Protein kinase A inhibition modulates the intracellular routing of gene delivery vehicles in HeLa cells, leading to productive transfection

Journal of Controlled Release

Volumn 156, Issue 1, 2011, Pages 76-84

  Rehman, Zia Ur ^a   Hoekstra, Dick ^a   Zuhorn, Inge S ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Cellular processing; Endocytosis; Gene delivery; Lipoplex; Polyplex; Protein kinase A

Indexed keywords

CONTROLLED DRUG DELIVERY; EFFICIENCY; ENZYMES; GENE TRANSFER; GENES; LANTHANUM COMPOUNDS; LIPOSOMES; NANOPARTICLES; NUCLEIC ACIDS; TARGETED DRUG DELIVERY;

ENDOCYTOSIS; GENE DELIVERY; LIPOPLEXES; POLYPLEXES; PROTEIN KINASE A;

MOLECULAR BIOLOGY;

CLATHRIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; LIPOPLEX; NANOPARTICLE; NUCLEIC ACID; POLYETHYLENEIMINE; POLYMER; DRUG CARRIER; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; LIPID; LIPOFECTAMINE; OLIGONUCLEOTIDE; PROTEIN KINASE INHIBITOR;

ARTICLE; CAVEOLA; CELL MIGRATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ENDOSOME; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENE TARGETING; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOME; PRIORITY JOURNAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENDOCYTOSIS; ENZYMOLOGY; GENE TRANSFER; GENETICS; METABOLISM;

CLATHRIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG CARRIERS; ENDOCYTOSIS; ENDOSOMES; GENE TRANSFER TECHNIQUES; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LIPIDS; LYSOSOMES; NANOPARTICLES; OLIGONUCLEOTIDES; POLYETHYLENEIMINE; PROTEIN KINASE INHIBITORS; TRANSFECTION;

EID: 84860848744     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.07.015     Document Type: Article

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