-
1
-
-
24644470065
-
--dependent neurotransmitter transporters
-
DOI 10.1038/nature03978
-
Yamashita, A., Singh, S.K., Kawate, T., Jin, Y. & Gouaux, E. Crystal structure of a bacterial homologue of Na +Cl-dependent neurotransmitter transporters. Nature 437, 215-223 (2005). (Pubitemid 41294479)
-
(2005)
Nature
, vol.437
, Issue.7056
, pp. 215-223
-
-
Yamashita, A.1
Singh, S.K.2
Kawate, T.3
Jin, Y.4
Gouaux, E.5
-
2
-
-
58149233796
-
A competitive inhibitor traps LeuT in an open-to-out conformation
-
Singh, S.K., Piscitelli, C.L., Yamashita, A. & Gouaux, E. A competitive inhibitor traps LeuT in an open-to-out conformation. Science 322, 1655-1661 (2008).
-
(2008)
Science
, vol.322
, pp. 1655-1661
-
-
Singh, S.K.1
Piscitelli, C.L.2
Yamashita, A.3
Gouaux, E.4
-
3
-
-
65249169367
-
Binding of an octylglucoside detergent molecule in the second substrate (S2) site of Leu Testablishes an inhibitor-bound conformation
-
Quick, M. et al. Binding of an octylglucoside detergent molecule in the second substrate (S2) site of Leu Testablishes an inhibitor-bound conformation. Proc. Natl. Acad. Sci. USA 106, 5563-5568 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 5563-5568
-
-
Quick, M.1
-
4
-
-
34548178234
-
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
-
DOI 10.1038/nature06038, PII NATURE06038
-
Singh, S.K., Yamashita, A. & Gouaux, E. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters. Nature 448, 952-956 (2007). (Pubitemid 47312772)
-
(2007)
Nature
, vol.448
, Issue.7156
, pp. 952-956
-
-
Singh, S.K.1
Yamashita, A.2
Gouaux, E.3
-
5
-
-
34548684744
-
LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake
-
DOI 10.1126/science.1147614
-
Zhou, Z. et al. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake. Science 317, 1390-1393 (2007). (Pubitemid 47417479)
-
(2007)
Science
, vol.317
, Issue.5843
, pp. 1390-1393
-
-
Zhou, Z.1
Zhen, J.2
Karpowich, N.K.3
Goetz, R.M.4
Law, C.J.5
Reith, M.E.A.6
Wang, D.-N.7
-
6
-
-
44949086583
-
+ and Substrate Is Triggered by Substrate in a Second Binding Site
-
DOI 10.1016/j.molcel.2008.05.008, PII S1097276508003596
-
Shi, L., Quick, M., Zhao, Y., Weinstein, H. & Javitch, J.A. The mechanism of a neurotransmitter:sodium symporter-inward release of Na+ and substrate is triggered by substrate in a second binding site. Mol. Cell 30, 667-677 (2008). (Pubitemid 351815131)
-
(2008)
Molecular Cell
, vol.30
, Issue.6
, pp. 667-677
-
-
Shi, L.1
Quick, M.2
Zhao, Y.3
Weinstein, H.4
Javitch, J.A.5
-
7
-
-
79957935490
-
Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue
-
Zhao, Y. et al. Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue. Nature 474, 109-113 (2011).
-
(2011)
Nature
, vol.474
, pp. 109-113
-
-
Zhao, Y.1
-
8
-
-
78650108546
-
Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms
-
Shi, L. & Weinstein, H. Conformational rearrangements to the intracellular open states of the LeuT and ApcT transporters are modulated by common mechanisms. Biophys. J. 99, L103-L105 (2010).
-
(2010)
Biophys. J.
, vol.99
-
-
Shi, L.1
Weinstein, H.2
-
9
-
-
47749083479
-
An intracellular interaction network regulates conformational transitions in the dopamine transporter
-
Kniazeff, J. et al. An intracellular interaction network regulates conformational transitions in the dopamine transporter. J. Biol. Chem. 283, 17691-17701 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 17691-17701
-
-
Kniazeff, J.1
-
10
-
-
79551598571
-
The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter
-
Shan, J., Javitch, J.A., Shi, L. & Weinstein, H. The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter. PLoS ONE 6, e16350 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Shan, J.1
Javitch, J.A.2
Shi, L.3
Weinstein, H.4
-
11
-
-
78650817193
-
Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site
-
Piscitelli, C.L., Krishnamurthy, H. & Gouaux, E. Neurotransmitter/ sodium symporter orthologue LeuT has a single high-affinity substrate site. Nature 468, 1129-1132 (2010).
-
(2010)
Nature
, vol.468
, pp. 1129-1132
-
-
Piscitelli, C.L.1
Krishnamurthy, H.2
Gouaux, E.3
-
12
-
-
77954383579
-
Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters
-
Claxton, D.P. et al. Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nat. Struct. Mol. Biol. 17, 822-829 (2010).
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 822-829
-
-
Claxton, D.P.1
-
13
-
-
78649520104
-
Tandem facial amphiphiles for membrane protein stabilization
-
Chae, P.S. et al. Tandem facial amphiphiles for membrane protein stabilization. J. Am. Chem. Soc. 132, 16750-16752 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 16750-16752
-
-
Chae, P.S.1
-
14
-
-
78650171241
-
Design function and structure of a monomeric ClC transporter
-
Robertson, J.L., Kolmakova-Partensky, L. & Miller, C. Design, function and structure of a monomeric ClC transporter. Nature 468, 844-847 (2010).
-
(2010)
Nature
, vol.468
, pp. 844-847
-
-
Robertson, J.L.1
Kolmakova-Partensky, L.2
Miller, C.3
-
15
-
-
77957014498
-
Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli
-
Bogdanov, M., Heacock, P., Guan, Z. & Dowhan, W. Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli. Proc. Natl. Acad. Sci. USA 107, 15057-15062 (2010).
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 15057-15062
-
-
Bogdanov, M.1
Heacock, P.2
Guan, Z.3
Dowhan, W.4
-
16
-
-
0029101114
-
Reconstitution of membrane proteins into liposomes: Application to energy-transducing membrane proteins
-
Rigaud, J.L., Pitard, B. & Levy, D. Reconstitution of membrane proteins into liposomes: application to energy-transducing membrane proteins. Biochim. Biophys. Acta 1231, 223-246 (1995).
-
(1995)
Biochim. Biophys. Acta
, vol.1231
, pp. 223-246
-
-
Rigaud, J.L.1
Pitard, B.2
Levy, D.3
-
18
-
-
0037173103
-
Employing Escherichia coli to functionally express, purify, and characterize a human transporter
-
DOI 10.1073/pnas.132266599
-
Quick, M. & Wright, E.M. Employing Escherichia coli to functionally express, purify, and characterize a human transporter. Proc. Natl. Acad. Sci. USA 99, 8597-8601 (2002). (Pubitemid 34693607)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.13
, pp. 8597-8601
-
-
Quick, M.1
Wright, E.M.2
-
19
-
-
0032190185
-
Amino acid residues that control pH modulation of transport-associated current in mammalian serotonin transporters
-
Cao, Y., Li, M., Mager, S. & Lester, H.A. Amino acid residues that control pH modulation of transport-associated current in mammalian serotonin transporters. J. Neurosci. 18, 7739-7749 (1998). (Pubitemid 28441015)
-
(1998)
Journal of Neuroscience
, vol.18
, Issue.19
, pp. 7739-7749
-
-
Cao, Y.1
Li, M.2
Mager, S.3
Lester, H.A.4
-
20
-
-
58549090142
-
Allosteric modulation of 5-HT(1A) receptors by zinc: Binding studies
-
Barrondo, S. & Salles, J. Allosteric modulation of 5-HT(1A) receptors by zinc: Binding studies. Neuropharmacology 56, 455-462 (2009).
-
(2009)
Neuropharmacology
, vol.56
, pp. 455-462
-
-
Barrondo, S.1
Salles, J.2
-
21
-
-
58149215954
-
Kinetic analysis of the regulation of the Na +H+ exchanger NHE-1 by osmotic shocks
-
Lacroix, J. et al. Kinetic analysis of the regulation of the Na +H+ exchanger NHE-1 by osmotic shocks. Biochemistry 47, 13674-13685 (2008).
-
(2008)
Biochemistry
, vol.47
, pp. 13674-13685
-
-
Lacroix, J.1
-
22
-
-
70350381113
-
Purification and functional reconstitution of monomeric mu-opioid receptors: Allosteric modulation of agonist binding by Gi2
-
Kuszak, A.J. et al. Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. J. Biol. Chem. 284, 26732-26741 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 26732-26741
-
-
Kuszak, A.J.1
-
23
-
-
76249126819
-
Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch
-
Bai, F. et al. Conformational spread as a mechanism for cooperativity in the bacterial flagellar switch. Science 327, 685-689 (2010).
-
(2010)
Science
, vol.327
, pp. 685-689
-
-
Bai, F.1
-
24
-
-
77953791638
-
Novel allosteric effects of amiodarone at the muscarinic M5 receptor
-
Stahl, E. & Ellis, J. Novel allosteric effects of amiodarone at the muscarinic M5 receptor. J. Pharmacol. Exp. Ther. 334, 214-222 (2010).
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.334
, pp. 214-222
-
-
Stahl, E.1
Ellis, J.2
-
25
-
-
44949086583
-
+ and Substrate Is Triggered by Substrate in a Second Binding Site
-
DOI 10.1016/j.molcel.2008.05.008, PII S1097276508003596
-
Shi, L., Quick, M., Zhao, Y., Weinstein, H. & Javitch, J.A. The mechanism of a neurotransmitter:sodium symporter-inward release of Na+ and substrate is triggered by substrate in a second binding site. Mol. Cell 30, 667-677 (2008). (Pubitemid 351815131)
-
(2008)
Molecular Cell
, vol.30
, Issue.6
, pp. 667-677
-
-
Shi, L.1
Quick, M.2
Zhao, Y.3
Weinstein, H.4
Javitch, J.A.5
-
26
-
-
35148815052
-
Mechanism of chloride interaction with neurotransmitter:sodium symporters
-
DOI 10.1038/nature06133, PII NATURE06133
-
Zomot, E. et al. Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature 449, 726-730 (2007). (Pubitemid 47552085)
-
(2007)
Nature
, vol.449
, Issue.7163
, pp. 726-730
-
-
Zomot, E.1
Bendahan, A.2
Quick, M.3
Zhao, Y.4
Javitch, J.A.5
Kanner, B.I.6
-
28
-
-
0015716692
-
A rapid, sensitive, and specific method for the determination of protein in dilute solution
-
Schaffner, W. & Weissmann, C. A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal. Biochem. 56, 502-514 (1973).
-
(1973)
Anal. Biochem.
, vol.56
, pp. 502-514
-
-
Schaffner, W.1
Weissmann, C.2
-
29
-
-
4244120872
-
Microdetermination of phosphorus
-
Chen, P.S., Toribara, T.Y. & Warner, H. Microdetermination of phosphorus. Anal. Chem. 28, 1756-1758 (1956).
-
(1956)
Anal. Chem.
, vol.28
, pp. 1756-1758
-
-
Chen, P.S.1
Toribara, T.Y.2
Warner, H.3
-
30
-
-
33749946901
-
Colorimetric method for the determination of sugars and related substances
-
Dubois, M., Gilles, D.A., Hamilton, J.K., Rebers, P.A. & Smith, F. Colorimetric method for the determination of sugars and related substances. Anal. Chem. 28, 350-356 (1956).
-
(1956)
Anal. Chem.
, vol.28
, pp. 350-356
-
-
Dubois, M.1
Gilles, D.A.2
Hamilton, J.K.3
Rebers, P.A.4
Smith, F.5
|