Prions, prionoids and pathogenic proteins in Alzheimer disease

Prion

Volumn 7, Issue 1, 2013, Pages 55-59

  Ashe, Karen H ^a,b   Aguzzi, Adriano ^c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Alzheimer disease; Amyloid ; Pathogenic proteins; Prionoids; Prions; PrP; Tau

Indexed keywords

AMYLOID BETA PROTEIN; ATAXIN 1; INITIATION FACTOR 2ALPHA; POLYGLUTAMINE; PRION PROTEIN;

ALZHEIMER DISEASE; CONFERENCE PAPER; CYTOSOL; DEGENERATIVE DISEASE; DEMENTIA; EXPERIMENTAL MOUSE; EXTRACELLULAR SPACE; HUMAN; NEUROTOXICITY; NONHUMAN; PROTEIN AGGREGATION;

ALZHEIMER'S DISEASE; AMYLOID-Β; PATHOGENIC PROTEINS; PRIONOIDS; PRIONS; PRP; TAU;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; HUMANS; PRIONS;

EID: 84874638938     PISSN: 19336896     EISSN: 1933690X     Source Type: Journal    
DOI: 10.4161/pri.23061     Document Type: Conference Paper

References (39)

1. Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science 1982; 216:136-44; PMID:6801762; http://dx.doi.org/10.1126/science. 6801762.
2. Basler K, Oesch B, Scott M, Westaway D, Wälchli M, Groth DF, et al. Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell 1986; 46:417-28; PMID:2873895; http://dx.doi.org/10.1016/0092-8674(86)90662-8.
3. Kane MD, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, et al. Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice. J Neurosci 2000; 20:3606-11; PMID:10804202.
4. Gaspar RC, Villarreal SA, Bowles N, Hepler RW, Joyce JG, Shughrue PJ. Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model. Exp Neurol 2010; 223:394-400; http://dx.doi.org/10. 1016/j.expneurol.2009.09.001; PMID:19744481.
5. Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science 2006; 313:1781- 4; http://dx.doi.org/10.1126/science. 1131864; PMID:16990547.
6. Morales R, Duran-Aniotz C, Castilla J, Estrada LD, Soto C. De novo induction of amyloid-beta deposition in vivo. Mol Psychiatry 2011; 17: 1347-53; http://dx.doi.org/10.1038/mp.2011.120; PMID:21968933.
7. Stöhr J, Watts JC, Mensinger ZL, Oehler A, Grillo SK, DeArmond SJ, et al. Purified and synthetic Alzheimer's amyloid beta (Aβ) prions. Proc Natl Acad Sci U S A 2012; 109:11025-30; http://dx.doi.org/10.1073/pnas. 1206555109 PMID:22711819.
8. Aguzzi A, Weissmann C. Spongiform encephalopathies: a suspicious signature. Nature 1996; 383:666-7; http://dx.doi.org/10.1038/383666a0 PMID:8878470.
9. Gajdusek DC, Gibbs CJ, Alpers M. Experimental transmission of a Kuru-like syndrome to chimpanzees. Nature 1966; 209:794-6; PMID:5922150; http://dx.doi.org/10.1038/209794a0.
10. Aguzzi A. Cell biology: Beyond the prion principle. Nature 2009; 459:924-5; http://dx.doi.org/10.1038/459924a PMID:19536253.
11. Aguzzi A, Rajendran L. The transcellular spread of cytosolic amyloids, prions, and prionoids. Neuron 2009; 64:783-90; http://dx.doi.org/10.1016/j. neuron.2009.12.016; PMID:20064386.
12. Aguzzi A, Calella AM. Prions: protein aggregation and infectious diseases. Physiol Rev 2009; 89:1105- 52; http://dx.doi.org/10.1152/physrev. 00006.2009; PMID:19789378.
13. Zhang B, Une Y, Fu X, Yan J, Ge F, Yao J, et al. Fecal transmission of AA amyloidosis in the cheetah contributes to high incidence of disease. Proc Natl Acad Sci U S A 2008; 105:7263-8; http://dx.doi.org/10.1073/pnas.0800367105 PMID:18474855.
14. Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 2005; 309:476-81; http://dx.doi.org/10.1126/science.1113694; PMID:16020737.
15. Rinne JO, Brooks DJ, Rossor MN, Fox NC, Bullock R, Klunk WE, et al. 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascendingdose study. Lancet Neurol 2010; 9:363-72; http://dx.doi.org/10.1016/S1474-4422(10)70043-0; PMID: 20189881.
16. Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, et al. Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci 2002; 5:452-7; http://dx.doi.org/10. 1038/nn842; PMID:11941374.
17. Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, et al. Reversible memory loss in a mouse transgenic model of Alzheimer'sdisease. J Neurosci 2002; 22:6331-5; PMID:12151510.
18. Orr HT, Chung MY, Banfi S, Kwiatkowski TJ Jr., Servadio A, Beaudet AL, et al. Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1. Nat Genet 1993; 4:221-6; http://dx.doi.org/10.1038/ng0793-221; PMID:8358429.
19. Ren PH, Lauckner JE, Kachirskaia I, Heuser JE, Melki R, Kopito RR. Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol 2009; 11:219-25; http://dx.doi.org/10. 1038/ncb1830 PMID:19151706.
20. Watase K, Weeber EJ, Xu B, Antalffy B, Yuva-Paylor L, Hashimoto K, et al. A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration. Neuron 2002; 34:905-19; PMID:12086639; http://dx.doi.org/10.1016/S0896-6273(02)00733-X.
21. Cummings CJ, Reinstein E, Sun Y, Antalffy B, Jiang Y, Ciechanover A, et al. Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron 1999; 24:879-92; PMID:10624951; http://dx.doi.org/10.1016/S0896-6273(00)81035-1.
22. Lim J, Crespo-Barreto J, Jafar-Nejad P, Bowman AB, Richman R, Hill DE, et al. Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. Nature 2008; 452:713-8; http://dx.doi.org/10.1038/ nature06731; PMID:18337722.
23. Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, et al. Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Nature 2012; 485:507-11; http://dx.doi.org/10.1038/ nature11058; PMID:22622579.
24. Sandberg MK, Al-Doujaily H, Sharps B, Clarke AR, Collinge J. Prion propagation and toxicity in vivo occur in two distinct mechanistic phases. Nature 2011; 470:540-2; http://dx.doi.org/10.1038/nature09768; PMID:21350487.
25. Hsiao KK, Scott M, Foster D, Groth DF, DeArmond SJ, Prusiner SB. Spontaneous neurodegeneration in transgenic mice with mutant prion protein. Science 1990; 250:1587-90; PMID:1980379; http://dx.doi.org/10.1126/science. 1980379.
26. Chiesa R, Harris DA. Fishing for prion protein function. PLoS Biol 2009; 7:e75; http://dx.doi.org/10.1371/journal.pbio.1000075; PMID:19338390.
27. Baumann F, Tolnay M, Brabeck C, Pahnke J, Kloz U, Niemann HH, et al. Lethal recessive myelin toxicity of prion protein lacking its central domain. EMBO J 2007; 26:538-47; http://dx.doi.org/10.1038/sj.emboj.7601510; PMID:17245436.
28. Calhoun ME, Wiederhold KH, Abramowski D, Phinney AL, Probst A, Sturchler-Pierrat C, et al. Neuron loss in APP transgenic mice. Nature 1998; 395:755-6; http://dx.doi.org/10.1038/27351; PMID:9796810.
29. Irizarry MC, Soriano F, McNamara M, Page KJ, Schenk D, Games D, et al. Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci 1997; 17:7053-9; PMID:9278541.
30. Urbanc B, Cruz L, Le R, Sanders J, Ashe KH, Duff K, et al. Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proc Natl Acad Sci U S A 2002; 99:13990- 5; http://dx.doi.org/10.1073/pnas.222433299; PMID:12374847.
31. Wilcock DM, Lewis MR, Van Nostrand WE, Davis J, Previti ML, Gharkholonarehe N, et al. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. J Neurosci 2008; 28:1537-45, doi:10.1523/JNEUROSCI.5066-07.2008; PMID:18272675.
32. West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet 1994; 344:769-72; PMID:7916070; http://dx.doi.org/10.1016/S0140-6736(94)92338-8.
33. Carlson GA, Borchelt DR, Dake A, Turner S, Danielson V, Coffin JD, et al. Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Hum Mol Genet 1997; 6:1951-9; PMID:9302276; http://dx.doi.org/10.1093/hmg/6.11.1951.
34. Ashe KH, Zahs KR. Probing the biology of Alzheimer's disease in mice. Neuron 2010; 66:631-45; http://dx.doi.org/10.1016/j.neuron.2010.04.031; PMID:20547123.
35. Bennett DA, Schneider JA, Wilson RS, Bienias JL, Arnold SE. Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch Neurol 2004; 61:378- 84; http://dx.doi.org/10.1001/archneur.61.3.378; PMID:15023815.
36. Gómez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 1997; 41:17-24; http://dx.doi.org/10.1002/ana. 410410106 PMID:9005861.
37. Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, et al. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006; 440:352-7; http://dx.doi.org/10.1038/nature04533; PMID:16541076.
38. Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, et al. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 1999; 2:271-6; http://dx.doi.org/10.1038/ 6374; PMID:10195221.
39. Brandner S, Isenmann S, Raeber A, Fischer M, Sailer A, Kobayashi Y, et al. Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature 1996; 379:339-43; http://dx.doi.org/10.1038/379339a0; PMID:8552188.