Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

EMBO Molecular Medicine

Volumn 5, Issue 12, 2013, Pages 1918-1934

  Syed, Yasir A ^a,b,c   Baer, Alexandra ^b   Hofer, Matthias P ^a   González, Ginez A ^a   Rundle, Jon ^a   Myrta, Szymon ^a   Huang, Jeffrey K ^a   Zhao, Chao ^a   Rossner, Moritz J ^c   Trotter, Matthew W B ^a   Lubec, Gert ^b   Franklin, Robin J M ^a   Kotter, Mark R ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Demyelination; Mapk signalling; Multiple sclerosis; Oligodendrocytes; Remyelination

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BUCLADESINE; CELL PROTEIN; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHODIESTERASE IV; ROLIPRAM; TOXIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; CELL DIFFERENTIATION; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEMYELINATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; NEWBORN; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; REMYELINIZATION; TISSUE CULTURE;

DEMYELINATION; MAPK SIGNALLING; MULTIPLE SCLEROSIS; OLIGODENDROCYTES; REMYELINATION;

ANIMALS; BUCLADESINE; CELL DIFFERENTIATION; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; HUMANS; IMMUNITY, INNATE; MITOGEN-ACTIVATED PROTEIN KINASES; MULTIPLE SCLEROSIS; MYELIN SHEATH; OLIGODENDROGLIA; PHOSPHODIESTERASE 4 INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTOME;

EID: 84897098050     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201303123     Document Type: Article

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