Quantitative measurement of delivery and gene silencing activities of siRNA polyplexes containing pyridylthiourea-grafted polyethylenimines

Journal of Controlled Release

Volumn 182, Issue 1, 2014, Pages 1-12

  Pinel, Sophie ^b   Aman, Emmanuel ^a   Erblang, Felix ^a   Dietrich, Jonathan ^a   Frisch, Benoit ^a   Sirman, Julien ^a   Kichler, Antoine ^a   Sibler, Annie Paule ^a   Dontenwill, Monique ^a   Schaffner, Florence ^a   Zuber, Guy ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Glioblastoma; In vivo; Polyethylenimine; Polyplexes; siRNA delivery

Indexed keywords

CELL CULTURE; CELLS; EXPERIMENTS; GENETIC ENGINEERING;

GLIOBLASTOMAS; IN-VIVO; POLYETHYLENIMINES; POLYPLEXES; SIRNA DELIVERY;

RNA;

CONCANAMYCIN A; DRUG CARRIER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; POLYETHYLENEIMINE; PYRIDYLTHIOUREA; SMALL INTERFERING RNA; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; THIOUREA;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VACUOLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; ENDOSOME; FEMALE; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; GLIOBLASTOMA; HEMOLYSIS; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LYSOSOME; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; HAMSTER; METABOLISM; NEOPLASMS; TUMOR CELL LINE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CRICETINAE; FEMALE; GENE SILENCING; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; NEOPLASMS; POLYETHYLENEIMINE; RNA, MESSENGER; RNA, SMALL INTERFERING; THIOUREA;

EID: 84897858887     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.03.001     Document Type: Article

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