-
1
-
-
33847638137
-
Estimates of the cancer incidence and mortality in Europe in 2006
-
Ferlay J., Autier P., Boniol M., et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007, 18:581-592.
-
(2007)
Ann Oncol
, vol.18
, pp. 581-592
-
-
Ferlay, J.1
Autier, P.2
Boniol, M.3
-
2
-
-
2342475760
-
A comparison of laparoscopically assisted and open colectomy for colon cancer
-
A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med 2004, 350:2050-2059.
-
(2004)
N Engl J Med
, vol.350
, pp. 2050-2059
-
-
-
3
-
-
33645752308
-
Current status of adjuvant therapy for colorectal cancer
-
O'Connell M.J. Current status of adjuvant therapy for colorectal cancer. Oncology (Williston Park) 2004, 18:751-755.
-
(2004)
Oncology (Williston Park)
, vol.18
, pp. 751-755
-
-
O'Connell, M.J.1
-
4
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004, 350:2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
-
5
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D., Humblet Y., Siena S., et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004, 351:337-345.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
-
6
-
-
0019473568
-
Natural history of patients with untreated liver metastases from colorectal cancer
-
Bengtsson G., Carlsson G., Hafström L., Jönsson P.E. Natural history of patients with untreated liver metastases from colorectal cancer. Am J Surg 1981, 141:586-589.
-
(1981)
Am J Surg
, vol.141
, pp. 586-589
-
-
Bengtsson, G.1
Carlsson, G.2
Hafström, L.3
Jönsson, P.E.4
-
7
-
-
0023154288
-
Diagnostic evaluation and survival analysis of colorectal cancer patients with liver metastases
-
de Brauw L.M., van de Velde C.J., Bouwhuis-Hoogerwerf M.L., Zwaveling A. Diagnostic evaluation and survival analysis of colorectal cancer patients with liver metastases. J Surg Oncol 1987, 34:81-86.
-
(1987)
J Surg Oncol
, vol.34
, pp. 81-86
-
-
de Brauw, L.M.1
van de Velde, C.J.2
Bouwhuis-Hoogerwerf, M.L.3
Zwaveling, A.4
-
8
-
-
0014310336
-
Factor influencing survival in patients with untreated hepatic metastases
-
Gaffe B.M., Donegan W.L., Watson F., Sprat J.S. Factor influencing survival in patients with untreated hepatic metastases. Surg Gynecol Obstet 1969, 127:1-11.
-
(1969)
Surg Gynecol Obstet
, vol.127
, pp. 1-11
-
-
Gaffe, B.M.1
Donegan, W.L.2
Watson, F.3
Sprat, J.S.4
-
9
-
-
1342290189
-
FOLFIRI followed by FOLFOX6 or reverse sequence in advanced colorectal cancer: a randomized GERCOR study
-
Tournigand C., André T., Achille E., et al. FOLFIRI followed by FOLFOX6 or reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 2004, 22:229-237.
-
(2004)
J Clin Oncol
, vol.22
, pp. 229-237
-
-
Tournigand, C.1
André, T.2
Achille, E.3
-
10
-
-
34548289390
-
FDA drug approval summary: panitumumab (Vectibix)
-
Giusti R.M., Shastri K.A., Cohen M.H., Keegan P., Pazdur R. FDA drug approval summary: panitumumab (Vectibix). Oncologist 2007, 12:577-583.
-
(2007)
Oncologist
, vol.12
, pp. 577-583
-
-
Giusti, R.M.1
Shastri, K.A.2
Cohen, M.H.3
Keegan, P.4
Pazdur, R.5
-
11
-
-
0034722889
-
The EGF receptor family as targets for cancer therapy
-
Mendelsohn J., Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 2000, 19:6550-6565.
-
(2000)
Oncogene
, vol.19
, pp. 6550-6565
-
-
Mendelsohn, J.1
Baselga, J.2
-
13
-
-
33749316418
-
The epidermal growth receptor pathway: a model for targeted therapy
-
Scaltriti M., Baselga J. The epidermal growth receptor pathway: a model for targeted therapy. Clin Cancer Res 2006, 12:5268-5272.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5268-5272
-
-
Scaltriti, M.1
Baselga, J.2
-
14
-
-
0029991439
-
Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer
-
Baselga J., Tripathy D., Mendelsohn J., et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. J Clin Oncol 1996, 14:737-744.
-
(1996)
J Clin Oncol
, vol.14
, pp. 737-744
-
-
Baselga, J.1
Tripathy, D.2
Mendelsohn, J.3
-
15
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon D.J., Leyland-Jones B., Shak S., et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001, 344:783-792.
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
-
16
-
-
34250180582
-
Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
-
Vermorken J.B., Trigo J., Hitt R., et al. Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J Clin Oncol 2007, 25:2171-2177.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2171-2177
-
-
Vermorken, J.B.1
Trigo, J.2
Hitt, R.3
-
17
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
-
Saltz L.B., Meropol N.J., Loehrer P.J., et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004, 22:1201-1208.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer, P.J.3
-
18
-
-
44249111440
-
EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
-
Sobrero A.F., Maurel J., Fehrenbacher L., et al. EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26:2311-2319.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2311-2319
-
-
Sobrero, A.F.1
Maurel, J.2
Fehrenbacher, L.3
-
19
-
-
34447264101
-
Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metatatic colorectal cancer: the Crystal trial
-
[abstract 4000]
-
Van Cutsem E., Nowacki M., Lang I., et al. Randomized phase III study of irinotecan and 5-FU/FA with or without cetuximab in the first-line treatment of patients with metatatic colorectal cancer: the Crystal trial. J Clin Oncol 2007, 25. [abstract 4000].
-
(2007)
J Clin Oncol
, vol.25
-
-
Van Cutsem, E.1
Nowacki, M.2
Lang, I.3
-
20
-
-
36348990562
-
Cetuximab plus 5-FU/FA/oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer: OPUS, a randomized phase II study
-
[abstract 4035]
-
Bokemeyer C., Bondarenko I., Makhson A., et al. Cetuximab plus 5-FU/FA/oxaliplatin (FOLFOX-4) versus FOLFOX-4 in the first-line treatment of metastatic colorectal cancer: OPUS, a randomized phase II study. J Clin Oncol 2007, 25. [abstract 4035].
-
(2007)
J Clin Oncol
, vol.25
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
-
22
-
-
84901290217
-
FDA drug approval summary: lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2
-
Ryan Q., Ibrahim A., Cohen M.H., et al. FDA drug approval summary: lapatinib in combination with capecitabine for previously treated metastatic breast cancer that overexpresses HER-2. Oncologist 2008, 13:1114-1119.
-
(2008)
Oncologist
, vol.13
, pp. 1114-1119
-
-
Ryan, Q.1
Ibrahim, A.2
Cohen, M.H.3
-
23
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
-
Kris M.G., Natale R.B., Herbst R.S., et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003, 290:2149-2158.
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
-
24
-
-
34548215663
-
Erlotinib in non-small cell lung cancer treatment: current status and future development
-
Gridelli C., Bareschino M.A., Schettino C., et al. Erlotinib in non-small cell lung cancer treatment: current status and future development. Oncologist 2007, 12:840-849.
-
(2007)
Oncologist
, vol.12
, pp. 840-849
-
-
Gridelli, C.1
Bareschino, M.A.2
Schettino, C.3
-
25
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
-
Moore M.J., Goldstein D., Hamm J., et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007, 25:1960-1966.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
26
-
-
33845674883
-
Panitumumab the first fully human monoclonal antibody: from the bench to the clinic
-
Cohenuram M., Saif M.W. Panitumumab the first fully human monoclonal antibody: from the bench to the clinic. Anticancer Drugs 2007, 18:7-15.
-
(2007)
Anticancer Drugs
, vol.18
, pp. 7-15
-
-
Cohenuram, M.1
Saif, M.W.2
-
27
-
-
77953363140
-
Mono and combination-therapeutic activity of panitumumab (ABX-EGF) on human A431 epidermoid and HT-29 colon carcinoma xenografts; correlation with pharmacodynamic parameters
-
Freeman D., McDorman K., Bush T., et al. Mono and combination-therapeutic activity of panitumumab (ABX-EGF) on human A431 epidermoid and HT-29 colon carcinoma xenografts; correlation with pharmacodynamic parameters. Proc Amer Assoc Cancer Res 2004, 27-31.
-
(2004)
Proc Amer Assoc Cancer Res
, pp. 27-31
-
-
Freeman, D.1
McDorman, K.2
Bush, T.3
-
28
-
-
0031039315
-
Functional transplant of magabase human immunoglobulin loci recapitulates human antibody response in mice
-
Mendez M.J., Green L.L., Corvalan J.R., et al. Functional transplant of magabase human immunoglobulin loci recapitulates human antibody response in mice. Nat Genet 1997, 15:146-156.
-
(1997)
Nat Genet
, vol.15
, pp. 146-156
-
-
Mendez, M.J.1
Green, L.L.2
Corvalan, J.R.3
-
29
-
-
0027428571
-
Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts
-
Fan Z., Baselga J., Masui H., Maendelsohn J. Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res 1993, 53:4637-4642.
-
(1993)
Cancer Res
, vol.53
, pp. 4637-4642
-
-
Fan, Z.1
Baselga, J.2
Masui, H.3
Maendelsohn, J.4
-
30
-
-
0033559606
-
Erradication of established tumors by a fully human monoclonal to the epidermal growth factor receptor without concomitant chemotherapy
-
Yang X.D., Jia X.C., Corvalan J.R., et al. Erradication of established tumors by a fully human monoclonal to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res 1999, 59:1236-1243.
-
(1999)
Cancer Res
, vol.59
, pp. 1236-1243
-
-
Yang, X.D.1
Jia, X.C.2
Corvalan, J.R.3
-
31
-
-
1242311463
-
Inhibition of vascular endothelial cell growth factor and interleukin-8 production in tumor and endothelial cell lines by a fully human monoclonal antibody to epidermal groth factor receptor
-
Jia X.C., Corvalan J.R.F., Zhang L. Inhibition of vascular endothelial cell growth factor and interleukin-8 production in tumor and endothelial cell lines by a fully human monoclonal antibody to epidermal groth factor receptor. Proc Amer Assoc Cancer Res 2000, 290.
-
(2000)
Proc Amer Assoc Cancer Res
, pp. 290
-
-
Jia, X.C.1
Corvalan, J.R.F.2
Zhang, L.3
-
32
-
-
1242333981
-
Inhibition of human cancer growth by ABX-EGF, a fully human anti-EGF receptor monoclonal antibody
-
Yang X.D., Corvalan J.R.F., Wang P. Inhibition of human cancer growth by ABX-EGF, a fully human anti-EGF receptor monoclonal antibody. Proc Am Assoc Cancer Res 2000, 530.
-
(2000)
Proc Am Assoc Cancer Res
, pp. 530
-
-
Yang, X.D.1
Corvalan, J.R.F.2
Wang, P.3
-
33
-
-
0036118248
-
Therapeutic potential of ABX-EGF: a fully antiepidermal growth factor reeptor monoclonal antibody for cancer treatment
-
Lynch D.H., Yang X.D. Therapeutic potential of ABX-EGF: a fully antiepidermal growth factor reeptor monoclonal antibody for cancer treatment. Semin Oncol 2002, 29:47-50.
-
(2002)
Semin Oncol
, vol.29
, pp. 47-50
-
-
Lynch, D.H.1
Yang, X.D.2
-
34
-
-
33749028607
-
Flexible dosing schedules of panitumumab in cancer patients
-
[abstract 3089]
-
Arends R., Yang B., Schwab G., et al. Flexible dosing schedules of panitumumab in cancer patients. J Clin Oncol 2005, 23. [abstract 3089].
-
(2005)
J Clin Oncol
, vol.23
-
-
Arends, R.1
Yang, B.2
Schwab, G.3
-
35
-
-
33244488713
-
Updated results from a dose and schedule study of Panitumumab monotherapy in patients with advanced solid malignancies
-
[abstract 3059]
-
Weiner L.M., Belldegrun A., Rowinsky E., et al. Updated results from a dose and schedule study of Panitumumab monotherapy in patients with advanced solid malignancies. J Clin Oncol 2005, 23. [abstract 3059].
-
(2005)
J Clin Oncol
, vol.23
-
-
Weiner, L.M.1
Belldegrun, A.2
Rowinsky, E.3
-
36
-
-
77953361993
-
Efficacy and safety of panitumumab across five clinical studies in patients with metastatic colorectal cancer
-
[Gastrointestinal cancers symposium, abstract 336]
-
Peeters M., Van Cutsem E., Hecht J.R., et al. Efficacy and safety of panitumumab across five clinical studies in patients with metastatic colorectal cancer. J Clin Oncol 2007, [Gastrointestinal cancers symposium, abstract 336].
-
(2007)
J Clin Oncol
-
-
Peeters, M.1
Van Cutsem, E.2
Hecht, J.R.3
-
37
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
-
Van Cutsem E., Peeters M., Siena S., et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007, 25:1658-1664.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
-
38
-
-
42649145667
-
Wild-type Kras is required for Panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado R.G., Wolf M., Peeters M., et al. Wild-type Kras is required for Panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26:1626-1634.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
39
-
-
38049044037
-
An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy
-
Van Cutsem E., Siena S., Humblet Y.S., et al. An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy. Ann Oncol 2008, 19:92-98.
-
(2008)
Ann Oncol
, vol.19
, pp. 92-98
-
-
Van Cutsem, E.1
Siena, S.2
Humblet, Y.S.3
-
40
-
-
77953363337
-
Panitumumab therapy with IFL in metastatic colorectal cancer patients: a pharmacokinetic analysis results
-
[Gastrointestinal cancers symposium, abstract 259]
-
Hecht J., Berlin J., Malik I., et al. Panitumumab therapy with IFL in metastatic colorectal cancer patients: a pharmacokinetic analysis results. J Clin Oncol 2005, [Gastrointestinal cancers symposium, abstract 259].
-
(2005)
J Clin Oncol
-
-
Hecht, J.1
Berlin, J.2
Malik, I.3
-
41
-
-
34247480064
-
Panitumumab with irinotecan/leucovorin/5-fluorouracil for first-line treatment of metastatic colorectal cancer
-
Berlin J., Posey J., Tchekmedyian S., et al. Panitumumab with irinotecan/leucovorin/5-fluorouracil for first-line treatment of metastatic colorectal cancer. Clin Colorectal Cancer 2007, 6:427-432.
-
(2007)
Clin Colorectal Cancer
, vol.6
, pp. 427-432
-
-
Berlin, J.1
Posey, J.2
Tchekmedyian, S.3
-
42
-
-
55249110754
-
Phase III study (20050181) of panitumumab with FOLFIRI compared to FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer (mCRC): preliminary safety results
-
[Gastrointestinal cancers symposium, abstract 335]
-
Peeters M., Wilson G., Hotko Y., et al. Phase III study (20050181) of panitumumab with FOLFIRI compared to FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer (mCRC): preliminary safety results. J Clin Oncol 2008, [Gastrointestinal cancers symposium, abstract 335].
-
(2008)
J Clin Oncol
-
-
Peeters, M.1
Wilson, G.2
Hotko, Y.3
-
43
-
-
77953360648
-
Phase III study (PRIME/20050203) of panitumumab with FOLFOX4 compared to FOLFOX4 alone in patients with previously untreated metastatic colorectal cancer (mCRC): preliminary safety data results
-
[Gastrointestinal cancers symposium, abstract 443]
-
Douillard J., Siena S., Cassidy J., et al. Phase III study (PRIME/20050203) of panitumumab with FOLFOX4 compared to FOLFOX4 alone in patients with previously untreated metastatic colorectal cancer (mCRC): preliminary safety data results. J Clin Oncol 2008, [Gastrointestinal cancers symposium, abstract 443].
-
(2008)
J Clin Oncol
-
-
Douillard, J.1
Siena, S.2
Cassidy, J.3
-
44
-
-
78649665921
-
Dermatological toxicities of panitumumab in the treatment of patients with metastatic colorectal cancer from three clinical studies
-
[abstract 14551]
-
Drelich D.A., Rose L., Ramirez M., Jacobs M., Mitchell E. Dermatological toxicities of panitumumab in the treatment of patients with metastatic colorectal cancer from three clinical studies. J Clin Oncol 2007, 25. [abstract 14551].
-
(2007)
J Clin Oncol
, vol.25
-
-
Drelich, D.A.1
Rose, L.2
Ramirez, M.3
Jacobs, M.4
Mitchell, E.5
-
45
-
-
24044500971
-
Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors
-
Segaert S., Van Cutsem E. Clinical signs, pathophysiology and management of skin toxicity during therapy with epidermal growth factor receptor inhibitors. Ann Oncol 2005, 16:1425-1433.
-
(2005)
Ann Oncol
, vol.16
, pp. 1425-1433
-
-
Segaert, S.1
Van Cutsem, E.2
-
46
-
-
77953363179
-
Safety of panitumumab, a fully human monoclonal antibody against the epidermal growth factor receptor, in patients with metastatic colorectal cancer across clinical trials
-
[abstract 4138]
-
Peeters M., Van Cutsem E., Berlin J., et al. Safety of panitumumab, a fully human monoclonal antibody against the epidermal growth factor receptor, in patients with metastatic colorectal cancer across clinical trials. J Clin Oncol 2007, 25. [abstract 4138].
-
(2007)
J Clin Oncol
, vol.25
-
-
Peeters, M.1
Van Cutsem, E.2
Berlin, J.3
-
47
-
-
40949091368
-
U.S. Food and Drug Administration approval: panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens
-
March (5)
-
Giusti R.M., Shastri K., Pilaro A.M., et al. U.S. Food and Drug Administration approval: panitumumab for epidermal growth factor receptor-expressing metastatic colorectal carcinoma with progression following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Clin Cancer Res 2008, 14(March (5)):1296-1302.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1296-1302
-
-
Giusti, R.M.1
Shastri, K.2
Pilaro, A.M.3
-
48
-
-
77953363068
-
-
(v3, rev October 2007) Amgen Inc.: Thousand Oaks, CA. Available at: (accessed 10.03.2008)
-
Anon. Vectibix (panitumumab) prescribing information. (v3, rev October 2007) Amgen Inc.: Thousand Oaks, CA. Available at: (accessed 10.03.2008). http://www.vectibix.com/pdfs/misc/vectibix_pi.pdf.
-
Anon, Vectibix (panitumumab) prescribing information
-
-
-
49
-
-
24644513947
-
Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?
-
Perez-Soler R., Saltz L. Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?. J Clin Oncol 2005, 22:5235-5241.
-
(2005)
J Clin Oncol
, vol.22
, pp. 5235-5241
-
-
Perez-Soler, R.1
Saltz, L.2
-
50
-
-
36949039745
-
Predictive value of skin toxicity severity for response to panitumumab in patients with metastatic colorectal cancer. A pooled analysis of five clinical trials
-
[abstract 4134]
-
Berlin J., Van Cutsem E., Peeters M., et al. Predictive value of skin toxicity severity for response to panitumumab in patients with metastatic colorectal cancer. A pooled analysis of five clinical trials. J Clin Oncol 2007, 25. [abstract 4134].
-
(2007)
J Clin Oncol
, vol.25
-
-
Berlin, J.1
Van Cutsem, E.2
Peeters, M.3
-
51
-
-
0012679970
-
ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with advanced cancer. Phase I clinical results
-
[abstract 35]
-
Figlin R.A., Belldegrun A.S., Crawford J., et al. ABX-EGF, a fully human anti-epidermal growth factor receptor monoclonal antibody in patients with advanced cancer. Phase I clinical results. J Clin Oncol 2002, 21. [abstract 35].
-
(2002)
J Clin Oncol
, vol.21
-
-
Figlin, R.A.1
Belldegrun, A.S.2
Crawford, J.3
-
52
-
-
34548147248
-
Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer
-
Hecht J.R., Patnaik A., Berlin J., et al. Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer. Cancer 2007, 110:980-988.
-
(2007)
Cancer
, vol.110
, pp. 980-988
-
-
Hecht, J.R.1
Patnaik, A.2
Berlin, J.3
-
53
-
-
35148842402
-
Panitumumab activity in metastatic colorectal cancer patients with low or negative tumor epidermal growth factor receptor levels: an updated analysis
-
[abstract 4082]
-
Mitchell E.P., Hercht J.R., Baranda J., et al. Panitumumab activity in metastatic colorectal cancer patients with low or negative tumor epidermal growth factor receptor levels: an updated analysis. J Clin Oncol 2007, 25. [abstract 4082].
-
(2007)
J Clin Oncol
, vol.25
-
-
Mitchell, E.P.1
Hercht, J.R.2
Baranda, J.3
-
54
-
-
16544377303
-
Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: implications for treatment with EGFR-targeted monoclonal antibodies
-
Scartozzi M., Bearzi I., Berardi R., et al. Epidermal growth factor receptor (EGFR) status in primary colorectal tumors does not correlate with EGFR expression in related metastatic sites: implications for treatment with EGFR-targeted monoclonal antibodies. J Clin Oncol 2004, 22:4772-4778.
-
(2004)
J Clin Oncol
, vol.22
, pp. 4772-4778
-
-
Scartozzi, M.1
Bearzi, I.2
Berardi, R.3
-
55
-
-
3042785708
-
Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections
-
Atkins D., Reiffen K.A., Tegtmeier C.L., et al. Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections. J Histochem Cytochem 2004, 52:893-901.
-
(2004)
J Histochem Cytochem
, vol.52
, pp. 893-901
-
-
Atkins, D.1
Reiffen, K.A.2
Tegtmeier, C.L.3
-
56
-
-
0030944455
-
ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signalling
-
Graus-Porta D., Beerli R., Daly J., Hynes N. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signalling. EMBO J 1997, 16:1647-1655.
-
(1997)
EMBO J
, vol.16
, pp. 1647-1655
-
-
Graus-Porta, D.1
Beerli, R.2
Daly, J.3
Hynes, N.4
-
57
-
-
0029814271
-
A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
-
Tzahar E., Waterman H., Chen X., et al. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol 1996, 16:5276-5287.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 5276-5287
-
-
Tzahar, E.1
Waterman, H.2
Chen, X.3
-
58
-
-
0032526729
-
Differential endocytic of homo- and hetero-dimeric ErbB tyrosine kinases confers signalling superiority to receptor heterodimers
-
Lenferink A., Pinkas-Kramarski R., van de Poll M., et al. Differential endocytic of homo- and hetero-dimeric ErbB tyrosine kinases confers signalling superiority to receptor heterodimers. EMBO J 1998, 17:3385-3397.
-
(1998)
EMBO J
, vol.17
, pp. 3385-3397
-
-
Lenferink, A.1
Pinkas-Kramarski, R.2
van de Poll, M.3
-
59
-
-
33646133900
-
HER-2 expression as a potential marker for response to therapy targeted to the EGFR
-
Emlet D.R., Schwartz R., Brown K.A., et al. HER-2 expression as a potential marker for response to therapy targeted to the EGFR. Br J Cancer 2006, 94:1144-1153.
-
(2006)
Br J Cancer
, vol.94
, pp. 1144-1153
-
-
Emlet, D.R.1
Schwartz, R.2
Brown, K.A.3
-
60
-
-
41949119777
-
Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 in advanced inflammatory breast cancer with Lapatinib monotherapy
-
Johnston S., Trudeau M., Kaufman B., et al. Phase II study of predictive biomarker profiles for response targeting human epidermal growth factor receptor 2 in advanced inflammatory breast cancer with Lapatinib monotherapy. J Clin Oncol 2008, 26:1066-1072.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1066-1072
-
-
Johnston, S.1
Trudeau, M.2
Kaufman, B.3
-
61
-
-
0023256456
-
Prevalence of ras gene mutations in human colorectal cancers
-
Bos J.L., Fearon E.R., Hamilton S.R., et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 1987, 327:293-297.
-
(1987)
Nature
, vol.327
, pp. 293-297
-
-
Bos, J.L.1
Fearon, E.R.2
Hamilton, S.R.3
-
62
-
-
77953357269
-
Efficacy of Panitumumab monotherapy in relation to KRAS mutational status for treating metastatic colorectal cancer from four clinical studies
-
[abstract 47]
-
Freeman D., Amado R., Wolf M., et al. Efficacy of Panitumumab monotherapy in relation to KRAS mutational status for treating metastatic colorectal cancer from four clinical studies. J Clin Oncol 2008, [abstract 47].
-
(2008)
J Clin Oncol
-
-
Freeman, D.1
Amado, R.2
Wolf, M.3
-
63
-
-
57449095367
-
Wild-type BRAF is required fo response to panitumumab or cetuximab in metastatic colorectal cancer
-
Di Nicolantonio F., Martini M., Molinari F., et al. Wild-type BRAF is required fo response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 2008, 26:5705-5712.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
-
64
-
-
64849108329
-
Additional value of EGFR downstream signaling phosphoprotein expression to KRAS mutation for response prediction to cetuximab in colorectal cancer
-
[abstract 4126]
-
Merlin J.L., Perkins G., Lievre A., et al. Additional value of EGFR downstream signaling phosphoprotein expression to KRAS mutation for response prediction to cetuximab in colorectal cancer. J Clin Oncol 2008, 26. [abstract 4126].
-
(2008)
J Clin Oncol
, vol.26
-
-
Merlin, J.L.1
Perkins, G.2
Lievre, A.3
-
65
-
-
17844362179
-
Gene copy number of epidermal growth factor receptor and clinical response to anti-EGFR treatment in colorectal cancer: a cohort study
-
Moroni M., Veronese S., Benvenuti S., et al. Gene copy number of epidermal growth factor receptor and clinical response to anti-EGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 2005, 6:279-286.
-
(2005)
Lancet Oncol
, vol.6
, pp. 279-286
-
-
Moroni, M.1
Veronese, S.2
Benvenuti, S.3
-
66
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lièvre A., Bachet J.B., Le Corre D., et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006, 66:3992-3995.
-
(2006)
Cancer Res
, vol.66
, pp. 3992-3995
-
-
Lièvre, A.1
Bachet, J.B.2
Le Corre, D.3
-
67
-
-
34548258303
-
Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with Panitumumab
-
Sartore-Bianchi A., Moroni M., Veronese S., et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with Panitumumab. J Clin Oncol 2007, 25:3238-3245.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3238-3245
-
-
Sartore-Bianchi, A.1
Moroni, M.2
Veronese, S.3
-
68
-
-
73449130097
-
EGFR polymorphisms as predictors of clinical outcome in patients with advanced colorectal cancer treated with cetuximab and panitumumab
-
[abstract 4124]
-
Carcereny E., Castellvi-Bel S., Alonso V., et al. EGFR polymorphisms as predictors of clinical outcome in patients with advanced colorectal cancer treated with cetuximab and panitumumab. J Clin Oncol 2008, 26. [abstract 4124].
-
(2008)
J Clin Oncol
, vol.26
-
-
Carcereny, E.1
Castellvi-Bel, S.2
Alonso, V.3
-
69
-
-
2342591455
-
The discovery of receptor tyrosine kinases: targets for cancer therapy
-
Gschwind A., Fischer O.M., Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 2004, 4:361-370.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 361-370
-
-
Gschwind, A.1
Fischer, O.M.2
Ullrich, A.3
-
70
-
-
0001223491
-
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors
-
Petit A.M.V., Rak J., Hung M.C., et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol 1997, 151:1523-1530.
-
(1997)
Am J Pathol
, vol.151
, pp. 1523-1530
-
-
Petit, A.M.V.1
Rak, J.2
Hung, M.C.3
-
71
-
-
0033818695
-
Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
-
Ciardiello F., Bianco R., Daminao V., et al. Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res 2000, 6:3739-3747.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3739-3747
-
-
Ciardiello, F.1
Bianco, R.2
Daminao, V.3
-
72
-
-
59949102930
-
A randomized phase IIIB trial of chemotherapy, bevacizumab and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
-
Hecht J.R., Mitchell E., Chidiac T., et al. A randomized phase IIIB trial of chemotherapy, bevacizumab and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009, 27:672-680.
-
(2009)
J Clin Oncol
, vol.27
, pp. 672-680
-
-
Hecht, J.R.1
Mitchell, E.2
Chidiac, T.3
-
73
-
-
49149109102
-
Randomized phase III study of capecitabine, oxaliplatin and bevacizumab with or without cetuximab in advanced colorectal cancer, the CAIRO2 study of yhe Dutch Colorectal Cancer Group
-
[abstract LBA 4011]
-
Punt C.J., Tol J., Rodenburg C.J., et al. Randomized phase III study of capecitabine, oxaliplatin and bevacizumab with or without cetuximab in advanced colorectal cancer, the CAIRO2 study of yhe Dutch Colorectal Cancer Group. J Clin Oncol 2008, 26(Suppl.):180s. [abstract LBA 4011].
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL.
-
-
Punt, C.J.1
Tol, J.2
Rodenburg, C.J.3
-
74
-
-
50249104632
-
Safety and pharmacokinetics of AMG706 with Panitumumab plus FOLFIRI or FOLFOX for the treatment of patients with metastatic colorectal cancer
-
[abstract 4081]
-
Schwartzberg L.S., Hurwitz H., Stephenson J., et al. Safety and pharmacokinetics of AMG706 with Panitumumab plus FOLFIRI or FOLFOX for the treatment of patients with metastatic colorectal cancer. J Clin Oncol 2007, 25. [abstract 4081].
-
(2007)
J Clin Oncol
, vol.25
-
-
Schwartzberg, L.S.1
Hurwitz, H.2
Stephenson, J.3
-
75
-
-
25844467799
-
Insulin-like growth factor-1 receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells
-
Jones H.E., Goddard L., Gee J.M.W., et al. Insulin-like growth factor-1 receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells. Endocrine-Related Cancer 2004, 11:1-22.
-
(2004)
Endocrine-Related Cancer
, vol.11
, pp. 1-22
-
-
Jones, H.E.1
Goddard, L.2
Gee, J.M.W.3
-
76
-
-
77953360121
-
AMG 479, a fully human anti IGF-1 receptor antibody, inhibits P3IK/Akt signalling and exerts potent antitumor effects in combination with EGFR inhibitors in pancreatic xenograft models
-
[Gastrointestinal cancers symposium, abstract 208]
-
Beltran P.J., Mitchell P., Moody G., et al. AMG 479, a fully human anti IGF-1 receptor antibody, inhibits P3IK/Akt signalling and exerts potent antitumor effects in combination with EGFR inhibitors in pancreatic xenograft models. J Clin Oncol 2007, [Gastrointestinal cancers symposium, abstract 208].
-
(2007)
J Clin Oncol
-
-
Beltran, P.J.1
Mitchell, P.2
Moody, G.3
-
77
-
-
84898701092
-
A phase Ib of AMG479, a type 1 insulin-like growth factor receptor antibody in combination with Panitumumab or Gemcitabine
-
[abstract 3583]
-
Sarantopoulos J., Mita A.C., Mulay M., et al. A phase Ib of AMG479, a type 1 insulin-like growth factor receptor antibody in combination with Panitumumab or Gemcitabine. J Clin Oncol 2008, 26. [abstract 3583].
-
(2008)
J Clin Oncol
, vol.26
-
-
Sarantopoulos, J.1
Mita, A.C.2
Mulay, M.3
-
78
-
-
67749104491
-
Panitumumab and cetuximab epitope mapping and in vitro activity
-
[abstract 14536]
-
Freeman D., Sun J., Bass R., et al. Panitumumab and cetuximab epitope mapping and in vitro activity. J Clin Oncol 2008, 26. [abstract 14536].
-
(2008)
J Clin Oncol
, vol.26
-
-
Freeman, D.1
Sun, J.2
Bass, R.3
-
79
-
-
55849119730
-
Institutional experiences with panitumumab monotherapy in metastatic colorectal cancer patients intolerant to cetuximab
-
[abstract 14579]
-
Langerak A.D., Mitchell E., Cheema G., River L., Shing M. Institutional experiences with panitumumab monotherapy in metastatic colorectal cancer patients intolerant to cetuximab. J Clin Oncol 2007, 25. [abstract 14579].
-
(2007)
J Clin Oncol
, vol.25
-
-
Langerak, A.D.1
Mitchell, E.2
Cheema, G.3
River, L.4
Shing, M.5
-
80
-
-
34447340247
-
Successful challenge with the fully human EGFR antibody panitumumab following an infusion reaction with the chimeric EGFR antibody cetuximab
-
Helbling D., Borner M. Successful challenge with the fully human EGFR antibody panitumumab following an infusion reaction with the chimeric EGFR antibody cetuximab. Ann Oncol 2007, 18:963-964.
-
(2007)
Ann Oncol
, vol.18
, pp. 963-964
-
-
Helbling, D.1
Borner, M.2
-
81
-
-
77953361168
-
Panitumumab with or without chemotherapy on metastatic colorectal cancer: safety and unusual activity, even following progression on Cetuximab
-
[Gastrointestinal cancers symposium, abstract 484]
-
Asmis T.R., Shah M.A., Haviland D., Kemeny N. Panitumumab with or without chemotherapy on metastatic colorectal cancer: safety and unusual activity, even following progression on Cetuximab. J Clin Oncol 2008, [Gastrointestinal cancers symposium, abstract 484].
-
(2008)
J Clin Oncol
-
-
Asmis, T.R.1
Shah, M.A.2
Haviland, D.3
Kemeny, N.4
-
82
-
-
35348908314
-
PTEN loss of expression predicts Cetuximab efficacy in metastatic colorectal cancer patients
-
Frattini M., Saletti P., Romagnani E., et al. PTEN loss of expression predicts Cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer 2007, 97:1139-1145.
-
(2007)
Br J Cancer
, vol.97
, pp. 1139-1145
-
-
Frattini, M.1
Saletti, P.2
Romagnani, E.3
-
83
-
-
34548536941
-
Nuclear factor-kB tumor expression predicts response and survival in irinotecan-refractory metastatic colorectal cancer treated with cetuximab-irinotecan therapy
-
Scartozzi M., Bearzi I., Pierantoni C., et al. Nuclear factor-kB tumor expression predicts response and survival in irinotecan-refractory metastatic colorectal cancer treated with cetuximab-irinotecan therapy. J Clin Oncol 2007, 25:3930-3935.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3930-3935
-
-
Scartozzi, M.1
Bearzi, I.2
Pierantoni, C.3
-
84
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford S., Garrett C.R., Meropol N.J., et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 2007, 25:3230-3237.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
-
85
-
-
0038718522
-
Developing inhibitors of the epidermal growth factor receptor for cancer treatment
-
Grunwald V., Hidalgo M. Developing inhibitors of the epidermal growth factor receptor for cancer treatment. J Natl Cancer Inst 2003, 95:851-867.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 851-867
-
-
Grunwald, V.1
Hidalgo, M.2
-
86
-
-
38949098886
-
Gene expression profiles can predict panitumumab monotherapy responsiveness in xenograft models: a balanced approach
-
[abstract 1]
-
Boedigiemer M., Freeman D., Fitzpatrick D., et al. Gene expression profiles can predict panitumumab monotherapy responsiveness in xenograft models: a balanced approach. Proc Amer Assoc Cancer Res 2005, 46. [abstract 1].
-
(2005)
Proc Amer Assoc Cancer Res
, vol.46
-
-
Boedigiemer, M.1
Freeman, D.2
Fitzpatrick, D.3
-
87
-
-
10744221765
-
Protein microarrays: meeting analytical challenges for clinical applications
-
Liotta L.A., Espina V., Mehta A.I., et al. Protein microarrays: meeting analytical challenges for clinical applications. Cancer Cell 2003, 3:317-325.
-
(2003)
Cancer Cell
, vol.3
, pp. 317-325
-
-
Liotta, L.A.1
Espina, V.2
Mehta, A.I.3
-
88
-
-
77953359597
-
In vivo biological effects of Panitumumab plus chemotherapy in advanced colorectal cancer patients
-
[abstract 14576]
-
Bencardino K., Ronzoni M., Manzoni M., et al. In vivo biological effects of Panitumumab plus chemotherapy in advanced colorectal cancer patients. J Clin Oncol 2008, 26. [abstract 14576].
-
(2008)
J Clin Oncol
, vol.26
-
-
Bencardino, K.1
Ronzoni, M.2
Manzoni, M.3
-
89
-
-
77956230239
-
Modulation and prognostic value of epidermal growth factor receptor expression in circulating tumour cells during chemotherapy in patients with metastatic colorectal cancer
-
[abstract 15038]
-
Hendlisz A., Marechal R., Durbecq V., et al. Modulation and prognostic value of epidermal growth factor receptor expression in circulating tumour cells during chemotherapy in patients with metastatic colorectal cancer. J Clin Oncol 2008, 26. [abstract 15038].
-
(2008)
J Clin Oncol
, vol.26
-
-
Hendlisz, A.1
Marechal, R.2
Durbecq, V.3
-
90
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis C.S., Khambata-Ford S., Jonker D.J., et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008, 359:1757-1765.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
|