BH3 mimetics modulate calcium homeostasis in platelets

Blood

Volumn 119, Issue 5, 2012, Pages 1321-1322

  Vogler, Meike ^a   Goodall, Alison H ^b   Cohen, Gerald M ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; BH3 PROTEIN; CALCIUM; CASPASE; NAVITOCLAX;

APOPTOSIS; CALCIUM BLOOD LEVEL; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL DENSITY; CHRONIC LYMPHATIC LEUKEMIA; DRUG EFFICACY; DUST EXPOSURE; ENZYME ACTIVATION; HUMAN; IN VIVO STUDY; LETTER; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN BINDING; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTOPATHY;

EID: 84856606959     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-12-393397     Document Type: Letter

References (4)

1. L-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function. Blood. 2012;119(5):1320-1321.
2. Schoenwaelder SM, Jarman KE, Gardiner EE, et al. Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood. 2011;118(6):1663-1674.
3. Vogler M, Hamali HA, Sun XM, et al. BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation. Blood. 2011;117(26):7145-7154.
4. Vogler M, Furdas SD, Jung M, Kuwana T, Dyer MJ, Cohen GM. Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood. Clin Cancer Res. 2010;16(16):4217-4225.