (2011) J Clin Oncol , vol.29 , pp. 1382-1391
    • van Engeland, M.1    Derks, S.2    Smits, K.M.3    Meijer, G.A.4    Herman, J.G.5
  • 138
    • 34247638013 scopus 로고    scopus 로고
    • CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma
    • [PMID: 17372756 DOI: 10.1007/s00428-007-0398-3]
    • Ogino S, Meyerhardt JA, Kawasaki T, Clark JW, Ryan DP, Kulke MH, Enzinger PC, Wolpin BM, Loda M, Fuchs CS. CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma. Virchows Arch 2007; 450: 529-537 [PMID: 17372756 DOI: 10.1007/s00428-007-0398-3]
    • (2007) Virchows Arch , vol.450 , pp. 529-537
    • Ogino, S.1    Meyerhardt, J.A.2    Kawasaki, T.3    Clark, J.W.4    Ryan, D.P.5    Kulke, M.H.6    Enzinger, P.C.7    Wolpin, B.M.8    Loda, M.9    Fuchs, C.S.10
  • 139
    • 61549091202 scopus 로고    scopus 로고
    • Pharmacoepigenomics in colorectal cancer: A step forward in predicting prognosis and treatment response
    • [PMID: 19072647 DOI: 10.2217/14622416.9.12.1903]
    • Smits KM, Cleven AH, Weijenberg MP, Hughes LA, Herman JG, de Bruïne AP, van Engeland M. Pharmacoepigenomics in colorectal cancer: a step forward in predicting prognosis and treatment response. Pharmacogenomics 2008; 9: 1903-1916 [PMID: 19072647 DOI: 10.2217/14622416.9.12.1903]
    • (2008) Pharmacogenomics , vol.9 , pp. 1903-1916
    • Smits, K.M.1    Cleven, A.H.2    Weijenberg, M.P.3    Hughes, L.A.4    Herman, J.G.5    de Bruïne, A.P.6    van Engeland, M.7
  • 141
    • 33645658128 scopus 로고    scopus 로고
    • Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer
    • [PMID: 16551870 DOI: 10.1158/1078-0432. CCR-05-2130]
    • Gagnon JF, Bernard O, Villeneuve L, Têtu B, Guillemette C. Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer. Clin Cancer Res 2006; 12: 1850-1858 [PMID: 16551870 DOI: 10.1158/1078-0432. CCR-05-2130]
    • (2006) Clin Cancer Res , vol.12 , pp. 1850-1858
    • Gagnon, J.F.1    Bernard, O.2    Villeneuve, L.3    Têtu, B.4    Guillemette, C.5
  • 142
    • 57849086513 scopus 로고    scopus 로고
    • Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: Is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup?
    • [PMID: 19093176 DOI: 10.1007/s10147-008-0854-3]
    • Iacopetta B, Kawakami K, Watanabe T. Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup? Int J Clin Oncol 2008; 13: 498-503 [PMID: 19093176 DOI: 10.1007/s10147-008-0854-3]
    • (2008) Int J Clin Oncol , vol.13 , pp. 498-503
    • Iacopetta, B.1    Kawakami, K.2    Watanabe, T.3
  • 144
    • 0042261728 scopus 로고    scopus 로고
    • Molecular prognostics in colorectal cancer
    • [PMID: 12957621 DOI: 10.1016/S0960-7404(03)00006-9]
    • Kahlenberg MS, Sullivan JM, Witmer DD, Petrelli NJ. Molecular prognostics in colorectal cancer. Surg Oncol 2003; 12: 173-186 [PMID: 12957621 DOI: 10.1016/S0960-7404(03)00006-9]
    • (2003) Surg Oncol , vol.12 , pp. 173-186
    • Kahlenberg, M.S.1    Sullivan, J.M.2    Witmer, D.D.3    Petrelli, N.J.4
  • 145
    • 0035560054 scopus 로고    scopus 로고
    • Prognostic biomarkers in resected colorectal cancer: Implications for adjuvant chemotherapy
    • [PMID: 12113030 DOI: 10.1586/14737140.1.2.247]
    • Graziano F, Catalano V, Baldelli AM, Cascinu S. Prognostic biomarkers in resected colorectal cancer: implications for adjuvant chemotherapy. Expert Rev Anticancer Ther 2001; 1: 247-257 [PMID: 12113030 DOI: 10.1586/14737140.1.2.247]
    • (2001) Expert Rev Anticancer Ther , vol.1 , pp. 247-257
    • Graziano, F.1    Catalano, V.2    Baldelli, A.M.3    Cascinu, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.