A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics

Journal of Biological Chemistry

Volumn 289, Issue 14, 2014, Pages 9535-9546

  McCoy, Jason G ^a   Rusinova, Radda ^a   Kim, Dorothy M ^a   Kowal, Julia ^c   Banerjee, Sourabh ^a,e   Cartagena, Alexis Jaramillo ^a,d   Thompson, Ameer N ^a   Kolmakova Partensky, Ludmila ^b   Stahlberg, Henning ^c   Andersen, Olaf S ^a   Nimigean, Crina M ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b BRANDEIS UNIVERSITY   (United States)

^c UNIVERSITY OF BASEL   (Switzerland)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e INSTITUTE OF MATERIALS RESEARCH AND ENGINEERING   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BINDING ENERGY; IONS; LIGANDS; LIPID BILAYERS; MICELLES; SIGNAL TRANSDUCTION; THERMODYNAMICS;

BINDING THERMODYNAMICS; BIOCHEMICAL CHARACTERIZATION; CONFORMATIONAL CHANGE; CYCLIC NUCLEOTIDE BINDING DOMAIN; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MECHANISM; POTASSIUM CHANNELS; TRANS-MEMBRANE DOMAINS;

NUCLEOTIDES;

CYCLIC AMP; CYCLIC NUCLEOTIDE GATED CHANNEL; ION CHANNEL; KCSA PROTEIN; MLOK1 PROTEIN; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CHIMERA; CONFORMATIONAL TRANSITION; ENERGY TRANSFER; HYPERPOLARIZATION; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; THERMODYNAMICS;

ELECTRON MICROSCOPY (EM); ENERGETICS; FLUORESCENCE; GATING; ION CHANNELS; ISOTHERMAL TITRATION CALORIMETRY; NANODISC; SINGLE-CHANNEL RECORDING;

BACTERIAL PROTEINS; CYCLIC AMP; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MEMBRANE LIPIDS; MESORHIZOBIUM; POTASSIUM CHANNELS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS;

EID: 84898067929     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.543389     Document Type: Article

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