메뉴 건너뛰기




Volumn 289, Issue 14, 2014, Pages 9710-9729

The molecular and metabolic influence of long term agmatine consumption

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; CARBOXYLATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; NUTRITION; TISSUE;

EID: 84898076199     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.544726     Document Type: Article
Times cited : (40)

References (61)
  • 1
    • 0028269271 scopus 로고
    • Agmatine: An endogenous clonidine-displacing substance in the brain
    • Li, G., Regunathan, S., Barrow, C. J., Eshraghi, J., Cooper, R., and Reis, D. J. (1994) Agmatine: an endogenous clonidine-displacing substance in the brain. Science 263, 966-969
    • (1994) Science , vol.263 , pp. 966-969
    • Li, G.1    Regunathan, S.2    Barrow, C.J.3    Eshraghi, J.4    Cooper, R.5    Reis, D.J.6
  • 3
    • 33646839950 scopus 로고    scopus 로고
    • Agmatine stimulates hepatic fatty acid oxidation: A possible mechanism for up-regulation of ureagenesis
    • Nissim, I., Daikhin, Y., Nissim, I., Luhovyy, B., Horyn, O., Wehrli, S. L., and Yudkoff, M. (2006) Agmatine stimulates hepatic fatty acid oxidation: a possible mechanism for up-regulation of ureagenesis. J. Biol. Chem. 281, 8486-8496
    • (2006) J. Biol. Chem. , vol.281 , pp. 8486-8496
    • Nissim, I.1    Daikhin, Y.2    Nissim, I.3    Luhovyy, B.4    Horyn, O.5    Wehrli, S.L.6    Yudkoff, M.7
  • 4
    • 83555166240 scopus 로고    scopus 로고
    • Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis
    • Jitrapakdee, S. (2012) Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis. Int. J. Biochem. Cell Biol. 44, 33-45
    • (2012) Int. J. Biochem. Cell Biol. , vol.44 , pp. 33-45
    • Jitrapakdee, S.1
  • 5
    • 70350417158 scopus 로고    scopus 로고
    • Akt2 is required for hepatic lipid accumulation in models of insulin resistance
    • Leavens, K. F., Easton, R. M., Shulman, G. I., Previs, S. F., and Birnbaum, M. J. (2009) Akt2 is required for hepatic lipid accumulation in models of insulin resistance. CellMetab. 10, 405-418
    • (2009) CellMetab. , vol.10 , pp. 405-418
    • Leavens, K.F.1    Easton, R.M.2    Shulman, G.I.3    Previs, S.F.4    Birnbaum, M.J.5
  • 8
    • 47549108691 scopus 로고    scopus 로고
    • Epac and PKA: A tale of two intracellular cAMP receptors
    • Cheng, X., Ji, Z., Tsalkova, T., and Mei, F. (2008) Epac and PKA: a tale of two intracellular cAMP receptors. Acta Biochim. Biophys. Sin. 40, 651-662
    • (2008) Acta Biochim. Biophys. Sin. , vol.40 , pp. 651-662
    • Cheng, X.1    Ji, Z.2    Tsalkova, T.3    Mei, F.4
  • 9
    • 0347359224 scopus 로고    scopus 로고
    • Localized effects of cAMP mediated by distinct routes of protein kinase A
    • Taskén, K., and Aandahl, E. M. (2004) Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol. Rev. 84, 137-167
    • (2004) Physiol. Rev. , vol.84 , pp. 137-167
    • Taskén, K.1    Aandahl, E.M.2
  • 10
    • 38149123363 scopus 로고    scopus 로고
    • Regulating gene transcription in response to cyclic AMP elevation
    • Sands, W. A., and Palmer, T. M. (2008) Regulating gene transcription in response to cyclic AMP elevation. Cell. Signal. 20, 460-466
    • (2008) Cell. Signal. , vol.20 , pp. 460-466
    • Sands, W.A.1    Palmer, T.M.2
  • 11
    • 0034530972 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators
    • Lazennec, G., Canaple, L., Saugy, D., and Wahli, W. (2000) Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Mol. Endocrinol. 14, 1962-1975
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1962-1975
    • Lazennec, G.1    Canaple, L.2    Saugy, D.3    Wahli, W.4
  • 12
    • 34547589477 scopus 로고    scopus 로고
    • Modulation of PPAR activity via phosphorylation
    • Burns, K. A., and Vanden Heuvel, J. P. (2007) Modulation of PPAR activity via phosphorylation. Biochim Biophys Acta 1771, 952-960
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 952-960
    • Burns, K.A.1    Vanden Heuvel, J.P.2
  • 14
    • 0035941425 scopus 로고    scopus 로고
    • The pleiotropic nature of the vascular PPAR gene regulatory pathway
    • Kelly, D. P. (2001) The pleiotropic nature of the vascular PPAR gene regulatory pathway. Circ. Res. 89, 935-937
    • (2001) Circ. Res. , vol.89 , pp. 935-937
    • Kelly, D.P.1
  • 15
    • 36148937475 scopus 로고    scopus 로고
    • Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1a: Implications for metabolic disease
    • Muoio, D. M., and Koves, T. R. (2007) Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1a: implications for metabolic disease. Appl. Physiol. Nutr. Metab. 32, 874-883
    • (2007) Appl. Physiol. Nutr. Metab. , vol.32 , pp. 874-883
    • Muoio, D.M.1    Koves, T.R.2
  • 16
    • 69949098108 scopus 로고    scopus 로고
    • Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARa and PPARS in liver cells
    • Gutgesell, A., Wen, G., König, B., Koch, A., Spielmann, J., Stangl, G. I., Eder, K., and Ringseis, R. (2009) Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARa and PPARS in liver cells. Biochim. Biophys. Acta 1790, 1206-1216
    • (2009) Biochim. Biophys. Acta , vol.1790 , pp. 1206-1216
    • Gutgesell, A.1    Wen, G.2    König, B.3    Koch, A.4    Spielmann, J.5    Stangl, G.I.6    Eder, K.7    Ringseis, R.8
  • 17
    • 1542283630 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor a target genes
    • Mandard, S., Müller, M., and Kersten, S. (2004) Peroxisome proliferator-activated receptor a target genes. Cell. Mol. Life Sci. 61, 393-416
    • (2004) Cell. Mol. Life Sci. , vol.61 , pp. 393-416
    • Mandard, S.1    Müller, M.2    Kersten, S.3
  • 18
    • 34548151116 scopus 로고    scopus 로고
    • PPARa-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation
    • van Vlies, N, Ferdinandusse, S., Turkenburg, M., Wanders, R. J., and Vaz, F. M. (2007) PPARa-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation. Biochim. Biophys. Acta 1767, 1134-1142
    • (2007) Biochim. Biophys. Acta , vol.1767 , pp. 1134-1142
    • Van Vlies, N.1    Ferdinandusse, S.2    Turkenburg, M.3    Wanders, R.J.4    Vaz, F.M.5
  • 19
    • 73649124171 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor a in transcriptional regulation of novel organic cation transporters
    • Eder, K., and Ringseis, R. (2010) The role of peroxisome proliferator-activated receptor a in transcriptional regulation of novel organic cation transporters. Eur. J. Pharmacol. 628, 1-5
    • (2010) Eur. J. Pharmacol. , vol.628 , pp. 1-5
    • Eder, K.1    Ringseis, R.2
  • 20
    • 69249113803 scopus 로고    scopus 로고
    • Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control
    • Noland, R. C, Koves, T. R., Seiler, S. E., Lum, H, Lust, R. M., Ilkayeva, O., Stevens, R. D., Hegardt, F. G., and Muoio, D. M. (2009) Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J. Biol. Chem. 284, 22840-22852
    • (2009) J. Biol. Chem. , vol.284 , pp. 22840-22852
    • Noland, R.C.1    Koves, T.R.2    Seiler, S.E.3    Lum, H.4    Lust, R.M.5    Ilkayeva, O.6    Stevens, R.D.7    Hegardt, F.G.8    Muoio, D.M.9
  • 23
    • 33744524787 scopus 로고    scopus 로고
    • Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: Differences between the mouse and the rat
    • van Vlies, N., Wanders, R. J., and Vaz, F. M. (2006) Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat. Anal. Biochem. 354, 132-139
    • (2006) Anal. Biochem. , vol.354 , pp. 132-139
    • Van Vlies, N.1    Wanders, R.J.2    Vaz, F.M.3
  • 24
    • 77953603769 scopus 로고    scopus 로고
    • Enzymology of the carnitine biosynthesis pathway
    • Strijbis, K., Vaz, F. M., and Distel, B. (2010) Enzymology of the carnitine biosynthesis pathway. IUBMB Life 62, 357-362
    • (2010) IUBMB Life , vol.62 , pp. 357-362
    • Strijbis, K.1    Vaz, F.M.2    Distel, B.3
  • 26
  • 28
    • 0029881541 scopus 로고    scopus 로고
    • Glycine attenuates maleate or ifos-famide induced Fanconi syndrome in rats
    • Nissim, I., and Weinberg, J. M. (1996) Glycine attenuates maleate or ifos-famide induced Fanconi syndrome in rats. Kidney Int. 49, 684-695
    • (1996) Kidney Int. , vol.49 , pp. 684-695
    • Nissim, I.1    Weinberg, J.M.2
  • 29
    • 21744451624 scopus 로고    scopus 로고
    • A soluble adenylyl cyclase from sea urchin spermatozoa
    • Nomura, M., Beltrán, C, Darszon, A., and Vacquier, V. D. (2005) A soluble adenylyl cyclase from sea urchin spermatozoa. Gene 353, 231-238
    • (2005) Gene , vol.353 , pp. 231-238
    • Nomura, M.1    Beltrán, C.2    Darszon, A.3    Vacquier, V.D.4
  • 30
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch, J., Lees, M., and Sloane Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 33
    • 52049085061 scopus 로고    scopus 로고
    • Metabo-lomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: II. Heterogeneity of metabolite labeling pattern
    • Yang, L., Kasumov, T., Kombu, R. S., Zhu, S.-H, Cendrowski, A. V., David, F., Anderson, V E., Kelleher, J. K., and Brunengraber, H. (2008) Metabo-lomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: II. Heterogeneity of metabolite labeling pattern. J. Biol. Chem. 283, 21988-21996
    • (2008) J. Biol. Chem. , vol.283 , pp. 21988-21996
    • Yang, L.1    Kasumov, T.2    Kombu, R.S.3    Zhu, S.-H.4    Cendrowski, A.V.5    David, F.6    Anderson, V.E.7    Kelleher, J.K.8    Brunengraber, H.9
  • 35
    • 65649131865 scopus 로고    scopus 로고
    • Brown adipose tissue: The molecular mechanism of its formation
    • Wolf, G. (2009) Brown adipose tissue: the molecular mechanism of its formation. Nutr. Rev. 67, 167-171
    • (2009) Nutr. Rev. , vol.67 , pp. 167-171
    • Wolf, G.1
  • 37
    • 80052160109 scopus 로고    scopus 로고
    • New aspects of mitochondrial uncoupling proteins (UCPs) and their roles in tumorigenesis
    • Robbins, D., and Zhao, Y. (2011) New aspects of mitochondrial uncoupling proteins (UCPs) and their roles in tumorigenesis. Int. J. Mol. Sci. 12, 5285-5293
    • (2011) Int. J. Mol. Sci. , vol.12 , pp. 5285-5293
    • Robbins, D.1    Zhao, Y.2
  • 38
    • 84860430699 scopus 로고    scopus 로고
    • (2012) Lipid-induced mitochondrial stress and insulin action in muscle
    • Muoio, D. M., and Neufer, P. D. (2012) (2012) Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metab. 15, 595-605
    • (2012) Cell Metab. , vol.15 , pp. 595-605
    • Muoio, D.M.1    Neufer, P.D.2
  • 40
    • 59649130350 scopus 로고    scopus 로고
    • Metabolic profiling of PPARa-/-mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation
    • Makowski, L., Noland, R. C, Koves, T. R., Xing, W., Ilkayeva, O. R., Muehlbauer, M. J., Stevens, R. D., and Muoio, D. M. (2009) Metabolic profiling of PPARa-/-mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. FASEBJ. 23, 586-604
    • (2009) FASEBJ. , vol.23 , pp. 586-604
    • Makowski, L.1    Noland, R.C.2    Koves, T.R.3    Xing, W.4    Ilkayeva, O.R.5    Muehlbauer, M.J.6    Stevens, R.D.7    Muoio, D.M.8
  • 41
    • 34548126519 scopus 로고    scopus 로고
    • Treatment with pharmacological peroxisome proliferator activated receptor a agonist clo-fibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats
    • Ringseis, R., Pösel, S., Hirche, F., and Eder, K. (2007) Treatment with pharmacological peroxisome proliferator activated receptor a agonist clo-fibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats. Pharmacol. Res. 56, 175-183
    • (2007) Pharmacol. Res. , vol.56 , pp. 175-183
    • Ringseis, R.1    Pösel, S.2    Hirche, F.3    Eder, K.4
  • 42
    • 33744801418 scopus 로고    scopus 로고
    • Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria
    • Lamhonwah, A. M., and Tein, I. (2006) Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria. Biochem. Biophys. Res. Commun. 345, 1315-1325
    • (2006) Biochem. Biophys. Res. Commun. , vol.345 , pp. 1315-1325
    • Lamhonwah, A.M.1    Tein, I.2
  • 43
    • 0023099179 scopus 로고
    • Mechanisms of hormonal regulation of hepatic glucose metabolism
    • Exton, J.H. (1987) Mechanisms of hormonal regulation of hepatic glucose metabolism. Diabetes Metab. Rev. 3, 163-183
    • (1987) Diabetes Metab. Rev. , vol.3 , pp. 163-183
    • Exton, J.H.1
  • 44
    • 33745865153 scopus 로고    scopus 로고
    • Diminished hepatic gluconeo-genesis via defects in tricarboxylic acid cycle flux in peroxisome prolifera-tor-activated receptor gamma coactivator-1a (PGC-1a)-deficient mice
    • Burgess, S. C, Leone, T. C, Wende, A. R., Croce, M. A., Chen, Z., Sherry, A. D., Malloy, C. R., and Finck, B. N. (2006) Diminished hepatic gluconeo-genesis via defects in tricarboxylic acid cycle flux in peroxisome prolifera-tor-activated receptor gamma coactivator-1a (PGC-1a)-deficient mice. J. Biol. Chem. 281, 19000-19008
    • (2006) J. Biol. Chem. , vol.281 , pp. 19000-19008
    • Burgess, S.C.1    Leone, T.C.2    Wende, A.R.3    Croce, M.A.4    Chen, Z.5    Sherry, A.D.6    Malloy, C.R.7    Finck, B.N.8
  • 45
    • 0031149321 scopus 로고    scopus 로고
    • L-Car-nitine stimulation of mitochondrial oxidative phosphorylation rate in isolated rat skeletal muscle mitochondria
    • Berthon, P., Van der Veer, M., Denis, C., and Freyssenet, D. (1997) L-Car-nitine stimulation of mitochondrial oxidative phosphorylation rate in isolated rat skeletal muscle mitochondria. Comp. Biochem. Physiol. A Physiol. 117, 141-145
    • (1997) Comp. Biochem. Physiol. A Physiol. , vol.117 , pp. 141-145
    • Berthon, P.1    Van Der Veer, M.2    Denis, C.3    Freyssenet, D.4
  • 47
    • 0033835813 scopus 로고    scopus 로고
    • Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase
    • Defer, N, Best-Belpomme, M., and Hanoune, J. (2000) Tissue specificity and physiological relevance of various isoforms of adenylyl cyclase. Am. J. Physiol. Renal Physiol. 279, F400-F416
    • (2000) Am. J. Physiol. Renal Physiol. , vol.279
    • Defer, N.1    Best-Belpomme, M.2    Hanoune, J.3
  • 48
    • 0036353267 scopus 로고    scopus 로고
    • Coupling cAMP signaling to transcription in the liver: Pivotal role of CREB and CREM.Exp
    • Servillo, G., Della Fazia, M. A., and Sassone-Corsi, P. (2002) Coupling cAMP signaling to transcription in the liver: pivotal role of CREB and CREM.Exp. Cell Res. 275, 143-154
    • (2002) Cell Res. , vol.275 , pp. 143-154
    • Servillo, G.1    Della Fazia, M.A.2    Sassone-Corsi, P.3
  • 49
    • 33748795587 scopus 로고    scopus 로고
    • UCP3 in muscle wasting, a role in modulating lipotoxicity?
    • Minnaard, R., Schrauwen, P., Schaart, G., and Hesselink, M. K. (2006) UCP3 in muscle wasting, a role in modulating lipotoxicity? FEBSLett. 580, 5172-5176
    • (2006) FEBSLett. , vol.580 , pp. 5172-5176
    • Minnaard, R.1    Schrauwen, P.2    Schaart, G.3    Hesselink, M.K.4
  • 50
    • 34250803903 scopus 로고    scopus 로고
    • A kingdom for PPARy
    • Anghel, S.I., and Wahli, W. (2007) A kingdom for PPARy. Cell Res. 17, 486-511
    • (2007) Cell Res. , vol.17 , pp. 486-511
    • Anghel, S.I.1    Wahli, W.2
  • 53
    • 77949318560 scopus 로고    scopus 로고
    • Metabolic reprogramming, caloric restriction and aging
    • Anderson, R. M., and Weindruch, R. (2010) Metabolic reprogramming, caloric restriction and aging. Trends Endocrinol. Metab. 21, 134-141
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 134-141
    • Anderson, R.M.1    Weindruch, R.2
  • 54
    • 23944515238 scopus 로고    scopus 로고
    • Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria
    • Bevilacqua, L., Ramsey, J. J., Hagopian, K., Weindruch, R., and Harper, M. E. (2005) Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria. Am. J. Physiol. Endocrinol. Metab. 289, E429-E438
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.289
    • Bevilacqua, L.1    Ramsey, J.J.2    Hagopian, K.3    Weindruch, R.4    Harper, M.E.5
  • 57
    • 33847068206 scopus 로고    scopus 로고
    • Overview of PDEs and their regulation
    • Omori, K., and Kotera, J. (2007) Overview of PDEs and their regulation. CircRes. 100, 309-327
    • (2007) CircRes. , vol.100 , pp. 309-327
    • Omori, K.1    Kotera, J.2
  • 58
    • 0021253305 scopus 로고
    • Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus
    • Dighe, R. R., Rojas, F. J., Birnbaumer, L., andGarber, A. J. (1984) Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus. J. Clin. Investig. 73, 1013-1023
    • (1984) J. Clin. Investig. , vol.73 , pp. 1013-1023
    • Dighe, R.R.1    Rojas, F.J.2    Birnbaumer, L.3    Garber, A.J.4
  • 59
    • 79961187526 scopus 로고    scopus 로고
    • Regulation of glucagon secretion by zinc: Lessons from the/3-cells-specific Znt8 knockout model
    • Hardy, A. B., Serino, A. S., Wijesekara, N, Chimienti, F., and Wheeler, M. B. (2011) Regulation of glucagon secretion by zinc: lessons from the/3-cells-specific Znt8 knockout model. Diabetes Obes. Metab. 13, (Suppl. 1) 112-117
    • (2011) Diabetes Obes. Metab. , vol.13 , Issue.SUPPL. 1 , pp. 112-117
    • Hardy, A.B.1    Serino, A.S.2    Wijesekara, N.3    Chimienti, F.4    Wheeler, M.B.5
  • 61
    • 84871655682 scopus 로고    scopus 로고
    • Dissociating fatty liver and diabetes
    • Sun, Z., and Lazar, M. A. (2013) Dissociating fatty liver and diabetes. Trends Endocrinol. Metab. 24, 4-12
    • (2013) Trends Endocrinol. Metab. , vol.24 , pp. 4-12
    • Sun, Z.1    Lazar, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.