메뉴 건너뛰기




Volumn 14, Issue 8, 2011, Pages 1009-1016

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; PROTEIN; PROTEIN AXIN2; PROTEIN INHIBITOR; TANKYRASE; UNCLASSIFIED DRUG; WNT PROTEIN; XAV 939;

EID: 79960764346     PISSN: 10976256     EISSN: 15461726     Source Type: Journal    
DOI: 10.1038/nn.2855     Document Type: Article
Times cited : (304)

References (37)
  • 4
    • 54149084585 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston, A. & Coles, A. Multiple sclerosis. Lancet 372, 1502-1517 (2008).
    • (2008) Lancet , vol.372 , pp. 1502-1517
    • Compston, A.1    Coles, A.2
  • 5
    • 0037122960 scopus 로고    scopus 로고
    • Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    • DOI 10.1056/NEJMoa010994
    • Chang, A., Tourtellotte, W.W., Rudick, R. & Trapp, B.D. Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis. N. Engl. J. Med. 346, 165-173 (2002). (Pubitemid 34438882)
    • (2002) New England Journal of Medicine , vol.346 , Issue.3 , pp. 165-173
    • Chang, A.1    Tourtellotte, W.W.2    Rudick, R.3    Trapp, B.D.4
  • 6
    • 46849098585 scopus 로고    scopus 로고
    • Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
    • DOI 10.1093/brain/awn096
    • Kuhlmann, T. et al. Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis. Brain 131, 1749-1758 (2008). (Pubitemid 351957453)
    • (2008) Brain , vol.131 , Issue.7 , pp. 1749-1758
    • Kuhlmann, T.1    Miron, V.2    Cuo, Q.3    Wegner, C.4    Antel, J.5    Bruck, W.6
  • 7
    • 29244440745 scopus 로고    scopus 로고
    • NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
    • DOI 10.1038/nature04302
    • Káradóttir, R., Cavelier, P., Bergersen, L.H. & Attwell, D. NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature 438, 1162-1166 (2005). (Pubitemid 41831686)
    • (2005) Nature , vol.438 , Issue.7071 , pp. 1162-1166
    • Karadottir, R.1    Cavelier, P.2    Bergersen, L.H.3    Attwell, D.4
  • 10
    • 67649655942 scopus 로고    scopus 로고
    • Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
    • Fancy, S.P.J. et al. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev. 23, 1571-1585 (2009).
    • (2009) Genes Dev. , vol.23 , pp. 1571-1585
    • Fancy, S.P.J.1
  • 11
    • 67649797866 scopus 로고    scopus 로고
    • HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction
    • Ye, F. et al. HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat. Neurosci. 12, 829-838 (2009).
    • (2009) Nat. Neurosci. , vol.12 , pp. 829-838
    • Ye, F.1
  • 13
    • 0032473355 scopus 로고    scopus 로고
    • Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3β and β-catenin and promotes GSK-3β-dependent phosphorylation of β-catenin
    • DOI 10.1093/emboj/17.5.1371
    • Ikeda, S. et al. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. EMBO J. 17, 1371-1384 (1998). (Pubitemid 28105516)
    • (1998) EMBO Journal , vol.17 , Issue.5 , pp. 1371-1384
    • Ikeda, S.1    Kishida, S.2    Yamamoto, H.3    Murai, H.4    Koyama, S.5    Kikuchi, A.6
  • 14
    • 0032562603 scopus 로고    scopus 로고
    • Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta
    • Behrens, J. et al. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280, 596-599 (1998).
    • (1998) Science , vol.280 , pp. 596-599
    • Behrens, J.1
  • 17
    • 0036148208 scopus 로고    scopus 로고
    • Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
    • Jho, E.H. et al. Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol. Cell. Biol. 22, 1172-1183 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1172-1183
    • Jho, E.H.1
  • 19
    • 77956628008 scopus 로고    scopus 로고
    • Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
    • Zeng, Y.A. & Nusse, R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 6, 568-577 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 568-577
    • Zeng, Y.A.1    Nusse, R.2
  • 20
    • 50649088457 scopus 로고    scopus 로고
    • Pattern formation in the vertebrate neural tube: A sonic hedgehog morphogen-regulated transcriptional network
    • Dessaud, E., McMahon, A.P. & Briscoe, J. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 135, 2489-2503 (2008).
    • (2008) Development , vol.135 , pp. 2489-2503
    • Dessaud, E.1    McMahon, A.P.2    Briscoe, J.3
  • 21
    • 73249137542 scopus 로고    scopus 로고
    • Axin2 regulates chondrocyte maturation and axial skeletal development
    • Dao, D.Y. et al. Axin2 regulates chondrocyte maturation and axial skeletal development. J. Orthop. Res. 28, 89-95 (2010).
    • (2010) J. Orthop. Res. , vol.28 , pp. 89-95
    • Dao, D.Y.1
  • 22
    • 67649667327 scopus 로고    scopus 로고
    • Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination
    • Emery, B. et al. Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell 138, 172-185 (2009).
    • (2009) Cell , vol.138 , pp. 172-185
    • Emery, B.1
  • 23
  • 25
    • 70349695861 scopus 로고    scopus 로고
    • Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling
    • Huang, S.M. et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling. Nature 461, 614-620 (2009).
    • (2009) Nature , vol.461 , pp. 614-620
    • Huang, S.M.1
  • 26
    • 78650632445 scopus 로고    scopus 로고
    • Retinoid X receptor gamma signaling accelerates CNS remyelination
    • Huang, J.K. et al. Retinoid X receptor gamma signaling accelerates CNS remyelination. Nat. Neurosci. 14, 45-53 (2011).
    • (2011) Nat. Neurosci. , vol.14 , pp. 45-53
    • Huang, J.K.1
  • 28
    • 30644476095 scopus 로고    scopus 로고
    • Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation
    • DOI 10.1523/JNEUROSCI.2615-05.2006
    • Kotter, M.R., Li, W.W., Zhao, C. & Franklin, R.J.M. Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation. J. Neurosci. 26, 328-332 (2006). (Pubitemid 43089546)
    • (2006) Journal of Neuroscience , vol.26 , Issue.1 , pp. 328-332
    • Kotter, M.R.1    Li, W.-W.2    Zhao, C.3    Franklin, R.J.M.4
  • 30
    • 73149124029 scopus 로고    scopus 로고
    • Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination
    • Zhang, Y. et al. Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc. Natl. Acad. Sci. USA 106, 19162-19167 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 19162-19167
    • Zhang, Y.1
  • 31
    • 55049091909 scopus 로고    scopus 로고
    • Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system
    • Watkins, T.A., Emery, B., Mulinyawe, S. & Barres, B.A. Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system. Neuron 60, 555-569 (2008).
    • (2008) Neuron , vol.60 , pp. 555-569
    • Watkins, T.A.1    Emery, B.2    Mulinyawe, S.3    Barres, B.A.4
  • 32
    • 78649289322 scopus 로고    scopus 로고
    • Towards improved animal models of neonatal white matter injury associated with cerebral palsy
    • Silbereis, J.C., Huang, E.J., Back, S.A. & Rowitch, D.H. Towards improved animal models of neonatal white matter injury associated with cerebral palsy. Dis. Model Mech. 3, 678-688 (2010).
    • (2010) Dis. Model Mech. , vol.3 , pp. 678-688
    • Silbereis, J.C.1    Huang, E.J.2    Back, S.A.3    Rowitch, D.H.4
  • 34
    • 48449105147 scopus 로고    scopus 로고
    • Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma
    • Schüller, U. et al. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 14, 123-134 (2008).
    • (2008) Cancer Cell , vol.14 , pp. 123-134
    • Schüller, U.1
  • 36
    • 78249258697 scopus 로고    scopus 로고
    • Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination
    • Harrington, E. et al. Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination. Ann. Neurol. 68, 703-716 (2010).
    • (2010) Ann. Neurol. , vol.68 , pp. 703-716
    • Harrington, E.1
  • 37
    • 4744349978 scopus 로고    scopus 로고
    • Lysolecithin induces demyelination in vitro in a cerebellar slice culture system
    • DOI 10.1002/jnr.20248
    • Birgbauer, E., Rao, T.S. & Webb, M. Lysolecithin induces demyelination in vitro in a cerebellar slice culture system. J. Neurosci. Rev. 78, 157-166 (2004). (Pubitemid 39313787)
    • (2004) Journal of Neuroscience Research , vol.78 , Issue.2 , pp. 157-166
    • Birgbauer, E.1    Rao, T.S.2    Webb, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.