The inducible nitric-oxide synthase (iNOS)/Src axis mediates toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to interferon- β synthesis in macrophages

Journal of Biological Chemistry

Volumn 289, Issue 13, 2014, Pages 9208-9220

  Hsieh, Ming Yu ^a   Chang, Miao Ying ^b   Chen, Yen Jen ^a   Li, Yung Kuo ^c   Chuang, Tsung Hsien ^d   Yu, Guann Yi ^a,d   Cheung, Chun Hei Antonio ^a   Chen, Hui Chen ^c   Maa, Ming Chei ^c   Leu, Tzeng Horng ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; GLYCOPROTEINS; MACROPHAGES; NITRIC OXIDE; RESTORATION; RNA; SIGNAL TRANSDUCTION;

DOUBLE-STRANDED RNA (DSRNA); ECTOPIC EXPRESSIONS; INDUCIBLE NITRIC OXIDE SYNTHASE (INOS); INTERFERON REGULATORY FACTORS; MOLECULAR CHANGES; NUCLEAR ACCUMULATION; SIGNALING PATHWAYS; TOLL-LIKE RECEPTOR 3;

PHOSPHORYLATION;

BETA INTERFERON; DOUBLE STRANDED RNA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 7; LIPOPOLYSACCHARIDE; PHENYLALANINE; PROTEIN TYROSINE KINASE; TOLL LIKE RECEPTOR 3; TYROSINE; IRF7 PROTEIN, MOUSE; PROTEIN KINASE P60;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STABILITY; ENZYME STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; RNA TRANSCRIPTION; ACTIVE TRANSPORT; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; CELL NUCLEUS; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PERITONEUM MACROPHAGE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRUS CELL TRANSFORMATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE; CELL NUCLEUS; CELL TRANSFORMATION, VIRAL; GENE EXPRESSION REGULATION; INTERFERON REGULATORY FACTOR-3; INTERFERON REGULATORY FACTOR-7; INTERFERON-BETA; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 3; TYROSINE;

EID: 84897415714     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.508663     Document Type: Article

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