-
1
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski CA , Lombardo F , Dominy BW , Feeney PJ: Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings . Adv Drug Deliv Rev 1997 ; 23: 3-26 .
-
(1997)
Adv Drug Deliv Rev
, vol.23
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
2
-
-
35748934487
-
The influence of drug-like concepts on decisionmaking in medicinal chemistry
-
Leeson PD , Springthorpe B: The influence of drug-like concepts on decisionmaking in medicinal chemistry . Nat Rev Drug Discov 2007 ; 6: 881-890 .
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
3
-
-
61649109015
-
The influence of lead discovery strategies on the properties of drug candidates
-
Keseru GM , Makara GM: The influence of lead discovery strategies on the properties of drug candidates . Nat Rev Drug Discov 2009 ; 8: 203-212 .
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 203-212
-
-
Keseru, G.M.1
Makara, G.M.2
-
4
-
-
65449179589
-
Defining optimum lipophilicity and molecular weight ranges for drug candidates-Molecular weight dependent lower logD limits based on permeability
-
Waring MJ: Defining optimum lipophilicity and molecular weight ranges for drug candidates-Molecular weight dependent lower logD limits based on permeability . Bioorg Med Chem Lett 2009 ; 19: 2844-2851 .
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 2844-2851
-
-
Waring, M.J.1
-
5
-
-
0345194306
-
Lipid bilayer expansion and mechanical disruption in solutions of water-soluble bile acid
-
( Hofmann AF , Paumgartner G , Stiehl A , eds.) Kluwer Academic Publishers , Dordrecht
-
Evans E , Rawicz W , Hofmann AF: Lipid bilayer expansion and mechanical disruption in solutions of water-soluble bile acid . In: Bile Acids in Gastroenterology: Basic and Clinical Advances ( Hofmann AF , Paumgartner G , Stiehl A , eds.), pp. 59 - 68 . Kluwer Academic Publishers , Dordrecht , 1995 .
-
(1995)
Bile Acids in Gastroenterology: Basic and Clinical Advances
, pp. 59-68
-
-
Evans, E.1
Rawicz, W.2
Hofmann, A.F.3
-
6
-
-
4143140746
-
The influence of short-chain alcohols on interfacial tension, mechanical properties, area/molecule, and permeability of fluid lipid bilayers
-
Ly HV , Longo ML: The influence of short-chain alcohols on interfacial tension, mechanical properties, area/molecule, and permeability of fluid lipid bilayers . Biophys J 2004 ; 87: 1013-1033 .
-
(2004)
Biophys J
, vol.87
, pp. 1013-1033
-
-
Ly, H.V.1
Longo, M.L.2
-
7
-
-
24144502833
-
Effect of salicylate on the elasticity, bending stiffness, and strength of SOPC membranes
-
Zhou Y , Raphael RM: Effect of salicylate on the elasticity, bending stiffness, and strength of SOPC membranes . Biophys J 2005 ; 89: 1789-1801 .
-
(2005)
Biophys J
, vol.89
, pp. 1789-1801
-
-
Zhou, Y.1
Raphael, R.M.2
-
8
-
-
0028053841
-
Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers
-
Lundbaek JA , Andersen OS: Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers . J Gen Physiol 1994 ; 104: 645-673 .
-
(1994)
J Gen Physiol
, vol.104
, pp. 645-673
-
-
Lundbaek, J.A.1
Andersen, O.S.2
-
9
-
-
0033737385
-
Inclusion-induced bilayer deformations: Effects of monolayer equilibrium curvature
-
Nielsen C , Andersen OS: Inclusion-induced bilayer deformations: effects of monolayer equilibrium curvature . Biophys J 2000 ; 79: 2583-2604 .
-
(2000)
Biophys J
, vol.79
, pp. 2583-2604
-
-
Nielsen, C.1
Andersen, O.S.2
-
10
-
-
34347262391
-
Bilayer thickness and membrane protein function: An energetic perspective
-
Andersen OS , Koeppe RE , II: Bilayer thickness and membrane protein function: an energetic perspective . Annu Rev Biophys Biomol Struct 2007 ; 36: 107-130 .
-
(2007)
Annu Rev Biophys Biomol Struct
, vol.36
, pp. 107-130
-
-
Andersen, O.S.1
Koeppe, I.I.R.E.2
-
11
-
-
76049124690
-
Lipid bilayer regulation of membrane protein function: Gramicidin channels as molecular force probes
-
doi: 10.1098/rsif.2009.0443
-
Lundbak JA , Collingwood SA , Ingolfsson HI , Kapoor R , Andersen OS: Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes . J R Soc Interface 2009 , doi: 10.1098/rsif.2009.0443.
-
(2009)
J R Soc Interface
-
-
Lundbak, J.A.1
Collingwood, S.A.2
Ingolfsson, H.I.3
Kapoor, R.4
Andersen, O.S.5
-
12
-
-
0345254912
-
Genistein can modulate channel function by a phosphorylation-independent mechanism: Importance of hydrophobic mismatch and bilayer mechanics
-
Hwang TC , Koeppe RE , II, Andersen OS: Genistein can modulate channel function by a phosphorylation-independent mechanism: importance of hydrophobic mismatch and bilayer mechanics . Biochemistry 2003 ; 42: 13646-13658 .
-
(2003)
Biochemistry
, vol.42
, pp. 13646-13658
-
-
Hwang, T.C.1
Koeppe, I.I.R.E.2
Andersen, O.S.3
-
13
-
-
2342469391
-
Regulation of sodium channel function by bilayer elasticity: The importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol
-
Lundbaek JA , Birn P , Hansen AJ , Sogaard R , Nielsen C , Girshman J , et al .: Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol . J Gen Physiol 2004 ; 123: 599-621 .
-
(2004)
J Gen Physiol
, vol.123
, pp. 599-621
-
-
Lundbaek, J.A.1
Birn, P.2
Hansen, A.J.3
Sogaard, R.4
Nielsen, C.5
Girshman, J.6
-
14
-
-
23944464223
-
Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity
-
Lundbaek JA , Birn P , Tape SE , Toombes GE , Sogaard R, Koeppe RE, II, et al.: Capsaicin regulates voltage-dependent sodium channels by altering lipid bilayer elasticity . Mol Pharmacol 2005 ; 68: 680-689 .
-
(2005)
Mol Pharmacol
, vol.68
, pp. 680-689
-
-
Lundbaek, J.A.1
Birn, P.2
Tape, S.E.3
Toombes, G.E.4
Sogaard, R.5
Koeppe, I.I.R.E.6
-
15
-
-
33751120420
-
2,3-butanedione monoxime affects cystic fibrosis transmembrane conductance regulator channel function through phosphorylation-dependent and phosphorylationindependent mechanisms: The role of bilayer material properties
-
Artigas P , Al'aref SJ , Hobart EA , Diaz LF , Sakaguchi M , Straw S , et al .: 2,3-butanedione monoxime affects cystic fibrosis transmembrane conductance regulator channel function through phosphorylation-dependent and phosphorylationindependent mechanisms: the role of bilayer material properties . Mol Pharmacol 2006 ; 70: 2015-2026 .
-
(2006)
Mol Pharmacol
, vol.70
, pp. 2015-2026
-
-
Artigas, P.1
Al'Aref, S.J.2
Hobart, E.A.3
Diaz, L.F.4
Sakaguchi, M.5
Straw, S.6
-
17
-
-
35148853739
-
Curcumin is a modulator of bilayer material properties
-
Ingolfsson HI , Koeppe RE , II, Andersen OS: Curcumin is a modulator of bilayer material properties . Biochemistry 2007 ; 46: 10384-10391 .
-
(2007)
Biochemistry
, vol.46
, pp. 10384-10391
-
-
Ingolfsson, H.I.1
Koeppe, R.E.2
Andersen II, O.S.3
-
18
-
-
0035468033
-
Physicochemical profiling (solubility, permeability and charge state)
-
Avdeef A: Physicochemical profiling (solubility, permeability and charge state) . Curr Top Med Chem 2001 ; 1: 277-351 .
-
(2001)
Curr Top Med Chem
, vol.1
, pp. 277-351
-
-
Avdeef, A.1
-
19
-
-
2042522271
-
-
Wiley-VCH, Weinheim , Germany
-
Seydel JK , Wiese M: Drug-Membrane Interactions: Analysis, Drug Distribution, Modeling . Wiley-VCH, Weinheim , Germany , 2002 .
-
(2002)
Drug-Membrane Interactions: Analysis, Drug Distribution, Modeling
-
-
Seydel, J.K.1
Wiese, M.2
-
20
-
-
33745634914
-
Regulation of membrane protein function by lipid bilayer elasticity: A single molecule technology to measure the bilayer properties experienced by an embedded protein
-
Lundbak JA: Regulation of membrane protein function by lipid bilayer elasticity: a single molecule technology to measure the bilayer properties experienced by an embedded protein . J Physics: Cond Matt 2006 ; 18: S1305-S1344 .
-
(2006)
J Physics: Cond Matt
, vol.18
-
-
Lundbak, J.A.1
-
21
-
-
42949098097
-
Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs
-
Lundbak JA: Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs . J Gen Physiol 2008 ; 131: 421-429 .
-
(2008)
J Gen Physiol
, vol.131
, pp. 421-429
-
-
Lundbak, J.A.1
-
22
-
-
36549058256
-
Single-molecule methods for monitoring changes in bilayer elastic properties
-
Andersen OS , Bruno MJ , Sun H , Koeppe RE , II: Single-molecule methods for monitoring changes in bilayer elastic properties . Methods Mol Biol 2007 ; 400: 543-570 .
-
(2007)
Methods Mol Biol
, vol.400
, pp. 543-570
-
-
Andersen, O.S.1
Bruno, M.J.2
Sun, H.3
Koeppe, I.I.R.E.4
-
23
-
-
0029879111
-
Membrane stiffness and channel function
-
Lundbaek JA , Birn P , Girshman J , Hansen AJ , Andersen OS: Membrane stiffness and channel function . Biochemistry 1996 ; 35: 3825-3830 .
-
(1996)
Biochemistry
, vol.35
, pp. 3825-3830
-
-
Lundbaek, J.A.1
Birn, P.2
Girshman, J.3
Hansen, A.J.4
Andersen, O.S.5
-
24
-
-
0019051984
-
Direct spectroscopic studies of cation translocation by Torpedo acetylcholine receptor on a time scale of physiological relevance
-
Moore HP , Raftery MA: Direct spectroscopic studies of cation translocation by Torpedo acetylcholine receptor on a time scale of physiological relevance . Proc Natl Acad Sci USA 1980 ; 77: 4509-4513 .
-
(1980)
Proc Natl Acad Sci USA
, vol.77
, pp. 4509-4513
-
-
Moore, H.P.1
Raftery, M.A.2
-
25
-
-
0022735095
-
Determination of the molecularity of the colicin E1 channel by stopped-flow ion flux kinetics
-
Bruggemann EP , Kayalar C: Determination of the molecularity of the colicin E1 channel by stopped-flow ion flux kinetics . Proc Natl Acad Sci USA 1986 ; 83: 4273-4276 .
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 4273-4276
-
-
Bruggemann, E.P.1
Kayalar, C.2
-
26
-
-
0021909644
-
Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential
-
Hope MJ , Bally MB , Webb G , Cullis PR: Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential . Biochim Biophys Acta 1985 ; 812: 55-62 .
-
(1985)
Biochim Biophys Acta
, vol.812
, pp. 55-62
-
-
Hope, M.J.1
Bally, M.B.2
Webb, G.3
Cullis, P.R.4
-
28
-
-
23044464822
-
Mathematical functions for the analysis of luminescence decays with underlying distributions 1. Kohlrausch decay function (stretched exponential)
-
Berberan-Santos MN , Bodunov EN , Valeur B: Mathematical functions for the analysis of luminescence decays with underlying distributions 1. Kohlrausch decay function (stretched exponential) . Chem Phys 2005 ; 315: 171-182 .
-
(2005)
Chem Phys
, vol.315
, pp. 171-182
-
-
Berberan-Santos, M.N.1
Bodunov, E.N.2
Valeur, B.3
-
29
-
-
0021033508
-
Cadmium and thallous ion permeabilities through lipid bilayer membranes
-
Gutknecht J: Cadmium and thallous ion permeabilities through lipid bilayer membranes . Biochim Biophys Acta 1983 ; 735: 185-188 .
-
(1983)
Biochim Biophys Acta
, vol.735
, pp. 185-188
-
-
Gutknecht, J.1
-
30
-
-
0016818713
-
Ionic specificity of the gramicidin channel and the thallous ion
-
Neher E: Ionic specificity of the gramicidin channel and the thallous ion . Biochim Biophys Acta 1975 ; 401: 540-544 .
-
(1975)
Biochim Biophys Acta
, vol.401
, pp. 540-544
-
-
Neher, E.1
-
31
-
-
0001798441
-
Ion transport through simple membranes
-
G. H. Giebisch and E. F. Purcell , . The Josiah Macy, Jr. Foundation , New York
-
Andersen OS: Ion transport through simple membranes . In: Renal Function G. H. Giebisch and E. F. Purcell , pp. 71 - 99 . The Josiah Macy, Jr. Foundation , New York , 1978 .
-
(1978)
Renal Function
, pp. 71-99
-
-
Andersen, O.S.1
-
32
-
-
0030777012
-
The capsaicin receptor: A heat-activated ion channel in the pain pathway
-
Caterina MJ , Schumacher MA , Tominaga M , Rosen TA , Levine JD , Julius D: The capsaicin receptor: a heat-activated ion channel in the pain pathway . Nature 1997 ; 389: 816-824 .
-
(1997)
Nature
, vol.389
, pp. 816-824
-
-
Caterina, M.J.1
Schumacher, M.A.2
Tominaga, M.3
Rosen, T.A.4
Levine, J.D.5
Julius, D.6
-
33
-
-
33751092021
-
GABA(A) receptor function is regulated by lipid bilayer elasticity
-
Sogaard R, Werge TM, Bertelsen C, Lundbye C, Madsen KL, Nielsen CH, et al.: GABA(A) receptor function is regulated by lipid bilayer elasticity . Biochemistry 2006 ; 45: 13118-13129 .
-
(2006)
Biochemistry
, vol.45
, pp. 13118-13129
-
-
Sogaard, R.1
Werge, T.M.2
Bertelsen, C.3
Lundbye, C.4
Madsen, K.L.5
Nielsen, C.H.6
-
34
-
-
34447129573
-
The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells
-
Adachi S, Nagao T, Ingolfsson HI, Maxfield FR, Andersen OS, Kopelovich L, et al.: The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells . Cancer Res 2007 ; 67: 6493-6501 .
-
(2007)
Cancer Res
, vol.67
, pp. 6493-6501
-
-
Adachi, S.1
Nagao, T.2
Ingolfsson, H.I.3
Maxfield, F.R.4
Andersen, O.S.5
Kopelovich, L.6
-
35
-
-
0025356942
-
Albumin protects against capsaicin- and adenosine-induced bronchoconstriction and reduces overflow of calcitonin gene-related peptide from guinea-pig lung
-
Kroll F , Karlsson JA , Lundberg JM , Persson CG: Albumin protects against capsaicin- and adenosine-induced bronchoconstriction and reduces overflow of calcitonin gene-related peptide from guinea-pig lung . Acta Physiol Scand 1990 ; 139: 223-232 .
-
(1990)
Acta Physiol Scand
, vol.139
, pp. 223-232
-
-
Kroll, F.1
Karlsson, J.A.2
Lundberg, J.M.3
Persson, C.G.4
-
36
-
-
0025667349
-
Kinetics of gramicidin channel formation in lipid bilayers: Transmembrane monomer association
-
O'Connell AM , Koeppe RE , II, Andersen OS: Kinetics of gramicidin channel formation in lipid bilayers: transmembrane monomer association . Science 1990 ; 250: 1256-1259 .
-
(1990)
Science
, vol.250
, pp. 1256-1259
-
-
O'Connell, A.M.1
Koeppe, R.E.2
Andersen II, O.S.3
|