Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes

Drug Metabolism and Disposition

Volumn 40, Issue 3, 2012, Pages 504-514

  Anwar Mohamed, Anwar ^a   Klotz, Lars Oliver ^a   El Kadi, Ayman O S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; ARSENIC TRIOXIDE; CELL PROTEIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 3A; CYTOCHROME P450 3A2; CYTOCHROME P450 3A23; HEAT SHOCK PROTEIN 90; HEME; HEME OXYGENASE 1; HEPATITIS B VIRUS X ASSOCIATED PROTEIN 2; MESSENGER RNA; PREGNANE X RECEPTOR; RIFAMPICIN; STANNSOPORFIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CATALYSIS; CELL ISOLATION; CELL NUCLEUS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INDUCTION; ENZYME INHIBITION; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING;

ANIMALS; ARSENITES; ARYL HYDROCARBON HYDROXYLASES; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES; CYTOSOL; HEAT-SHOCK PROTEINS; HEME; HEME OXYGENASE (DECYCLIZING); HEPATOCYTES; MALE; MEMBRANE PROTEINS; METALLOPORPHYRINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, STEROID; RIFAMPIN; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; TRANS-ACTIVATORS;

EID: 84857375104     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.042564     Document Type: Article

References (40)

1. Albores A, Cebrián ME, Bach PH, Connelly JC, Hinton RH, and Bridges JW (1989) Sodium arsenite induced alterations in bilirubin excretion and heme metabolism. J Biochem Toxicol 4:73-78.
2. Anwar-Mohamed A and El-Kadi AO (2007) Induction of cytochrome P450 1a1 by the food flavoring agent, maltol. Toxicol In Vitro 21:685-690. (Pubitemid 46550753)
3. Anwar-Mohamed A and El-Kadi AO (2010) Arsenite down-regulates cytochrome P450 1A1 at the transcriptional and posttranslational levels in human HepG2 cells. Free Radic Biol Med 48:1399-1409.
4. Anwar-Mohamed A, Elbekai RH, and El-Kadi AO (2008) MG-132 inhibits the TCDD-mediated induction of Cyp1a1 at the catalytic activity but not the mRNA or protein levels in Hepa 1c1c7 cells. Toxicol Lett 182:121-126.
5. Anwar-Mohamed A, Elbekai RH, and El-Kadi AO (2009) Regulation of CYP1A1 by heavy metals and consequences for drug metabolism. Expert Opin Drug Metab Toxicol. 5:501-521.
6. Bertilsson G, Heidrich J, Svensson K, Asman M, Jendeberg L, Sydow-Bäckman M, Ohlsson R, Postlind H, Blomquist P, and Berkenstam A (1998) Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci USA 95:12208-12213. (Pubitemid 28483744)
7. Bessette EE, Fasco MJ, Pentecost BT, Reilly A, and Kaminsky LS (2009) Investigations of the posttranslational mechanism of arsenite-mediated downregulation of human cytochrome P4501A1 levels: the role of heme oxygenase-1. J Biochem Mol Toxicol 23:222-232.
8. Bock KW (2011) From differential induction of UDP- glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans. Biochem Pharmacol 82:9-16.
9. Cavigelli M, Li WW, Lin A, Su B, Yoshioka K, and Karin M (1996) The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. EMBO J 15:6269-6279. (Pubitemid 26397900)
10. de Vera ME, Kim YM, Wong HR, Wang Q, Billiar TR, and Geller DA (1996) Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes. Hepatology 24:1238-1245. (Pubitemid 26365932)
11. Denison MS, Fisher JM, and Whitlock JP Jr (1989) Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex. J Biol Chem 264:16478-16482. (Pubitemid 19243535)
12. Denison MS, Pandini A, Nagy SR, Baldwin EP, and Bonati L (2002) Ligand binding and activation of the Ah receptor. Chem Biol Interact 141:3-24. (Pubitemid 35229988)
13. El-Kadi AO, Maurice H, Ong H, and du Souich P (1997) Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver. Br J Pharmacol 121:1164-1170. (Pubitemid 27303586)
14. Elbekai RH and El-Kadi AO (2004) Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium. Toxicology 202:249-269. (Pubitemid 39165399)
15. Evans WE and Relling MV (1999) Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286:487-491.
16. Goodwin B, Redinbo MR, and Kliewer SA (2002) Regulation of cyp3a gene transcription by the pregnane x receptor. Annu Rev Pharmacol Toxicol 42:1-23. (Pubitemid 34160517)
17. Guengerich FP, Hosea NA, Parikh A, Bell-Parikh LC, Johnson WW, Gillam EM, and Shimada T (1998) Twenty years of biochemistry of human P450s: purification, expression, mechanism, and relevance to drugs. Drug Metab Dispos 26:1175-1178. (Pubitemid 29028635)
18. Hankinson O (1995) The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35:307-340.
19. Jacobs J, Roussel R, Roberts M, Marek D, Wood S, Walton H, Dwyer B, Sinclair P, and Sinclair J (1998) Effect of arsenite on induction of CYP1A and CYP2H in primary cultures of chick hepatocytes. Toxicol Appl Pharmacol 150:376-382. (Pubitemid 28302522)
20. Jacobs JM, Nichols CE, Andrew AS, Marek DE, Wood SG, Sinclair PR, Wrighton SA, Kostrubsky VE, and Sinclair JF (1999) Effect of arsenite on induction of CYP1A, CYP2B, and CYP3A in primary cultures of rat hepatocytes. Toxicol Appl Pharmacol 157:51-59. (Pubitemid 29250253)
21. Klaassen CD (2001) Cassarett and Doull's Toxicology. The Basic Science of Poisons. McGraw-Hill, New York.
22. Livak KJ and Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408. (Pubitemid 34164012)
23. Lorenzen A and Kennedy SW (1993) A fluorescence-based protein assay for use with a microplate reader. Anal Biochem 214:346-348. (Pubitemid 23300401)
24. Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275.
25. Marilena G (1997) New physiological importance of two classic residual products: carbon monoxide and bilirubin. Biochem Mol Med 61:136-142.
26. Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, et al. (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J Biol Chem 275:15122-15127. (Pubitemid 30337234)
27. Nicoll-Griffith DA, Chauret N, Houle R, Day SH, D'Antoni M, and Silva JM (2004) Use of a benzyloxy-substituted lactone cyclooxygenase-2 inhibitor as a selective fluorescent probe for CYP3A activity in primary cultured rat and human hepatocytes. Drug Metab Dispos 32:1509-1515. (Pubitemid 39564573)
28. Patrick L (2003) Toxic metals and antioxidants: Part II. The role of antioxidants in arsenic and cadmium toxicity. Altern Med Rev 8:106-128.
29. Pollenz RS (2002) The mechanism of AH receptor protein down-regulation (degradation) and its impact on AH receptor-mediated gene regulation. Chem Biol Interact 141:41-61.
30. Schuller DJ, Wilks A, Ortiz de Montellano P, and Poulos TL (1998) Crystallization of recombinant human heme oxygenase-1. Protein Sci 7:1836-1838. (Pubitemid 29133190)
31. Schweikl H, Taylor JA, Kitareewan S, Linko P, Nagorney D, and Goldstein JA (1993) Expression of CYP1A1 and CYP1A2 genes in human liver. Pharmacogenetics 3:239-249. (Pubitemid 23333093)
32. Seglen PO (1976) Preparation of isolated rat liver cells. Methods Cell Biol 13:29-83.
33. Shertzer HG, Genter MB, Talaska G, Curran CP, Nebert DW, and Dalton TP (2007) 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis 28:1371-1378. (Pubitemid 47062699)
34. Siller FR, Quintanilla-Vega B, Cebrián ME, and Albores A (1997) Effects of arsenite pretreatment on the acute toxicity of parathion. Toxicology 116:59-65. (Pubitemid 27051272)
35. Song X, Xie M, Zhang H, Li Y, Sachdeva K, and Yan B (2004) The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes. Drug Metab Dispos 32:35-42. (Pubitemid 38112533)
36. Vakharia DD, Liu N, Pause R, Fasco M, Bessette E, Zhang QY, and Kaminsky LS (2001) Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures. Toxicol Appl Pharmacol 170:93-103. (Pubitemid 32108684)
37. Watkins PB, Murray SA, Thomas PE, and Wrighton SA (1990) Distribution of cytochromes P-450, cytochrome b5, and NADPH-cytochrome P-450 reductase in an entire human liver. Biochem Pharmacol 39:471-476. (Pubitemid 20041914)
38. Whitelaw ML, Gustafsson JA, and Poellinger L (1994) Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation. Mol Cell Biol 14:8343-8355. (Pubitemid 24373583)
39. Xu L, Li AP, Kaminski DL, and Ruh MF (2000) 2,3,7,8 Tetrachlorodibenzo-p- dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes. Chem Biol Interact 124:173-189. (Pubitemid 30072751)
40. Yamazaki H and Shimada T (1997) Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys 346:161-169. (Pubitemid 27415307)