Coupling cAMP signaling to transcription in the liver: Pivotal role of CREB and CREM

Experimental Cell Research

Volumn 275, Issue 2, 2002, Pages 143-154

  Servillo, Giuseppe ^a,b   Della Fazia, Maria Agnese ^a,b   Sassone Corsi, Paolo ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b POLICLINICO MONTELUCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP EARLY REPRESSOR PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR PROTEIN; ENZYME ACTIVATOR; HISTONE; HISTONE ACETYLTRANSFERASE; PHOSPHOTRANSFERASE; PROTEIN C FOS; PROTEIN CAMKIV; PROTEIN RSK 2; REGULATOR PROTEIN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AFT 1; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; AUTOREGULATION; CELL PROLIFERATION; CHROMATIN STRUCTURE; DEPHOSPHORYLATION; DOWN REGULATION; EARLY RESPONSE GENE; ENZYME ACTIVITY; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENE INDUCTION; HUMAN; LIVER CELL; LIVER FUNCTION; LIVER REGENERATION; NONHUMAN; PARTIAL HEPATECTOMY; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; REGULATORY MECHANISM; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION;

MAMMALIA;

EID: 0036353267     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5491     Document Type: Article

References (131)

1. The language of covalent histone modifications
2. Structure and function in the nucleus
3. Signaling to chromatin through histone modifications
4. RNA polymerase II and the integration of nuclear events
5. Signaling 2000 and beyond
6. The oncogene jun and nuclear signalling
7. MAPKs: New JNK expands the group
8. Differential regulation and expression of jun, c-fos and c-myc proto-oncogenes during mouse liver regeneration and after inhibition of protein synthesis
9. Regulation of signal transduction during liver regeneration
10. Liver regeneration
11. Role of growth factors and cytokines in hepatic regeneration
12. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice
13. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
14. Transcriptional control of liver regeneration
15. The mitogen-activated protein kinase kinase/extracellular signal-regulated kinase cascade activation is a key signalling pathway involved in the regulation of G(1) phase progression in proliferating hepatocytes
16. Differential expression of guanine nucleotide-binding proteins enhances cAMP synthesis in regenerating rat liver
17. The regulatory diversity of the mammalian adenylyl cyclases
18. Analysis of the cAMP-dependent protein kinase system using molecular genetic approaches
19. Dual effects of glucagon and cyclic AMP on DNA synthesis in cultured rat hepatocytes: Stimulatory regulation in early G1 and inhibition shortly before the S phase entry
20. Elevated cAMP gives short-term inhibition and long-term stimulation of hepatocyte DNA replication: Roles of the cAMP-dependent protein kinase subunits
21. Characterization of the inhibitory effect of glucocorticoids on the DNA replication of adult rat hepatocytes growing at various cell densities
22. On the mechanisms of the growth-promoting effect of prostaglandins in hepatocytes: The relationship between stimulation of DNA synthesis and signaling mediated by adenylyl cyclase and phosphoinositide-specific phospholipase C
23. 2+/calmodulin-dependent protein kinase in primary hepatocytes
24. 2+-dependent signal pathways in Rat-1 cells
25. Cyclic AMP signalling
26. Structure and function of cyclic nucleotide-dependent protein kinases
27. The cAMP-dependent protein kinases and cAMP signal transduction
28. Cyclic AMP and the induction of eukaryotic gene expression
29. Signal transduction and gene regulation: The nuclear response to cAMP
30. Isolation of a cDNA clone for the type I regulatory subunit of bovine cAMP-dependent protein kinase
31. Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase
32. The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain
33. Browner M, Molecular cloning, cDNA structure, and regulation of the regulatory subunit of type II cAMP-dependent protein kinase from rat ovarian granulosa cells
34. Multiple mRNA species code for the catalytic subunit of the cAMP-dependent protein kinase from LLC-PK1 cells. Evidence for two forms of the catalytic subunit
35. Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase
36. Molecular structure of the C beta catalytic subunit of rat cAMP-dependent protein kinase and differential expression of C alpha and C beta isoforms in rat tissues and cultured cells
37. The expression of cAMP-dependent protein kinase subunits is differently regulated during liver regeneration
38. The expression of cAMP-dependent protein kinase subunits in primary rat hepatocyte cultures. Cyclic AMP down-regulates its own effector system by decreasing the amount of catalytic subunit and increasing the mRNAs for the inhibitory (R) subunits of cAMP-dependent protein kinase
39. Transcription factors: A new family gathers at the cAMP response site
40. A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1
41. Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements
42. Identification of regions in the rat serine dehydratase gene responsible for regulation by cyclic AMP alone and in the presence of glucocorticoids
43. The role of HNF1 alpha, HNF3 gamma, and cyclic AMP in glucose-6-phosphatase gene activation
44. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression
45. Regulation of the synthesis of tyrosine aminotransferase: The relationship to mRNA TAT
46. Analysis of the cAMP response on liver-specific gene expression in transgenic mice
47. A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1
48. Identification of multiple protein binding domains in the promoter-regulatory region of the phosphoenolpyruvate carboxykinase (GTP) gene
49. The cAMP response element binding protein synergizes with other transcription factors to mediate cAMP responsiveness
50. Transcription factors responsive to cAMP
51. Transcriptional regulation by cyclic AMP
52. Cyclic AMP-responsive DNA-binding protein: Structure based on a cloned placental cDNA
53. Transcription factor ATF cDNA clones: An extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
54. More is better: Activators and repressors from the same gene
55. CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription
56. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at Ser133
57. The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A
58. Transcriptional repression by a novel member of the bZip of transcription factors
59. Molecular cloning of human CREB-2: An ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response
60. Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor
61. Adrenergic signals direct rhytmic expression of transcriptional repressor CREM in the pineal gland
62. Cyclic-AMP-responsive transcriptional activation involves interdipendent phosphorylated subdomains
63. Multiple and cooperative phosphorylation events regulate the CREM activator function
64. Phosphorylation and negative regulation of the transcriptional activator CREM by p34cdc2
65. Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB
66. 2+/calmodulin- as well as cAMP-dependent protein kinase
67. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB
68. Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene
69. Insulin stimulates cAMP-response element binding protein activity in HepG2 and 3T3-L1 cell lines
70. Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
71. How MAP kinases are regulated
72. Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
73. Induction of neurite outgrowth by MAP kinase in PC12 cells
74. Identification of p90RSK as the probable CREB-Ser133 kinase in human melanocytes
75. Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: An alternative route to mitogen-induced gene expression
76. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome
77. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
78. Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements
79. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine activation motif
80. The functional versatility of CREM is determined by its modular structure
81. Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors
82. Phosphorylated CREB binds specifically to the nuclear protein CBP
83. Nuclear protein CBP is a coactivator for the transcription factor CREB
84. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor
85. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators
86. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation
87. p300 and CBP as transcriptional regulators and targets of oncogenic events
88. p300 and CBP: Partners for life and death
89. RNA helicase A mediates association of CBP with RNA polymerase II
90. The CBP co-activator is a histone acetyltransferase
91. Transcription factor-specific requirements for coactivators and their acetyltransferase functions
92. The multifunctional role of the co-activator CBP in transcriptional regulation
93. Transcription. A growing coactivator network
94. CBP-independent activation of CREM and CREB by the LIM-only protein ACT
95. Phosphorylation of CREB affects its binding to high and low affinity sites: Implications for cAMP induced gene transcription
96. Cross-talk in signal transduction: Ras-dependent induction of cAMP-responsive transcriptional repressor ICER by nerve growth factor
97. Pituitary follicle-stimulating hormone (FSH) induces CREM gene expression in Sertoli cells: Involvement in long-term desensitization of the FSH receptor
98. Thyroid-stimulating hormone (TSH)-directed induction of the CREM gene in the thyroid gland participates in the long-term desensitization of the TSH receptor
99. Ectopic ICER expression in pituitary corticotroph AtT20 cells: Effects on morphology, cell cycle, and hormonal production
100. Transcriptional control of circadian hormone synthesis via the CREM feedback loop
101. In vivo monitoring of a cAMP-stimulated DNA-binding activity
102. Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene
103. Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP)
104. Evidence for the involvement of at least two distinct transcription factors, one of which is liver-enriched, for the activation of the phosphoenolpyruvate carboxykinase gene promoter by cAMP
105. Cyclic AMP signalling pathway and cellular proliferation: Induction of CREM during liver regeneration
106. Increases in rat liver cyclic AMP concentrations prior to the initiation of DNA synthesis following partial hepatectomy or hormone infusion
107. Requirement for cAMP-response element (CRE) binding protein/CRE modulator transcription factors in thyrotropin-induced proliferation of dog thyroid cells in primary culture
108. Transcription factor CREM coordinates the timing of hepatocyte proliferation in the regenerating liver
109. Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome
110. Localization of the sites along nucleosome DNA which interact with NH2-terminal histone regions
111. Use of selectively trypsinized nucleosome core particles to analyze the role of the histone "tails" in the stabilization of the nucleosome
112. Reversible histone modifications and the chromosome cell cycle
113. The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase
114. Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in tetrahymena
115. Regulation of chromatin structure by site-specific histone H3 methyltransferases
116. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
117. Rad6-dependent ubiquitination of histone H2B in yeast
118. Requirement of Rsk-2 for epidermal growth factor-activated phosphorylation of histone H3
119. Nuclear localization and regulation of erk- and rsk-encoded protein kinases
120. Signal transduction via the MAP kinases: Proceed at your own RSK
121. Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation
122. Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation
123. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
124. Histone H3 phosphorylation is required for the initiation, but not maintenance, of mammalian chromosome condensation
125. Aurora/Ipllp-related kinases, a new oncogenic family of mitotic serine-threonine kinases
126. The Aurora/Ipllp kinase family: Regulators of chromosome segregation and cytokinesis
127. Mitotic phosphorylation of histone H3: Spatio-temporal regulation by mammalian Aurora kinases
128. Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells
129. Signaling routes to CREM and CREB: Plasticity in transcriptional activation