MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Shi, Liangliang ^a   Zhang, Sheng ^a   Wu, Hongge ^a   Zhang, Lilin ^a   Dai, Xiaofang ^a   Hu, Jianli ^a   Xue, Jun ^a   Liu, Tao ^a   Liang, Yichen ^a   Wu, Gang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA 200C; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; MICRORNA; MIRN200 MICRORNA, HUMAN; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

A549 CELL LINE; ANGIOGENESIS; ARTICLE; AUTOCRINE EFFECT; BIOINFORMATICS; CANCER CELL; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; LUCIFERASE ASSAY; NON SMALL CELL LUNG CANCER; PARACRINE SIGNALING; RADIOSENSITIVITY; RADIOSENSITIZATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; RADIATION DOSE; TUMOR CELL LINE;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MICRORNAS; RADIATION TOLERANCE; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84889661365     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078344     Document Type: Article

References (19)

1. Siegel R, Naishadham D, Jemal A (2013) Cancer statistics, 2013. CA Cancer J Clin 63: 11-30.
2. Sechler M, Cizmic AD, Avasarala S, Van Scoyk M, Brzezinski C, et al. (2013) Non-small-cell lung. cancer: molecular targeted therapy and personalized medicine-drug resistance, mechanisms, and strategies. Pharmgenomics Pers Med 6: 25-36.
3. Rowell NP, O'Rourke N P (2004) Concurrent chemoradiotherapy in non-small cell lung cancer Cochrane Database Syst Rev: CD002140.
4. Peng F, Xu Z, Wang J, Chen Y, Li Q, et al. (2012) Recombinant human endostatin normalizes tumor vasculature and enhances radiation response in xenografted human nasopharyngeal carcinoma models. PLoS One 7: e34646.
5. Wachsberger PR, Burd R, Cardi C, Thakur M, Daskalakis C, et al. (2007) VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. Int J Radiat Oncol Biol Phys 67: 1526-1537.
6. Shibuya K, Komaki R, Shintani T, Itasaka S, Ryan A, et al. (2007) Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 69: 1534-1543.
7. Li J, Huang S, Armstrong EA, Fowler JF, Harari PM (2005) Angiogenesis and radiation response modulation after vascular endothelial growth factor receptor-2 (VEGFR2) blockade. Int J Radiat. Oncol Biol Phys 62: 1477-1485.
8. Solberg TD, Nearman J, Mullins J, Li S, Baranowska-Kortylewicz J (2008) Correlation between tumor growth delay and expression of cancer and host VEGF, VEGFR2, and osteopontin in response to radiotherapy. Int J Radiat Oncol Biol Phys 72: 918-926.
9. Wang Y, Weng T, Gou D, Chen Z, Chintagari NR, et al. (2007) Identification of rat lung-specific microRNAs by micoRNA microarray: valuable discoveries for the facilitation of lung research. BMC Genomics 8: 29.
10. Ceppi P, Mudduluru G, Kumarswamy R, Rapa I, Scagliotti GV, et al. (2010) Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res 8: 1207-1216.
11. Cittelly DM, Dimitrova I, Howe EN, Cochrane DR, Jean A, et al. (2012) Restoration of miR-200c to ovarian cancer reduces tumor burden and increases sensitivity to paclitaxel. Mol Cancer Ther 11: 2556-2565.
12. Wu Y, Xiao Y, Ding X, Zhuo Y, Ren P, et al. (2011) A miR-200b/200c/429-binding site polymorphism in the 39 untranslated region of the AP-2alpha gene is associated with cisplatin resistance. PLoS One 6: e29043.
13. Li ZY, Zhu F, Hu JL, Peng G, Chen J, et al. (2011) Sp1 inhibition-mediated upregulation of VEGF165 b induced by rh-endostatin enhances antiangiogenic and anticancer effect of rh-endostatin in A549. Tumour Biol 32: 677-687.
14. Zhu F, Zhang Z, Wu G, Li Z, Zhang R, et al. (2011) Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549. Med Oncol 28: 565-571.
15. Wang Q, Zhao W, Wu G (2009) Valsartan inhibits NPC cell line CNE-2 proliferation and invasion and promotes its sensitivity to radiation. Eur J Cancer Prev 18: 510-517.
16. Larsen AK, Ouaret D, El Ouadrani K, Petitprez A (2011) Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis. Pharmacol Ther 131: 80-90.
17. Knizetova P, Ehrmann J, Hlobilkova A, Vancova I, Kalita O, et al. (2008) Autocrine regulation of glioblastoma cell cycle progression, viability and radioresistance through the VEGF-VEGFR2 (KDR) interplay. Cell Cycle 7: 2553-2561.
18. Abdollahi A, Lipson KE, Han X, Krempien R, Trinh T, et al. (2003) SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Cancer Res 63: 3755-3763.
19. Wang N, Wang ZY, Mo SL, Loo TY, Wang DM, et al. (2012) Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer. Breast Cancer Res Treat 134: 943-955.