-
1
-
-
0041629450
-
Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
-
Mendelsohn J., Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 2003, 21:2787-2799.
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 2787-2799
-
-
Mendelsohn, J.1
Baselga, J.2
-
2
-
-
33745828702
-
EGF-ERBB signalling: towards the systems level
-
Citri A., Yarden Y. EGF-ERBB signalling: towards the systems level. Nat. Rev. Mol. Cell Biol. 2006, 7:505-516.
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 505-516
-
-
Citri, A.1
Yarden, Y.2
-
4
-
-
0031900740
-
Signal transduction through MAP kinase cascades
-
Lewis T.S., Shapiro P.S., Ahn N.G. Signal transduction through MAP kinase cascades. Adv. Cancer Res. 1998, 74:49-139.
-
(1998)
Adv. Cancer Res.
, vol.74
, pp. 49-139
-
-
Lewis, T.S.1
Shapiro, P.S.2
Ahn, N.G.3
-
5
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I., Sawyers C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2002, 2:489-501.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
6
-
-
0030795612
-
The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions
-
Alroy I., Yarden Y. The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett. 1997, 410:83-86.
-
(1997)
FEBS Lett.
, vol.410
, pp. 83-86
-
-
Alroy, I.1
Yarden, Y.2
-
7
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman J.A., Luo J., Cantley L.C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 2006, 7:606-619.
-
(2006)
Nat. Rev. Genet.
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
9
-
-
0036500831
-
Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy
-
Herbst R.S., Shin D.M. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer 2002, 94:1593-1611.
-
(2002)
Cancer
, vol.94
, pp. 1593-1611
-
-
Herbst, R.S.1
Shin, D.M.2
-
10
-
-
0034777482
-
Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival
-
Brabender J., Danenberg K.D., Metzger R., Schneider P.M., Park J., Salonga D., et al. Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival. Clin. Cancer Res. 2001, 7:1850-1855.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1850-1855
-
-
Brabender, J.1
Danenberg, K.D.2
Metzger, R.3
Schneider, P.M.4
Park, J.5
Salonga, D.6
-
11
-
-
0029025332
-
Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas
-
Wikstrand C.J., Hale L.P., Batra S.K., Hill M.L., Humphrey P.A., Kurpad S.N., et al. Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Cancer Res. 1995, 55:3140-3148.
-
(1995)
Cancer Res.
, vol.55
, pp. 3140-3148
-
-
Wikstrand, C.J.1
Hale, L.P.2
Batra, S.K.3
Hill, M.L.4
Humphrey, P.A.5
Kurpad, S.N.6
-
12
-
-
0030787340
-
Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)
-
Chu C.T., Everiss K.D., Wikstrand C.J., Batra S.K., Kung H.J., Bigner D.D. Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). Biochem. J. 1997, 324:855-861.
-
(1997)
Biochem. J.
, vol.324
, pp. 855-861
-
-
Chu, C.T.1
Everiss, K.D.2
Wikstrand, C.J.3
Batra, S.K.4
Kung, H.J.5
Bigner, D.D.6
-
13
-
-
0028819660
-
Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
-
Goldstein N.I., Prewett M., Zuklys K., Rockwell P., Mendelsohn J. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin. Cancer Res. 1995, 1:1311-1318.
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 1311-1318
-
-
Goldstein, N.I.1
Prewett, M.2
Zuklys, K.3
Rockwell, P.4
Mendelsohn, J.5
-
14
-
-
0020933452
-
Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors
-
Sato J.D., Kawamoto T., Le A.D., Mendelsohn J., Polikoff J., Sato G.H. Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol. Biol. Med. 1983, 1:511-529.
-
(1983)
Mol. Biol. Med.
, vol.1
, pp. 511-529
-
-
Sato, J.D.1
Kawamoto, T.2
Le, A.D.3
Mendelsohn, J.4
Polikoff, J.5
Sato, G.H.6
-
15
-
-
0035409904
-
IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer
-
Herbst R.S., Kim E.S., Harari P.M. IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer. Expert Opin. Biol. Ther. 2001, 1:719-732.
-
(2001)
Expert Opin. Biol. Ther.
, vol.1
, pp. 719-732
-
-
Herbst, R.S.1
Kim, E.S.2
Harari, P.M.3
-
16
-
-
0034084314
-
Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
-
Huang S.M., Harari P.M. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin. Cancer Res. 2000, 6:2166-2174.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2166-2174
-
-
Huang, S.M.1
Harari, P.M.2
-
17
-
-
0033559606
-
Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy
-
Yang X.D., Jia X.C., Corvalan J.R., Wang P., Davis C.G., Jakobovits A. Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res. 1999, 59:1236-1243.
-
(1999)
Cancer Res.
, vol.59
, pp. 1236-1243
-
-
Yang, X.D.1
Jia, X.C.2
Corvalan, J.R.3
Wang, P.4
Davis, C.G.5
Jakobovits, A.6
-
18
-
-
0035117355
-
Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
-
Yang X.D., Jia X.C., Corvalan J.R., Wang P., Davis C.G. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit. Rev. Oncol. Hematol. 2001, 38:17-23.
-
(2001)
Crit. Rev. Oncol. Hematol.
, vol.38
, pp. 17-23
-
-
Yang, X.D.1
Jia, X.C.2
Corvalan, J.R.3
Wang, P.4
Davis, C.G.5
-
19
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D., Humblet Y., Siena S., Khayat D., Bleiberg H., Santoro A., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 2004, 351:337-345.
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
-
20
-
-
36148941301
-
Cetuximab for the treatment of colorectal cancer
-
Jonker D.J., O'Callaghan C.J., Karapetis C.S., Zalcberg J.R., Tu D., Au H.J., et al. Cetuximab for the treatment of colorectal cancer. N. Engl. J. Med. 2007, 357:2040-2048.
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 2040-2048
-
-
Jonker, D.J.1
O'Callaghan, C.J.2
Karapetis, C.S.3
Zalcberg, J.R.4
Tu, D.5
Au, H.J.6
-
21
-
-
44249111440
-
EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
-
Sobrero A.F., Maurel J., Fehrenbacher L., Scheithauer W., Abubakr Y.A., Lutz M.P., et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J. Clin. Oncol. 2008, 26:2311-2319.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2311-2319
-
-
Sobrero, A.F.1
Maurel, J.2
Fehrenbacher, L.3
Scheithauer, W.4
Abubakr, Y.A.5
Lutz, M.P.6
-
22
-
-
36749067866
-
Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer
-
Tabernero J., Van Cutsem E., Diaz-Rubio E., Cervantes A., Humblet Y., Andre T., et al. Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 2007, 25:5225-5232.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 5225-5232
-
-
Tabernero, J.1
Van Cutsem, E.2
Diaz-Rubio, E.3
Cervantes, A.4
Humblet, Y.5
Andre, T.6
-
23
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C., Bondarenko I., Makhson A., Hartmann J.T., Aparicio J., de Braud F., et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 2009, 27:663-671.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
Hartmann, J.T.4
Aparicio, J.5
de Braud, F.6
-
24
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E., Kohne C.H., Hitre E., Zaluski J., ChangChien C.R., Makhson A., et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med. 2009, 360:1408-1417.
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
Zaluski, J.4
ChangChien, C.R.5
Makhson, A.6
-
25
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van Cutsem E., Peeters M., Siena S., Humblet Y., Hendlisz A., Neyns B., et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. 2007, 25:1658-1664.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
-
26
-
-
0344773402
-
The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies
-
(abstr 817)
-
Saltz L., Kies M., Abbruzzese J., Azarnia N., Needle M. The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies. Proc. Am. Soc. Clin. Oncol. 2003, 22. (abstr 817).
-
(2003)
Proc. Am. Soc. Clin. Oncol.
, vol.22
-
-
Saltz, L.1
Kies, M.2
Abbruzzese, J.3
Azarnia, N.4
Needle, M.5
-
27
-
-
63449142391
-
Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy
-
Peeters M., Siena S., Van Cutsem E., Sobrero A., Hendlisz A., Cascinu S., et al. Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy. Cancer 2009, 115:1544-1554.
-
(2009)
Cancer
, vol.115
, pp. 1544-1554
-
-
Peeters, M.1
Siena, S.2
Van Cutsem, E.3
Sobrero, A.4
Hendlisz, A.5
Cascinu, S.6
-
28
-
-
36949037220
-
Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): pharmacokinetic (PK), Pharmacodynamic (PD) and efficacy data
-
Tejpar S., Peeters M., Humblet Y., Gelderblom H., Vermorken J., Viret F., et al. Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): pharmacokinetic (PK), Pharmacodynamic (PD) and efficacy data. J. Clin. Oncol. (Meeting Abstracts) 2007, 25:4037.
-
(2007)
J. Clin. Oncol. (Meeting Abstracts)
, vol.25
, pp. 4037
-
-
Tejpar, S.1
Peeters, M.2
Humblet, Y.3
Gelderblom, H.4
Vermorken, J.5
Viret, F.6
-
29
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz L.B., Meropol N.J., Loehrer P.J., Needle M.N., Kopit J., Mayer R.J. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J. Clin. Oncol. 2004, 22:1201-1208.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer, P.J.3
Needle, M.N.4
Kopit, J.5
Mayer, R.J.6
-
30
-
-
20144381957
-
Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
-
Chung K.Y., Shia J., Kemeny N.E., Shah M., Schwartz G.K., Tse A., et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J. Clin. Oncol. 2005, 23:1803-1810.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 1803-1810
-
-
Chung, K.Y.1
Shia, J.2
Kemeny, N.E.3
Shah, M.4
Schwartz, G.K.5
Tse, A.6
-
31
-
-
25144491785
-
Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study
-
Shia J., Klimstra D.S., Li A.R., Qin J., Saltz L., Teruya-Feldstein J., et al. Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study. Mod. Pathol. 2005, 18:1350-1356.
-
(2005)
Mod. Pathol.
, vol.18
, pp. 1350-1356
-
-
Shia, J.1
Klimstra, D.S.2
Li, A.R.3
Qin, J.4
Saltz, L.5
Teruya-Feldstein, J.6
-
32
-
-
33750615769
-
Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
-
Lenz H.J., Van Cutsem E., Khambata-Ford S., Mayer R.J., Gold P., Stella P., et al. Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J. Clin. Oncol. 2006, 24:4914-4921.
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 4914-4921
-
-
Lenz, H.J.1
Van Cutsem, E.2
Khambata-Ford, S.3
Mayer, R.J.4
Gold, P.5
Stella, P.6
-
33
-
-
17844362179
-
Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study
-
Moroni M., Veronese S., Benvenuti S., Marrapese G., Sartore-Bianchi A., Di Nicolantonio F., et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol. 2005, 6:279-286.
-
(2005)
Lancet Oncol.
, vol.6
, pp. 279-286
-
-
Moroni, M.1
Veronese, S.2
Benvenuti, S.3
Marrapese, G.4
Sartore-Bianchi, A.5
Di Nicolantonio, F.6
-
34
-
-
34548258303
-
Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab
-
Sartore-Bianchi A., Moroni M., Veronese S., Carnaghi C., Bajetta E., Luppi G., et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J. Clin. Oncol. 2007, 25:3238-3245.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3238-3245
-
-
Sartore-Bianchi, A.1
Moroni, M.2
Veronese, S.3
Carnaghi, C.4
Bajetta, E.5
Luppi, G.6
-
35
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2004, 350:2129-2139.
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
36
-
-
22044446497
-
Responsiveness to cetuximab without mutations in EGFR
-
Tsuchihashi Z., Khambata-Ford S., Hanna N., Janne P.A. Responsiveness to cetuximab without mutations in EGFR. N. Engl. J. Med. 2005, 353:208-209.
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 208-209
-
-
Tsuchihashi, Z.1
Khambata-Ford, S.2
Hanna, N.3
Janne, P.A.4
-
37
-
-
19944422060
-
Somatic mutations of EGFR in colorectal cancers and glioblastomas
-
Barber T.D., Vogelstein B., Kinzler K.W., Velculescu V.E. Somatic mutations of EGFR in colorectal cancers and glioblastomas. N. Engl. J. Med. 2004, 351:2883.
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 2883
-
-
Barber, T.D.1
Vogelstein, B.2
Kinzler, K.W.3
Velculescu, V.E.4
-
38
-
-
34547160398
-
Ras oncogenes and their downstream targets
-
Rajalingam K., Schreck R., Rapp U.R., Albert S. Ras oncogenes and their downstream targets. Biochim. Biophys. Acta 2007, 1773:1177-1195.
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 1177-1195
-
-
Rajalingam, K.1
Schreck, R.2
Rapp, U.R.3
Albert, S.4
-
39
-
-
28844481452
-
The KRAS oncogene: past, present, and future
-
Kranenburg O. The KRAS oncogene: past, present, and future. Biochim. Biophys. Acta 2005, 1756:81-82.
-
(2005)
Biochim. Biophys. Acta
, vol.1756
, pp. 81-82
-
-
Kranenburg, O.1
-
41
-
-
0023256456
-
Prevalence of ras gene mutations in human colorectal cancers
-
Bos J.L., Fearon E.R., Hamilton S.R., Verlaan-de Vries M., van Boom J.H., van der Eb A.J., et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 1987, 327:293-297.
-
(1987)
Nature
, vol.327
, pp. 293-297
-
-
Bos, J.L.1
Fearon, E.R.2
Hamilton, S.R.3
Verlaan-de Vries, M.4
van Boom, J.H.5
van der Eb, A.J.6
-
42
-
-
0023748414
-
Genetic alterations during colorectal-tumor development
-
Vogelstein B., Fearon E.R., Hamilton S.R., Kern S.E., Preisinger A.C., Leppert M., et al. Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 1988, 319:525-532.
-
(1988)
N. Engl. J. Med.
, vol.319
, pp. 525-532
-
-
Vogelstein, B.1
Fearon, E.R.2
Hamilton, S.R.3
Kern, S.E.4
Preisinger, A.C.5
Leppert, M.6
-
43
-
-
66849140563
-
PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
-
Loupakis F., Pollina L., Stasi I., Ruzzo A., Scartozzi M., Santini D., et al. PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer. J. Clin. Oncol. 2009, 27:2622-2629.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 2622-2629
-
-
Loupakis, F.1
Pollina, L.2
Stasi, I.3
Ruzzo, A.4
Scartozzi, M.5
Santini, D.6
-
44
-
-
0036739336
-
Specific codon 13K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12K-ras mutations are associated with mucinous histotype
-
Bazan V., Migliavacca M., Zanna I., Tubiolo C., Grassi N., Latteri M.A., et al. Specific codon 13K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12K-ras mutations are associated with mucinous histotype. Ann. Oncol. 2002, 13:1438-1446.
-
(2002)
Ann. Oncol.
, vol.13
, pp. 1438-1446
-
-
Bazan, V.1
Migliavacca, M.2
Zanna, I.3
Tubiolo, C.4
Grassi, N.5
Latteri, M.A.6
-
45
-
-
0028596162
-
The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival
-
Dix B.R., Robbins P., Soong R., Jenner D., House A.K., Iacopetta B.J. The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival. Int. J. Cancer 1994, 59:747-751.
-
(1994)
Int. J. Cancer
, vol.59
, pp. 747-751
-
-
Dix, B.R.1
Robbins, P.2
Soong, R.3
Jenner, D.4
House, A.K.5
Iacopetta, B.J.6
-
46
-
-
0032948553
-
P53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer
-
Tortola S., Marcuello E., Gonzalez I., Reyes G., Arribas R., Aiza G., et al. p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. J. Clin. Oncol. 1999, 17:1375-1381.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 1375-1381
-
-
Tortola, S.1
Marcuello, E.2
Gonzalez, I.3
Reyes, G.4
Arribas, R.5
Aiza, G.6
-
47
-
-
0027412665
-
Prognostic significance of K-ras mutations in colorectal carcinoma
-
Benhattar J., Losi L., Chaubert P., Givel J.C., Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104:1044-1048.
-
(1993)
Gastroenterology
, vol.104
, pp. 1044-1048
-
-
Benhattar, J.1
Losi, L.2
Chaubert, P.3
Givel, J.C.4
Costa, J.5
-
48
-
-
0032490124
-
Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study
-
Andreyev H.J., Norman A.R., Cunningham D., Oates J.R., Clarke P.A. Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study. J. Natl. Cancer Inst. 1998, 90:675-684.
-
(1998)
J. Natl. Cancer Inst.
, vol.90
, pp. 675-684
-
-
Andreyev, H.J.1
Norman, A.R.2
Cunningham, D.3
Oates, J.R.4
Clarke, P.A.5
-
49
-
-
0035444798
-
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study
-
Andreyev H.J., Norman A.R., Cunningham D., Oates J., Dix B.R., Iacopetta B.J., et al. Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br. J. Cancer 2001, 85:692-696.
-
(2001)
Br. J. Cancer
, vol.85
, pp. 692-696
-
-
Andreyev, H.J.1
Norman, A.R.2
Cunningham, D.3
Oates, J.4
Dix, B.R.5
Iacopetta, B.J.6
-
50
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis C.S., Khambata-Ford S., Jonker D.J., O'Callaghan C.J., Tu D., Tebbutt N.C., et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N. Engl. J. Med. 2008, 359:1757-1765.
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
O'Callaghan, C.J.4
Tu, D.5
Tebbutt, N.C.6
-
51
-
-
73149107502
-
KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803
-
Ogino S., Meyerhardt J.A., Irahara N., Niedzwiecki D., Hollis D., Saltz L.B., et al. KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803. Clin. Cancer Res. 2009, 15:7322-7329.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 7322-7329
-
-
Ogino, S.1
Meyerhardt, J.A.2
Irahara, N.3
Niedzwiecki, D.4
Hollis, D.5
Saltz, L.B.6
-
52
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lievre A., Bachet J.B., Le Corre D., Boige V., Landi B., Emile J.F., et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 2006, 66:3992-3995.
-
(2006)
Cancer Res.
, vol.66
, pp. 3992-3995
-
-
Lievre, A.1
Bachet, J.B.2
Le Corre, D.3
Boige, V.4
Landi, B.5
Emile, J.F.6
-
53
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
Lievre A., Bachet J.B., Boige V., Cayre A., Le Corre D., Buc E., et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J. Clin. Oncol. 2008, 26:374-379.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 374-379
-
-
Lievre, A.1
Bachet, J.B.2
Boige, V.3
Cayre, A.4
Le Corre, D.5
Buc, E.6
-
54
-
-
34047248571
-
Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
-
Benvenuti S., Sartore-Bianchi A., Di Nicolantonio F., Zanon C., Moroni M., Veronese S., et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 2007, 67:2643-2648.
-
(2007)
Cancer Res.
, vol.67
, pp. 2643-2648
-
-
Benvenuti, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
Zanon, C.4
Moroni, M.5
Veronese, S.6
-
55
-
-
34247278727
-
Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
-
Di Fiore F., Blanchard F., Charbonnier F., Le Pessot F., Lamy A., Galais M.P., et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br. J. Cancer 2007, 96:1166-1169.
-
(2007)
Br. J. Cancer
, vol.96
, pp. 1166-1169
-
-
Di Fiore, F.1
Blanchard, F.2
Charbonnier, F.3
Le Pessot, F.4
Lamy, A.5
Galais, M.P.6
-
56
-
-
40149088765
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
-
De Roock W., Piessevaux H., De Schutter J., Janssens M., De Hertogh G., Personeni N., et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann. Oncol. 2008, 19:508-515.
-
(2008)
Ann. Oncol.
, vol.19
, pp. 508-515
-
-
De Roock, W.1
Piessevaux, H.2
De Schutter, J.3
Janssens, M.4
De Hertogh, G.5
Personeni, N.6
-
57
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford S., Garrett C.R., Meropol N.J., Basik M., Harbison C.T., Wu S., et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J. Clin. Oncol. 2007, 25:3230-3237.
-
(2007)
J. Clin. Oncol.
, vol.25
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
Basik, M.4
Harbison, C.T.5
Wu, S.6
-
58
-
-
46349092797
-
Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients
-
Cappuzzo F., Varella-Garcia M., Finocchiaro G., Skokan M., Gajapathy S., Carnaghi C., et al. Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients. Br. J. Cancer 2008, 99:83-89.
-
(2008)
Br. J. Cancer
, vol.99
, pp. 83-89
-
-
Cappuzzo, F.1
Varella-Garcia, M.2
Finocchiaro, G.3
Skokan, M.4
Gajapathy, S.5
Carnaghi, C.6
-
59
-
-
63849202055
-
The EVEREST study: relationship between efficacy and K-ras mutation status in patients with irinotecan-refractory mCRC treated with irinotecan and standard or escalating doses of cetuximab
-
Tejpar S., Peeters M., Humblet Y., Gelderblom H., Vermorken J., De Hertogh G., et al. The EVEREST study: relationship between efficacy and K-ras mutation status in patients with irinotecan-refractory mCRC treated with irinotecan and standard or escalating doses of cetuximab. Ann. Oncol. 2008, 19:vi14.
-
(2008)
Ann. Oncol.
, vol.19
-
-
Tejpar, S.1
Peeters, M.2
Humblet, Y.3
Gelderblom, H.4
Vermorken, J.5
De Hertogh, G.6
-
60
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado R.G., Wolf M., Peeters M., Van Cutsem E., Siena S., Freeman D.J., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 2008, 26:1626-1634.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
Van Cutsem, E.4
Siena, S.5
Freeman, D.J.6
-
61
-
-
44449101007
-
-
Abstract 435
-
Tabernero J., Cervantes A., Ciardiello F., Vega-Villegas E., Macarulla T., Rodriguez-Braun E., et al. Correlation of efficacy to KRAS status (wt vs. mut) in patients (pts) with metastatic colorectal cancer (mCRC), treated with weekly (q1w) and q2w schedules of cetuximab combined with FOLFIRI 2008, Abstract 435.
-
(2008)
Correlation of efficacy to KRAS status (wt vs. mut) in patients (pts) with metastatic colorectal cancer (mCRC), treated with weekly (q1w) and q2w schedules of cetuximab combined with FOLFIRI
-
-
Tabernero, J.1
Cervantes, A.2
Ciardiello, F.3
Vega-Villegas, E.4
Macarulla, T.5
Rodriguez-Braun, E.6
-
62
-
-
59749091477
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
-
Tol J., Koopman M., Cats A., Rodenburg C.J., Creemers G.J., Schrama J.G., et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N. Engl. J. Med. 2009, 360:563-572.
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 563-572
-
-
Tol, J.1
Koopman, M.2
Cats, A.3
Rodenburg, C.J.4
Creemers, G.J.5
Schrama, J.G.6
-
63
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
Hecht J.R., Mitchell E., Chidiac T., Scroggin C., Hagenstad C., Spigel D., et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J. Clin. Oncol. 2009, 27:672-680.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
Scroggin, C.4
Hagenstad, C.5
Spigel, D.6
-
64
-
-
68149159455
-
-
Abstract 273
-
Hecht J.R., Mitchell E., Chidiac T., Scroggin C., Hagenstad C., Spigel D., et al. An updated analysis of safety and efficacy of oxaliplatin (Ox)/bevacizumab (bev) +/- panitumumab (pmab) for first-line treatment (tx) of metastatic colorectal cancer (mCRC) from a randomized, controlled trial (PACCE) 2008, Abstract 273.
-
(2008)
An updated analysis of safety and efficacy of oxaliplatin (Ox)/bevacizumab (bev) +/- panitumumab (pmab) for first-line treatment (tx) of metastatic colorectal cancer (mCRC) from a randomized, controlled trial (PACCE)
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
Scroggin, C.4
Hagenstad, C.5
Spigel, D.6
-
65
-
-
65349189958
-
American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
-
Allegra C.J., Jessup J.M., Somerfield M.R., Hamilton S.R., Hammond E.H., Hayes D.F., et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J. Clin. Oncol. 2009, 27:2091-2096.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 2091-2096
-
-
Allegra, C.J.1
Jessup, J.M.2
Somerfield, M.R.3
Hamilton, S.R.4
Hammond, E.H.5
Hayes, D.F.6
-
66
-
-
34249988201
-
Liver resection for colorectal liver metastasis
-
Lochan R., White S.A., Manas D.M. Liver resection for colorectal liver metastasis. Surg. Oncol. 2007, 16:33-45.
-
(2007)
Surg. Oncol.
, vol.16
, pp. 33-45
-
-
Lochan, R.1
White, S.A.2
Manas, D.M.3
-
67
-
-
73249130298
-
Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial
-
Folprecht G., Gruenberger T., Bechstein W.O., Raab H.R., Lordick F., Hartmann J.T., et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol. 2010, 11:38-47.
-
(2010)
Lancet Oncol.
, vol.11
, pp. 38-47
-
-
Folprecht, G.1
Gruenberger, T.2
Bechstein, W.O.3
Raab, H.R.4
Lordick, F.5
Hartmann, J.T.6
-
68
-
-
58149345226
-
Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer
-
Bertolini F., Chiara S., Bengala C., Antognoni P., Dealis C., Zironi S., et al. Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2009, 73:466-472.
-
(2009)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.73
, pp. 466-472
-
-
Bertolini, F.1
Chiara, S.2
Bengala, C.3
Antognoni, P.4
Dealis, C.5
Zironi, S.6
-
69
-
-
34047179551
-
Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer
-
Machiels J.P., Sempoux C., Scalliet P., Coche J.C., Humblet Y., Van Cutsem E., et al. Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer. Ann. Oncol. 2007, 18:738-744.
-
(2007)
Ann. Oncol.
, vol.18
, pp. 738-744
-
-
Machiels, J.P.1
Sempoux, C.2
Scalliet, P.3
Coche, J.C.4
Humblet, Y.5
Van Cutsem, E.6
-
70
-
-
61649088414
-
Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer
-
Bengala C., Bettelli S., Bertolini F., Salvi S., Chiara S., Sonaglio C., et al. Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer. Ann. Oncol. 2009, 20:469-474.
-
(2009)
Ann. Oncol.
, vol.20
, pp. 469-474
-
-
Bengala, C.1
Bettelli, S.2
Bertolini, F.3
Salvi, S.4
Chiara, S.5
Sonaglio, C.6
-
71
-
-
0036898005
-
Effect of fixatives and tissue processing on the content and integrity of nucleic acids
-
Srinivasan M., Sedmak D., Jewell S. Effect of fixatives and tissue processing on the content and integrity of nucleic acids. Am. J. Pathol. 2002, 161:1961-1971.
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 1961-1971
-
-
Srinivasan, M.1
Sedmak, D.2
Jewell, S.3
-
72
-
-
3042785708
-
Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections
-
Atkins D., Reiffen K.A., Tegtmeier C.L., Winther H., Bonato M.S., Storkel S. Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections. J. Histochem. Cytochem. 2004, 52:893-901.
-
(2004)
J. Histochem. Cytochem.
, vol.52
, pp. 893-901
-
-
Atkins, D.1
Reiffen, K.A.2
Tegtmeier, C.L.3
Winther, H.4
Bonato, M.S.5
Storkel, S.6
-
73
-
-
77955874914
-
-
Abstract 1811
-
Juan T., Suggs S., Wolf M., Sarosi I., Freeman D., Oliner K., et al. A comparability study of 4 commercial KRAS tests 2008, Abstract 1811.
-
(2008)
A comparability study of 4 commercial KRAS tests
-
-
Juan, T.1
Suggs, S.2
Wolf, M.3
Sarosi, I.4
Freeman, D.5
Oliner, K.6
-
74
-
-
77957129235
-
High sensitivity of both sequencing and real-time PCR analysis of KRAS mutations in colorectal cancer tissue
-
(Epub ahead of print)
-
Tol J., Dijkstra J.R., Vink-Borger M.E., Nagtegaal I.D., Punt C.J., van Krieken J.H., et al. High sensitivity of both sequencing and real-time PCR analysis of KRAS mutations in colorectal cancer tissue. J. Cell. Mol. Med. 2009, (Epub ahead of print).
-
(2009)
J. Cell. Mol. Med.
-
-
Tol, J.1
Dijkstra, J.R.2
Vink-Borger, M.E.3
Nagtegaal, I.D.4
Punt, C.J.5
van Krieken, J.H.6
-
75
-
-
77955611350
-
The German quality assurance system for the molecular-pathological detection of KRAS-mutations in colorectal cancer
-
Jung A., Baretton G., Dietel M., Gabbert H., Kreipe H., Schlake W., et al. The German quality assurance system for the molecular-pathological detection of KRAS-mutations in colorectal cancer. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4018.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 4018
-
-
Jung, A.1
Baretton, G.2
Dietel, M.3
Gabbert, H.4
Kreipe, H.5
Schlake, W.6
-
76
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., et al. Mutations of the BRAF gene in human cancer. Nature 2002, 417:949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
-
77
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
Rajagopalan H., Bardelli A., Lengauer C., Kinzler K.W., Vogelstein B., Velculescu V.E. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002, 418:934.
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
Velculescu, V.E.6
-
78
-
-
1342299898
-
Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas
-
Fransen K., Klintenas M., Osterstrom A., Dimberg J., Monstein H.J., Soderkvist P. Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. Carcinogenesis 2004, 25:527-533.
-
(2004)
Carcinogenesis
, vol.25
, pp. 527-533
-
-
Fransen, K.1
Klintenas, M.2
Osterstrom, A.3
Dimberg, J.4
Monstein, H.J.5
Soderkvist, P.6
-
79
-
-
21644473447
-
Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression
-
Calistri D., Rengucci C., Seymour I., Lattuneddu A., Polifemo A.M., Monti F., et al. Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression. J. Cell. Physiol. 2005, 204:484-488.
-
(2005)
J. Cell. Physiol.
, vol.204
, pp. 484-488
-
-
Calistri, D.1
Rengucci, C.2
Seymour, I.3
Lattuneddu, A.4
Polifemo, A.M.5
Monti, F.6
-
80
-
-
0038697566
-
Raf proteins and cancer: B-Raf is identified as a mutational target
-
Mercer K.E., Pritchard C.A. Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim. Biophys. Acta 2003, 1653:25-40.
-
(2003)
Biochim. Biophys. Acta
, vol.1653
, pp. 25-40
-
-
Mercer, K.E.1
Pritchard, C.A.2
-
81
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F., Martini M., Molinari F., Sartore-Bianchi A., Arena S., Saletti P., et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J. Clin. Oncol. 2008, 26:5705-5712.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
Sartore-Bianchi, A.4
Arena, S.5
Saletti, P.6
-
82
-
-
78249247981
-
Selecting subjects for a therapeutic target in colorectal cancer (CRC): using a clinical database to enrich for patients harboring the BRAFV600E mutation
-
Tie J., Sieber O.M., Gibbs P., Lipton L., Jorissen R.N., Langland R., et al. Selecting subjects for a therapeutic target in colorectal cancer (CRC): using a clinical database to enrich for patients harboring the BRAFV600E mutation. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:11003.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 11003
-
-
Tie, J.1
Sieber, O.M.2
Gibbs, P.3
Lipton, L.4
Jorissen, R.N.5
Langland, R.6
-
83
-
-
72449185665
-
The role of KRAS, BRAF, NRAS, and PIK3CA mutations as markers of resistance to cetuximab in chemorefractory metastatic colorectal cancer
-
Lambrechts D., De Roock W., Prenen H., De Schutter J., Jacobs B., Biesmans B., et al. The role of KRAS, BRAF, NRAS, and PIK3CA mutations as markers of resistance to cetuximab in chemorefractory metastatic colorectal cancer. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4020.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 4020
-
-
Lambrechts, D.1
De Roock, W.2
Prenen, H.3
De Schutter, J.4
Jacobs, B.5
Biesmans, B.6
-
84
-
-
72449142814
-
Predictive biomarkers to improve treatment of metastatic colorectal cancer (mCRC): outcomes with cetuximab plus FOLFIRI in the CRYSTAL trial
-
Kohne C., Stroiakovski D., Chang-chien C., Lim R., Pinter T., Bodoky G., et al. Predictive biomarkers to improve treatment of metastatic colorectal cancer (mCRC): outcomes with cetuximab plus FOLFIRI in the CRYSTAL trial. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4068.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 4068
-
-
Kohne, C.1
Stroiakovski, D.2
Chang-chien, C.3
Lim, R.4
Pinter, T.5
Bodoky, G.6
-
85
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana P., Warne P.H., Dhand R., Vanhaesebroeck B., Gout I., Fry M.J., et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 1994, 370:527-532.
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
Fry, M.J.6
-
86
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
-
Ma L., Chen Z., Erdjument-Bromage H., Tempst P., Pandolfi P.P. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005, 121:179-193.
-
(2005)
Cell
, vol.121
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
-
87
-
-
51349164790
-
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
-
Carracedo A., Ma L., Teruya-Feldstein J., Rojo F., Salmena L., Alimonti A., et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J. Clin. Invest. 2008, 118:3065-3074.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3065-3074
-
-
Carracedo, A.1
Ma, L.2
Teruya-Feldstein, J.3
Rojo, F.4
Salmena, L.5
Alimonti, A.6
-
88
-
-
35348908314
-
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
-
Frattini M., Saletti P., Romagnani E., Martin V., Molinari F., Ghisletta M., et al. PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br. J. Cancer 2007, 97:1139-1145.
-
(2007)
Br. J. Cancer
, vol.97
, pp. 1139-1145
-
-
Frattini, M.1
Saletti, P.2
Romagnani, E.3
Martin, V.4
Molinari, F.5
Ghisletta, M.6
-
89
-
-
59049089201
-
PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
-
Perrone F., Lampis A., Orsenigo M., Di Bartolomeo M., Gevorgyan A., Losa M., et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann. Oncol. 2009, 20:84-90.
-
(2009)
Ann. Oncol.
, vol.20
, pp. 84-90
-
-
Perrone, F.1
Lampis, A.2
Orsenigo, M.3
Di Bartolomeo, M.4
Gevorgyan, A.5
Losa, M.6
-
90
-
-
66849140563
-
PTEN Expression and KRAS Mutations on Primary Tumors and Metastases in the Prediction of Benefit From Cetuximab Plus Irinotecan for Patients With Metastatic Colorectal Cancer
-
Loupakis F., Pollina L., Stasi I., Ruzzo A., Scartozzi M., Santini D., et al. PTEN Expression and KRAS Mutations on Primary Tumors and Metastases in the Prediction of Benefit From Cetuximab Plus Irinotecan for Patients With Metastatic Colorectal Cancer. J. Clin. Oncol. 2009, 27:2622-2629.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 2622-2629
-
-
Loupakis, F.1
Pollina, L.2
Stasi, I.3
Ruzzo, A.4
Scartozzi, M.5
Santini, D.6
-
91
-
-
34250837538
-
Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history
-
Mounawar M., Mukeria A., Le Calvez F., Hung R.J., Renard H., Cortot A., et al. Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history. Cancer Res. 2007, 67:5667-5672.
-
(2007)
Cancer Res.
, vol.67
, pp. 5667-5672
-
-
Mounawar, M.1
Mukeria, A.2
Le Calvez, F.3
Hung, R.J.4
Renard, H.5
Cortot, A.6
-
92
-
-
65349149003
-
TP53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy
-
Oden-Gangloff A., Di Fiore F., Bibeau F., Lamy A., Bougeard G., Charbonnier F., et al. TP53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy. Br. J. Cancer 2009, 100:1330-1335.
-
(2009)
Br. J. Cancer
, vol.100
, pp. 1330-1335
-
-
Oden-Gangloff, A.1
Di Fiore, F.2
Bibeau, F.3
Lamy, A.4
Bougeard, G.5
Charbonnier, F.6
-
93
-
-
72449204284
-
High epiregulin (EREG) gene expression plus K-ras wild-type (WT) status as predictors of cetuximab benefit in the treatment of advanced colorectal cancer (ACRC): results from NCIC CTG CO.17-A phase III trial of cetuximab versus best supportive care (BSC)
-
Jonker D.J., Karapetis C., Harbison C., O'Callaghan C.J., Tu D., Simes R.J., et al. High epiregulin (EREG) gene expression plus K-ras wild-type (WT) status as predictors of cetuximab benefit in the treatment of advanced colorectal cancer (ACRC): results from NCIC CTG CO.17-A phase III trial of cetuximab versus best supportive care (BSC). J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4016.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 4016
-
-
Jonker, D.J.1
Karapetis, C.2
Harbison, C.3
O'Callaghan, C.J.4
Tu, D.5
Simes, R.J.6
-
94
-
-
72449164578
-
Use of amphiregulin and epiregulin mRNA expression in primary tumors to predict outcome in metastatic colorectal cancer treated with cetuximab
-
Prenen H., Jacobs B., De Roock W., Van Oirbeek R., Biesmans B., De Schutter J., et al. Use of amphiregulin and epiregulin mRNA expression in primary tumors to predict outcome in metastatic colorectal cancer treated with cetuximab. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4019.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 4019
-
-
Prenen, H.1
Jacobs, B.2
De Roock, W.3
Van Oirbeek, R.4
Biesmans, B.5
De Schutter, J.6
-
95
-
-
65549143792
-
The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer
-
Garm Spindler K.L., Pallisgaard N., Rasmussen A.A., Lindebjerg J., Andersen R.F., Cruger D., et al. The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer. Ann. Oncol. 2009, 20:879-884.
-
(2009)
Ann. Oncol.
, vol.20
, pp. 879-884
-
-
Garm Spindler, K.L.1
Pallisgaard, N.2
Rasmussen, A.A.3
Lindebjerg, J.4
Andersen, R.F.5
Cruger, D.6
-
96
-
-
61449239114
-
Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan
-
Bibeau F., Lopez-Crapez E., Di Fiore F., Thezenas S., Ychou M., Blanchard F., et al. Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J. Clin. Oncol. 2009, 27:1122-1129.
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 1122-1129
-
-
Bibeau, F.1
Lopez-Crapez, E.2
Di Fiore, F.3
Thezenas, S.4
Ychou, M.5
Blanchard, F.6
-
97
-
-
0036141447
-
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
-
Chakravarti A., Loeffler J.S., Dyson N.J. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res. 2002, 62:200-207.
-
(2002)
Cancer Res.
, vol.62
, pp. 200-207
-
-
Chakravarti, A.1
Loeffler, J.S.2
Dyson, N.J.3
-
98
-
-
77955856575
-
Correlation of insulin-like growth factor 1 (IGF-1) expression and clinical outcome in K-RAS wild-type colorectal cancer patients treated with cetuximab-irinotecan
-
Scartozzi M., Bearzi I., Mandolesi A., Loupakis F., Zaniboni A., Berardi R., et al. Correlation of insulin-like growth factor 1 (IGF-1) expression and clinical outcome in K-RAS wild-type colorectal cancer patients treated with cetuximab-irinotecan. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4017.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 4017
-
-
Scartozzi, M.1
Bearzi, I.2
Mandolesi, A.3
Loupakis, F.4
Zaniboni, A.5
Berardi, R.6
-
99
-
-
67650354361
-
Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer
-
Cohen S.J., Punt C.J., Iannotti N., Saidman B.H., Sabbath K.D., Gabrail N.Y., et al. Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer. Ann. Oncol. 2009, 20:1223-1229.
-
(2009)
Ann. Oncol.
, vol.20
, pp. 1223-1229
-
-
Cohen, S.J.1
Punt, C.J.2
Iannotti, N.3
Saidman, B.H.4
Sabbath, K.D.5
Gabrail, N.Y.6
-
100
-
-
51349141191
-
Circulating mutant DNA to assess tumor dynamics
-
Diehl F., Schmidt K., Choti M.A., Romans K., Goodman S., Li M., et al. Circulating mutant DNA to assess tumor dynamics. Nat. Med. 2008, 14:985-990.
-
(2008)
Nat. Med.
, vol.14
, pp. 985-990
-
-
Diehl, F.1
Schmidt, K.2
Choti, M.A.3
Romans, K.4
Goodman, S.5
Li, M.6
-
101
-
-
34347369084
-
Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
-
Konstantinopoulos P.A., Karamouzis M.V., Papavassiliou A.G. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets. Nat. Rev. Drug Discov. 2007, 6:541-555.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 541-555
-
-
Konstantinopoulos, P.A.1
Karamouzis, M.V.2
Papavassiliou, A.G.3
-
102
-
-
67651246671
-
Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer
-
Flaherty K., Puzanov I., Sosman J., Kim K., Ribas A., McArthur G., et al. Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:9000.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 9000
-
-
Flaherty, K.1
Puzanov, I.2
Sosman, J.3
Kim, K.4
Ribas, A.5
McArthur, G.6
-
103
-
-
50649090571
-
Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway
-
Sebolt-Leopold J.S. Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway. Clin. Cancer Res. 2008, 14:3651-3656.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 3651-3656
-
-
Sebolt-Leopold, J.S.1
-
104
-
-
23944439944
-
Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies
-
Lorusso P.M., Adjei A.A., Varterasian M., Gadgeel S., Reid J., Mitchell D.Y., et al. Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies. J. Clin. Oncol. 2005, 23:5281-5293.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5281-5293
-
-
Lorusso, P.M.1
Adjei, A.A.2
Varterasian, M.3
Gadgeel, S.4
Reid, J.5
Mitchell, D.Y.6
-
105
-
-
14844285975
-
Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer
-
Rinehart J., Adjei A.A., Lorusso P.M., Waterhouse D., Hecht J.R., Natale R.B., et al. Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J. Clin. Oncol. 2004, 22:4456-4462.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 4456-4462
-
-
Rinehart, J.1
Adjei, A.A.2
Lorusso, P.M.3
Waterhouse, D.4
Hecht, J.R.5
Natale, R.B.6
-
106
-
-
31544450194
-
A phase 1-2 clinical study of a second generation oral MEK inhibitor, PD 0325901 in patients with advanced cancer
-
Lorusso P., Krishnamurthi S., Rinehart J.R., Nabell L., Croghan G., Varterasian M., et al. A phase 1-2 clinical study of a second generation oral MEK inhibitor, PD 0325901 in patients with advanced cancer. J. Clin. Oncol. (Meeting Abstracts) 2005, 23:3011.
-
(2005)
J. Clin. Oncol. (Meeting Abstracts)
, vol.23
, pp. 3011
-
-
Lorusso, P.1
Krishnamurthi, S.2
Rinehart, J.R.3
Nabell, L.4
Croghan, G.5
Varterasian, M.6
-
107
-
-
43749103335
-
Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
-
Adjei A.A., Cohen R.B., Franklin W., Morris C., Wilson D., Molina J.R., et al. Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J. Clin. Oncol. 2008, 26:2139-2146.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 2139-2146
-
-
Adjei, A.A.1
Cohen, R.B.2
Franklin, W.3
Morris, C.4
Wilson, D.5
Molina, J.R.6
-
108
-
-
70350176755
-
A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765, a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced solid tumors
-
LoRusso P., Markman B., Tabernero J., Shazer R., Nguyen L., Heath E., et al. A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765, a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced solid tumors. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:3502.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 3502
-
-
LoRusso, P.1
Markman, B.2
Tabernero, J.3
Shazer, R.4
Nguyen, L.5
Heath, E.6
-
109
-
-
76749171098
-
Phase I dose-escalation study of XL147, a PI3K inhibitor administered orally to patients with solid tumors
-
Shapiro G., Kwak E., Baselga J., Rodon J., Scheffold C., Laird A.D., et al. Phase I dose-escalation study of XL147, a PI3K inhibitor administered orally to patients with solid tumors. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:3500.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 3500
-
-
Shapiro, G.1
Kwak, E.2
Baselga, J.3
Rodon, J.4
Scheffold, C.5
Laird, A.D.6
-
110
-
-
76749136608
-
A first-in-human phase I study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors
-
Wagner A.J., Von Hoff D.H., LoRusso P.M., Tibes R., Mazina K.E., Ware J.A., et al. A first-in-human phase I study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:3501.
-
(2009)
J. Clin. Oncol. (Meeting Abstracts)
, vol.27
, pp. 3501
-
-
Wagner, A.J.1
Von Hoff, D.H.2
LoRusso, P.M.3
Tibes, R.4
Mazina, K.E.5
Ware, J.A.6
-
111
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman J.A., Chen L., Tan X., Crosby K., Guimaraes A.R., Upadhyay R., et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat. Med. 2008, 14:1351-1356.
-
(2008)
Nat. Med.
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
Crosby, K.4
Guimaraes, A.R.5
Upadhyay, R.6
-
112
-
-
46749156706
-
Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
-
Guix M., Faber A.C., Wang S.E., Olivares M.G., Song Y., Qu S., et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J. Clin. Invest. 2008, 118:2609-2619.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 2609-2619
-
-
Guix, M.1
Faber, A.C.2
Wang, S.E.3
Olivares, M.G.4
Song, Y.5
Qu, S.6
|