Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in israel

Cancer

Volumn 115, Issue 4, 2009, Pages 760-769

  Vilkin, Alex ^b   Niv, Yaron ^b   Nagasaka, Takeshi ^c   Morgenstern, Sarah ^b   Levi, Zohar ^b   Fireman, Zvi ^d   Fuerst, Florentine ^c   Goel, Ajay ^a,c   Boland, C Richard ^c  

^a University Medical Center   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^d HILLEL YAFFE MEDICAL CENTER   (Israel)

Author keywords

Braf mutation; Colorectal cancer; Methylation; Microsatellite instability; Mutl homolog 1

Indexed keywords

B RAF KINASE; BISULFITE; DNA; GLUTAMIC ACID; PROTEIN MLH1; PROTEIN MSH2; VALINE;

AGED; ARAB; ARTICLE; COLORECTAL CANCER; DNA EXTRACTION; DNA SEQUENCE; ENVIRONMENTAL FACTOR; ETHNIC DIFFERENCE; FEMALE; GENE INACTIVATION; GENE MUTATION; GENETIC ANALYSIS; HUMAN; ISRAEL; JEW; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MICRODISSECTION; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; RESTRICTION MAPPING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; ARABS; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; ISRAEL; JEWS; MALE; MICROSATELLITE INSTABILITY; MUTATION; NUCLEAR PROTEINS; PHENOTYPE; POLYMERASE CHAIN REACTION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS B-RAF;

EID: 60849109516     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.24019     Document Type: Article

References (31)

1. Barchana M, Liphshitz I, Rozen P. Trends in colorectal cancer incidence and mortality in the Israeli Jewish ethnic populations. Fam Cancer. 2004; 3:207-214.
2. Fireman Z, Sandler E, Kopelman Y, Segal A, Sternberg A. Ethnic differences in colorectal cancer among Arab and Jewish neighbors in Israel. Am J Gastroenterol. 2001; 96:204-207.
3. Laken SJ, Petersen GM, Gruber SB, et al. Familial colorec- tal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet. 1997; 17:79-83.
4. Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation
5. in colorectal carcinoma. Proc Natl Acad Sci USA. 1998; 95:6870-6875.
6. Aaltonen LA, Peltomaki P, Leach FS, et al. Clues to the pathogenesis of familial colorectal cancer. Science. 1993; 260:812-816.
7. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science. 1993; 260:816-819.
8. Lynch HT, Smyrk TC, Watson P, et al. Genetics, natural history, tumor spectrum, and pathology of hereditary non- polyposis colorectal cancer: an updated review. Gastroenterology. 1993; 104:1535-1549.
9. Carethers JM, Smith EJ, Behling CA, et al. Use of 5-fluo- rouracil and survival in patients with microsatellite-unstable colorectal cancer. Gastroenterology. 2004; 126:394-401.
10. Niv Y. Microsatellite instability and MLH1 promoter hy- permethylation in colorectal cancer. World J Gastroenterol. 2007; 13:1767-1769.
11. Deng G, Chen A, Hong J, Chae HS, Kim YS. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res. 1999; 59:2029-2033.
12. Miyakura Y, Sugano K, Konishi F, et al. Extensive methylation of hMLH1 promoter region predominates in proximal colon cancer with microsatellite instability. Gastroenterology. 2001; 121:1300-1309.
13. Nagasaka T, Sasamoto H, Notohara K, et al. Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. JClin Oncol. 2004; 22:4584-4594.
14. Diergaarde B, Braam H, van Muijen GN, Ligtenberg MJ, Kok FJ, Kampman E. Dietary factors and microsatellite instability in sporadic colon carcinomas. Cancer Epidemiol Biomarkers Prev. 2003; 12:1130-1136.
15. Samowitz WS, Albertsen H, Sweeney C, et al. Association of smoking, CpG island methylator phenotype, and V600E BRAF mutations in colon cancer. J Natl Cancer Inst. 2006; 98:1731-1738.
16. Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature. 2002; 417:949-954.
17. Goel A, Nagasaka T, Arnold CN, et al. The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroen- terology. 2007; 132:127-138.
18. Rajagopalan H, Bardelli A, Lengauer C, Kinzler KW, Vogel- stein B, Velculescu VE. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature. 2002; 418: 934-934.
19. Koinuma K, Shitoh K, Miyakura Y, et al. Mutations of BRAF are associated with extensive hMLH1 promoter methylation in sporadic colorectal carcinomas. Int JCancer. 2004; 108:237-242.
20. McGivern A, Wynter CV, Whitehall VL, et al. Promoter hypermethylation frequency and BRAF mutations distinguish hereditary non-polyposis colon cancer from sporadic MSI-H colon cancer. Fam Cancer. 2004; 3:101-107.
21. Domingo E, Laiho P, Ollikainen M, et al. BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing. J Med Genet. 2004; 41:664-668.
22. Umar A, Boland CR, Terdiman JP, et al. Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst. 2004; 96:261-268.
23. Suraweera N, Duval A, Reperant M, et al. Evaluation of tumor microsatellite instability using 5 quasimonomorphic mononucleotide repeats and pentaplex PCR. Gastroenterology. 2002; 123:1804-1811.
24. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature. 1997; 386:623-627.
25. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA. 1999; 96:8681-8686.
26. Toyota M, Ohe-Toyota M, Ahuja N, Issa JP. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype. Proc Natl Acad Sci USA. 2000; 97:710-715.
27. Weisenberger DJ, Siegmund KD, Campan M, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet. 2006; 38:787-793.
28. Hitchins MP, Wong JJ, Suthers G, et al. Inheritance of a cancer-associated MLH1 germ-line epimutation. N Engl J Med. 2007; 356:697-705.
29. Ghafoor A, Jemal A, Cokkinides V, et al. Cancer statistics for African Americans. CA Cancer J Clin. 2002; 52:326-341.
30. Shpitz B, Millman M, Ziv Y, Klein E, Grankin M, Goch- berg S, et al. Predominance of younger age, advanced stage, poorly differentiated and mucinous histology in Israeli Arab patients with colorectal cancer. Anticancer Res. 2006; 26:533-537.
31. Samowitz WS, Albertsen H, Herrick J, et al. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology. 2005; 129:837-845.