메뉴 건너뛰기




Volumn 119, Issue 24, 2012, Pages 5850-5858

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; PROTEIN BCL XL; PROTEIN MCL 1;

EID: 84862496374     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-12-398834     Document Type: Article
Times cited : (72)

References (41)
  • 2
    • 0033552631 scopus 로고    scopus 로고
    • Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes
    • DOI 10.1083/jcb.147.6.1299
    • Italiano J, Lecine P, Shivdasani R, Hartwig J. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999;147(6):1299-1312. (Pubitemid 30012814)
    • (1999) Journal of Cell Biology , vol.147 , Issue.6 , pp. 1299-1312
    • Italiano Jr., J.E.1    Lecine, P.2    Shivdasani, R.A.3    Hartwig, J.H.4
  • 3
    • 0017260175 scopus 로고
    • The transmural passage of blood cells into myeloid sinusoids and the entry of platelets into the sinusoidal circulation; a scanning electron microscopic investigation
    • Becker RP, De Bruyn PP. The transmural passage of blood cells into myeloid sinusoids and the entry of platelets into the sinusoidal circulation; a scanning electron microscopic investigation. Am J Anat. 1976;145(2):183-205.
    • (1976) Am J Anat , vol.145 , Issue.2 , pp. 183-205
    • Becker, R.P.1    De Bruyn, P.P.2
  • 4
    • 0010980106 scopus 로고
    • Determination of the life of human blood platelets using labelled diisopropylfluorophosphanate
    • Leeksma C, Cohen J. Determination of the life of human blood platelets using labelled diisopropylfluorophosphanate. Nature. 1955;175(4456):552-553.
    • (1955) Nature , vol.175 , Issue.4456 , pp. 552-553
    • Leeksma, C.1    Cohen, J.2
  • 5
    • 0029127976 scopus 로고
    • In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation
    • Ault KA, Knowles C. In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation. Exp Hematol. 1995;23(9):996-1001.
    • (1995) Exp Hematol , vol.23 , Issue.9 , pp. 996-1001
    • Ault, K.A.1    Knowles, C.2
  • 6
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 2008;9(1):47-59.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , Issue.1 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 8
    • 77952737960 scopus 로고    scopus 로고
    • Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice
    • Kodama T, Takehara T, Hikita H, et al. Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice. Gastroenterology. 2010;138(7):2487-2498.
    • (2010) Gastroenterology , vol.138 , Issue.7 , pp. 2487-2498
    • Kodama, T.1    Takehara, T.2    Hikita, H.3
  • 9
    • 80555150785 scopus 로고    scopus 로고
    • Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
    • Josefsson EC, James C, Henley KJ, et al. Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med. 2011;208(10):2017-2031.
    • (2011) J Exp Med , vol.208 , Issue.10 , pp. 2017-2031
    • Josefsson, E.C.1    James, C.2    Henley, K.J.3
  • 11
    • 44849112219 scopus 로고    scopus 로고
    • ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor
    • Tse C, Shoemaker AR, Adickes J, et al. ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 2008;68(9):3421-3428.
    • (2008) Cancer Res , vol.68 , Issue.9 , pp. 3421-3428
    • Tse, C.1    Shoemaker, A.R.2    Adickes, J.3
  • 12
    • 78649460021 scopus 로고    scopus 로고
    • Platelet senescence and phosphatidylserine exposure
    • Dasgupta SK, Argaiz ER, Mercado JE, et al. Platelet senescence and phosphatidylserine exposure. Transfusion. 2010;50(10):2167-2175.
    • (2010) Transfusion , vol.50 , Issue.10 , pp. 2167-2175
    • Dasgupta, S.K.1    Argaiz, E.R.2    Mercado, J.E.3
  • 13
    • 67649541305 scopus 로고    scopus 로고
    • Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function
    • Schoenwaelder SM, Yuan Y, Josefsson EC, et al. Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood. 2009;114(3):663-666.
    • (2009) Blood , vol.114 , Issue.3 , pp. 663-666
    • Schoenwaelder, S.M.1    Yuan, Y.2    Josefsson, E.C.3
  • 14
    • 79959828108 scopus 로고    scopus 로고
    • BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation
    • Vogler M, Hamali HA, Sun XM, et al. BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation. Blood. 2011;117(26):7145-7154.
    • (2011) Blood , vol.117 , Issue.26 , pp. 7145-7154
    • Vogler, M.1    Hamali, H.A.2    Sun, X.M.3
  • 16
    • 80051606228 scopus 로고    scopus 로고
    • Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets
    • Schoenwaelder SM, Jarman KE, Gardiner EE, et al. Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets. Blood. 2011;118(6):1663-1674.
    • (2011) Blood , vol.118 , Issue.6 , pp. 1663-1674
    • Schoenwaelder, S.M.1    Jarman, K.E.2    Gardiner, E.E.3
  • 17
    • 84863116430 scopus 로고    scopus 로고
    • Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: Results of a phase I study of navitoclax in patients with relapsed or refractory disease
    • Roberts AW, Seymour JF, Brown JR, et al. Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease. J Clin Oncol. 2012;30(5):488-496.
    • (2012) J Clin Oncol , vol.30 , Issue.5 , pp. 488-496
    • Roberts, A.W.1    Seymour, J.F.2    Brown, J.R.3
  • 18
    • 78649630259 scopus 로고    scopus 로고
    • Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: A phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
    • Wilson WH, O'Connor OA, Czuczman MS, et al. Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity. Lancet Oncol. 2010;11(12):1149-1159.
    • (2010) Lancet Oncol , vol.11 , Issue.12 , pp. 1149-1159
    • Wilson, W.H.1    O'Connor, O.A.2    Czuczman, M.S.3
  • 19
    • 33846914830 scopus 로고    scopus 로고
    • The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages
    • DOI 10.1182/blood-2006-03-013771
    • Dzhagalov I, St John A, He Y. The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages. Blood. 2007;109(4):1620-1626. (Pubitemid 46239596)
    • (2007) Blood , vol.109 , Issue.4 , pp. 1620-1626
    • Dzhagalov, I.1    St., J.A.2    He, Y.-W.3
  • 20
    • 13844319184 scopus 로고    scopus 로고
    • Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells
    • DOI 10.1126/science.1106114
    • Opferman J, Iwasaki H, Ong C, et al. Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells. Science. 2005;307(5712):1101- 1104. (Pubitemid 40262114)
    • (2005) Science , vol.307 , Issue.5712 , pp. 1101-1104
    • Opferman, J.T.1    Iwasaki, H.2    Ong, C.C.3    Suh, H.4    Mizuno, S.-I.5    Akashi, K.6    Korsmeyer, S.J.7
  • 21
    • 0348148880 scopus 로고    scopus 로고
    • Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    • DOI 10.1038/nature02067
    • Opferman J, Letai A, Beard C, Sorcinelli M, Ong C, Korsmeyer S. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003;426(6967):671-676. (Pubitemid 38009376)
    • (2003) Nature , vol.426 , Issue.6967 , pp. 671-676
    • Opferman, J.T.1    Letai, A.2    Beard, C.3    Sorcinelli, M.D.4    Ong, C.C.5    Korsmeyer, S.J.6
  • 22
    • 0034463161 scopus 로고    scopus 로고
    • Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis
    • Rucker EB, 3rd Dierisseau P, Wagner KU, et al. Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol Endocrinol. 2000;14(7):1038-1052.
    • (2000) Mol Endocrinol , vol.14 , Issue.7 , pp. 1038-1052
    • Rucker III, E.B.1    Dierisseau, P.2    Wagner, K.U.3
  • 23
    • 33846911975 scopus 로고    scopus 로고
    • Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo
    • DOI 10.1182/blood-2006-04-020362
    • Tiedt R, Schomber T, Hao-Shen H, Skoda RC. Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood. 2007;109(4):1503-1506. (Pubitemid 46239582)
    • (2007) Blood , vol.109 , Issue.4 , pp. 1503-1506
    • Tiedt, R.1    Schomber, T.2    Hao-Shen, H.3    Skoda, R.C.4
  • 24
    • 0029960265 scopus 로고    scopus 로고
    • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl
    • Alexander W, Roberts A, Nicola N, Li R, Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl. Blood. 1996;87(6):2162-2170.
    • (1996) Blood , vol.87 , Issue.6 , pp. 2162-2170
    • Alexander, W.1    Roberts, A.2    Nicola, N.3    Li, R.4    Metcalf, D.5
  • 25
    • 69549138554 scopus 로고    scopus 로고
    • Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage
    • Kruse EA, Loughran SJ, Baldwin TM, et al. Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A. 2009;106(33):13814-13819.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.33 , pp. 13814-13819
    • Kruse, E.A.1    Loughran, S.J.2    Baldwin, T.M.3
  • 26
    • 0343906556 scopus 로고
    • Platelet sequestration in man. I. Methods
    • Aster RH, Jandl JH. Platelet sequestration in man. I. Methods. J Clin Invest. 1964;43:843-855.
    • (1964) J Clin Invest , vol.43 , pp. 843-855
    • Aster, R.H.1    Jandl, J.H.2
  • 27
    • 77956582335 scopus 로고    scopus 로고
    • Platelet senescence is regulated by an internal timer, not damage inflicted by hits
    • Dowling MR, Josefsson EC, Henley KJ, Hodgkin PD, Kile BT. Platelet senescence is regulated by an internal timer, not damage inflicted by hits. Blood. 2010;116(10):1776-1778.
    • (2010) Blood , vol.116 , Issue.10 , pp. 1776-1778
    • Dowling, M.R.1    Josefsson, E.C.2    Henley, K.J.3    Hodgkin, P.D.4    Kile, B.T.5
  • 28
    • 77952885004 scopus 로고    scopus 로고
    • Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling
    • Bertozzi CC, Schmaier AA, Mericko P, et al. Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling. Blood. 2010;116(4):661-670.
    • (2010) Blood , vol.116 , Issue.4 , pp. 661-670
    • Bertozzi, C.C.1    Schmaier, A.A.2    Mericko, P.3
  • 29
    • 77951296956 scopus 로고    scopus 로고
    • Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis
    • Carramolino L, Fuentes J, Garcia-Andres C, Azcoitia V, Riethmacher D, Torres M. Platelets play an essential role in separating the blood and lymphatic vasculatures during embryonic angiogenesis. Circ Res. 2010;106(7):1197-1201.
    • (2010) Circ Res , vol.106 , Issue.7 , pp. 1197-1201
    • Carramolino, L.1    Fuentes, J.2    Garcia-Andres, C.3    Azcoitia, V.4    Riethmacher, D.5    Torres, M.6
  • 30
    • 0023756168 scopus 로고
    • The ultrastructure of megakaryopoietic cells of the yolk sac and liver in mouse embryo
    • Matsumura G, Sasaki K. The ultrastructure of megakaryopoietic cells of the yolk sac and liver in mouse embryo. Anat Rec. 1988;222(2):164-169.
    • (1988) Anat Rec , vol.222 , Issue.2 , pp. 164-169
    • Matsumura, G.1    Sasaki, K.2
  • 31
    • 33846907357 scopus 로고    scopus 로고
    • The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis
    • DOI 10.1182/blood-2006-06-031898
    • Tober J, Koniski A, McGrath KE, et al. The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis. Blood. 2007;109(4):1433-1441. (Pubitemid 46239574)
    • (2007) Blood , vol.109 , Issue.4 , pp. 1433-1441
    • Tober, J.1    Koniski, A.2    McGrath, K.E.3    Vemishetti, R.4    Emerson, R.5    De Mesy-Bentley, K.K.L.6    Waugh, R.7    Palis, J.8
  • 32
    • 0038046166 scopus 로고    scopus 로고
    • Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation
    • DOI 10.1101/gad.1093903
    • Nijhawan D, Fang M, Traer E, et al. Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev. 2003;17(12):1475-1486. (Pubitemid 36734705)
    • (2003) Genes and Development , vol.17 , Issue.12 , pp. 1475-1486
    • Nijhawan, D.1    Fang, M.2    Traer, E.3    Zhong, Q.4    Gao, W.5    Du, F.6    Wang, X.7
  • 33
  • 34
    • 18244369756 scopus 로고    scopus 로고
    • Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients
    • DOI 10.1182/blood-2004-06-2108
    • Houwerzijl EJ, Blom NR, van der Want JJL, et al. Increased peripheral platelet destruction and caspase-3-independent programmed cell death of bone marrow megakaryocytes in myelodysplastic patients. Blood. 2005;105(9):3472-3479. (Pubitemid 40628188)
    • (2005) Blood , vol.105 , Issue.9 , pp. 3472-3479
    • Houwerzijl, E.J.1    Blom, N.R.2    Van Der, W.J.J.L.3    Louwes, H.4    Esselink, M.T.5    Smit, J.W.6    Vellenga, E.7    De Wolf, J.Th.M.8
  • 36
    • 33750353416 scopus 로고    scopus 로고
    • Megakaryocytic dysfunction in myelodysplastic syndromes and idiopathic thrombocytopenic purpura is in part due to different forms of cell death
    • DOI 10.1038/sj.leu.2404385, PII 2404385
    • Houwerzijl EJ, Blom NR, van der Want JJL, Vellenga E, de Wolf JTM. Megakaryocytic dysfunction in myelodysplastic syndromes and idiopathic thrombocytopenic purpura is in part due to different forms of cell death. Leukemia. 2006;20(11):1937-1942. (Pubitemid 44614881)
    • (2006) Leukemia , vol.20 , Issue.11 , pp. 1937-1942
    • Houwerzijl, E.J.1    Blom, N.R.2    Van Der Want, J.J.L.3    Vellenga, E.4    De Wolf, J.T.M.5
  • 37
    • 79954584820 scopus 로고    scopus 로고
    • Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes
    • Liu ZJ, Italiano J Jr, Ferrer-Marin F, et al. Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes. Blood. 2011;117(15):4106-4117.
    • (2011) Blood , vol.117 , Issue.15 , pp. 4106-4117
    • Liu, Z.J.1    Italiano Jr., J.2    Ferrer-Marin, F.3
  • 38
    • 83355166908 scopus 로고    scopus 로고
    • The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo
    • Chen J, Jin S, Abraham V, et al. The Bcl-2/Bcl-X(L)/Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo. Mol Cancer Ther. 2011;10(12):2340-2349.
    • (2011) Mol Cancer Ther , vol.10 , Issue.12 , pp. 2340-2349
    • Chen, J.1    Jin, S.2    Abraham, V.3
  • 39
    • 79952112980 scopus 로고    scopus 로고
    • Drugs targeting Bcl-2 family members as an emerging strategy in cancer
    • Leber B, Geng F, Kale J, Andrews DW. Drugs targeting Bcl-2 family members as an emerging strategy in cancer. Expert Rev Mol Med. 2010;12:e28.
    • (2010) Expert Rev Mol Med , vol.12
    • Leber, B.1    Geng, F.2    Kale, J.3    Andrews, D.W.4
  • 41
    • 77958048793 scopus 로고    scopus 로고
    • Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR
    • Petros AM, Huth JR, Oost T, et al. Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. Bioorg Med Chem Lett. 2010;20(22):6587-6591.
    • (2010) Bioorg Med Chem Lett , vol.20 , Issue.22 , pp. 6587-6591
    • Petros, A.M.1    Huth, J.R.2    Oost, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.