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Volumn 55, Issue SUPPL. 2, 2011, Pages

Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet

Author keywords

Carnitine synthesis; Endurance exercise; High fat diet; Obesity; Peroxisome proliferator activated receptor

Indexed keywords

ACETYLCARNITINE; CARNITINE; FATTY ACID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

EID: 80053264450     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201100040     Document Type: Article
Times cited : (35)

References (37)
  • 1
    • 0031043030 scopus 로고    scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
    • McGarry, J. D., Brown, N. F., The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur. J. Biochem. 1997, 244, 1-14.
    • (1997) Eur. J. Biochem. , vol.244 , pp. 1-14
    • McGarry, J.D.1    Brown, N.F.2
  • 2
    • 33847646640 scopus 로고    scopus 로고
    • Carnitine revisited: potential use as adjunctive treatment in diabetes
    • Power, R. A., Hulver, M. W., Zhang, J. Y., Dubois, J. et al., Carnitine revisited: potential use as adjunctive treatment in diabetes. Diabetologia 2007, 50, 824-832.
    • (2007) Diabetologia , vol.50 , pp. 824-832
    • Power, R.A.1    Hulver, M.W.2    Zhang, J.Y.3    Dubois, J.4
  • 3
    • 0031816464 scopus 로고    scopus 로고
    • Carnitine metabolism and its regulation in microorganisms and mammals
    • Rebouche, C. J., Seim, H., Carnitine metabolism and its regulation in microorganisms and mammals. Annu. Rev. Nutr. 1998, 18, 39-61.
    • (1998) Annu. Rev. Nutr. , vol.18 , pp. 39-61
    • Rebouche, C.J.1    Seim, H.2
  • 4
    • 4444315751 scopus 로고    scopus 로고
    • Carnitine: a nutritional, biosynthetic, and functional perspective
    • Steiber, A., Kerner, J., Hoppel, C. L., Carnitine: a nutritional, biosynthetic, and functional perspective. Mol. Aspects Med. 2004, 25, 455-473.
    • (2004) Mol. Aspects Med. , vol.25 , pp. 455-473
    • Steiber, A.1    Kerner, J.2    Hoppel, C.L.3
  • 5
    • 0036471216 scopus 로고    scopus 로고
    • Carnitine biosynthesis in mammals
    • Vaz, F. M., Wanders, R. J., Carnitine biosynthesis in mammals. Biochem. J. 2002, 361, 417-429.
    • (2002) Biochem. J. , vol.361 , pp. 417-429
    • Vaz, F.M.1    Wanders, R.J.2
  • 6
    • 33744524787 scopus 로고    scopus 로고
    • Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat
    • Van Vlies, N., Wanders, R. J. A., Vaz, F. M., Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat. Anal. Biochem. 2006, 354, 132-139.
    • (2006) Anal. Biochem. , vol.354 , pp. 132-139
    • Van Vlies, N.1    Wanders, R.J.A.2    Vaz, F.M.3
  • 7
    • 77952321987 scopus 로고    scopus 로고
    • The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats
    • Schürch, R., Todesco, L., Novakova, K., Mevissen, M. et al., The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats. Eur. J. Pharmacol. 2010, 635, 171-176.
    • (2010) Eur. J. Pharmacol. , vol.635 , pp. 171-176
    • Schürch, R.1    Todesco, L.2    Novakova, K.3    Mevissen, M.4
  • 8
    • 0032493741 scopus 로고    scopus 로고
    • Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2
    • Tamai, I., Ohashi, R., Nezu, J., Yabuuchi, H. et al., Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J. Biol. Chem. 1998, 273, 20378-20382.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20378-20382
    • Tamai, I.1    Ohashi, R.2    Nezu, J.3    Yabuuchi, H.4
  • 9
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: nuclear control of metabolism
    • Desvergne, B., Wahli, W., Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 1999, 20, 649-688.
    • (1999) Endocr. Rev. , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 10
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting
    • Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J. et al., Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J. Clin. Invest. 1999, 103, 1489-1498.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4
  • 11
    • 40149101595 scopus 로고    scopus 로고
    • PPARα mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis
    • Koch, A., König, B., Stangl, G. I., Eder, K., PPARα mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis. Exp. Biol. Med. 2008, 233, 356-365.
    • (2008) Exp. Biol. Med. , vol.233 , pp. 356-365
    • Koch, A.1    König, B.2    Stangl, G.I.3    Eder, K.4
  • 12
    • 71749092757 scopus 로고    scopus 로고
    • Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species
    • Ringseis, R., Wege, N., Wen, G., Rauer, C. et al., Carnitine synthesis and uptake into cells are stimulated by fasting in pigs as a model of nonproliferating species. J. Nutr. Biochem. 2009, 20, 840-847.
    • (2009) J. Nutr. Biochem. , vol.20 , pp. 840-847
    • Ringseis, R.1    Wege, N.2    Wen, G.3    Rauer, C.4
  • 13
    • 34548151116 scopus 로고    scopus 로고
    • PPARα-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation
    • Van Vlies, N., Ferdinandusse, S., Turkenburg, M., Wanders, R. J., Vaz, F. M., PPARα-activation results in enhanced carnitine biosynthesis and OCTN2-mediated hepatic carnitine accumulation. Biochim. Biophys. Acta 2007, 1767, 1134-1142.
    • (2007) Biochim. Biophys. Acta , vol.1767 , pp. 1134-1142
    • Van Vlies, N.1    Ferdinandusse, S.2    Turkenburg, M.3    Wanders, R.J.4    Vaz, F.M.5
  • 14
    • 71849088563 scopus 로고    scopus 로고
    • Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor α (PPARα) via a PPRE located in the first intron
    • Wen, G., Ringseis, R., Eder, K., Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor α (PPARα) via a PPRE located in the first intron. Biochem. Pharmacol. 2010, 79, 768-776.
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 768-776
    • Wen, G.1    Ringseis, R.2    Eder, K.3
  • 15
    • 58249085228 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats
    • Gutgesell, A., Ringseis, R., Brandsch, C., Stangl, G. I. et al., Peroxisome proliferator-activated receptor alpha and enzymes of carnitine biosynthesis in the liver are down-regulated during lactation in rats. Metabolism 2009, 58, 226-232.
    • (2009) Metabolism , vol.58 , pp. 226-232
    • Gutgesell, A.1    Ringseis, R.2    Brandsch, C.3    Stangl, G.I.4
  • 16
    • 59649130350 scopus 로고    scopus 로고
    • -/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation
    • -/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. Faseb J. 2009, 23, 586-604.
    • (2009) Faseb J. , vol.23 , pp. 586-604
    • Makowski, L.1    Noland, R.C.2    Koves, T.R.3    Xing, W.4
  • 17
    • 69249113803 scopus 로고    scopus 로고
    • Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control
    • Noland, R. C., Koves, T. R., Seiler, S. E., Lum, H. et al., Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J. Biol. Chem. 2009, 284, 22840-22852.
    • (2009) J. Biol. Chem. , vol.284 , pp. 22840-22852
    • Noland, R.C.1    Koves, T.R.2    Seiler, S.E.3    Lum, H.4
  • 18
    • 37449020075 scopus 로고    scopus 로고
    • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    • Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D. et al., Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 2008, 7, 45-56.
    • (2008) Cell Metab. , vol.7 , pp. 45-56
    • Koves, T.R.1    Ussher, J.R.2    Noland, R.C.3    Slentz, D.4
  • 19
    • 34250740323 scopus 로고    scopus 로고
    • Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator
    • Li, X., Monks, B., Ge, Q., Birnbaum, M. J., Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 2007, 447, 1012-1016.
    • (2007) Nature , vol.447 , pp. 1012-1016
    • Li, X.1    Monks, B.2    Ge, Q.3    Birnbaum, M.J.4
  • 20
    • 25844432311 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency
    • Koves, T. R., Li, P., An, J., Akimoto, T. et al., Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J. Biol. Chem. 2005, 280, 33588-33598.
    • (2005) J. Biol. Chem. , vol.280 , pp. 33588-33598
    • Koves, T.R.1    Li, P.2    An, J.3    Akimoto, T.4
  • 23
    • 67649158723 scopus 로고    scopus 로고
    • Determination of carnitine, its short chain acyl esters and metabolic precursors trimethyllysine and gamma-butyrobetaine by quasi-solid phase extraction and MS/MS detection
    • Hirche, F., Fischer, M., Keller, J., Eder, K., Determination of carnitine, its short chain acyl esters and metabolic precursors trimethyllysine and gamma-butyrobetaine by quasi-solid phase extraction and MS/MS detection. J. Chromatogr. B 2009, 877, 2158-2162.
    • (2009) J. Chromatogr. B , vol.877 , pp. 2158-2162
    • Hirche, F.1    Fischer, M.2    Keller, J.3    Eder, K.4
  • 24
    • 0024822538 scopus 로고
    • Utilization of dietary precursors for carnitine synthesis in human adults
    • Rebouche, C. J., Bosch, E. P., Chenard, C. A., Schabold, K. J., Nelson, S. E., Utilization of dietary precursors for carnitine synthesis in human adults. J. Nutr. 1989, 119, 1907-1913.
    • (1989) J. Nutr. , vol.119 , pp. 1907-1913
    • Rebouche, C.J.1    Bosch, E.P.2    Chenard, C.A.3    Schabold, K.J.4    Nelson, S.E.5
  • 25
    • 0021088859 scopus 로고
    • Effect of dietary carnitine isomers and gamma-butyrobetaine on L-carnitine biosynthesis and metabolism in the rat
    • Rebouche, C. J., Effect of dietary carnitine isomers and gamma-butyrobetaine on L-carnitine biosynthesis and metabolism in the rat. J. Nutr. 1983, 113, 1906-1913.
    • (1983) J. Nutr. , vol.113 , pp. 1906-1913
    • Rebouche, C.J.1
  • 26
    • 67649814105 scopus 로고    scopus 로고
    • LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney
    • Feingold, K. R., Wang, Y., Moser, A., Shigenaga, J. K., Grunfeld, C., LPS decreases fatty acid oxidation and nuclear hormone receptors in the kidney. J. Lipid Res. 2008, 49, 2179-2187.
    • (2008) J. Lipid Res. , vol.49 , pp. 2179-2187
    • Feingold, K.R.1    Wang, Y.2    Moser, A.3    Shigenaga, J.K.4    Grunfeld, C.5
  • 27
    • 34547604561 scopus 로고    scopus 로고
    • Transcription coactivators for peroxisome proliferator-activated receptors
    • Yu, S., Reddy, J. K., Transcription coactivators for peroxisome proliferator-activated receptors. Biochim. Biophys. Acta 2007, 1771, 936-951.
    • (2007) Biochim. Biophys. Acta , vol.1771 , pp. 936-951
    • Yu, S.1    Reddy, J.K.2
  • 28
    • 21144445376 scopus 로고    scopus 로고
    • Tissue carnitine homeostasis in very-long-chain acyl-CoA dehydrogenase-deficient mice
    • Spiekerkoetter, U., Tokunaga, C., Wendel, U., Mayatepek, E. et al., Tissue carnitine homeostasis in very-long-chain acyl-CoA dehydrogenase-deficient mice. Pediatr. Res. 2005, 57, 760-764.
    • (2005) Pediatr. Res. , vol.57 , pp. 760-764
    • Spiekerkoetter, U.1    Tokunaga, C.2    Wendel, U.3    Mayatepek, E.4
  • 29
    • 77953231581 scopus 로고    scopus 로고
    • Pre-exercise medium-chain triglyceride application prevents acylcarnitine accumulation in skeletal muscle from very-long-chain acyl-CoA-dehydrogenase-deficient mice
    • Primassin, S., Tucci, S., Herebian, D., Seibt, A. et al., Pre-exercise medium-chain triglyceride application prevents acylcarnitine accumulation in skeletal muscle from very-long-chain acyl-CoA-dehydrogenase-deficient mice. J. Inherit. Metab. Dis. 2010, 33, 237-246.
    • (2010) J. Inherit. Metab. Dis. , vol.33 , pp. 237-246
    • Primassin, S.1    Tucci, S.2    Herebian, D.3    Seibt, A.4
  • 30
    • 33745841299 scopus 로고    scopus 로고
    • Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content
    • Bruce, C. R., Thrush, A. B., Mertz, V. A., Bezaire, V. et al., Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. Am. J. Physiol. Endocrinol. Metab. 2006, 291, E99-E107.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291
    • Bruce, C.R.1    Thrush, A.B.2    Mertz, V.A.3    Bezaire, V.4
  • 31
    • 0033851801 scopus 로고    scopus 로고
    • Effect of endurance training on lipid metabolism in women: a potential role for PPARα in the metabolic response to training
    • Horowitz, J. F., Leone, T. C., Feng, W., Kelly, D. P., Klein, S., Effect of endurance training on lipid metabolism in women: a potential role for PPARα in the metabolic response to training. Am. J. Physiol. Endocrinol. Metab. 2000, 279, E348-E355.
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.279
    • Horowitz, J.F.1    Leone, T.C.2    Feng, W.3    Kelly, D.P.4    Klein, S.5
  • 32
    • 33845875491 scopus 로고    scopus 로고
    • Effect of L-carnitine supplementation and aerobic training on FABPc content and beta-HAD activity in human skeletal muscle
    • Lee, J. K., Lee, J. S., Park, H., Cha, Y. S. et al., Effect of L-carnitine supplementation and aerobic training on FABPc content and beta-HAD activity in human skeletal muscle. Eur. J. Appl. Physiol. 2007, 99, 193-199.
    • (2007) Eur. J. Appl. Physiol. , vol.99 , pp. 193-199
    • Lee, J.K.1    Lee, J.S.2    Park, H.3    Cha, Y.S.4
  • 33
    • 77955159072 scopus 로고    scopus 로고
    • Endurance exercise induces mRNA expression of oxidative enzymes in human skeletal muscle late in recovery
    • Leick, L., Plomgaard, P., Grønløkke, L., Al-Abaiji, F. et al., Endurance exercise induces mRNA expression of oxidative enzymes in human skeletal muscle late in recovery. Scand. J. Med. Sci. Sports 2010, 20, 593-599.
    • (2010) Scand. J. Med. Sci. Sports , vol.20 , pp. 593-599
    • Leick, L.1    Plomgaard, P.2    Grønløkke, L.3    Al-Abaiji, F.4
  • 34
    • 60549102898 scopus 로고    scopus 로고
    • Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise
    • Smith, I. J., Huffman, K. M., Durheim, M. T., Duscha, B. D., Kraus, W. E., Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise. Physiol. Genomics 2009, 36, 149-157.
    • (2009) Physiol. Genomics , vol.36 , pp. 149-157
    • Smith, I.J.1    Huffman, K.M.2    Durheim, M.T.3    Duscha, B.D.4    Kraus, W.E.5
  • 35
    • 0033938601 scopus 로고    scopus 로고
    • Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats
    • Chul-Hee, K., Youn, J. H., Park, J. Y., Hong, S. K. et al., Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats. Am. J. Physiol. Endocrinol. Metab. 2000, 278, E977-E984.
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.278
    • Chul-Hee, K.1    Youn, J.H.2    Park, J.Y.3    Hong, S.K.4
  • 36
    • 33847797255 scopus 로고    scopus 로고
    • Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise
    • Corcoran, M. P., Lamon-Fava, S., Fielding, R. A., Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise. Am. J. Clin. Nutr. 2007, 85, 662-677.
    • (2007) Am. J. Clin. Nutr. , vol.85 , pp. 662-677
    • Corcoran, M.P.1    Lamon-Fava, S.2    Fielding, R.A.3
  • 37
    • 0036021855 scopus 로고    scopus 로고
    • Effects of acute exercise and exercise training on improved insulin resistance
    • Henrikesen, E. J., Effects of acute exercise and exercise training on improved insulin resistance. J. Appl. Physiol. 2002, 93, 788-796.
    • (2002) J. Appl. Physiol. , vol.93 , pp. 788-796
    • Henrikesen, E.J.1


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