Activation of caspases-9, -3 and -8 in human platelets triggered by BH3-only mimetic ABT-737 and calcium ionophore A23187: Caspase-8 is activated via bypass of the death receptors

British Journal of Haematology

Volumn 159, Issue 5, 2012, Pages 565-571

  Mutlu, Asuman ^a   Gyulkhandanyan, Armen V ^a   Freedman, John ^a,b,c   Leytin, Valery ^a,b,c,d  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b Toronto Platelet Immunobiology Group   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d RYERSON UNIVERSITY   (Canada)

Author keywords

BH3 only mimetic ABT 737; Calcium ionophore A23187; Caspases; Platelet activation; Platelet apoptosis

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; CALCIMYCIN; CASPASE 3; CASPASE 8; CASPASE 9; DEATH RECEPTOR; PADGEM PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE DEPOLARIZATION; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE MEMBRANE;

APOPTOSIS; BIOMIMETIC MATERIALS; BIPHENYL COMPOUNDS; BLOOD PLATELETS; CALCIMYCIN; CALCIUM IONOPHORES; CASPASES; ENZYME ACTIVATION; HUMANS; ISOENZYMES; MITOCHONDRIA; NITROPHENOLS; PIPERAZINES; PLATELET ACTIVATION; RECEPTORS, DEATH DOMAIN; SULFONAMIDES;

EID: 84869080924     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12066     Document Type: Article

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