Phenolic-enriched fractions from brewers' spent grain possess cellular antioxidant and immunomodulatory effects in cell culture model systems

Journal of the Science of Food and Agriculture

Volumn 94, Issue 7, 2014, Pages 1373-1379

  Mccarthy, Aoife L ^a   O'Callaghan, Yvonne C ^a   Connolly, Alan ^b   Piggott, Charles O ^b   Fitzgerald, Richard J ^b   O'Brien, Nora M ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY OF LIMERICK   (Ireland)

Author keywords

Anti inflammatory; Antioxidant; Brewers' spent grain (BSG); Phenolic extracts

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; COUMARIC ACID; CYTOKINE; IMMUNOLOGIC FACTOR; INDUSTRIAL WASTE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENOL DERIVATIVE; PLANT EXTRACT;

ANALYSIS; ANTAGONISTS AND INHIBITORS; BEER; CEREAL; CHEMISTRY; COMPARATIVE STUDY; DIET SUPPLEMENTATION; ECONOMICS; ENZYMOLOGY; FOOD INDUSTRY; HUMAN; IMMUNOLOGY; INDUSTRIAL WASTE; IRELAND; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MONOCYTE; PIGMENTATION; RECYCLING; T CELL LEUKEMIA; TUMOR CELL LINE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; BEER; CELL LINE, TUMOR; CEREALS; COUMARIC ACIDS; CYTOKINES; FOOD, FORTIFIED; FOOD-PROCESSING INDUSTRY; HUMANS; IMMUNOLOGIC FACTORS; INDUSTRIAL WASTE; IRELAND; LEUKEMIA, T-CELL; MONOCYTES; PHENOLS; PIGMENTATION; PLANT EXTRACTS; RECYCLING;

EID: 84897963491     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.6421     Document Type: Article

References (42)

1. Fillaudeau L, Blanpain-Avet P and Daufin G, Water, wastewater and waste management in brewing industries. J Clean Prod 14:463-471 (2006).
2. Reinold MR, Manual pratico de cervejaria. Aden Editora e Comunicacoes Ltda, Sao Paulo (1997).
3. Mussatto S, Dragone G and Roberto I, Brewers' spent grain: generation, characteristics and potential applications. J Cereal Sci 43:1-14 (2006).
4. McCarthy AL, McCarthy AL, O'Callaghan YC, Neugart S, Piggott CO, Connolly A, Jansen MAK, Krumbein A, Schreiner M, FitzGerald RJ and O'Brien NM, The hydroxycinnamic acid content of barley and brewers' spent grain (BSG) and the potential to incorporate phenolic extracts of BSG as antioxidants into fruit beverages. Food Chem 141:2567-2574 (2013).
5. Pragasam SJ, Venkatesan V and Rasool MK, Immunomodulatory and anti-inflammatory effect of p-coumaric acid: a common dietary polyphenol on experimental inflammation in rats. Inflammation 36:169-176 (2013).
6. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA et al., Atherosclerosis: basic mechanisms: oxidation, inflammation, and genetics. Circulation 91:2488-2496 (1995).
7. Salloway S, Mintzer J, Weiner MF and Cummings JL, Disease-modifying therapies in Alzheimer's disease. Alzheimers Dement 4:65-79 (2008).
8. Hald A and Lotharius J, Oxidative stress and inflammation in Parkinson's disease: is there a causal link? Exp Neurol 193:279-290 (2005).
9. Chen JH and Ho CT, Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds. J Agric Food Chem 45:2374-2378 (1997).
10. Nardini M, D'Aquino M, Tomassi G, Gentili V, Di Felice M and Scaccini C, Inhibition of human low-density lipoprotein oxidation by caffeic acid and other hydroxycinnamic acid derivatives. Free Radical Bio Med 19:541-552 (1995).
11. McCarthy AL, O'Callaghan YC, Connolly A, Piggott CO, FitzGerald RJ and O'Brien NM, Phenolic extracts of brewers' spent grain (BSG) as functional ingredients: assessment of their DNA protective effect against oxidant-induced DNA single strand breaks in U937 cells. Food Chem 134:641-646 (2012).
12. Mansour RB, Gargouri B, Bouaziz M, Elloumi N, Jilani IB, Ghrabi Z et al., Antioxidant activity of ethanolic extract of inflorescence of Ormenis Africana in vitro and in cell cultures. Lipids Health Dis 10:78-84 (2011).
13. Hissin PJ and Hilf R, A fluorometric method for determination of oxidised and reduced glutathione in tissues. Anal Biochem 74:214-226 (1976).
14. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD et al., Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85 (1985).
15. Nakagawa H, Hasumi K, Woo J-T, Nagai K and Wachi M, Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate. Carcinogenesis 25:1567-1574 (2004).
16. Whitton P, Inflammation as a causative factor in the aetiology of Parkinson's disease. Br J Pharmacol 150:963-976 (2009).
17. Holmes C, Cunningham C, Zotova E, Woolford J, Dean C, Kerr S et al., Systemic inflammation and disease progression in Alzheimer disease. Neurology 73:768-774 (2009).
18. Papadakis KA and Targan SR, Role of cytokines in the pathogenesis of inflammatory bowel disease. Annu Rev Med 51:289-298 (2000).
19. Feldmann M, Brennan FM and Maini RN, Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397-440 (1996).
20. Spellberg B and Edwards JE, Type 1/Type 2 immunity in infectious diseases. Clin Infect Dis 32:76-102 (2001).
21. Khajuria A, Gupta A, Suden P, Singh S, Malik F, Singh J et al., Srinivas V and Ella K, Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata. Phytother Res 22:340-348 (2008).
22. Kikuzaki H, Hisamoto M, Hirose K, Akiyama K and Taniguchi H, Antioxidant properties of ferulic acid and its related compounds. J Agric Food Chem 50:2161-2168 (2002).
23. Hole AS, Grimmer S, Jensen MR and Sahlstrøm S, Synergistic and suppressive effects of dietary phenolic acids and other phytochemicals from cereal extracts on nuclear factor kappa B activity. Food Chem 133:969-977 (2012).
24. Andreasen MF, Landbo A-K, Christensen LP, Hansen Å and Meyer AS, Antioxidant effects of phenolic rye (Secale cereale L.) extracts, monomeric hydroxycinnamates, and ferulic acid dehydrodimers on human low-density lipoproteins. J Agric Food Chem 49:4090-4096 (2001).
25. Youdim KA, McDonald J, Kalt W and Joseph JA, Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults. J Nutr Biochem 13:282-288 (2002).
26. Kim EO, Min KJ, Kwon TK, Um BH, Moreau RA and Choi SW, Anti-inflammatory activity of hydroxycinnamic acid derivatives isolated from corn bran in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food Chem Toxicol 50:1309-1316 (2012).
27. Couper KN, Blount DG and Riley EM, IL-10: the master regulator of immunity to infection. J Immunol 180:5771-5777 (2008).
28. Fubini B and Hubbard A, Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radical Bio Med 34:1507-1516 (2003).
29. Barrett EG, Johnston C, Oberdörster G and Finkelstein JN, Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure. Toxicol Appl Pharm 158:211-220 (1999).
30. Roberts CK and Sindhu KK, Oxidative stress and metabolic syndrome. Life Sci 84:705-712 (2009).
31. Jenner P, Oxidative stress as a cause of Parkinson's disease. Acta Neurol Scand 84:6-15 (2009).
32. Zawia NH, Lahiri DK and Cardozo-Pelaez F, Epigenetics, oxidative stress and Alzheimer's disease. Free Radical Bio Med 46:1241-1249 (2009).
33. Yu J, Ahmedna M and Goktepe I, Effects of processing methods and extraction solvents on concentration and antioxidant activity of peanut skin phenolics. Food Chem 90:199-206 (2005).
34. Obied H, Bedgood D, Prenzler P and Robards K, Bioscreening of Australian olive mill waste extracts: biophenol content, antioxidant, antimicrobial and molluscicidal activities. Food Chem Toxicol 45:1238-1248 (2007).
35. Gorinstein S, Martin-Belloso O, Lojek A, Číž M, Soliva-Fortuny R, Park YS et al., Comparative content of some phytochemicals in Spanish apples, peaches and pears. J Sci Food Agric 82:1166-1170 (2002).
36. Sotillo DR, Hadley M and Holm E, Potato peel waste: stability and antioxidant activity of a freeze-dried extract. J Food Sci 59:1031-1033 (2006).
37. Makris DP, Boskou G and Andrikopoulos NK, Polyphenolic content and in vitro antioxidant characteristics of wine industry and other agri-food solid waste extracts. J Food Compos Anal 20:125-132 (2007).
38. Prentice N, Kissell L, Lindsay R and Yamazaki W, High-fiber cookies containing brewers' spent grain. Cereal Chem 55:712-721 (1978).
39. Öztürk S, Özboy Ö, Cavidoglu I and Köksel H, Effects of brewer's spent grain on the quality and dietary fibre content of cookies. J Inst Brew 108:23-27 (2002).
40. Ainsworth P, Ibanoglu S, Plunkett A, Ibanoglu E and Stojceska V, Effect of brewers spent grain addition and screw speed on the selected physical and nutritional properties of an extruded snack. J Food Eng 81:702-709 (2007).
41. Stojceska V, Ainsworth P and Plunkett A, The recycling of brewer's processing by-product into ready-to-eat snacks using extrusion technology. J Cereal Sci 47:469-479 (2008).
42. Huang D, Ou B and Ronald L, The chemistry behind antioxidant capacity assays. J Agric Food Chem 53:1841-1856 (2005).