Ligand Binding and Activation in a Prokaryotic Cyclic Nucleotide-modulated Channel

Journal of Molecular Biology

Volumn 371, Issue 5, 2007, Pages 1325-1337

  Nimigean, Crina M ^a   Pagel, Matthew D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

affinity; binding; channel; MloK1; sensitivity

Indexed keywords

AMINO ACID; CYCLIC AMP; CYCLIC GMP; ION CHANNEL; NUCLEOTIDE; PROTEIN MLOK1; RUBIDIUM 86; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; ELECTROPHYSIOLOGY; LIGAND BINDING; MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROKARYOTE;

EUKARYOTA; PROKARYOTA;

EID: 34547598211     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.06.030     Document Type: Article

References (39)

1. LeMasurier M., Heginbotham L., and Miller C. KcsA: it's a potassium channel. J. Gen. Physiol. 118 (2001) 303-314
2. + channel. Biochemistry 37 (1998) 3229-3236
3. Heginbotham L., LeMasurier M., Kolmakova-Partensky L., and Miller C. Single streptomyces lividans K(+) channels: functional asymmetries and sidedness of proton activation. J. Gen. Physiol. 114 (1999) 551-560
4. + channels. Cell 126 (2006) 1161-1173
5. Zadek B., and Nimigean C.M. Calcium-dependent gating of MthK, a prokaryotic potassium channel. J. Gen. Physiol. 127 (2006) 673-685
6. Accardi A., and Miller C. Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels. Nature 427 (2004) 803-807
7. + channel. J. Gen. Physiol. 124 (2004) 203-210
8. Clayton G.M., Silverman W.R., Heginbotham L., and Morais-Cabral J.H. Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel. Cell 119 (2004) 615-627
9. Kaupp U.B., and Seifert R. Molecular diversity of pacemaker ion channels. Annu. Rev. Physiol. 63 (2001) 235-257
10. Kaupp U.B., and Seifert R. Cyclic nucleotide-gated ion channels. Physiol. Rev. 82 (2002) 769-824
11. Cobbs W.H., and Pugh Jr. E.N. Kinetics and components of the flash photocurrent of isolated retinal rods of the larval salamander, Ambystoma tigrinum. J. Physiol. 394 (1987) 529-572
12. Lazareno S. Quantification of receptor interactions using binding methods. J. Recept. Signal Transduct. Res. 21 (2001) 139-165
13. Rovati G.E. Rational experimental design and data analysis for ligand binding studies: tricks, tips and pitfalls. Pharmacol. Res. 28 (1993) 277-299
14. Swillens S. Interpretation of binding curves obtained with high receptor concentrations: practical aid for computer analysis. Mol. Pharmacol. 47 (1995) 1197-1203
15. Colquhoun D. Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Brit. J. Pharmacol. 125 (1998) 924-947
16. Altenhofen W., Ludwig J., Eismann E., Kraus W., Bonigk W., and Kaupp U.B. Control of ligand specificity in cyclic nucleotide-gated channels from rod photoreceptors and olfactory epithelium. Proc. Natl Acad. Sci. USA 88 (1991) 9868-9872
17. Varnum M.D., Black K.D., and Zagotta W.N. Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels. Neuron 15 (1995) 619-625
18. Zagotta W.N., Olivier N.B., Black K.D., Young E.C., Olson R., and Gouaux E. Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature 425 (2003) 200-205
19. Gordon S.E., Oakley J.C., Varnum M.D., and Zagotta W.N. Altered ligand specificity by protonation in the ligand binding domain of cyclic nucleotide-gated channels. Biochemistry 35 (1996) 3994-4001
20. Varnum M.D., and Zagotta W.N. Interdomain interactions underlying activation of cyclic nucleotide-gated channels. Science 278 (1997) 110-113
21. Shabb J.B., and Corbin J.D. Cyclic nucleotide-binding domains in proteins having diverse functions. J. Biol. Chem. 267 (1992) 5723-5726
22. Weber I.T., and Steitz T.A. Structure of a complex of catabolite gene activator protein and cyclic AMP refined at 2.5 Å resolution. J. Mol. Biol. 198 (1987) 311-326
23. McKay D.B., Weber I.T., and Steitz T.A. Structure of catabolite gene activator protein at 2.9-A resolution. Incorporation of amino acid sequence and interactions with cyclic AMP. J. Biol. Chem. 257 (1982) 9518-9524
24. Chen S., Wang J., and Siegelbaum S.A. Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. J. Gen. Physiol. 117 (2001) 491-504
25. Tibbs G.R., Liu D.T., Leypold B.G., and Siegelbaum S.A. A state-independent interaction between ligand and a conserved arginine residue in cyclic nucleotide-gated channels reveals a functional polarity of the cyclic nucleotide binding site. J. Biol. Chem. 273 (1998) 4497-4505
26. Biskup C., Kusch J., Schulz E., Nache V., Schwede F., Lehmann F., Hagen V., and Benndorf K. Relating ligand binding to activation gating in CNGA2 channels. Nature 446 (2007) 440-443
27. Nache V., Kusch J., Hagen V., and Benndorf K. Gating of cyclic nucleotide-gated (CNGA1) channels by cGMP jumps and depolarizing voltage steps. Biophys. J. 90 (2006) 3146-3154
28. 2+ in cyclic nucleotide-gated channels. Proc. Natl Acad. Sci. USA 92 (1995) 10222-10226
29. Gordon S.E., and Zagotta W.N. Localization of regions affecting an allosteric transition in cyclic nucleotide-activated channels. Neuron 14 (1995) 857-864
30. Gordon S.E., and Zagotta W.N. A histidine residue associated with the gate of the cyclic nucleotide-activated channels in rod photoreceptors. Neuron 14 (1995) 177-183
31. Ildefonse M., and Bennett N. Single-channel study of the cGMP-dependent conductance of retinal rods from incorporation of native vesicles into planar lipid bilayers. J. Membr. Biol. 123 (1991) 133-147
32. Johnson Jr. J.P., and Zagotta W.N. Rotational movement during cyclic nucleotide-gated channel opening. Nature 412 (2001) 917-921
33. Karpen J.W., Brown R.L., Stryer L., and Baylor D. A. Interactions between divalent cations and the gating machinery of cyclic GMP-activated channels in salamander retinal rods. J. Gen. Physiol. 101 (1993) 1-25
34. Paoletti P., Young E.C., and Siegelbaum S.A. C-Linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating. J. Gen. Physiol. 113 (1999) 17-34
35. Zong X., Zucker H., Hofmann F., and Biel M. Three amino acids in the C-linker are major determinants of gating in cyclic nucleotide-gated channels. EMBO J. 17 (1998) 353-362
36. Skerra A. Use of the tetracycline promoter for the tightly regulated production of a murine antibody fragment in Escherichia coli. Gene 151 (1994) 131-135
37. Nimigean C.M. A radioactive uptake assay for the measurement of ion transport across ion channel-containing liposomes. Nature Protocols 1 (2006) 1207-1212
38. Cheng Y., and Prusoff W.H. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem. Pharmacol. 22 (1973) 3099-3108
39. van Zoelen E.J. Analysis of receptor binding displacement curves by a nonhomologous ligand, on the basis of an equivalent competition principle. Anal. Biochem. 200 (1992) 393-399