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Volumn 51, Issue C, 2010, Pages 71-119

EGFR and KRAS in Colorectal Cancer

Author keywords

Biomarker; BRAF; Cetuximab; Colorectal cancer; Epidermal growth factor receptor; KRAS; Monoclonal antibody; Panitumumab; Predictive; Prognostic

Indexed keywords

B RAF KINASE; BRAF PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN; RAS PROTEIN; TUMOR MARKER;

EID: 77955860591     PISSN: 00652423     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2423(10)51004-7     Document Type: Book
Times cited : (101)

References (112)
  • 1
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J., Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 2003, 21:2787-2799.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 2
    • 33745828702 scopus 로고    scopus 로고
    • EGF-ERBB signalling: towards the systems level
    • Citri A., Yarden Y. EGF-ERBB signalling: towards the systems level. Nat. Rev. Mol. Cell Biol. 2006, 7:505-516.
    • (2006) Nat. Rev. Mol. Cell Biol. , vol.7 , pp. 505-516
    • Citri, A.1    Yarden, Y.2
  • 4
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • Lewis T.S., Shapiro P.S., Ahn N.G. Signal transduction through MAP kinase cascades. Adv. Cancer Res. 1998, 74:49-139.
    • (1998) Adv. Cancer Res. , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 5
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I., Sawyers C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2002, 2:489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 6
    • 0030795612 scopus 로고    scopus 로고
    • The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions
    • Alroy I., Yarden Y. The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett. 1997, 410:83-86.
    • (1997) FEBS Lett. , vol.410 , pp. 83-86
    • Alroy, I.1    Yarden, Y.2
  • 7
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman J.A., Luo J., Cantley L.C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat. Rev. Genet. 2006, 7:606-619.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 9
    • 0036500831 scopus 로고    scopus 로고
    • Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy
    • Herbst R.S., Shin D.M. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer 2002, 94:1593-1611.
    • (2002) Cancer , vol.94 , pp. 1593-1611
    • Herbst, R.S.1    Shin, D.M.2
  • 10
    • 0034777482 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival
    • Brabender J., Danenberg K.D., Metzger R., Schneider P.M., Park J., Salonga D., et al. Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival. Clin. Cancer Res. 2001, 7:1850-1855.
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1850-1855
    • Brabender, J.1    Danenberg, K.D.2    Metzger, R.3    Schneider, P.M.4    Park, J.5    Salonga, D.6
  • 11
    • 0029025332 scopus 로고
    • Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas
    • Wikstrand C.J., Hale L.P., Batra S.K., Hill M.L., Humphrey P.A., Kurpad S.N., et al. Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Cancer Res. 1995, 55:3140-3148.
    • (1995) Cancer Res. , vol.55 , pp. 3140-3148
    • Wikstrand, C.J.1    Hale, L.P.2    Batra, S.K.3    Hill, M.L.4    Humphrey, P.A.5    Kurpad, S.N.6
  • 12
    • 0030787340 scopus 로고    scopus 로고
    • Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)
    • Chu C.T., Everiss K.D., Wikstrand C.J., Batra S.K., Kung H.J., Bigner D.D. Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII). Biochem. J. 1997, 324:855-861.
    • (1997) Biochem. J. , vol.324 , pp. 855-861
    • Chu, C.T.1    Everiss, K.D.2    Wikstrand, C.J.3    Batra, S.K.4    Kung, H.J.5    Bigner, D.D.6
  • 13
    • 0028819660 scopus 로고
    • Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
    • Goldstein N.I., Prewett M., Zuklys K., Rockwell P., Mendelsohn J. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin. Cancer Res. 1995, 1:1311-1318.
    • (1995) Clin. Cancer Res. , vol.1 , pp. 1311-1318
    • Goldstein, N.I.1    Prewett, M.2    Zuklys, K.3    Rockwell, P.4    Mendelsohn, J.5
  • 14
    • 0020933452 scopus 로고
    • Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors
    • Sato J.D., Kawamoto T., Le A.D., Mendelsohn J., Polikoff J., Sato G.H. Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol. Biol. Med. 1983, 1:511-529.
    • (1983) Mol. Biol. Med. , vol.1 , pp. 511-529
    • Sato, J.D.1    Kawamoto, T.2    Le, A.D.3    Mendelsohn, J.4    Polikoff, J.5    Sato, G.H.6
  • 15
    • 0035409904 scopus 로고    scopus 로고
    • IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer
    • Herbst R.S., Kim E.S., Harari P.M. IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody, for treatment of head and neck cancer. Expert Opin. Biol. Ther. 2001, 1:719-732.
    • (2001) Expert Opin. Biol. Ther. , vol.1 , pp. 719-732
    • Herbst, R.S.1    Kim, E.S.2    Harari, P.M.3
  • 16
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis
    • Huang S.M., Harari P.M. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clin. Cancer Res. 2000, 6:2166-2174.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2166-2174
    • Huang, S.M.1    Harari, P.M.2
  • 17
    • 0033559606 scopus 로고    scopus 로고
    • Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy
    • Yang X.D., Jia X.C., Corvalan J.R., Wang P., Davis C.G., Jakobovits A. Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res. 1999, 59:1236-1243.
    • (1999) Cancer Res. , vol.59 , pp. 1236-1243
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3    Wang, P.4    Davis, C.G.5    Jakobovits, A.6
  • 18
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
    • Yang X.D., Jia X.C., Corvalan J.R., Wang P., Davis C.G. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit. Rev. Oncol. Hematol. 2001, 38:17-23.
    • (2001) Crit. Rev. Oncol. Hematol. , vol.38 , pp. 17-23
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3    Wang, P.4    Davis, C.G.5
  • 19
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D., Humblet Y., Siena S., Khayat D., Bleiberg H., Santoro A., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 2004, 351:337-345.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6
  • 21
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • Sobrero A.F., Maurel J., Fehrenbacher L., Scheithauer W., Abubakr Y.A., Lutz M.P., et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J. Clin. Oncol. 2008, 26:2311-2319.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3    Scheithauer, W.4    Abubakr, Y.A.5    Lutz, M.P.6
  • 22
    • 36749067866 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer
    • Tabernero J., Van Cutsem E., Diaz-Rubio E., Cervantes A., Humblet Y., Andre T., et al. Phase II trial of cetuximab in combination with fluorouracil, leucovorin, and oxaliplatin in the first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 2007, 25:5225-5232.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 5225-5232
    • Tabernero, J.1    Van Cutsem, E.2    Diaz-Rubio, E.3    Cervantes, A.4    Humblet, Y.5    Andre, T.6
  • 23
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C., Bondarenko I., Makhson A., Hartmann J.T., Aparicio J., de Braud F., et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 2009, 27:663-671.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3    Hartmann, J.T.4    Aparicio, J.5    de Braud, F.6
  • 25
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E., Peeters M., Siena S., Humblet Y., Hendlisz A., Neyns B., et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J. Clin. Oncol. 2007, 25:1658-1664.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3    Humblet, Y.4    Hendlisz, A.5    Neyns, B.6
  • 26
    • 0344773402 scopus 로고    scopus 로고
    • The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies
    • (abstr 817)
    • Saltz L., Kies M., Abbruzzese J., Azarnia N., Needle M. The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies. Proc. Am. Soc. Clin. Oncol. 2003, 22. (abstr 817).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22
    • Saltz, L.1    Kies, M.2    Abbruzzese, J.3    Azarnia, N.4    Needle, M.5
  • 27
    • 63449142391 scopus 로고    scopus 로고
    • Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy
    • Peeters M., Siena S., Van Cutsem E., Sobrero A., Hendlisz A., Cascinu S., et al. Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy. Cancer 2009, 115:1544-1554.
    • (2009) Cancer , vol.115 , pp. 1544-1554
    • Peeters, M.1    Siena, S.2    Van Cutsem, E.3    Sobrero, A.4    Hendlisz, A.5    Cascinu, S.6
  • 28
    • 36949037220 scopus 로고    scopus 로고
    • Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): pharmacokinetic (PK), Pharmacodynamic (PD) and efficacy data
    • Tejpar S., Peeters M., Humblet Y., Gelderblom H., Vermorken J., Viret F., et al. Phase I/II study of cetuximab dose-escalation in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): pharmacokinetic (PK), Pharmacodynamic (PD) and efficacy data. J. Clin. Oncol. (Meeting Abstracts) 2007, 25:4037.
    • (2007) J. Clin. Oncol. (Meeting Abstracts) , vol.25 , pp. 4037
    • Tejpar, S.1    Peeters, M.2    Humblet, Y.3    Gelderblom, H.4    Vermorken, J.5    Viret, F.6
  • 29
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz L.B., Meropol N.J., Loehrer P.J., Needle M.N., Kopit J., Mayer R.J. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J. Clin. Oncol. 2004, 22:1201-1208.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer, P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 30
    • 20144381957 scopus 로고    scopus 로고
    • Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry
    • Chung K.Y., Shia J., Kemeny N.E., Shah M., Schwartz G.K., Tse A., et al. Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry. J. Clin. Oncol. 2005, 23:1803-1810.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 1803-1810
    • Chung, K.Y.1    Shia, J.2    Kemeny, N.E.3    Shah, M.4    Schwartz, G.K.5    Tse, A.6
  • 31
    • 25144491785 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study
    • Shia J., Klimstra D.S., Li A.R., Qin J., Saltz L., Teruya-Feldstein J., et al. Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study. Mod. Pathol. 2005, 18:1350-1356.
    • (2005) Mod. Pathol. , vol.18 , pp. 1350-1356
    • Shia, J.1    Klimstra, D.S.2    Li, A.R.3    Qin, J.4    Saltz, L.5    Teruya-Feldstein, J.6
  • 32
    • 33750615769 scopus 로고    scopus 로고
    • Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines
    • Lenz H.J., Van Cutsem E., Khambata-Ford S., Mayer R.J., Gold P., Stella P., et al. Multicenter phase II and translational study of cetuximab in metastatic colorectal carcinoma refractory to irinotecan, oxaliplatin, and fluoropyrimidines. J. Clin. Oncol. 2006, 24:4914-4921.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 4914-4921
    • Lenz, H.J.1    Van Cutsem, E.2    Khambata-Ford, S.3    Mayer, R.J.4    Gold, P.5    Stella, P.6
  • 33
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study
    • Moroni M., Veronese S., Benvenuti S., Marrapese G., Sartore-Bianchi A., Di Nicolantonio F., et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol. 2005, 6:279-286.
    • (2005) Lancet Oncol. , vol.6 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3    Marrapese, G.4    Sartore-Bianchi, A.5    Di Nicolantonio, F.6
  • 34
    • 34548258303 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab
    • Sartore-Bianchi A., Moroni M., Veronese S., Carnaghi C., Bajetta E., Luppi G., et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J. Clin. Oncol. 2007, 25:3238-3245.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 3238-3245
    • Sartore-Bianchi, A.1    Moroni, M.2    Veronese, S.3    Carnaghi, C.4    Bajetta, E.5    Luppi, G.6
  • 35
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D.W., Sordella R., Gurubhagavatula S., Okimoto R.A., Brannigan B.W., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2004, 350:2129-2139.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3    Gurubhagavatula, S.4    Okimoto, R.A.5    Brannigan, B.W.6
  • 39
    • 28844481452 scopus 로고    scopus 로고
    • The KRAS oncogene: past, present, and future
    • Kranenburg O. The KRAS oncogene: past, present, and future. Biochim. Biophys. Acta 2005, 1756:81-82.
    • (2005) Biochim. Biophys. Acta , vol.1756 , pp. 81-82
    • Kranenburg, O.1
  • 43
    • 66849140563 scopus 로고    scopus 로고
    • PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer
    • Loupakis F., Pollina L., Stasi I., Ruzzo A., Scartozzi M., Santini D., et al. PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer. J. Clin. Oncol. 2009, 27:2622-2629.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2622-2629
    • Loupakis, F.1    Pollina, L.2    Stasi, I.3    Ruzzo, A.4    Scartozzi, M.5    Santini, D.6
  • 44
    • 0036739336 scopus 로고    scopus 로고
    • Specific codon 13K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12K-ras mutations are associated with mucinous histotype
    • Bazan V., Migliavacca M., Zanna I., Tubiolo C., Grassi N., Latteri M.A., et al. Specific codon 13K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12K-ras mutations are associated with mucinous histotype. Ann. Oncol. 2002, 13:1438-1446.
    • (2002) Ann. Oncol. , vol.13 , pp. 1438-1446
    • Bazan, V.1    Migliavacca, M.2    Zanna, I.3    Tubiolo, C.4    Grassi, N.5    Latteri, M.A.6
  • 45
    • 0028596162 scopus 로고
    • The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival
    • Dix B.R., Robbins P., Soong R., Jenner D., House A.K., Iacopetta B.J. The common molecular genetic alterations in Dukes' B and C colorectal carcinomas are not short-term prognostic indicators of survival. Int. J. Cancer 1994, 59:747-751.
    • (1994) Int. J. Cancer , vol.59 , pp. 747-751
    • Dix, B.R.1    Robbins, P.2    Soong, R.3    Jenner, D.4    House, A.K.5    Iacopetta, B.J.6
  • 46
    • 0032948553 scopus 로고    scopus 로고
    • P53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer
    • Tortola S., Marcuello E., Gonzalez I., Reyes G., Arribas R., Aiza G., et al. p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. J. Clin. Oncol. 1999, 17:1375-1381.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1375-1381
    • Tortola, S.1    Marcuello, E.2    Gonzalez, I.3    Reyes, G.4    Arribas, R.5    Aiza, G.6
  • 47
    • 0027412665 scopus 로고
    • Prognostic significance of K-ras mutations in colorectal carcinoma
    • Benhattar J., Losi L., Chaubert P., Givel J.C., Costa J. Prognostic significance of K-ras mutations in colorectal carcinoma. Gastroenterology 1993, 104:1044-1048.
    • (1993) Gastroenterology , vol.104 , pp. 1044-1048
    • Benhattar, J.1    Losi, L.2    Chaubert, P.3    Givel, J.C.4    Costa, J.5
  • 51
    • 73149107502 scopus 로고    scopus 로고
    • KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803
    • Ogino S., Meyerhardt J.A., Irahara N., Niedzwiecki D., Hollis D., Saltz L.B., et al. KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803. Clin. Cancer Res. 2009, 15:7322-7329.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 7322-7329
    • Ogino, S.1    Meyerhardt, J.A.2    Irahara, N.3    Niedzwiecki, D.4    Hollis, D.5    Saltz, L.B.6
  • 52
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lievre A., Bachet J.B., Le Corre D., Boige V., Landi B., Emile J.F., et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 2006, 66:3992-3995.
    • (2006) Cancer Res. , vol.66 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3    Boige, V.4    Landi, B.5    Emile, J.F.6
  • 53
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Lievre A., Bachet J.B., Boige V., Cayre A., Le Corre D., Buc E., et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J. Clin. Oncol. 2008, 26:374-379.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 374-379
    • Lievre, A.1    Bachet, J.B.2    Boige, V.3    Cayre, A.4    Le Corre, D.5    Buc, E.6
  • 54
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • Benvenuti S., Sartore-Bianchi A., Di Nicolantonio F., Zanon C., Moroni M., Veronese S., et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 2007, 67:2643-2648.
    • (2007) Cancer Res. , vol.67 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Zanon, C.4    Moroni, M.5    Veronese, S.6
  • 55
    • 34247278727 scopus 로고    scopus 로고
    • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
    • Di Fiore F., Blanchard F., Charbonnier F., Le Pessot F., Lamy A., Galais M.P., et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br. J. Cancer 2007, 96:1166-1169.
    • (2007) Br. J. Cancer , vol.96 , pp. 1166-1169
    • Di Fiore, F.1    Blanchard, F.2    Charbonnier, F.3    Le Pessot, F.4    Lamy, A.5    Galais, M.P.6
  • 56
    • 40149088765 scopus 로고    scopus 로고
    • KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
    • De Roock W., Piessevaux H., De Schutter J., Janssens M., De Hertogh G., Personeni N., et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann. Oncol. 2008, 19:508-515.
    • (2008) Ann. Oncol. , vol.19 , pp. 508-515
    • De Roock, W.1    Piessevaux, H.2    De Schutter, J.3    Janssens, M.4    De Hertogh, G.5    Personeni, N.6
  • 57
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford S., Garrett C.R., Meropol N.J., Basik M., Harbison C.T., Wu S., et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J. Clin. Oncol. 2007, 25:3230-3237.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3    Basik, M.4    Harbison, C.T.5    Wu, S.6
  • 59
    • 63849202055 scopus 로고    scopus 로고
    • The EVEREST study: relationship between efficacy and K-ras mutation status in patients with irinotecan-refractory mCRC treated with irinotecan and standard or escalating doses of cetuximab
    • Tejpar S., Peeters M., Humblet Y., Gelderblom H., Vermorken J., De Hertogh G., et al. The EVEREST study: relationship between efficacy and K-ras mutation status in patients with irinotecan-refractory mCRC treated with irinotecan and standard or escalating doses of cetuximab. Ann. Oncol. 2008, 19:vi14.
    • (2008) Ann. Oncol. , vol.19
    • Tejpar, S.1    Peeters, M.2    Humblet, Y.3    Gelderblom, H.4    Vermorken, J.5    De Hertogh, G.6
  • 60
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado R.G., Wolf M., Peeters M., Van Cutsem E., Siena S., Freeman D.J., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 2008, 26:1626-1634.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3    Van Cutsem, E.4    Siena, S.5    Freeman, D.J.6
  • 63
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht J.R., Mitchell E., Chidiac T., Scroggin C., Hagenstad C., Spigel D., et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J. Clin. Oncol. 2009, 27:672-680.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3    Scroggin, C.4    Hagenstad, C.5    Spigel, D.6
  • 65
    • 65349189958 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
    • Allegra C.J., Jessup J.M., Somerfield M.R., Hamilton S.R., Hammond E.H., Hayes D.F., et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J. Clin. Oncol. 2009, 27:2091-2096.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2091-2096
    • Allegra, C.J.1    Jessup, J.M.2    Somerfield, M.R.3    Hamilton, S.R.4    Hammond, E.H.5    Hayes, D.F.6
  • 66
    • 34249988201 scopus 로고    scopus 로고
    • Liver resection for colorectal liver metastasis
    • Lochan R., White S.A., Manas D.M. Liver resection for colorectal liver metastasis. Surg. Oncol. 2007, 16:33-45.
    • (2007) Surg. Oncol. , vol.16 , pp. 33-45
    • Lochan, R.1    White, S.A.2    Manas, D.M.3
  • 67
    • 73249130298 scopus 로고    scopus 로고
    • Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial
    • Folprecht G., Gruenberger T., Bechstein W.O., Raab H.R., Lordick F., Hartmann J.T., et al. Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol. 2010, 11:38-47.
    • (2010) Lancet Oncol. , vol.11 , pp. 38-47
    • Folprecht, G.1    Gruenberger, T.2    Bechstein, W.O.3    Raab, H.R.4    Lordick, F.5    Hartmann, J.T.6
  • 68
    • 58149345226 scopus 로고    scopus 로고
    • Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer
    • Bertolini F., Chiara S., Bengala C., Antognoni P., Dealis C., Zironi S., et al. Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2009, 73:466-472.
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.73 , pp. 466-472
    • Bertolini, F.1    Chiara, S.2    Bengala, C.3    Antognoni, P.4    Dealis, C.5    Zironi, S.6
  • 69
    • 34047179551 scopus 로고    scopus 로고
    • Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer
    • Machiels J.P., Sempoux C., Scalliet P., Coche J.C., Humblet Y., Van Cutsem E., et al. Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer. Ann. Oncol. 2007, 18:738-744.
    • (2007) Ann. Oncol. , vol.18 , pp. 738-744
    • Machiels, J.P.1    Sempoux, C.2    Scalliet, P.3    Coche, J.C.4    Humblet, Y.5    Van Cutsem, E.6
  • 70
    • 61649088414 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer
    • Bengala C., Bettelli S., Bertolini F., Salvi S., Chiara S., Sonaglio C., et al. Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer. Ann. Oncol. 2009, 20:469-474.
    • (2009) Ann. Oncol. , vol.20 , pp. 469-474
    • Bengala, C.1    Bettelli, S.2    Bertolini, F.3    Salvi, S.4    Chiara, S.5    Sonaglio, C.6
  • 71
    • 0036898005 scopus 로고    scopus 로고
    • Effect of fixatives and tissue processing on the content and integrity of nucleic acids
    • Srinivasan M., Sedmak D., Jewell S. Effect of fixatives and tissue processing on the content and integrity of nucleic acids. Am. J. Pathol. 2002, 161:1961-1971.
    • (2002) Am. J. Pathol. , vol.161 , pp. 1961-1971
    • Srinivasan, M.1    Sedmak, D.2    Jewell, S.3
  • 72
    • 3042785708 scopus 로고    scopus 로고
    • Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections
    • Atkins D., Reiffen K.A., Tegtmeier C.L., Winther H., Bonato M.S., Storkel S. Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections. J. Histochem. Cytochem. 2004, 52:893-901.
    • (2004) J. Histochem. Cytochem. , vol.52 , pp. 893-901
    • Atkins, D.1    Reiffen, K.A.2    Tegtmeier, C.L.3    Winther, H.4    Bonato, M.S.5    Storkel, S.6
  • 74
    • 77957129235 scopus 로고    scopus 로고
    • High sensitivity of both sequencing and real-time PCR analysis of KRAS mutations in colorectal cancer tissue
    • (Epub ahead of print)
    • Tol J., Dijkstra J.R., Vink-Borger M.E., Nagtegaal I.D., Punt C.J., van Krieken J.H., et al. High sensitivity of both sequencing and real-time PCR analysis of KRAS mutations in colorectal cancer tissue. J. Cell. Mol. Med. 2009, (Epub ahead of print).
    • (2009) J. Cell. Mol. Med.
    • Tol, J.1    Dijkstra, J.R.2    Vink-Borger, M.E.3    Nagtegaal, I.D.4    Punt, C.J.5    van Krieken, J.H.6
  • 75
    • 77955611350 scopus 로고    scopus 로고
    • The German quality assurance system for the molecular-pathological detection of KRAS-mutations in colorectal cancer
    • Jung A., Baretton G., Dietel M., Gabbert H., Kreipe H., Schlake W., et al. The German quality assurance system for the molecular-pathological detection of KRAS-mutations in colorectal cancer. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4018.
    • (2009) J. Clin. Oncol. (Meeting Abstracts) , vol.27 , pp. 4018
    • Jung, A.1    Baretton, G.2    Dietel, M.3    Gabbert, H.4    Kreipe, H.5    Schlake, W.6
  • 80
    • 0038697566 scopus 로고    scopus 로고
    • Raf proteins and cancer: B-Raf is identified as a mutational target
    • Mercer K.E., Pritchard C.A. Raf proteins and cancer: B-Raf is identified as a mutational target. Biochim. Biophys. Acta 2003, 1653:25-40.
    • (2003) Biochim. Biophys. Acta , vol.1653 , pp. 25-40
    • Mercer, K.E.1    Pritchard, C.A.2
  • 82
    • 78249247981 scopus 로고    scopus 로고
    • Selecting subjects for a therapeutic target in colorectal cancer (CRC): using a clinical database to enrich for patients harboring the BRAFV600E mutation
    • Tie J., Sieber O.M., Gibbs P., Lipton L., Jorissen R.N., Langland R., et al. Selecting subjects for a therapeutic target in colorectal cancer (CRC): using a clinical database to enrich for patients harboring the BRAFV600E mutation. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:11003.
    • (2009) J. Clin. Oncol. (Meeting Abstracts) , vol.27 , pp. 11003
    • Tie, J.1    Sieber, O.M.2    Gibbs, P.3    Lipton, L.4    Jorissen, R.N.5    Langland, R.6
  • 83
    • 72449185665 scopus 로고    scopus 로고
    • The role of KRAS, BRAF, NRAS, and PIK3CA mutations as markers of resistance to cetuximab in chemorefractory metastatic colorectal cancer
    • Lambrechts D., De Roock W., Prenen H., De Schutter J., Jacobs B., Biesmans B., et al. The role of KRAS, BRAF, NRAS, and PIK3CA mutations as markers of resistance to cetuximab in chemorefractory metastatic colorectal cancer. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4020.
    • (2009) J. Clin. Oncol. (Meeting Abstracts) , vol.27 , pp. 4020
    • Lambrechts, D.1    De Roock, W.2    Prenen, H.3    De Schutter, J.4    Jacobs, B.5    Biesmans, B.6
  • 84
    • 72449142814 scopus 로고    scopus 로고
    • Predictive biomarkers to improve treatment of metastatic colorectal cancer (mCRC): outcomes with cetuximab plus FOLFIRI in the CRYSTAL trial
    • Kohne C., Stroiakovski D., Chang-chien C., Lim R., Pinter T., Bodoky G., et al. Predictive biomarkers to improve treatment of metastatic colorectal cancer (mCRC): outcomes with cetuximab plus FOLFIRI in the CRYSTAL trial. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4068.
    • (2009) J. Clin. Oncol. (Meeting Abstracts) , vol.27 , pp. 4068
    • Kohne, C.1    Stroiakovski, D.2    Chang-chien, C.3    Lim, R.4    Pinter, T.5    Bodoky, G.6
  • 86
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • Ma L., Chen Z., Erdjument-Bromage H., Tempst P., Pandolfi P.P. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005, 121:179-193.
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 87
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • Carracedo A., Ma L., Teruya-Feldstein J., Rojo F., Salmena L., Alimonti A., et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J. Clin. Invest. 2008, 118:3065-3074.
    • (2008) J. Clin. Invest. , vol.118 , pp. 3065-3074
    • Carracedo, A.1    Ma, L.2    Teruya-Feldstein, J.3    Rojo, F.4    Salmena, L.5    Alimonti, A.6
  • 88
    • 35348908314 scopus 로고    scopus 로고
    • PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
    • Frattini M., Saletti P., Romagnani E., Martin V., Molinari F., Ghisletta M., et al. PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br. J. Cancer 2007, 97:1139-1145.
    • (2007) Br. J. Cancer , vol.97 , pp. 1139-1145
    • Frattini, M.1    Saletti, P.2    Romagnani, E.3    Martin, V.4    Molinari, F.5    Ghisletta, M.6
  • 89
    • 59049089201 scopus 로고    scopus 로고
    • PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
    • Perrone F., Lampis A., Orsenigo M., Di Bartolomeo M., Gevorgyan A., Losa M., et al. PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann. Oncol. 2009, 20:84-90.
    • (2009) Ann. Oncol. , vol.20 , pp. 84-90
    • Perrone, F.1    Lampis, A.2    Orsenigo, M.3    Di Bartolomeo, M.4    Gevorgyan, A.5    Losa, M.6
  • 90
    • 66849140563 scopus 로고    scopus 로고
    • PTEN Expression and KRAS Mutations on Primary Tumors and Metastases in the Prediction of Benefit From Cetuximab Plus Irinotecan for Patients With Metastatic Colorectal Cancer
    • Loupakis F., Pollina L., Stasi I., Ruzzo A., Scartozzi M., Santini D., et al. PTEN Expression and KRAS Mutations on Primary Tumors and Metastases in the Prediction of Benefit From Cetuximab Plus Irinotecan for Patients With Metastatic Colorectal Cancer. J. Clin. Oncol. 2009, 27:2622-2629.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2622-2629
    • Loupakis, F.1    Pollina, L.2    Stasi, I.3    Ruzzo, A.4    Scartozzi, M.5    Santini, D.6
  • 91
    • 34250837538 scopus 로고    scopus 로고
    • Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history
    • Mounawar M., Mukeria A., Le Calvez F., Hung R.J., Renard H., Cortot A., et al. Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history. Cancer Res. 2007, 67:5667-5672.
    • (2007) Cancer Res. , vol.67 , pp. 5667-5672
    • Mounawar, M.1    Mukeria, A.2    Le Calvez, F.3    Hung, R.J.4    Renard, H.5    Cortot, A.6
  • 92
    • 65349149003 scopus 로고    scopus 로고
    • TP53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy
    • Oden-Gangloff A., Di Fiore F., Bibeau F., Lamy A., Bougeard G., Charbonnier F., et al. TP53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy. Br. J. Cancer 2009, 100:1330-1335.
    • (2009) Br. J. Cancer , vol.100 , pp. 1330-1335
    • Oden-Gangloff, A.1    Di Fiore, F.2    Bibeau, F.3    Lamy, A.4    Bougeard, G.5    Charbonnier, F.6
  • 93
    • 72449204284 scopus 로고    scopus 로고
    • High epiregulin (EREG) gene expression plus K-ras wild-type (WT) status as predictors of cetuximab benefit in the treatment of advanced colorectal cancer (ACRC): results from NCIC CTG CO.17-A phase III trial of cetuximab versus best supportive care (BSC)
    • Jonker D.J., Karapetis C., Harbison C., O'Callaghan C.J., Tu D., Simes R.J., et al. High epiregulin (EREG) gene expression plus K-ras wild-type (WT) status as predictors of cetuximab benefit in the treatment of advanced colorectal cancer (ACRC): results from NCIC CTG CO.17-A phase III trial of cetuximab versus best supportive care (BSC). J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4016.
    • (2009) J. Clin. Oncol. (Meeting Abstracts) , vol.27 , pp. 4016
    • Jonker, D.J.1    Karapetis, C.2    Harbison, C.3    O'Callaghan, C.J.4    Tu, D.5    Simes, R.J.6
  • 94
    • 72449164578 scopus 로고    scopus 로고
    • Use of amphiregulin and epiregulin mRNA expression in primary tumors to predict outcome in metastatic colorectal cancer treated with cetuximab
    • Prenen H., Jacobs B., De Roock W., Van Oirbeek R., Biesmans B., De Schutter J., et al. Use of amphiregulin and epiregulin mRNA expression in primary tumors to predict outcome in metastatic colorectal cancer treated with cetuximab. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4019.
    • (2009) J. Clin. Oncol. (Meeting Abstracts) , vol.27 , pp. 4019
    • Prenen, H.1    Jacobs, B.2    De Roock, W.3    Van Oirbeek, R.4    Biesmans, B.5    De Schutter, J.6
  • 95
    • 65549143792 scopus 로고    scopus 로고
    • The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer
    • Garm Spindler K.L., Pallisgaard N., Rasmussen A.A., Lindebjerg J., Andersen R.F., Cruger D., et al. The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer. Ann. Oncol. 2009, 20:879-884.
    • (2009) Ann. Oncol. , vol.20 , pp. 879-884
    • Garm Spindler, K.L.1    Pallisgaard, N.2    Rasmussen, A.A.3    Lindebjerg, J.4    Andersen, R.F.5    Cruger, D.6
  • 96
    • 61449239114 scopus 로고    scopus 로고
    • Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan
    • Bibeau F., Lopez-Crapez E., Di Fiore F., Thezenas S., Ychou M., Blanchard F., et al. Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan. J. Clin. Oncol. 2009, 27:1122-1129.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1122-1129
    • Bibeau, F.1    Lopez-Crapez, E.2    Di Fiore, F.3    Thezenas, S.4    Ychou, M.5    Blanchard, F.6
  • 97
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • Chakravarti A., Loeffler J.S., Dyson N.J. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res. 2002, 62:200-207.
    • (2002) Cancer Res. , vol.62 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3
  • 98
    • 77955856575 scopus 로고    scopus 로고
    • Correlation of insulin-like growth factor 1 (IGF-1) expression and clinical outcome in K-RAS wild-type colorectal cancer patients treated with cetuximab-irinotecan
    • Scartozzi M., Bearzi I., Mandolesi A., Loupakis F., Zaniboni A., Berardi R., et al. Correlation of insulin-like growth factor 1 (IGF-1) expression and clinical outcome in K-RAS wild-type colorectal cancer patients treated with cetuximab-irinotecan. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:4017.
    • (2009) J. Clin. Oncol. (Meeting Abstracts) , vol.27 , pp. 4017
    • Scartozzi, M.1    Bearzi, I.2    Mandolesi, A.3    Loupakis, F.4    Zaniboni, A.5    Berardi, R.6
  • 99
    • 67650354361 scopus 로고    scopus 로고
    • Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer
    • Cohen S.J., Punt C.J., Iannotti N., Saidman B.H., Sabbath K.D., Gabrail N.Y., et al. Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer. Ann. Oncol. 2009, 20:1223-1229.
    • (2009) Ann. Oncol. , vol.20 , pp. 1223-1229
    • Cohen, S.J.1    Punt, C.J.2    Iannotti, N.3    Saidman, B.H.4    Sabbath, K.D.5    Gabrail, N.Y.6
  • 101
    • 34347369084 scopus 로고    scopus 로고
    • Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets
    • Konstantinopoulos P.A., Karamouzis M.V., Papavassiliou A.G. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets. Nat. Rev. Drug Discov. 2007, 6:541-555.
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 541-555
    • Konstantinopoulos, P.A.1    Karamouzis, M.V.2    Papavassiliou, A.G.3
  • 102
    • 67651246671 scopus 로고    scopus 로고
    • Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer
    • Flaherty K., Puzanov I., Sosman J., Kim K., Ribas A., McArthur G., et al. Phase I study of PLX4032: proof of concept for V600E BRAF mutation as a therapeutic target in human cancer. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:9000.
    • (2009) J. Clin. Oncol. (Meeting Abstracts) , vol.27 , pp. 9000
    • Flaherty, K.1    Puzanov, I.2    Sosman, J.3    Kim, K.4    Ribas, A.5    McArthur, G.6
  • 103
    • 50649090571 scopus 로고    scopus 로고
    • Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway
    • Sebolt-Leopold J.S. Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway. Clin. Cancer Res. 2008, 14:3651-3656.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 3651-3656
    • Sebolt-Leopold, J.S.1
  • 104
    • 23944439944 scopus 로고    scopus 로고
    • Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies
    • Lorusso P.M., Adjei A.A., Varterasian M., Gadgeel S., Reid J., Mitchell D.Y., et al. Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies. J. Clin. Oncol. 2005, 23:5281-5293.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5281-5293
    • Lorusso, P.M.1    Adjei, A.A.2    Varterasian, M.3    Gadgeel, S.4    Reid, J.5    Mitchell, D.Y.6
  • 105
    • 14844285975 scopus 로고    scopus 로고
    • Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer
    • Rinehart J., Adjei A.A., Lorusso P.M., Waterhouse D., Hecht J.R., Natale R.B., et al. Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J. Clin. Oncol. 2004, 22:4456-4462.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 4456-4462
    • Rinehart, J.1    Adjei, A.A.2    Lorusso, P.M.3    Waterhouse, D.4    Hecht, J.R.5    Natale, R.B.6
  • 107
    • 43749103335 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
    • Adjei A.A., Cohen R.B., Franklin W., Morris C., Wilson D., Molina J.R., et al. Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J. Clin. Oncol. 2008, 26:2139-2146.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2139-2146
    • Adjei, A.A.1    Cohen, R.B.2    Franklin, W.3    Morris, C.4    Wilson, D.5    Molina, J.R.6
  • 108
    • 70350176755 scopus 로고    scopus 로고
    • A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765, a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced solid tumors
    • LoRusso P., Markman B., Tabernero J., Shazer R., Nguyen L., Heath E., et al. A phase I dose-escalation study of the safety, pharmacokinetics (PK), and pharmacodynamics of XL765, a PI3K/TORC1/TORC2 inhibitor administered orally to patients (pts) with advanced solid tumors. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:3502.
    • (2009) J. Clin. Oncol. (Meeting Abstracts) , vol.27 , pp. 3502
    • LoRusso, P.1    Markman, B.2    Tabernero, J.3    Shazer, R.4    Nguyen, L.5    Heath, E.6
  • 110
    • 76749136608 scopus 로고    scopus 로고
    • A first-in-human phase I study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors
    • Wagner A.J., Von Hoff D.H., LoRusso P.M., Tibes R., Mazina K.E., Ware J.A., et al. A first-in-human phase I study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors. J. Clin. Oncol. (Meeting Abstracts) 2009, 27:3501.
    • (2009) J. Clin. Oncol. (Meeting Abstracts) , vol.27 , pp. 3501
    • Wagner, A.J.1    Von Hoff, D.H.2    LoRusso, P.M.3    Tibes, R.4    Mazina, K.E.5    Ware, J.A.6
  • 111
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    • Engelman J.A., Chen L., Tan X., Crosby K., Guimaraes A.R., Upadhyay R., et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat. Med. 2008, 14:1351-1356.
    • (2008) Nat. Med. , vol.14 , pp. 1351-1356
    • Engelman, J.A.1    Chen, L.2    Tan, X.3    Crosby, K.4    Guimaraes, A.R.5    Upadhyay, R.6
  • 112
    • 46749156706 scopus 로고    scopus 로고
    • Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins
    • Guix M., Faber A.C., Wang S.E., Olivares M.G., Song Y., Qu S., et al. Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins. J. Clin. Invest. 2008, 118:2609-2619.
    • (2008) J. Clin. Invest. , vol.118 , pp. 2609-2619
    • Guix, M.1    Faber, A.C.2    Wang, S.E.3    Olivares, M.G.4    Song, Y.5    Qu, S.6


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