AMPK induces MUC5B expression via p38 MAPK in NCI-H292 airway epithelial cells

Biochemical and Biophysical Research Communications

Volumn 409, Issue 4, 2011, Pages 669-674

  Bae, Chang Hoon ^a   Kim, Jun Woo ^a   Ye, Sang Baik ^a   Song, Si Youn ^a   Kim, Yong Woon ^a   Park, So Young ^a   Kim, Yong Dae ^a,b  

^a Yeungnam University College of Medicine   (South Korea)

^b Yeungnam University Hospital   (South Korea)

Author keywords

Adenosine monophosphate activated protein kinase; MUC5B; NCI H292 cell; P38 mitogen activated protein kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOSINE DEAMINASE INHIBITOR; ADENOSINE MONOPHOSPHATE DEAMINASE; COMPOUND C; MESSENGER RNA; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MUCIN 5B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADENOVIRUS; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELL LINE; GENE EXPRESSION REGULATION; HUMANS; METFORMIN; MUCIN-5B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASES; RESPIRATORY MUCOSA;

ADENOVIRIDAE;

EID: 79959232579     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.05.062     Document Type: Article

References (30)

1. Ali M.S., Pearson J.P. Upper airway mucin gene expression: a review. Laryngoscope 2007, 117:932-938.
2. Rogers D.F. Physiology of airway mucus secretion and pathophysiology of hypersecretion. Resp. Care 2007, 52:1134-1146.
3. Turner J., Jones C.E. Regulation of mucin expression in respiratory diseases. Biochem. Soc. Trans. 2009, 37:877-881.
4. Rose M.C., Voynow J.A. Respiratory tract mucin genes and mucin glycoproteins in health and diseases. Physiol. Rev. 2006, 86:245-278.
5. Hardie D.G., Hawley S.A., Scott J.W. AMP-activated protein kinase-development of the energy sensor concept. J. Physiol. 2006, 574:7-15.
6. Kemp B.E., Stapleton D., Campbell D.J., Chen Z.P., Murthy S., Walter M., Gupta A., Adams J.J., Katsis F., van Denderen B., Jennings I.G., Iseli T., Michell B.J., Witters L.A. AMP-activated protein kinase, super metabolic regulator. Biochem. Soc. Trans. 2003, 31:162-168.
7. Carling D. The AMP-activated protein kinase cascade - a unifying system for energy control. Trends Biochem. Sci. 2004, 29:18-24.
8. Vucicevic L., Misirkic M., Janjetovic K., Harhaji-Trajkovic L., Prica M., Stevanovic D., Isenovic E., Sudar E., Sumarac-Dumanovic M., Micic D., Trajkovic V. AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C. Biochem. Pharmacol. 2009, 77:1684-1693.
9. Woo H.J., Yoo W.J., Bae C.H., Song S.Y., Kim Y.W., Park S.Y., Kim Y.D. Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway. Exp. Lung Res. 2010, 36:262-269.
10. Song S.Y., Woo H.J., Bae C.H., Kim Y.W., Kim Y.D. Expression of leptin receptor in nasal polyps: leptin as a mucosecretagogue. Laryngoscope 2010, 120:1046-1050.
11. Hallows K.R., Fitch A.C., Richardson C.A., Reynolds P.R., Clancy J.P., Dagher P.C., Witters L.A., Kolls J.K., Pilewski J.M. Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation. J. Biol. Chem. 2006, 281:4231-4241.
12. Zhao X., Zmijewski J.W., Lorne E., Liu G., Park Y.J., Tsuruta Y., Abraham E. Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol. 2008, 295:497-504.
13. Woo H.J., Bae C.H., Song S.Y., Lee H.M., Kim Y.D. Expression of membrane-bound mucins in human nasal mucosa: different patterns for MUC4 and MUC16. Arch. Otolaryngol. Head Neck Surg. 2010, 136:603-609.
14. Bernacki S.H., Nelson A.L., Abdullah L., Sheehan J.K., Harris A., Davis C.W., Randell S.H. Mucin gene expression during differentiation of human airway epithelia in vitro. Muc4 and muc5b are strongly induced. Am. J. Respir. Cell Mol. Biol. 1999, 20:595-604.
15. Kim Y.D., Kwon E.J., Park D.W., Song S.Y., Yoon S.K., Baek S.H. Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol. Pharmacol. 2002, 62:1112-1118.
16. Kim C.H., Kim H.J., Song K.S., Seong J.K., Kim K.S., Lee J.G., Yoon J.H. MUC8 as a ciliated cell marker in human nasal epithelium. Acta Otolaryngol. 2005, 125:76-81.
17. Lee M., Hwang J.T., Lee H.J., Jung S.N., Kang I., Chi S.G., Kim S.S., Ha J. AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 cells. J. Biol. Chem. 2003, 278:39653-39661.
18. Lee W.J., Lee I.K., Kim H.S., Kim Y.M., Koh E.H., Won J.C., Han S.M., Kim M.S., Jo I., Oh G.T., Park I.S., Youn J.H., Park S.W., Lee K.U., Park J.Y. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2488-2494.
19. Kim H.S., Hwang J.T., Yun H., Chi S.G., Lee S.J., Kang I., Yoon K.S., Choe W.J., Kim S.S., Ha J. Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53. J. Biol. Chem. 2008, 283:3731-3742.
20. Williams O.W., Sharafkhaneh A., Kim V., Dickey B.F., Evans C.M. Airway mucus: from production to secretion. Am. J. Respir. Cell Mol. Biol. 2006, 34:527-536.
21. Zhou G., Myers R., Li Y., Chen Y., Shen X., Fenyk-Melody J., Wu M., Ventre J., Doebber T., Fujii N., Musi N., Hirshman M.F., Goodyear L.J., Moller D.E. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 2001, 108:1167-1174.
22. Nagata D., Mogi M., Walsh K. AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stress. J. Biol. Chem. 2003, 278:31000-31006.
23. Winder W.W., Thomson D.M. Cellular energy sensing and signaling by AMP-activated protein kinase. Cell Biochem. Biophys. 2007, 47:332-347.
24. Kim Y.D., Park K.G., Lee Y.S., Park Y.Y., Kim D.K., Nedumaran B., Jang W.G., Cho W.J., Ha J., Lee I.K., Lee C.H., Choi H.S. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 2008, 57:306-314.
25. Alba G., El Bekay R., Alvarez-Maqueda M., Chacón P., Vega A., Monteseirín J., Santa María C., Pintado E., Bedoya F.J., Bartrons R., Sobrino F. Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils. FEBS Lett. 2004, 573:219-225.
26. Unal M., Eskandari G., Muşlu N., Pata Y.S., Akbaş Y. Serum leptin levels in patients with allergic rhinitis. Otolaryngol. Head Neck Surg. 2006, 134:331-333.
27. Bruno A., Pace E., Chanez P., Gras D., Vachier I., Chiappara G., La Guardia M., Gerbino S., Profit M., Gjomarkaj M. Leptin and leptin receptor expression in asthma. J. Allergy Clin. Immunol. 2009, 124:230-237.
28. Hou C.H., Tan T.W., Tang C.H. AMP-activated protein kinase is involved in COX-2 expression in response to ultrasound in cultured osteoblasts. Cell Signal. 2008, 20:978-988.
29. Chang M.Y., Ho F.M., Wang J.S., Kang H.C., Chang Y., Ye Z.X., Lin W.W. AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen- activated protein kinase signaling pathway. Biochem. Pharmacol. 2010, 80:1210-1220.
30. Nader N., Ng S.S., Lambrou G.I., Pervanidou P., Wang Y., Chrousos G.P., Kino T. AMPK regulates metabolic actions of glucocorticoids by phosphorylating the glucocorticoid receptor through p38 MAPK. Mol. Endocrinol. 2010, 24:1748-1764.