Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: A cohort study

Lancet Oncology

Volumn 6, Issue 5, 2005, Pages 279-286

  Moroni, Mauro ^a   Veronese, Silvio ^a   Benvenuti, Silvia ^b   Marrapese, Giovanna ^a   Sartore Bianchi, Andrea ^a   Di Nicolantonio, Federica ^b   Gambacorta, Marcello ^a   Siena, Salvatore ^a   Bardelli, Alberto ^c  

^a OSPEDALE NIGUARDA CA GRANDA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; IRINOTECAN; OXALIPLATIN; PANITUMUMAB;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL LINE; CLINICAL ARTICLE; CLINICAL TRIAL; COHORT ANALYSIS; COLORECTAL CANCER; COMPUTER ASSISTED TOMOGRAPHY; CORRELATION ANALYSIS; DISEASE COURSE; DNA EXTRACTION; DOWNSTREAM PROCESSING; DRUG ACTIVITY; DRUG EFFICACY; DRUG TARGETING; EXON; FEMALE; FISHER EXACT TEST; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE MUTATION; GENETIC SCREENING; HUMAN; IMMUNOHISTOCHEMISTRY; ITALY; LIGAND BINDING; MALE; METASTASIS; MISSENSE MUTATION; MOLECULAR MECHANICS; MONOTHERAPY; MUTATIONAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT SELECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TREATMENT OUTCOME;

AGED; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CAMPTOTHECIN; CLINICAL TRIALS; COHORT STUDIES; COLORECTAL NEOPLASMS; FEMALE; GENE DOSAGE; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM METASTASIS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 17844362179     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(05)70102-9     Document Type: Article

References (28)

1. JA Meyerhardt RJ Mayer Systemic therapy for colorectal cancer N Engl J Med 352 2005 476-487
2. LB Saltz NJ Meropol PJ Loehrer Sr et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor J Clin Oncol 22 2004 1201-1208
3. D Cunningham Y Humblet S Siena et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer N Engl J Med 351 2004 337-345
4. JR Hecht A Patnaik I Malik et al. ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): An updated analysis Proc Am Soc Clin Oncol 22 suppl 2004 3511
5. F Ciardiello G Tortora Epidermal growth factor receptor (EGFR) as a target in cancer therapy: Understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs Eur J Cancer 39 2003 1348-1354
6. T Holbro NE Hynes ErbB receptors: Directing key signaling networks throughout life Annu Rev Pharmacol Toxicol 44 2004 195-217
7. B Vogelstein KW Kinzler Cancer genes and the pathways they control Nat Med 10 2004 789-799
8. A Bardelli VE Velculescu Mutational analysis of gene families in human cancer Curr On Genet Dev 15 2005 5-12
9. J Mendelsohn J Baselga Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer J Clin Oncol 21 2003 2787-2799
10. DH Lynch XD Yang Therapeutic potential of ABX-EGF: A fully human anti-epidermal growth factor receptor monoclonal antibody for cancer treatment Semin Oncol 29 2002 47-50
11. S Rozen HJ Skaletsky Primer3 on the www for general users and for biological programmes In: S Krawetz S Misener (Eds.) Bioinformatics methods and protocols: Methods in molecular biology 2000 Humana Press Totowa 365-386
12. A Bardelli DW Parsons N Silliman et al. Mutational analysis of the tyrosine kinome in colorectal cancers Science 300 2003 949
13. TL Wang C Rago N Silliman et al. Prevalence of somatic alterations in the colorectal cancer cell genome Proc Natl Acad Sci USA 99 2002 3076-3080
14. TL Wang C Maierhofer MR Speicher et al. Digital karyotyng Proc Natl Acad Sci USA 99 2002 16156-16161
15. EL Wiley LK Diaz High-quality HER-2 testing: Setting a standard for oncologic biomarker assessment JAMA 291 2004 2019-2020
16. M Moroni S Veronese R Schiavo Epidermal growth factor receptor expression and activation in nonseminomatous germ cell tumors Clin Cancer Res 7 2001 2770-2775
17. JL Yang XJ Qu PJ Russell D Goldstein Regulation of epidermal growth factor receptor in human colon cancer cell lines by interferon alpha Gut 53 2004 123-129
18. TD Barber B Vogelstein KW Kinzler VE Velculescu Somatic mutations of EGFR in colorectal cancers and glioblastomas N Engl J Med 351 2004 2883
19. D Schrag The price tag on progress - chemotherapy for colorectal cancer N Engl J Med 351 2004 317-319
20. TJ Lynch DW Bell R Sordella et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 2004 2129-2139
21. JG Paez PA Janne JC Lee et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 2004 1497-1500
22. W Pao V Miller M Zakowski et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib Proc Natl Acad Sci USA 101 2004 13306-13311
23. H Rajagopalan A Bardelli C Lengauer et al. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status Nature 418 2002 934
24. D Atkins KA Reiffen CL Tegtmeier et al. Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: Variation in staining intensity due to choise of fixative and storage time of tissue sections J Histochem Cytochem 52 2004 893-901
25. A Ooi T Takehana X Li et al. Protein overexpression and gene amplification of HER-2 and EGFR in colorectal cancers: An immunohistochemical and fluorescent in situ hybridization study Mod Pathol 17 2004 895-904
26. LJ Layfield PS Bernard NS Goldstein Color multiplex polymerase chain reaction for quantitative analysis of epidermal growth factor receptor genes in colorectal adenocarcinoma J Surg Oncol 83 2003 227-231
27. P Matar F Rojo R Cassia et al. Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): Superiority over single-agent receptor targeting Clin Cancer Res 10 2004 6487-6501
28. MF Di Renzo M Olivero A Giacomini et al. Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer Clin Cancer Res 1 1995 147-154