Down-regulation of Hepatic Urea Synthesis by Oxypurines: Xanthine and uric acid inhibit N-acetylglutamate synthase

Journal of Biological Chemistry

Volumn 286, Issue 25, 2011, Pages 22055-22068

  Nissim, Itzhak ^a,d   Horyn, Oksana ^a   Nissim, Ilana ^a   Daikhin, Yevgeny ^a   Caldovic, Ljubica ^b   Barcelona, Belen ^c   Cervera, Javier ^c   Tuchman, Mendel ^b   Yudkoff, Marc ^a,d  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

^c CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE   (Spain)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; APPARENT K; CARBAMOYL PHOSPHATES; CITRULLINE; DISEASE STATE; DOSE-DEPENDENT; DOWN-REGULATION; HEPATOCYTES; L-ARGININE; NOVEL CONCEPT; SYNTHASES; SYNTHETASES; UREA SYNTHESIS; URIC ACIDS;

AMINO ACIDS; MAMMALS; METABOLISM; PHYSIOLOGY;

UREA;

CARBAMOYL PHOSPHATE SYNTHASE; CITRULLINE; GLUTAMATE ACETYLTRANSFERASE; GLUTAMIC ACID; ISOBUTYLMETHYLXANTHINE; N ACETYLGLUTAMIC ACID; URIC ACID; XANTHINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; LIVER CELL; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; UREA CYCLE;

1-METHYL-3-ISOBUTYLXANTHINE; AMINO-ACID N-ACETYLTRANSFERASE; ANIMALS; CARBAMOYL-PHOSPHATE SYNTHASE (AMMONIA); CITRULLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GLUTAMATES; HEPATOCYTES; KINETICS; LIVER; MALE; MICE; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; UREA; URIC ACID; XANTHINE;

EID: 79959329918     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.209023     Document Type: Article

References (46)

1. Meijer, A. J., Lamers, W. H., and Chamuleau, R. A. (1990) Physiol. Rev. 70, 701-748
2. Gropman, A. L., Summar, M., and Leonard, J. V. (2007) J. Inherit. Metab. Dis. 30, 865-879
3. Ahuja, V., and Powers-Lee, S. G. (2008) J. Inherit. Metab. Dis. 31, 481-491
4. Holden, H. M., Thoden, J. B., and Raushel, F. M. (1999) Cell Mol. Life Sci. 56, 507-522
5. McCudden, C. R., and Powers-Lee, S. G. I. (1996) J. Biol. Chem. 271, 18285-18294
6. Raijman, L., and Jones, M. E. (1976) Arch. Biochem. Biophys. 175, 270-278
7. Britton, H. G., and Rubio, V. (1988) Eur. J. Biochem. 171, 615-622
8. Rubio, V., Britton, H. G., and Grisolia, S. (1983) Eur. J. Biochem. 134, 337-343
9. Caldovic, L., and Tuchman, M. (2003) Biochem. J. 372, 279-290
10. Cohen, N. S., Cheung, C. W., Sijuwade, E., and Raijman, L. (1992) Biochem. J. 282, 173-180
11. Lusty, C. J. (1978) Eur. J. Biochem. 85, 373-383
12. Clarke, S. A. (1976) J. Biol. Chem. 251, 950-961
13. Coude, F. X., Sweetman, L., and Nyhan, W. L. (1979) J. Clin. Invest. 64, 1544-1551
14. Coude, F. X., Grimber, G., Parvy, P., Rabier, D., and Petit, F. (1983) Biochem. J. 216, 233-236
15. Nissim, I., Horyn, O., Nissim, I., Daikhin, Y., Wehrli, S. L., and Yudkoff, M. (2008) J. Biol. Chem. 283, 15063-15071
16. Kim, S., Paik, W. K., and Cohen, P. P. (1972) Proc. Natl. Acad. Sci. U.S.A. 69, 3530-3533
17. Tuchman, M., Caldovic, L., Daikhin, Y., Horyn, O., Nissim, I., Nissim, I., Korson, M., Burton, B., and Yudkoff, M. (2008) Pediatr. Res. 64, 213-217
18. Ah Mew, N., Payan, I., Daikhin, Y., Nissim, I., Nissim, I., Tuchman, M., and Yudkoff, M. (2009) Mol. Genet. Metab. 98, 325-330
19. Nissim, I., Luhovyy, B., Horyn, O., Daikhin, Y., Nissim, I., and Yudkoff, M. (2005) J. Biol. Chem. 280, 17715-17724
20. Kawamoto, S., Sonoda, T., Ohtake, A., and Tatibana, M. (1985) Biochem. J. 232, 329-334
21. Morimoto, B. H., Brady, J. F., and Atkinson, D. E. (1990) Biochem. J. 272, 671-675
22. McGivan, J. D., Bradford, N. M., and Mendes-Mourão, J. (1976) Biochem. J. 154, 415-421
23. Coman, D., Yaplito-Lee, J., and Boneh, A. (2008) Clin. Nutr. 27, 489-496
24. Lund, P., and Wiggins, D. (1987) Biochem. J., 243, 273-276
25. Caldovic, L, Lopez, G. Y., Haskins, N., Panglao, M., Shi, D., Morizono, H., and Tuchman, M. (2006) Mol. Genet. Metab. 87, 226-232
26. Cohen, N. S., Cheung, C. W., Kyan, F. S., Jones, E. E., and Raijman, L. (1982) J. Biol. Chem. 257, 6898-6907
27. Cohen, N. S., and Cheung, C. W. (1984) Arch. Biochem. Biophys. 234, 31-44
28. Guthöhrlein, G., and Knappe, J. (1968) Eur. J. Biochem. 7, 119-127
29. Penefsky, H. S., (1977) J. Biol. Chem. 252, 2891-2899
30. Alonso, E., Cervera, J., García-España, A., Bendala, E., and Rubio, V. (1992) J. Biol. Chem. 267, 4524-4532
31. Nissim, I., Yudkoff, M., and Brosnan, J. T. (1996) J. Biol. Chem. 271, 31234-31242
32. Jones, B. N., and Gilligan, J. P. (1983) J. Chromatogr. 266, 471-482
33. Aoyagi, K., Mori, M., and Tatibana, M. (1979) Biochim. Biophys. Acta 587, 515-521
34. Caldovic, L., Ah Mew, N., Shi, D., Morizono, H., Yudkoff, M., and Tuchman, M., (2010) Mol. Genet. Metab. 100, S13-S19
35. Alonso, E., and Rubio, V. (1983) Eur. J. Biochem. 135, 331-337
36. Treberg, J. R., Brosnan, M. E., Watford, M., and Brosnan, J. T. (2010) Adv. Enzyme Regul. 50, 34-43
37. Qu, Q., Morizono, H., Shi, D., Tuchman, M., and Caldovic, L. (2007) BMC Biochemistry 8, 4
38. Shi, D., Sagar, V., Jin, Z., Yu, X., Caldovic, L., Morizono, H., Allewell, N. M., and Tuchman, M. (2008) J. Biol. Chem. 283, 7176-7184
39. Nishino, T., Okamoto, K., Eger, B. T., Pai, E. F., and Nishino, T. (2008) FEBS J. 275, 3278-3289
40. Min, L., Jin, Z., Caldovic, L., Morizono, H., Allewell, N. M., Tuchman, M., and Shi, D. (2009) J. Biol. Chem. 284, 4873-4880
41. Sancho-Vaello, E., Fernández-Murga, M. L., and Rubio, V. (2009) FEBS Lett. 583, 202-206
42. Rus, D. A, Sastre, J., Viña J., and Pallardó, F. V. (2007) Front. Biosci. 12, 1184-1189
43. Nybo, L., and Secher, N. H. (2004) Prog. Neurobiol. 72, 223-261
44. Tsouli, S. G., Liberopoulos, E. N., Mikhailidis, D. P., Athyros, V. G., and Elisaf, M. S. (2006) Metabolism 55, 1293-1301
45. Jaing, T. H., Lin, J. L., Lin, Y. P., Yang, S. H., Lin, J. J., and Hsia, S. H. (2009) J. Pediatr. Hematol. Oncol. 31, 955-956
46. Nissim, I., Daikhin, Y., Nissim, I., Luhovyy, B., Horyn, O., Wehrli, S. L., and Yudkoff, M. (2006) J. Biol. Chem. 281, 8486-8496