Implications of prion adaptation and evolution paradigm for human neurodegenerative diseases

Prion

Volumn 8, Issue 1, 2014, Pages

  Kabir, M Enamul ^a   Safar, Jiri G ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Conformational evolution; Human PrPSc coexistence; Neurodegeneration; Prion strains; Sporadic Creutzfeldt Jakob disease (sCJD)

Indexed keywords

AMYLOID BETA PROTEIN; METHIONINE; PRESENILIN 1; PRESENILIN 2; PRION PROTEIN; PROTEINASE K; RECOMBINANT AMYLOID BETA PROTEIN; RECOMBINANT PROTEIN; RECOMBINANT TAU PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG; PRION;

ADAPTATION; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; BINDING COMPETITION; DEGENERATIVE DISEASE; DRUG TARGETING; GENE EXPRESSION; HUMAN; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; MOLECULAR PATHOLOGY; NONHUMAN; PARKINSON DISEASE; PARTICLE SIZE; PATHOGENESIS; PHENOTYPE; PRION; PRION DISEASE; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; REVIEW; SPORADIC CREUTZFELDT JAKOB DISEASE; VIRUS PARTICLE; VIRUS REPLICATION; VIRUS STRAIN; EVOLUTION; NEURODEGENERATIVE DISEASES;

BIOLOGICAL EVOLUTION; HUMANS; NEURODEGENERATIVE DISEASES; PRIONS;

EID: 84896981556     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.27661     Document Type: Review

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