The anti-proliferative effect of metformin in triple-negative MDA-MB-231 breast cancer cells is highly dependent on glucose concentration: Implications for cancer therapy and prevention

Biochimica et Biophysica Acta - General Subjects

Volumn 1840, Issue 6, 2014, Pages 1943-1957

  Zordoky, Beshay N M ^a   Bark, Diana ^a   Soltys, Carrie L ^a   Sung, Miranda M ^a   Dyck, Jason R B ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

AMP activated protein kinase; Breast cancer; Diabetes; MDA MB 231; Metformin

Indexed keywords

GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OCTAMER TRANSCRIPTION FACTOR 1; S6 KINASE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER PATIENT; CANCER PREVENTION; CANCER THERAPY; CELL CULTURE; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DIABETIC PATIENT; DRUG SENSITIZATION; ENZYME ACTIVATION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HYPERGLYCEMIA; MDA MB 231 CELL; MTT ASSAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRIPLE NEGATIVE BREAST CANCER; WESTERN BLOTTING; ANIMAL CELL; CANCER CELL LINE; CONCENTRATION RESPONSE; DRUG MECHANISM; FIBROBLAST; MDA MB 231 CELL LINE; MOUSE; NONHUMAN; SENSITIZATION;

AMP-ACTIVATED PROTEIN KINASE; BREAST CANCER; DIABETES; MDA-MB-231; METFORMIN;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; GLUCOSE; HUMANS; INSULIN; MAP KINASE SIGNALING SYSTEM; METFORMIN; OCTAMER TRANSCRIPTION FACTOR-1; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84897036925     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.01.023     Document Type: Article

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