메뉴 건너뛰기




Volumn 165, Issue 2, 2014, Pages 217-226

The role of apoptosis in megakaryocytes and platelets

Author keywords

Apoptosis; BH3 mimetic; Megakaryocytes; Platelets; Thrombopoiesis

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; PROTEIN BCL 2; PROTEIN BCL XL;

EID: 84898058584     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12757     Document Type: Review
Times cited : (104)

References (95)
  • 2
    • 0029127976 scopus 로고
    • In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation
    • Ault, K.A. & Knowles, C. (1995) In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation. Experimental Hematology, 23, 996-1001.
    • (1995) Experimental Hematology , vol.23 , pp. 996-1001
    • Ault, K.A.1    Knowles, C.2
  • 3
    • 0038646211 scopus 로고    scopus 로고
    • Apoptotic markers are increased in platelets stored at 37 degrees C
    • Bertino, A., Qi, X., Li, J., Xia, Y. & Kuter, D. (2003) Apoptotic markers are increased in platelets stored at 37 degrees C. Transfusion, 43, 857-866.
    • (2003) Transfusion , vol.43 , pp. 857-866
    • Bertino, A.1    Qi, X.2    Li, J.3    Xia, Y.4    Kuter, D.5
  • 4
    • 0020052831 scopus 로고
    • Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets
    • Bevers, E.M., Comfurius, P., van Rijn, J.L.M.L. & Hemker, H.C. (1982) Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets. European Journal of Biochemistry, 122, 429-436.
    • (1982) European Journal of Biochemistry , vol.122 , pp. 429-436
    • Bevers, E.M.1    Comfurius, P.2    van Rijn, J.L.M.L.3    Hemker, H.C.4
  • 5
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    • Bouillet, P., Metcalf, D., Huang, D., Tarlinton, D., Kay, T., Kontgen, F., Adams, J. & Strasser, A. (1999) Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science, 286, 1735-1738.
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.3    Tarlinton, D.4    Kay, T.5    Kontgen, F.6    Adams, J.7    Strasser, A.8
  • 8
    • 19944432123 scopus 로고    scopus 로고
    • Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function
    • Chen, L., Willis, S., Wei, A., Smith, B., Fletcher, J., Hinds, M., Colman, P., Day, C., Adams, J. & Huang, D. (2005) Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Molecular Cell, 17, 393-403.
    • (2005) Molecular Cell , vol.17 , pp. 393-403
    • Chen, L.1    Willis, S.2    Wei, A.3    Smith, B.4    Fletcher, J.5    Hinds, M.6    Colman, P.7    Day, C.8    Adams, J.9    Huang, D.10
  • 10
    • 0037450786 scopus 로고    scopus 로고
    • Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death
    • Clarke, M., Savill, J., Jones, D., Noble, B. & Brown, S. (2003) Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death. Journal of Cell Biology, 160, 5577-5587.
    • (2003) Journal of Cell Biology , vol.160 , pp. 5577-5587
    • Clarke, M.1    Savill, J.2    Jones, D.3    Noble, B.4    Brown, S.5
  • 11
    • 0036762153 scopus 로고    scopus 로고
    • Thrombin activity and platelet microparticle formation are increased in type 2 diabetic platelets: a potential correlation with caspase activation
    • Cohen, Z., Gonzales, R., Davis-Gorman, G., Copeland, J. & McDonagh, P. (2002) Thrombin activity and platelet microparticle formation are increased in type 2 diabetic platelets: a potential correlation with caspase activation. Thrombosis Research, 107, 217-221.
    • (2002) Thrombosis Research , vol.107 , pp. 217-221
    • Cohen, Z.1    Gonzales, R.2    Davis-Gorman, G.3    Copeland, J.4    McDonagh, P.5
  • 15
    • 77950859902 scopus 로고    scopus 로고
    • Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases
    • van Delft, M.F., Smith, D.P., Lahoud, M.H., Huang, D.C.S. & Adams, J.M. (2010) Apoptosis and non-inflammatory phagocytosis can be induced by mitochondrial damage without caspases. Cell Death and Differentiation, 17, 821-832.
    • (2010) Cell Death and Differentiation , vol.17 , pp. 821-832
    • van Delft, M.F.1    Smith, D.P.2    Lahoud, M.H.3    Huang, D.C.S.4    Adams, J.M.5
  • 16
    • 0020956849 scopus 로고
    • The relation of blood platelets to hemorrhagic disease
    • Duke, W. (1910) The relation of blood platelets to hemorrhagic disease. The Journal of the American Medical Association, 250, 1201-1209.
    • (1910) The Journal of the American Medical Association , vol.250 , pp. 1201-1209
    • Duke, W.1
  • 17
    • 66649135382 scopus 로고
    • The rate of regeneration of blood platelets
    • Duke, W. (1911) The rate of regeneration of blood platelets. Journal of Experimental Medicine, 14, 265-273.
    • (1911) Journal of Experimental Medicine , vol.14 , pp. 265-273
    • Duke, W.1
  • 20
    • 0007424513 scopus 로고
    • A comparative study of the effect of transfusion of fresh and preserved whole blood on bleeding in patients with acute leukemia
    • Freireich, E.J., Schmidt, P.J., Schneiderman, M.A. & Frei, E. III (1959) A comparative study of the effect of transfusion of fresh and preserved whole blood on bleeding in patients with acute leukemia. New England Journal of Medicine, 260, 6-11.
    • (1959) New England Journal of Medicine , vol.260 , pp. 6-11
    • Freireich, E.J.1    Schmidt, P.J.2    Schneiderman, M.A.3    Frei III, E.4
  • 22
    • 84860833041 scopus 로고    scopus 로고
    • Bcl-xL-inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores
    • Harper, M.T. & Poole, A.W. (2012) Bcl-xL-inhibitory BH3 mimetic ABT-737 depletes platelet calcium stores. Blood, 119, 4337-4338.
    • (2012) Blood , vol.119 , pp. 4337-4338
    • Harper, M.T.1    Poole, A.W.2
  • 23
    • 0026766379 scopus 로고
    • Apoptotic megakaryocyte dysplasia in the myelodysplastic syndromes
    • Hatfill, S., Fester, E. & Steytler, J. (1992) Apoptotic megakaryocyte dysplasia in the myelodysplastic syndromes. Hematologic Pathology, 6, 87-93.
    • (1992) Hematologic Pathology , vol.6 , pp. 87-93
    • Hatfill, S.1    Fester, E.2    Steytler, J.3
  • 24
    • 0942287736 scopus 로고    scopus 로고
    • Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura
    • Houwerzijl, E., Blom, N., van der Want, J., Esselink, M., Koornstra, J., Smit, J., Louwes, H., Vellenga, E. & de Wolf, J. (2004) Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Blood, 103, 500-506.
    • (2004) Blood , vol.103 , pp. 500-506
    • Houwerzijl, E.1    Blom, N.2    van der Want, J.3    Esselink, M.4    Koornstra, J.5    Smit, J.6    Louwes, H.7    Vellenga, E.8    de Wolf, J.9
  • 25
    • 18244369756 scopus 로고    scopus 로고
    • Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients
    • Houwerzijl, E.J., Blom, N.R., van der Want, J.J.L., Louwes, H., Esselink, M.T., Smit, J.W., Vellenga, E. & de Wolf, J.T.M. (2005) Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients. Blood, 105, 3472-3479.
    • (2005) Blood , vol.105 , pp. 3472-3479
    • Houwerzijl, E.J.1    Blom, N.R.2    van der Want, J.J.L.3    Louwes, H.4    Esselink, M.T.5    Smit, J.W.6    Vellenga, E.7    de Wolf, J.T.M.8
  • 27
    • 84898059237 scopus 로고    scopus 로고
    • Cell death in the hematopoietic system
    • (eds. by Yin, X.M. & Dong, Z.) Humana Press Inc., New York, NY.
    • Josefsson, E.C. & Kile, B.T. (2009) Cell death in the hematopoietic system. In: Essentials of Apoptosis (eds. by Yin, X.M. & Dong, Z.), pp. 443-459. Humana Press Inc., New York, NY.
    • (2009) Essentials of Apoptosis , pp. 443-459
    • Josefsson, E.C.1    Kile, B.T.2
  • 29
    • 84882725666 scopus 로고    scopus 로고
    • The regulation of platelet life span
    • (ed. by Michelson, A.D.) Elsevier/Academic Press, Amsterdam, The Netherlands.
    • Josefsson, E.C., Dowling, M.R., Lebois, M. & Kile, B.T. (2013) The regulation of platelet life span. In: Platelets (ed. by Michelson, A.D.), pp. 51-65. Elsevier/Academic Press, Amsterdam, The Netherlands.
    • (2013) Platelets , pp. 51-65
    • Josefsson, E.C.1    Dowling, M.R.2    Lebois, M.3    Kile, B.T.4
  • 32
    • 0036721472 scopus 로고    scopus 로고
    • BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation
    • Kaluzhny, Y., Yu, G., Sun, S., Toselli, P., Nieswandt, B., Jackson, C. & Ravid, K. (2002) BclxL overexpression in megakaryocytes leads to impaired platelet fragmentation. Blood, 100, 1670-1678.
    • (2002) Blood , vol.100 , pp. 1670-1678
    • Kaluzhny, Y.1    Yu, G.2    Sun, S.3    Toselli, P.4    Nieswandt, B.5    Jackson, C.6    Ravid, K.7
  • 33
    • 0029914215 scopus 로고    scopus 로고
    • The thrombocytopenia of cancer. Prospects for effective cytokine therapy
    • Kaushansky, K. (1996) The thrombocytopenia of cancer. Prospects for effective cytokine therapy. Hematology/Oncology Clinics of North America, 10, 431-455.
    • (1996) Hematology/Oncology Clinics of North America , vol.10 , pp. 431-455
    • Kaushansky, K.1
  • 35
    • 0015383455 scopus 로고
    • Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J., Wyllie, A. & Currie, A. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. British Journal of Cancer, 26, 239-257.
    • (1972) British Journal of Cancer , vol.26 , pp. 239-257
    • Kerr, J.1    Wyllie, A.2    Currie, A.3
  • 36
    • 0037040982 scopus 로고    scopus 로고
    • Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways
    • Kirito, K., Watanabe, T., Sawada, K.-I., Endo, H., Ozawa, K. & Komatsu, N. (2002) Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways. The Journal of Biological Chemistry, 277, 8329-8337.
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 8329-8337
    • Kirito, K.1    Watanabe, T.2    Sawada, K.-I.3    Endo, H.4    Ozawa, K.5    Komatsu, N.6
  • 39
    • 34250183122 scopus 로고    scopus 로고
    • Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL
    • Kozuma, Y., Kojima, H., Yuki, S., Suzuki, H. & Nagasawa, T. (2007) Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL. Journal of Thrombosis and Haemostasis, 5, 1274-1282.
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , pp. 1274-1282
    • Kozuma, Y.1    Kojima, H.2    Yuki, S.3    Suzuki, H.4    Nagasawa, T.5
  • 42
    • 0010980106 scopus 로고
    • Determination of the life of human blood platelets using labelled diisopropylfluorophosphanate
    • Leeksma, C. & Cohen, J. (1955) Determination of the life of human blood platelets using labelled diisopropylfluorophosphanate. Nature, 175, 552-553.
    • (1955) Nature , vol.175 , pp. 552-553
    • Leeksma, C.1    Cohen, J.2
  • 43
    • 84856527134 scopus 로고    scopus 로고
    • Apoptosis in the anucleate platelet
    • Leytin, V. (2012) Apoptosis in the anucleate platelet. Blood Reviews, 26, 51-63.
    • (2012) Blood Reviews , vol.26 , pp. 51-63
    • Leytin, V.1
  • 44
    • 0033725182 scopus 로고    scopus 로고
    • The mechanism of apoptosis in human platelets during storage
    • Li, J., Xia, Y., Bertino, A.M., Coburn, J.P. & Kuter, D.J. (2000) The mechanism of apoptosis in human platelets during storage. Transfusion, 40, 1320-1329.
    • (2000) Transfusion , vol.40 , pp. 1320-1329
    • Li, J.1    Xia, Y.2    Bertino, A.M.3    Coburn, J.P.4    Kuter, D.J.5
  • 52
    • 84869080924 scopus 로고    scopus 로고
    • Activation of caspases-9, -3 and -8 in human platelets triggered by BH3-only mimetic ABT-737 and calcium ionophore A23187: caspase-8 is activated via bypass of the death receptors
    • Mutlu, A., Gyulkhandanyan, A.V., Freedman, J. & Leytin, V. (2012) Activation of caspases-9, -3 and -8 in human platelets triggered by BH3-only mimetic ABT-737 and calcium ionophore A23187: caspase-8 is activated via bypass of the death receptors. British Journal of Haematology, 159, 565-571.
    • (2012) British Journal of Haematology , vol.159 , pp. 565-571
    • Mutlu, A.1    Gyulkhandanyan, A.V.2    Freedman, J.3    Leytin, V.4
  • 55
    • 0033567901 scopus 로고    scopus 로고
    • Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment
    • Ogilvy, S., Metcalf, D., Gibson, L., Bath, M., Harris, A. & Adams, J. (1999) Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Blood, 94, 1855-1863.
    • (1999) Blood , vol.94 , pp. 1855-1863
    • Ogilvy, S.1    Metcalf, D.2    Gibson, L.3    Bath, M.4    Harris, A.5    Adams, J.6
  • 57
    • 84863781835 scopus 로고    scopus 로고
    • Ruxolitinib for myelofibrosis therapy: current context, pros and cons
    • Pardanani, A. (2012) Ruxolitinib for myelofibrosis therapy: current context, pros and cons. Leukemia, 26, 1449-1451.
    • (2012) Leukemia , vol.26 , pp. 1449-1451
    • Pardanani, A.1
  • 59
    • 85047689942 scopus 로고
    • Fate of senescent megakaryocytes in the bone marrow
    • Radley, J. & Haller, C. (1983) Fate of senescent megakaryocytes in the bone marrow. British Journal of Haematology, 53, 277-287.
    • (1983) British Journal of Haematology , vol.53 , pp. 277-287
    • Radley, J.1    Haller, C.2
  • 60
    • 0036794390 scopus 로고    scopus 로고
    • Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
    • Rathmell, J., Lindsten, T., Zong, W. & Thompson, C. (2002) Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nature Immunology, 3, 932-939.
    • (2002) Nature Immunology , vol.3 , pp. 932-939
    • Rathmell, J.1    Lindsten, T.2    Zong, W.3    Thompson, C.4
  • 64
    • 84872874344 scopus 로고    scopus 로고
    • Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers
    • Schattner, M., Rivadeneyra, L., Pozner, R.G. & Gomez, R.M. (2013) Pathogenic mechanisms involved in the hematological alterations of arenavirus-induced hemorrhagic fevers. Viruses, 5, 340-351.
    • (2013) Viruses , vol.5 , pp. 340-351
    • Schattner, M.1    Rivadeneyra, L.2    Pozner, R.G.3    Gomez, R.M.4
  • 65
    • 84856603735 scopus 로고    scopus 로고
    • Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function
    • Schoenwaelder, S.M. & Jackson, S.P. (2012) Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function. Blood, 119, 1320-1321.
    • (2012) Blood , vol.119 , pp. 1320-1321
    • Schoenwaelder, S.M.1    Jackson, S.P.2
  • 69
    • 77049147737 scopus 로고
    • Collection, preservation and transfusion of platelets; with special reference to the factors affecting the survival rate and the clinical effectiveness of transfused platelets
    • Stefanini, M. & Dameshek, W. (1953) Collection, preservation and transfusion of platelets; with special reference to the factors affecting the survival rate and the clinical effectiveness of transfused platelets. New England Journal of Medicine, 248, 797-802.
    • (1953) New England Journal of Medicine , vol.248 , pp. 797-802
    • Stefanini, M.1    Dameshek, W.2
  • 70
    • 33644763298 scopus 로고    scopus 로고
    • Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis
    • Temkin, V., Huang, Q., Liu, H., Osada, H. & Pope, R.M. (2006) Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Molecular and Cellular Biology, 26, 2215-2225.
    • (2006) Molecular and Cellular Biology , vol.26 , pp. 2215-2225
    • Temkin, V.1    Huang, Q.2    Liu, H.3    Osada, H.4    Pope, R.M.5
  • 71
    • 0020956854 scopus 로고
    • Density distribution and size of megakaryocytes in inflammatory reactions of the bone marrow (myelitis) and chronic myeloproliferative diseases
    • Thiele, J., Holgado, S., Choritz, H. & Georgii, A. (1983) Density distribution and size of megakaryocytes in inflammatory reactions of the bone marrow (myelitis) and chronic myeloproliferative diseases. Scandinavian Journal of Haematology, 31, 329-341.
    • (1983) Scandinavian Journal of Haematology , vol.31 , pp. 329-341
    • Thiele, J.1    Holgado, S.2    Choritz, H.3    Georgii, A.4
  • 73
    • 0031457994 scopus 로고    scopus 로고
    • Alterations in Bcl-2/Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis
    • Vanags, D.M. & Orrenius, S. (1997) Alterations in Bcl-2/Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis. British Journal of Haematology, 99, 824-831.
    • (1997) British Journal of Haematology , vol.99 , pp. 824-831
    • Vanags, D.M.1    Orrenius, S.2
  • 76
    • 84856606959 scopus 로고    scopus 로고
    • Response: BH3 mimetics modulate calcium homeostasis in platelets
    • Vogler, M., Goodall, A.H. & Cohen, G.M. (2012) Response: BH3 mimetics modulate calcium homeostasis in platelets. Blood, 119, 1321-1322.
    • (2012) Blood , vol.119 , pp. 1321-1322
    • Vogler, M.1    Goodall, A.H.2    Cohen, G.M.3
  • 83
    • 0033199115 scopus 로고    scopus 로고
    • Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation
    • Wolf, B., Goldstein, J., Stennicke, H., Beere, H., Amarante-Mendes, G., Salvesen, G. & Green, D. (1999) Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. Blood, 94, 1683-1692.
    • (1999) Blood , vol.94 , pp. 1683-1692
    • Wolf, B.1    Goldstein, J.2    Stennicke, H.3    Beere, H.4    Amarante-Mendes, G.5    Salvesen, G.6    Green, D.7
  • 84
    • 78650175369 scopus 로고    scopus 로고
    • zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway
    • Wu, Y.-T., Tan, H.-L., Huang, Q., Sun, X.-J., Zhu, X. & Shen, H.-M. (2011) zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway. Cell Death and Differentiation, 18, 26-37.
    • (2011) Cell Death and Differentiation , vol.18 , pp. 26-37
    • Wu, Y.-T.1    Tan, H.-L.2    Huang, Q.3    Sun, X.-J.4    Zhu, X.5    Shen, H.-M.6
  • 85
    • 78549239285 scopus 로고    scopus 로고
    • Contributions of TRAIL-mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia
    • Yang, L., Wang, L., Zhao, C.-H., Zhu, X.-J., Hou, Y., Jun, P. & Hou, M. (2010) Contributions of TRAIL-mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia. Blood, 116, 4307-4316.
    • (2010) Blood , vol.116 , pp. 4307-4316
    • Yang, L.1    Wang, L.2    Zhao, C.-H.3    Zhu, X.-J.4    Hou, Y.5    Jun, P.6    Hou, M.7
  • 86
    • 77953646713 scopus 로고    scopus 로고
    • P-selectin-dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection
    • Yeh, J.-J., Tsai, S., Wu, D.-C., Wu, J.-Y., Liu, T.-C. & Chen, A. (2010) P-selectin-dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection. Blood, 115, 4247-4253.
    • (2010) Blood , vol.115 , pp. 4247-4253
    • Yeh, J.-J.1    Tsai, S.2    Wu, D.-C.3    Wu, J.-Y.4    Liu, T.-C.5    Chen, A.6
  • 87
    • 0033607006 scopus 로고    scopus 로고
    • Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
    • Yin, X., Wang, K., Gross, A., Zhao, Y., Zinkel, S., Klocke, B., Roth, K. & Korsmeyer, S. (1999) Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature, 400, 886-891.
    • (1999) Nature , vol.400 , pp. 886-891
    • Yin, X.1    Wang, K.2    Gross, A.3    Zhao, Y.4    Zinkel, S.5    Klocke, B.6    Roth, K.7    Korsmeyer, S.8
  • 88
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: opposing activities that mediate cell death
    • Youle, R.J. & Strasser, A. (2008) The BCL-2 protein family: opposing activities that mediate cell death. Nature Reviews Molecular Cell Biology, 9, 47-59.
    • (2008) Nature Reviews Molecular Cell Biology , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 92
    • 79952780505 scopus 로고    scopus 로고
    • Functional complementation between FADD and RIP1 in embryos and lymphocytes
    • Zhang, H., Zhou, X., Mcquade, T., Li, J., Chan, F.K.-M. & Zhang, J. (2011) Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature, 471, 373-376.
    • (2011) Nature , vol.471 , pp. 373-376
    • Zhang, H.1    Zhou, X.2    Mcquade, T.3    Li, J.4    Chan, F.-M.5    Zhang, J.6
  • 94
    • 0024344474 scopus 로고
    • Structural changes in the megakaryocytes of patients infected with the human immune deficiency virus (HIV-1)
    • Zucker-Franklin, D., Termin, C. & Cooper, M. (1989) Structural changes in the megakaryocytes of patients infected with the human immune deficiency virus (HIV-1). American Journal of Pathology, 134, 1295-1303.
    • (1989) American Journal of Pathology , vol.134 , pp. 1295-1303
    • Zucker-Franklin, D.1    Termin, C.2    Cooper, M.3
  • 95
    • 0017387155 scopus 로고
    • Membrane asymmetry and blood coagulation
    • Zwaal, R.F., Comfurius, P. & van Deenen, L.L. (1977) Membrane asymmetry and blood coagulation. Nature, 268, 358-360.
    • (1977) Nature , vol.268 , pp. 358-360
    • Zwaal, R.F.1    Comfurius, P.2    van Deenen, L.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.