The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma

Clinical Cancer Research

Volumn 8, Issue 7, 2002, Pages 2085-2090

  Shen, Zan ^a   Wen, Xian Feng ^a   Lan, Fei ^a   Shen, Zhen Zhou ^a   Shao, Zhi Ming ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PROGESTERONE RECEPTOR; PROTEIN KINASE LKB1; PROTEIN P21; TUMOR MARKER; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN E; CYCLINE; ESTROGEN RECEPTOR; MESSENGER RNA; PRIMER DNA; PROTEIN SERINE THREONINE KINASE; STK11 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CELL CYCLE G1 PHASE; CELL GROWTH; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; HISTOPATHOLOGY; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; INTESTINE POLYP; LKB1 GENE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MITOSIS INHIBITION; PEUTZ JEGHERS SYNDROME; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RELAPSE; TUMOR SUPPRESSOR GENE; TUMOR VOLUME; BREAST TUMOR; CELL CULTURE; CHEMISTRY; FLOW CYTOMETRY; GENETIC TRANSFECTION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; BREAST NEOPLASMS; CYCLIN D1; CYCLIN E; CYCLINS; DNA PRIMERS; FEMALE; FLOW CYTOMETRY; G1 PHASE; GENES, TUMOR SUPPRESSOR; HUMAN; MIDDLE AGE; PROGNOSIS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; MIDDLE AGED;

EID: 0035992276     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
2. Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer
3. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
4. In situ analysis of LKB1/STKII mRNA expression in human normal tissue and tumours
5. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth
6. 2/M arrest, and apoptosis
7. LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest
8. Pathological prognostic factors in breast cancer, the value of histological grade in breast cancer: Experience from a large study with long-term follow-up
9. Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome
10. 1 cell cycle arrest
11. Cancer cell cycle
12. Cell cycle and cancer: Critical events at the G1 restriction point
13. Barrett's esophagus, dysplasia, and adenocarcinoma
14. Mutation of cell cycle regulators: Biological and clinical implications for human neoplasia
15. 1 → S-phase progression
16. p53, the cellular gatekeeper for growth and division
17. 1 arrest in UV-irradiated human skin fibroblasts
18. 1 arrest and apoptosis induced by a novel retinoid in human breast cancer cells
19. p53: Puzzle and paradigm
20. Molecular epidemiology of human cancer: Contribution of mutation spectra studies of tumor suppressor genes
21. 1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts