MicroRNAs-role in lung cancer

Disease Markers

Volumn 2014, Issue , 2014, Pages

  Guz, Małgorzata ^a   Rivero Müller, Adolfo ^b   Okoń, Estera ^a   Stenzel Bembenek, Agnieszka ^a   Polberg, Krzysztof ^c   Słomka, Maria ^a   Stepulak, Andrzej ^a,c  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^b UNIVERSITY OF TURKU   (Finland)

^c MSW Hospital   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; ANGIOGENIC PROTEIN; TUMOR MARKER;

ANGIOGENESIS; APOPTOSIS; BIOGENESIS; CANCER GROWTH; CANCER PROGNOSIS; CELL CYCLE; CELL PROLIFERATION; GENE CONTROL; GENE EXPRESSION; HUMAN; LUNG CANCER; PRIORITY JOURNAL; REVIEW; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PHYSIOLOGY; RNA INTERFERENCE; VASCULARIZATION;

ANGIOGENIC PROTEINS; ANIMALS; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; RNA INTERFERENCE; TUMOR MARKERS, BIOLOGICAL;

EID: 84897002093     PISSN: 02780240     EISSN: 18758630     Source Type: Journal    
DOI: 10.1155/2014/218169     Document Type: Review

References (178)

1. C. Lopez-Camarillo, L. A. Marchat, E. Arechaga-Ocampo et al. , "MetastamiRs: non-coding microRNAs driving cancer invasion andmetastasis, " International Journal ofMolecular Sciences, vol. 13, no. 2, pp. 1347-1379, 2012.
2. D. Hanahan andR. A. Weinberg, "The hallmarks of cancer, " Cell, vol. 100, no. 1, pp. 57-70, 2000.
3. Y. Lazebnik, "What are the hallmarks of cancer" Nature Reviews Cancer, vol. 10, no. 4, pp. 232-233, 2010.
4. A. J. Schetter, S. Y. Leung, J. J. Sohn et al. , "MicroRNAexpression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma, " The Journal of the American Medical Association, vol. 299, no. 4, pp. 425-436, 2008.
5. C. M. Croce, "Causes and consequences of microRNA dysregulation in cancer, " Nature Reviews Genetics, vol. 10, no. 10, pp. 704-714, 2009.
6. J. Brennecke, D. R. Hipfner, A. Stark, R. B. Russell, and S. M. Cohen, "Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila, " Cell, vol. 113, no. 1, pp. 25-36, 2003.
7. A. Gaur, D. A. Jewell, Y. Liang et al. , "Characterization of microRNA expression levels and their biological correlates in human cancer cell lines, " Cancer Research, vol. 67, no. 6, pp. 2456-2468, 2007.
8. J. Jiang, E. J. Lee, Y. Gusev, and T. D. Schmittgen, "Real-time expression profiling of microRNA precursors in human cancer cell lines, " Nucleic Acids Research, vol. 33, no. 17, pp. 5394-5403, 2005.
9. J. Lu, G. Getz, E. A. Miska et al. , "MicroRNA expression profiles classify human cancers, " Nature, vol. 435, no. 7043, pp. 834-838, 2005.
10. Y. Murakami, T. Yasuda, K. Saigo et al. , "Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues, " Oncogene, vol. 25, no. 17, pp. 2537-2545, 2006.
11. M. V. Iorio, M. Ferracin, C. -G. Liu et al. , "MicroRNA gene expression deregulation in human breast cancer, " Cancer Research, vol. 65, no. 16, pp. 7065-7070, 2005.
12. M. V. Iorio, R. Visone, G. Di Leva et al. , "MicroRNA signatures in human ovarian cancer, " Cancer Research, vol. 67, no. 18, pp. 8699-8707, 2007.
13. G. A. Calin, M. Ferracin, A. Cimmino et al. , "A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia, " The New England Journal of Medicine, vol. 353, no. 17, pp. 1793-1801, 2005.
14. A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu, and M. J. Thun, "Cancer statistics, 2007, " CA: A Cancer Journal for Clinicians, vol. 57, no. 1, pp. 43-66, 2007.
15. G. A. Calin and C. M. Croce, "MicroRNA signatures in human cancers, " Nature Reviews Cancer, vol. 6, no. 11, pp. 857-866, 2006.
16. J. Takamizawa, H. Konishi, K. Yanagisawa et al. , "Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival, " Cancer Research, vol. 64, no. 11, pp. 3753-3756, 2004.
17. L. Esposito, D. Conti, R. Ailavajhala, N. Khalil, andA. Giordano, "Lung cancer: are we up to the challenge" Current Genomics, vol. 11, no. 7, pp. 513-518, 2010.
18. R. C. Lee, R. L. Feinbaum, and V. Ambros, "The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, " Cell, vol. 75, no. 5, pp. 843-854, 1993.
19. A. Rodriguez, S. Griffiths-Jones, J. L. Ashurst, and A. Bradley, "Identification of mammalian microRNA host genes and transcription units, " Genome Research, vol. 14, no. 10, pp. 1902-1910, 2004.
20. A. M. Denli, B. B. J. Tops, R. H. A. Plasterk, R. F. Ketting, and G. J. Hannon, "Processing of primary microRNAs by the Microprocessor complex, " Nature, vol. 432, no. 7014, pp. 231- 235, 2004.
21. J. Han, Y. Lee, K. -H. Yeom, Y. -K. Kim, H. Jin, and V. N. Kim, "The Drosha-DGCR8 complex in primary microRNA processing, " Genes and Development, vol. 18, no. 24, pp. 3016- 3027, 2004.
22. Y. Lee, M. Kim, J. Han et al. , "MicroRNA genes are transcribed by RNA polymerase II, " The EMBO Journal, vol. 23, no. 20, pp. 4051-4060, 2004.
23. A. Esquela-Kerscher and F. J. Slack, "Oncomirs-microRNAs with a role in cancer, " Nature Reviews Cancer, vol. 6, no. 4, pp. 259-269, 2006.
24. J. Winter, S. Jung, S. Keller, R. I. Gregory, and S. Diederichs, "Many roads to maturity: microRNA biogenesis pathways and their regulation, " Nature Cell Biology, vol. 11, no. 3, pp. 228-234, 2009.
25. C. D. Jeffries, H. M. Fried, and D. O. Perkins, "Nuclear and cytoplasmic localization of neural stem cell microRNAs, " RNA, vol. 17, no. 4, pp. 675-686, 2011.
26. M. Selbach, B. Schwanhausser, N. Thierfelder, Z. Fang, R. Khanin, and N. Rajewsky, "Widespread changes in protein synthesis induced by microRNAs, " Nature, vol. 455, no. 7209, pp. 58-63, 2008.
27. Z. Földes-Papp, K. König, H. Studier et al. , "Trafficking of mature miRNA-122 into the nucleus of live liver cells, " Current Pharmaceutical Biotechnology, vol. 10, no. 6, pp. 569-578, 2009.
28. H. -W. Hwang, E. A. Wentzel, and J. T. Mendell, "A hexanucleotide element directs microRNA nuclear import, " Science, vol. 315, no. 5808, pp. 97-100, 2007.
29. D. H. Kim, P. Strom, O. Snve Jr. , and J. J. Rossi, " MicroRNAdirected transcriptional gene silencing in mammalian cells, " Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 42, pp. 16230-16235, 2008.
30. E. Marcon, T. Babak, G. Chua, T. Hughes, and P. B. Moens, "MiRNA and piRNA localization in the male mammalian meiotic nucleus, " Chromosome Research, vol. 16, no. 2, pp. 243- 260, 2008.
31. T. Ohrt, J. Mütze, W. Staroske et al. , "Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells, " Nucleic Acids Research, vol. 36, no. 20, pp. 6439-6449, 2008.
32. J. -Y. Liao, L. -M. Ma, Y. -H. Guo et al. , "Deep sequencing of human nuclear and cytoplasmic small RNAS reveals an unexpectedly complex subcellular distribution of mirnas and tRNA 3 trailers, " PLoS ONE, vol. 5, no. 5, Article ID e10563, 2010.
33. J. C. R. Politz, E. M. Hogan, andT. Pederson, "MicroRNAs with a nucleolar location, " RNA, vol. 15, no. 9, pp. 1705-1715, 2009.
34. B. J. Reinhart, F. J. Slack, M. Basson et al. , "The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans, " Nature, vol. 403, no. 6772, pp. 901-906, 2000.
35. B. Wightman, I. Ha, and G. Ruvkun, "Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans, " Cell, vol. 75, no. 5, pp. 855-862, 1993.
36. O. Slaby, M. Svoboda, J. Michalek, and R. Vyzula, "MicroRNAs in colorectal cancer: translation of molecular biology into clinical application, " Molecular Cancer, vol. 8, article 102, 2009.
37. R. C. Friedman, K. K. -H. Farh, C. B. Burge, and D. P. Bartel, "Most mammalian mRNAs are conserved targets of microRNAs, " Genome Research, vol. 19, no. 1, pp. 92-105, 2009.
38. T. A. Farazi, J. I. Spitzer, P. Morozov, and T. Tuschl, "MiRNAs in human cancer, " The Journal of Pathology, vol. 223, no. 2, pp. 102-115, 2011.
39. S. Volinia, G. A. Calin, C. -G. Liu et al. , "A microRNA expression signature of human solid tumors defines cancer gene targets, " Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 7, pp. 2257-2261, 2006.
40. B. Zhang, X. Pan, G. P. Cobb, and T. A. Anderson, "MicroRNAs as oncogenes and tumor suppressors, " Developmental Biology, vol. 302, no. 1, pp. 1-12, 2007.
41. X. He, C. Duan, J. Chen et al. , "Let-7a elevates p211 levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells, " FEBS Letters, vol. 583, no. 21, pp. 3501-3507, 2009.
42. L. Ma, J. Liu, J. Shen et al. , "Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells, " Cancer Biology and Therapy, vol. 9, no. 7, pp. 554- 561, 2010.
43. X. Wang, K. Dong, P. Gao et al. , "MicroRNA-34a sensitizes lung cancer cell lines to DDP treatment independent of p53 status, " Cancer Biotherapy and Radiopharmaceuticals, vol. 28, no. 1, pp. 45-50, 2013.
44. L. G. Wang, Y. Ni, B. H. Su, X. R. Mu, H. C. Shen, and J. J. Du, "MicroRNA-34b functions as a tumor suppressor and acts as a nodal point in the feedback loop with Met, " International Journal of Oncology, vol. 42, no. 3, pp. 957-962, 2013.
45. L. Jiang, Q. Huang, J. Chang, E. Wang, and X. Qiu, "MicroRNA HSA-miR-125a-5p induces apoptosis by activating p53 in lung cancer cells, " Experimental Lung Research, vol. 37, no. 7, pp. 387- 398, 2011.
46. Y. S. Zang, Y. F. Zhong, Z. Fang, B. Li, and J. An, "MiR- 155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression, " Cancer Gene Therapy, vol. 19, pp. 773-778, 2012.
47. S. Feng, S. Cong, X. Zhang et al. , "MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells, " Nucleic Acids Research, vol. 39, no. 15, pp. 6669-6678, 2011.
48. Y. Peng, Y. Dai, C. Hitchcock, X. Yang, E. S. Kassis et al. , "Insulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNAin lung cancer, " Proceedings of the NationalAcademy of Sciences of theUnited States ofAmerica, vol. 110, no. 37, pp. 15043-15048, 2013.
49. Q. Sun, M. Hang, X. Guo, W. Shao, and G. Zeng, "Expression and significance of miRNA-21 and BTG2 in lung cancer, " Tumor Biology, vol. 34, no. 6, pp. 4017-4026, 2013.
50. X. Wu, T. Liu, O. Fang, L. J. Leach, X. Hu, and Z. Luo, "MiR- 194 suppressesmetastasis of non-small cell lung cancer through regulating expression of BMP1 and p271, " Oncogene, 2013.
51. J. Cai, J. Wu, H. Zhang, L. Fang, Y. Huang et al. , "MiR-186 downregulation correlates with poor survival in lung adenocarcinoma, where it interferes with cell-cycle regulation, " Cancer Research, vol. 73, pp. 756-766, 2013.
52. J. -G. Zhang, J. -F. Guo, D. -L. Liu, Q. Liu, and J. -J. Wang, "MicroRNA-101 exerts tumor-suppressive functions in nonsmall cell lung cancer through directly targeting enhancer of zeste homolog 2, " Journal ofThoracic Oncology, vol. 6, no. 4, pp. 671-678, 2011.
53. J. D. Roybal, Y. Zang, Y. -H. Ahn et al. , "MiR-200 inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1, " Molecular Cancer Research, vol. 9, no. 1, pp. 25- 35, 2011.
54. J. Wu, J. Qian, C. Li et al. , "MiR-129 regulates cell proliferation by downregulating Cdk6 expression, " Cell Cycle, vol. 9, no. 9, pp. 1809-1818, 2010.
55. J. Balca-Silva, S. S. Neves, A. C. Goncalves et al. , "Effect of miR- 34b overexpression on the radiosensitivity of non-small cell lung cancer cell lines, " Anticancer Research, vol. 32, no. 5, pp. 1603-1609, 2012.
56. H. Hu, S. Li, J. Liu, and B. Ni, "MicroRNA-193b modulates proliferation, migration, and invasion of non-small cell lung cancer cells, " Acta Biochimica et Biophysica Sinica, vol. 44, no. 5, pp. 424-430, 2012.
57. N. Zhang, X. Wei, and L. Xu, "MiR-150 promotes the proliferation of lung cancer cells by targeting P53, " FEBS Letters, vol. 587, no. 15, pp. 2346-2351, 2013.
58. W. Nian, X. Ao, Y. Wu et al. , "MiR-223 functions as a potent tumor suppressor of the Lewis lung carcinoma cell line by targeting insulin-like growth factor-1 receptor and cyclindependent kinase 2, " Oncology Letters, vol. 6, no. 2, pp. 359-366, 2013.
59. C. Liu, K. Kelnar, B. Liu et al. , "The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44, " Nature Medicine, vol. 17, no. 2, pp. 211-215, 2011.
60. J. -H. Lee, J. Voortman, A. -M. C. Dingemans et al. , "MicroRNA expression and clinical outcome of small cell lung cancer, " PLoS ONE, vol. 6, no. 6, Article ID e21300, 2011.
61. G. M. Cooper and National Center for Biotechnology Information (U. S. ), The Cell: A Molecular Approach, ASM Press, Washington, DC, USA; Sinauer Associates, Sunderland, Mass, USA, 2nd edition, 2000.
62. K. Inamura, Y. Togashi, K. Nomura et al. , "Let-7 microRNA expression is reduced in bronchioloalveolar carcinoma, a noninvasive carcinoma, and is not correlated with prognosis, " Lung Cancer, vol. 58, no. 3, pp. 392-396, 2007.
63. N. Yanaihara, N. Caplen, E. Bowman et al. , "Unique microRNA molecular profiles in lung cancer diagnosis and prognosis, " Cancer Cell, vol. 9, no. 3, pp. 189-198, 2006.
64. N. Bandi, S. Zbinden, M. Gugger et al. , "MiR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer, " Cancer Research, vol. 69, no. 13, pp. 5553-5559, 2009.
65. X. Zhu, Y. Li, H. Shen, H. Li, L. Long et al. , "MiR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6, " FEBS Letters, vol. 587, no. 1, pp. 73-81, 2013.
66. L. Galluzzi, E. Morselli, I. Vitale et al. , "MiR-181a and miR-630 regulate cisplatin-induced cancer cell death, " Cancer Research, vol. 70, no. 5, pp. 1793-1803, 2010.
67. K. Vermeulen, D. R. van Bockstaele, and Z. N. Berneman, "The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer, " Cell Proliferation, vol. 36, no. 3, pp. 131-149, 2003.
68. C. J. Sherr, "G1 phase progression: cycling on cue, " Cell, vol. 79, no. 4, pp. 551-555, 1994.
69. M. Ohtsubo, A. M. Theodoras, J. Schumacher, J. M. Roberts, and M. Pagano, "Human cyclin E, a nuclear protein essential for the G1-to-S phase transition, " Molecular and Cellular Biology, vol. 15, no. 5, pp. 2612-2624, 1995.
70. F. Girard, U. Strausfeld, A. Fernandez, andN. J. C. Lamb, "Cyclin A is required for the onset of DNA replication in mammalian fibroblasts, " Cell, vol. 67, no. 6, pp. 1169-1179, 1991.
71. D. H. Walker and J. L. Maller, "Role for cyclin A in the dependence of mitosis on completion of DNA replication, " Nature, vol. 354, no. 6351, pp. 314-317, 1991.
72. M. Arellano and S. Moreno, "Regulation of CDK/cyclin complexes during the cell cycle, " International Journal of Biochemistry and Cell Biology, vol. 29, no. 4, pp. 559-573, 1997.
73. R. W. King, P. K. Jackson, and M. W. Kirschner, "Mitosis in transition, " Cell, vol. 79, no. 4, pp. 563-571, 1994.
74. H. Salim, A. Arvanitis, L. de Petris et al. , "MiRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression, " Genes Chromosomes and Cancer, vol. 52, no. 10, pp. 895-911, 2013.
75. F. Sun, H. Fu, Q. Liu et al. , "Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest, " FEBS Letters, vol. 582, no. 10, pp. 1564-1568, 2008.
76. A. Alteri, F. de Vito, G. Messina et al. , "Cyclin D1 is a major target of miR-206 in cell differentiation and transformation, " Cell Cycle, vol. 12, no. 24, pp. 3781-3790, 2013.
77. X. Liu, L. F. Sempere, F. Galimberti et al. , "Uncovering growth-suppressivemicroRNAs in lung cancer, " Clinical Cancer Research, vol. 15, no. 4, pp. 1177-1183, 2009.
78. C. J. Sherr and J. M. Roberts, "Inhibitors of mammalian G1 cyclin-dependent kinases, " Genes and Development, vol. 9, no. 10, pp. 1149-1163, 1995.
79. A. Carnero and G. J. Hannon, "The INK4 family of CDK inhibitors, " in Cyclin Dependent Kinase (CDK) Inhibitors, vol. 227 of Current Topics in Microbiology and Immunology, pp. 43- 55, Springer, Berlin, Germany, 1998.
80. L. Hengst and S. I. Reed, "Inhibitors of the Cip/Kip family, " in Cyclin Dependent Kinase (CDK) Inhibitors, vol. 227 of Current Topics in Microbiology and Immunology, pp. 25-41, Springer, Berlin, Germany, 1998.
81. S. Donzelli, G. Fontemaggi, F. Fazi et al. , "MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function, " Cell Death and Differentiation, vol. 19, pp. 1038-1048, 2012.
82. M. Acunzo, R. Visone, G. Romano et al. , "MiR-130a targetsMET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222, " Oncogene, vol. 31, no. 5, pp. 634-642, 2012.
83. S. L. Harris and A. J. Levine, "The p53 pathway: positive and negative feedback loops, " Oncogene, vol. 24, no. 17, pp. 2899- 2908, 2005.
84. A. L. Kasinski and F. J. Slack, "MiRNA-34 prevents cancer initiation and progression in a therapeutically resistant Kras and p53-induced mouse model of lung adenocarcinoma, " Cancer Research, vol. 72, no. 21, pp. 5576-5587, 2012.
85. D. T. Wang, Z. L. Ma, Y. L. Li et al. , "MiR-150, p53 protein and relevant miRNAs consist of a regulatory network in NSCLC tumorigenesis, " Oncology Reports, vol. 30, no. 1, pp. 492-498, 2013.
86. Y. -J. Li, Y. -X. Zhang, P. -Y. Wang et al. , "Regression of A549 lung cancer tumors by anti-miR-150 vector, " Oncology Reports, vol. 27, no. 1, pp. 129-134, 2012.
87. L. He, X. He, L. P. Lim et al. , "A microRNA component of the p53 tumour suppressor network, " Nature, vol. 447, no. 7148, pp. 1130-1134, 2007.
88. S. Zhang, C. Zhang, Y. Li, P. Wang, Z. Yue, and S. Xie, "MiR-98 regulates cisplatin-induced A549 cell death by inhibiting TP53 pathway, " Biomedicine and Pharmacotherapy, vol. 65, no. 6, pp. 436-442, 2011.
89. K. Skrzypek, M. Tertil, S. Golda et al. , "Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis, " Antioxidants and Redox Signaling, vol. 19, no. 7, pp. 644-660, 2013.
90. S. -Y. Park, J. H. Lee, M. Ha, J. -W. Nam, and V. N. Kim, "MiR- 29 miRNAs activate p53 by targeting p85and CDC42, " Nature Structural and Molecular Biology, vol. 16, no. 1, pp. 23-29, 2009.
91. X. Liu, L. F. Sempere, H. Ouyang et al. , "MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors, " Journal of Clinical Investigation, vol. 120, no. 4, pp. 1298-1309, 2010.
92. Y. Li, J. Pei, H. Xia, H. Ke, H. Wang, and W. Tao, "Lats2, a putative tumor suppressor, inhibits G1/S transition, " Oncogene, vol. 22, no. 28, pp. 4398-4405, 2003.
93. P. R. Clarke, I. Hoffmann, G. Draetta, and E. Karsenti, "Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts, " Molecular Biology of the Cell, vol. 4, no. 4, pp. 397-411, 1993.
94. P. -Y. Lin, S. -L. Yu, and P. -C. Yang, "MicroRNA in lung cancer, " British Journal of Cancer, vol. 103, no. 8, pp. 1144-1148, 2010.
95. D. R. Green and G. I. Evan, "A matter of life and death, " Cancer Cell, vol. 1, no. 1, pp. 19-30, 2002.
96. R. M. Locksley, N. Killeen, and M. J. Lenardo, "The TNF and TNF receptor superfamilies: integrating mammalian biology, " Cell, vol. 104, no. 4, pp. 487-501, 2001.
97. M. Liu, Z. Wang, S. Yang et al. , "TNF-is a novel target of miR- 19a, " International Journal of Oncology, vol. 38, no. 4, pp. 1013- 1022, 2011.
98. M. Garofalo, Y. J. Jeon, G. J. Nuovo et al. , "MiR-34a/cdependent PDGFR-downregulation inhibits tumorigenesis and enhances TRAIL-induced apoptosis in lung cancer, " PLoS ONE, vol. 8, no. 6, Article ID e67581, 2013.
99. M. Incoronato, M. Garofalo, L. Urso et al. , "MiR-212 increases tumor necrosis factor-related apoptosis-inducing ligand sensitivity in non-small cell lung cancer by targeting the antiapoptotic protein PED, " Cancer Research, vol. 70, no. 9, pp. 3638- 3646, 2010.
100. G. Romano, M. Acunzo, M. Garofalo et al. , "MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation, " Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 41, pp. 16570-16575, 2012.
101. M. Garofalo, C. Quintavalle, G. Di Leva et al. , "MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer, " Oncogene, vol. 27, no. 27, pp. 3845-3855, 2008.
102. J. -C. Martinou and R. J. Youle, "Mitochondria in apoptosis: bcl- 2 family members and mitochondrial dynamics, " Developmental Cell, vol. 21, no. 1, pp. 92-101, 2011.
103. N. J. Waterhouse, J. C. Goldstein, O. von Ahsen, M. Schuler, D. D. Newmeyer, and D. R. Green, "Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process, " Journal of Cell Biology, vol. 153, no. 2, pp. 319-328, 2001.
104. H. Zou, W. J. Henzel, X. Liu, A. Lutschg, and X. Wang, "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3, " Cell, vol. 90, no. 3, pp. 405-413, 1997.
105. P. Li, D. Nijhawan, I. Budihardjo et al. , "Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade, " Cell, vol. 91, no. 4, pp. 479- 489, 1997.
106. T. Nakagawa, H. Zhu, N. Morishima et al. , "Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-" Nature, vol. 403, no. 6765, pp. 98-103, 2000.
107. T. Qiu, L. Zhou, T. Wang et al. , "MiR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl- 2, " International Journal ofMolecularMedicine, vol. 32, no. 3, pp. 593-598, 2013.
108. W. Zhu, X. Shan, T. Wang, Y. Shu, and P. Liu, "MiR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines, " International Journal of Cancer, vol. 127, no. 11, pp. 2520-2529, 2010.
109. W. Zhu, H. Xu, D. Zhu et al. , "MiR-200bc/429 clustermodulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP, " Cancer Chemotherapy and Pharmacology, vol. 69, no. 3, pp. 723-731, 2012.
110. W. Zhu, D. Zhu, S. Lu et al. , "MiR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2, " Medical Oncology, vol. 19, no. 1, pp. 384-391, 2012.
111. S. Y. Cui, J. Y. Huang, Y. T. Chen et al. , "Let-7c governs the acquisition of chemo- or radioresistance and epithelial-tomesenchymal transition phenotypes in docetaxel-resistant lung adenocarcinoma, " Molecular Cancer Research, vol. 11, pp. 699- 713, 2013.
112. J. Gong, J. P. Zhang, B. Li et al. , "MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL- 6R, " Oncogene, vol. 32, no. 25, pp. 3071-3079, 2013.
113. C. Zhang, J. Zhang, A. Zhang et al. , "PUMA is a novel target of miR-221/222 in human epithelial cancers, " International Journal of Oncology, vol. 37, no. 6, pp. 1621-1626, 2010.
114. B. Dai, J. Meng, M. Peyton et al. , "STAT3 mediates resistance to MEK inhibitor through microRNA miR-17, " Cancer Research, vol. 71, no. 10, pp. 3658-3668, 2011.
115. M. Garofalo, G. Romano, G. Di Leva et al. , "EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers, " Nature Medicine, vol. 18, no. 1, pp. 74-82, 2012.
116. S. Catuogno, L. Cerchia, G. Romano, P. Pognonec, G. Condorelli, and V. de Franciscis, "MiR-34c may protect lung cancer cells from paclitaxel-induced apoptosis, " Oncogene, vol. 32, no. 3, pp. 341-351, 2013.
117. J. Zhang, Y. Du, C. Wu et al. , "Curcumin promotes apoptosis in human lung adenocarcinoma cells through miR-186? signaling pathway, " Oncology Reports, vol. 24, no. 5, pp. 1217-1223, 2010.
118. M. W. Nasser, J. Datta, G. Nuovo et al. , "Down-regulation of micro-RNA-1 (miR-1) in lung cancer: suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1, " The Journal of Biological Chemistry, vol. 283, no. 48, pp. 33394-33405, 2008.
119. A. Druz, Y. C. Chen, R. Guha, M. Betenbaugh, S. E. Martin, and J. Shiloach, "Large-scale screening identifies a novel microRNA, miR-15a-3p, which induces apoptosis in human cancer cell lines, " RNA Biology, vol. 10, no. 2, pp. 287-300, 2013.
120. L. Du, R. Borkowski, Z. Zhao et al. , "A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response topaclitaxel, "RNABiology, vol. 10, no. 11, pp. 1700- 1713, 2013.
121. D. Liao and R. S. Johnson, "Hypoxia: a key regulator of angiogenesis in cancer, " Cancer andMetastasis Reviews, vol. 26, no. 2, pp. 281-290, 2007.
122. E. Jusufovic, M. Rijavec, D. Keser et al. , "Let-7b andmiR-126 are down-regulated in tumor tissue and correlate with microvessel density and survival outcomes in non-small-cell lung cancer, " PLoS ONE, vol. 7, no. 9, Article ID e45577, 2012.
123. A. Chamorro-Jorganes, E. Araldi, L. O. F. Penalva, D. Sandhu, C. Fernandez-Hernando, and Y. Suarez, "MicroRNA-16 and MicroRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 31, no. 11, pp. 2595-2606, 2011.
124. C. -Z. Chen, L. Li, H. F. Lodish, and D. P. Bartel, "MicroRNAs modulate hematopoietic lineage differentiation, " Science, vol. 303, no. 5654, pp. 83-86, 2004.
125. M. N. Poy, L. Eliasson, J. Krutzfeldt et al. , "A pancreatic isletspecific microRNAregulates insulin secretion, " Nature, vol. 432, no. 7014, pp. 226-230, 2004.
126. E. van Rooij, L. B. Sutherland, X. Qi, J. A. Richardson, J. Hill, and E. N. Olson, "Control of stress-dependent cardiac growth and gene expression by a microRNA, " Science, vol. 316, no. 5824, pp. 575-579, 2007.
127. R. Pocock, "Invited review: decoding the microRNA response to hypoxia, " Pflügers Archiv, vol. 461, no. 3, pp. 307-315, 2011.
128. A. Taguchi, K. Yanagisawa, M. Tanaka et al. , "Identification of hypoxia-inducible factor-1as a novel target for miR-17-92 microRNA cluster, " Cancer Research, vol. 68, no. 14, pp. 5540- 5545, 2008.
129. S. -T. Cha, P. -S. Chen, G. Johansson et al. , "MicroRNA-519c suppresses hypoxia-inducible factor-1expression and tumor angiogenesis, " Cancer Research, vol. 70, no. 7, pp. 2675-2685, 2010.
130. X. Huang, L. Ding, K. L. Bennewith et al. , "Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation, " Molecular Cell, vol. 35, no. 6, pp. 856-867, 2009.
131. S. Grosso, J. Doyen, S. K. Parks et al. , "MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines, " Cell Death and Disease, vol. 4, article e544, 2013.
132. L. Geng, E. Donnelly, G. McMahon et al. , "Inhibitionof vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy, " Cancer Research, vol. 61, no. 6, pp. 2413-2419, 2001.
133. H. Harada, S. Kizaka-Kondoh, G. Li et al. , "Significance of HIF- 1-active cells in angiogenesis and radioresistance, " Oncogene, vol. 26, no. 54, pp. 7508-7516, 2007.
134. B. J. Moeller, Y. Cao, C. Y. Li, and M. W. Dewhirst, "Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules, " Cancer Cell, vol. 5, no. 5, pp. 429-441, 2004.
135. K. A. Houck, D. W. Leung, A. M. Rowland, J. Winer, and N. Ferrara, "Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms, " The Journal of Biological Chemistry, vol. 267, no. 36, pp. 26031- 26037, 1992.
136. T. Veikkola, M. Karkkainen, L. Claesson-Welsh, and K. Alitalo, "Regulation of angiogenesis via vascular endothelial growth factor receptors, " Cancer Research, vol. 60, no. 2, pp. 203-212, 2000.
137. T. Donnem, K. Lonvik, K. Eklo et al. , "Independent and tissuespecific prognostic impact of miR-126 in non-small cell lung cancer: coexpression with vascular endothelial growth factor- A predicts poor survival, " Cancer, vol. 117, no. 14, pp. 3193-3200, 2011.
138. X. Zhu, H. Li, L. Long et al. , "MiR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A, " Acta Biochimica et Biophysica Sinica, vol. 44, no. 6, pp. 519-526, 2012.
139. L. Shi, S. Zhang, H. Wu et al. , "MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway, " PLoS ONE, vol. 8, no. 10, Article ID e78344, 2013.
140. R. M. Bremnes, C. Camps, and R. Sirera, "Angiogenesis in nonsmall cell lung cancer: the prognostic impact of neoangiogenesis and the cytokines VEGF and bFGF in tumours and blood, " Lung Cancer, vol. 51, no. 2, pp. 143-158, 2006.
141. M. Korc and R. E. Friesel, "The role of fibroblast growth factors in tumor growth, " Current Cancer Drug Targets, vol. 9, no. 5, pp. 639-651, 2009.
142. M. Presta, P. DellEra, S. Mitola, E. Moroni, R. Ronca, and M. Rusnati, "Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis, " Cytokine and Growth Factor Reviews, vol. 16, no. 2, pp. 159-178, 2005.
143. G. Seghezzi, S. Patel, C. J. Ren et al. , "Fibroblast growth factor- 2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis, " Journal of Cell Biology, vol. 141, no. 7, pp. 1659-1673, 1998.
144. T. Donnem, C. G. Fenton, K. Lonvik et al. , "MicroRNA signatures in tumor tissue related to angiogenesis in non-small cell lung cancer, " PLoS ONE, vol. 7, no. 1, Article ID e29671, 2012.
145. G. Murugaiyan and B. Saha, "Protumor vs antitumor functions of IL-17, " The Journal of Immunology, vol. 183, no. 7, pp. 4169- 4175, 2009.
146. A. Yuan, J. J. W. Chen, P. -L. Yao, and P. -C. Yang, "The role of interleukin-8 in cancer cells and microenvironment interaction, " Frontiers in Bioscience, vol. 10, pp. 853-865, 2005.
147. M. Orditura, F. de Vita, G. Catalano et al. , "Elevated serum levels of interleukin-8 in advanced non-small cell lung cancer patients: relationship with prognosis, " Journal of Interferon and Cytokine Research, vol. 22, no. 11, pp. 1129-1135, 2002.
148. C. V. Pecot, R. Rupaimoole, D. Yang et al. , "Tumour angiogenesis regulation by the miR-200 family, " Nature Communications, vol. 4, article 2427, 2013.
149. S. I. Rothschild, M. P. Tschan, R. Jaggi, M. F. Fey, M. Gugger, and O. Gautschi, "MicroRNA-381 represses ID1 and is deregulated in lung adenocarcinoma, " Journal ofThoracic Oncology, vol. 7, no. 7, pp. 1069-1077, 2012.
150. B. Liu, X. Wu, B. Liu et al. , "MiR-26a enhances metastasis potential of lung cancer cells via AKT pathway by targeting PTEN, " Biochimica et BiophysicaActa , vol. 1822, no. 11, pp. 1692- 1704, 2012.
151. N. Kosaka, H. Iguchi, and T. Ochiya, "Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis, " Cancer Science, vol. 101, no. 10, pp. 2087-2092, 2010.
152. H. Hu, B. Wang, M. Borde et al. , "Foxp1 is an essential transcriptional regulator of B cell development, "Nature Immunology, vol. 7, no. 8, pp. 819-826, 2006.
153. P. S. Mitchell, R. K. Parkin, E. M. Kroh et al. , "Circulating microRNAs as stable blood-based markers for cancer detection, " Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 30, pp. 10513-10518, 2008.
154. M. S. Kumar, J. Lu, K. L. Mercer, T. R. Golub, and T. Jacks, "Impaired microRNA processing enhances cellular transformation and tumorigenesis, " Nature Genetics, vol. 39, no. 5, pp. 673- 677, 2007.
155. G. Rabinowits, C. Gercel-Taylor, J. M. Day, D. D. Taylor, and G. H. Kloecker, "Exosomal microRNA: a diagnostic marker for lung cancer, " Clinical Lung Cancer, vol. 10, no. 1, pp. 42-46, 2009.
156. H. B. Le, W. Y. Zhu, D. D. Chen et al. , "Evaluation of dynamic change of serum miR-21 and miR-24 in pre- and post-operative lung carcinoma patients, " Medical Oncology, vol. 29, no. 5, pp. 3190-3197, 2012.
157. A. V. Kossenkov, A. Vachani, C. Chang et al. , "Resection of nonsmall cell lung cancers reverses tumor-induced gene expression changes in the peripheral immune system, " Clinical Cancer Research, vol. 17, no. 18, pp. 5867-5877, 2011.
158. P. Leidinger, A. Keller, C. Backes, H. Huwer, and E. Meese, "MicroRNA expression changes after lung cancer resection: a follow-up study, " RNA Biology, vol. 9, no. 6, pp. 900-910, 2012.
159. J. Skog, T. Würdinger, S. van Rijn et al. , "Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers, " Nature Cell Biology, vol. 10, no. 12, pp. 1470-1476, 2008.
160. G. Zhuang, X. Wu, Z. Jiang et al. , "Tumour-secreted miR- 9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway, " The EMBO Journal, vol. 31, no. 17, pp. 3513-3523, 2012.
161. V. N. Aushev, I. B. Zborovskaya, K. K. Laktionov et al. , "Comparisons ofmicroRNA patterns in plasma before and after tumor removal reveal New biomarkers of lung squamous cell carcinoma, " PLoS ONE, vol. 8, no. 10, Article IDe78649, 2013.
162. L. Yu, N. W. Todd, L. Xing et al. , "Early detection of lung adenocarcinoma in sputum by a panel of microRNA markers, " International Journal of Cancer, vol. 127, no. 12, pp. 2870-2878, 2010.
163. L. Xing, N. W. Todd, L. Yu, H. Fang, and F. Jiang, "Early detection of squamous cell lung cancer in sputum by a panel of microRNAmarkers, " Modern Pathology, vol. 23, no. 8, pp. 1157- 1164, 2010.
164. C. Roth, S. Kasimir-Bauer, K. Pantel, and H. Schwarzenbach, "Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer, " Molecular Oncology, vol. 5, no. 3, pp. 281-291, 2011.
165. W. Gao, Y. Yu, H. Cao et al. , "Deregulated expression of miR- 21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis, " Biomedicine and Pharmacotherapy, vol. 64, no. 6, pp. 399- 408, 2010.
166. J. A. Bishop, H. Benjamin, H. Cholakh, A. Chajut, D. P. Clark, andW. H. Westra, "Accurate classification of non-small cell lung carcinoma using a novel microRNA-based approach, " Clinical Cancer Research, vol. 16, no. 2, pp. 610-619, 2010.
167. Y. Lu, R. Govindan, L. Wang et al. , "MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer, " Carcinogenesis, vol. 33, no. 5, pp. 1046-1054, 2012.
168. M. Jiang, P. Zhang, G. Hu et al. , "Relative expressions of miR-205-5p, miR-205-3p, and miR-21 in tissues and serum of non-small cell lung cancer patients, " Molecular and Cellular Biochemistry, vol. 383, no. 1-2, pp. 67-75, 2013.
169. Y. Sun, B. Su, P. Zhang et al. , "Expression of miR-150 and miR-3940-5p is reduced in non-small cell lung carcinoma and correlates with clinicopathological features, " Oncology Reports, vol. 29, no. 2, pp. 704-712, 2013.
170. M. -P. Puissegur, N. M. Mazure, T. Bertero et al. , "MiR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity, " Cell Death and Differentiation, vol. 18, no. 3, pp. 465- 478, 2011.
171. K. M. Foss, C. Sima, D. Ugolini, M. Neri, K. E. Allen, and G. J. Weiss, "MiR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer, " Journal of Thoracic Oncology, vol. 6, no. 3, pp. 482-488, 2011.
172. I. Barshack, G. Lithwick-Yanai, A. Afek et al. , "MicroRNA expression differentiates between primary lung tumors and metastases to the lung, " Pathology Research and Practice, vol. 206, no. 8, pp. 578-584, 2010.
173. A. Navarro, T. Diaz, E. Gallardo et al. , "Prognostic implications of miR-16 expression levels in resected non-small-cell lung cancer, " Journal of Surgical Oncology, vol. 103, no. 5, pp. 411-415, 2011.
174. A. Markou, E. G. Tsaroucha, L. Kaklamanis, M. Fotinou, V. Georgoulias, and E. S. Lianidou, "Prognostic value of mature MicroRNA-21 andMicroRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR, " Clinical Chemistry, vol. 54, no. 10, pp. 1696-1704, 2008.
175. I. A. Babar, J. Czochor, A. Steinmetz, J. B. Weidhaas, P. M. Glazer, and F. J. Slack, "Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells, " Cancer Biology and Therapy, vol. 12, no. 10, pp. 908-914, 2011.
176. J. F. Wiggins, L. Ruffino, K. Kelnar et al. , "Development of a lung cancer therapeutic based on the tumor suppressor microRNA- 34, " Cancer Research, vol. 70, no. 14, pp. 5923-5930, 2010.
177. J. Voortman, A. Goto, J. Mendiboure et al. , "MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma, " Cancer Research, vol. 70, no. 21, pp. 8288-8298, 2010.
178. X. Pu, J. A. Roth, M. A. Hildebrandt et al. , "MicroRNA-related genetic variants associated with clinical outcomes in early-stage non-small cell lung cancer patients, " Cancer Research, vol. 73, no. 6, pp. 1867-1875, 2013.