-
1
-
-
42149181885
-
Structural diversity of G protein-coupled receptors and significance for drug discovery
-
Lagerström, M. C., and Schiöth, H. B. (2008) Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat. Rev. Drug Discov. 7, 339-357
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 339-357
-
-
Lagerström, M.C.1
Schiöth, H.B.2
-
2
-
-
33947379232
-
Impact of GPCRs in clinical medicine: Monogenic diseases, genetic variants and drug targets
-
DOI 10.1016/j.bbamem.2006.09.029, PII S0005273606003865
-
Insel, P. A., Tang, C. M., Hahntow, I., and Michel, M. C. (2007) Impact of GPCRs in clinical medicine: monogenic diseases, genetic variants and drug targets. Biochim. Biophys. Acta 1768, 994-1005 (Pubitemid 46452544)
-
(2007)
Biochimica et Biophysica Acta - Biomembranes
, vol.1768
, Issue.4
, pp. 994-1005
-
-
Insel, P.A.1
Tang, C.-M.2
Hahntow, I.3
Michel, M.C.4
-
3
-
-
34250306407
-
Heterologous GPCR expression: A bottleneck to obtaining crystal structures
-
DOI 10.1021/bp060349b
-
McCusker, E. C., Bane, S. E., O'Malley, M. A., and Robinson, A. S. (2007) Heterologous GPCR expression: A bottleneck to obtaining crystal structures. Biotechnol. Prog. 23, 540-547 (Pubitemid 46911176)
-
(2007)
Biotechnology Progress
, vol.23
, Issue.3
, pp. 540-547
-
-
McCusker, E.C.1
Bane, S.E.2
O'Malley, M.A.3
Robinson, A.S.4
-
4
-
-
84872024032
-
Emerging opportunities for allosteric modulation of G-protein coupled receptors
-
Wang, C. I., and Lewis, R. J. (2013) Emerging opportunities for allosteric modulation of G-protein coupled receptors. Biochem. Pharmacol. 85, 153-162
-
(2013)
Biochem. Pharmacol.
, vol.85
, pp. 153-162
-
-
Wang, C.I.1
Lewis, R.J.2
-
5
-
-
27844519281
-
New concepts in drug discovery: Collateral efficacy and permissive antagonism
-
Kenakin, T. (2005) New concepts in drug discovery: collateral efficacy and permissive antagonism. Nat. Rev. Drug Discov. 4, 919-927
-
(2005)
Nat. Rev. Drug Discov.
, vol.4
, pp. 919-927
-
-
Kenakin, T.1
-
6
-
-
33747181100
-
Allosteric agonists of 7TM receptors: Expanding the pharmacological toolbox
-
DOI 10.1016/j.tips.2006.07.009, PII S0165614706001805
-
Langmead, C. J., and Christopoulos, A. (2006) Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox. Trends Pharmacol. Sci. 27, 475-481 (Pubitemid 44233695)
-
(2006)
Trends in Pharmacological Sciences
, vol.27
, Issue.9
, pp. 475-481
-
-
Langmead, C.J.1
Christopoulos, A.2
-
7
-
-
33847122495
-
Allosteric modulation of G protein-coupled receptors
-
DOI 10.1146/annurev.pharmtox.47.120505.105159
-
May, L. T., Leach, K., Sexton, P. M., and Christopoulos, A. (2007) Allosteric modulation of G protein-coupled receptors. Annu. Rev. Pharmacol. Toxicol. 47, 1-51 (Pubitemid 46277033)
-
(2007)
Annual Review of Pharmacology and Toxicology
, vol.47
, pp. 1-51
-
-
May, L.T.1
Leach, K.2
Sexton, P.M.3
Christopoulos, A.4
-
8
-
-
58149193205
-
Allosteric modulators of GPCRs: A novel approach for the treatment of CNS disorders
-
Conn, P. J., Christopoulos, A., and Lindsley, C. W. (2009) Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders. Nat. Rev. Drug Discov. 8, 41-54
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 41-54
-
-
Conn, P.J.1
Christopoulos, A.2
Lindsley, C.W.3
-
9
-
-
84859479825
-
Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation
-
Ahn, K. H., Mahmoud, M. M., and Kendall, D. A. (2012) Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activation. J. Biol. Chem. 287, 12070-12082
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 12070-12082
-
-
Ahn, K.H.1
Mahmoud, M.M.2
Kendall, D.A.3
-
10
-
-
65449146377
-
Emerging strategies for exploiting cannabinoid receptor agonists as medicines
-
Pertwee, R. G. (2009) Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br. J. Pharmacol. 156, 397-411
-
(2009)
Br. J. Pharmacol.
, vol.156
, pp. 397-411
-
-
Pertwee, R.G.1
-
11
-
-
78650960433
-
An overview of the metabolic effects of rimonabant in randomized controlled trials: Potential for other cannabinoid 1 receptor blockers in obesity
-
Christopoulou, F. D., and Kiortsis, D. N. (2011) An overview of the metabolic effects of rimonabant in randomized controlled trials: potential for other cannabinoid 1 receptor blockers in obesity. J. Clin. Pharm. Ther. 36, 10-18
-
(2011)
J. Clin. Pharm. Ther.
, vol.36
, pp. 10-18
-
-
Christopoulou, F.D.1
Kiortsis, D.N.2
-
12
-
-
35648962852
-
Allosterism and cannabinoid CB(1) receptors: The shape of things to come
-
Ross, R. A. (2007) Allosterism and cannabinoid CB(1) receptors: the shape of things to come. Trends Pharmacol. Sci. 28, 567-572
-
(2007)
Trends Pharmacol. Sci.
, vol.28
, pp. 567-572
-
-
Ross, R.A.1
-
13
-
-
24044539957
-
1 receptor
-
DOI 10.1124/mol.105.016162
-
Price, M. R., Baillie, G. L., Thomas, A., Stevenson, L. A., Easson, M., Goodwin, R., McLean, A., McIntosh, L., Goodwin, G., Walker, G., Westwood, P., Marrs, J., Thomson, F., Cowley, P., Christopoulos, A., Pertwee, R. G., and Ross, R. A. (2005) Allosteric modulation of the cannabinoid CB1 receptor. Mol. Pharmacol. 68, 1484-1495 (Pubitemid 41540004)
-
(2005)
Molecular Pharmacology
, vol.68
, Issue.5
, pp. 1484-1495
-
-
Price, M.R.1
Baillie, G.L.2
Thomas, A.3
Stevenson, L.A.4
Easson, M.5
Goodwin, R.6
McLean, A.7
McIntosh, L.8
Goodwin, G.9
Walker, G.10
Westwood, P.11
Marrs, J.12
Thomson, F.13
Cowley, P.14
Christopoulos, A.15
Pertwee, R.G.16
Ross, R.A.17
-
14
-
-
84872716271
-
CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity
-
Baillie, G. L., Horswill, J. G., Anavi-Goffer, S., Reggio, P. H., Bolognini, D., Abood, M. E., McAllister, S., Strange, P. G., Stephens, G. J., Pertwee, R. G., and Ross, R. A. (2013) CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity. Mol. Pharmacol. 83, 322-338
-
(2013)
Mol. Pharmacol.
, vol.83
, pp. 322-338
-
-
Baillie, G.L.1
Horswill, J.G.2
Anavi-Goffer, S.3
Reggio, P.H.4
Bolognini, D.5
Abood, M.E.6
McAllister, S.7
Strange, P.G.8
Stephens, G.J.9
Pertwee, R.G.10
Ross, R.A.11
-
15
-
-
77957055780
-
-
Sealfon, S. C. ed Academic Press, San Diego
-
Ballesteros, J. A., and Weinstein, H. (1995) in Methods in Neuroscience (Sealfon, S. C. ed) pp. 366-428, Academic Press, San Diego
-
(1995)
Methods in Neuroscience
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.2
-
16
-
-
0029078977
-
Construction of a 3D model of the cannabinoid CB1 receptor: Determination of helix ends and helix orientation
-
Bramblett, R. D., Panu, A. M., Ballesteros, J. A., and Reggio, P. H. (1995) Construction of a 3D model of the cannabinoid CB1 receptor: determination of helix ends and helix orientation. Life Sci. 56, 1971-1982
-
(1995)
Life Sci.
, vol.56
, pp. 1971-1982
-
-
Bramblett, R.D.1
Panu, A.M.2
Ballesteros, J.A.3
Reggio, P.H.4
-
17
-
-
84896878358
-
-
January 14, U. S. Patent WO2010/006130
-
Ripka, A., Shapiro, G., and Chesworth, R. (January 14, 2010) U. S. Patent WO2010/006130
-
(2010)
-
-
Ripka, A.1
Shapiro, G.2
Chesworth, R.3
-
18
-
-
84896899448
-
-
July 30, Patent EP1331221A1
-
Okazaki, K., Uchida, M., Mukaiyama, H., Kobayashi, H., Kai, Y., Takeuchi, H., Yokoyama, K., Terao, Y., Hoyano, Y., Shiohara, H., and Kikuchi, N. (July 30, 2003) Patent EP1331221A1
-
(2003)
-
-
Okazaki, K.1
Uchida, M.2
Mukaiyama, H.3
Kobayashi, H.4
Kai, Y.5
Takeuchi, H.6
Yokoyama, K.7
Terao, Y.8
Hoyano, Y.9
Shiohara, H.10
Kikuchi, N.11
-
19
-
-
84896878279
-
-
December 11, U. S. Patent 2003/0229026 A1
-
Al-Awar, R. S., Hecker, K. A., Ray, J. E., Huang, J., Joseph, S., Li, T., Paal, M., Rathnachalam, R., Shih, C., Wald, P. P., Zhou, X., and Zhu, G. (December 11, 2003) U. S. Patent 2003/0229026 A1
-
(2003)
-
-
Al-Awar, R.S.1
Hecker, K.A.2
Ray, J.E.3
Huang, J.4
Joseph, S.5
Li, T.6
Paal, M.7
Rathnachalam, R.8
Shih, C.9
Wald, P.P.10
Zhou, X.11
Zhu, G.12
-
20
-
-
84896815204
-
-
February 2, U. S. Patent Application 20120029016 A1
-
Pelcman, B., Olofsson, K., Katkevics, M., Ozola, V., Suna, E., Kalvins, I., Trapencieris, P., Katkevica, D., and Schaal, W. (February 2, 2006) U. S. Patent Application 20120029016 A1
-
(2006)
-
-
Pelcman, B.1
Olofsson, K.2
Katkevics, M.3
Ozola, V.4
Suna, E.5
Kalvins, I.6
Trapencieris, P.7
Katkevica, D.8
Schaal, W.9
-
21
-
-
9144224914
-
1 receptor activation
-
DOI 10.1074/jbc.M406648200
-
McAllister, S. D., Hurst, D. P., Barnett-Norris, J., Lynch, D., Reggio, P. H., and Abood, M. E. (2004) Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation. J. Biol. Chem. 279, 48024-48037 (Pubitemid 39540955)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.46
, pp. 48024-48037
-
-
McAllister, S.D.1
Hurst, D.P.2
Barnett-Norris, J.3
Lynch, D.4
Reggio, P.H.5
Abood, M.E.6
-
22
-
-
0242522905
-
1 Receptor Constitutes an Agonist/Inverse Agonist Binding Region
-
DOI 10.1021/jm0302647
-
McAllister, S. D., Rizvi, G., Anavi-Goffer, S., Hurst, D. P., Barnett-Norris, J., Lynch, D. L., Reggio, P. H., and Abood, M. E. (2003) An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region. J. Med. Chem. 46, 5139-5152 (Pubitemid 37414184)
-
(2003)
Journal of Medicinal Chemistry
, vol.46
, Issue.24
, pp. 5139-5152
-
-
McAllister, S.D.1
Rizvi, G.2
Anavi-Goffer, S.3
Hurst, D.P.4
Barnett-Norris, J.5
Lynch, D.L.6
Reggio, P.H.7
Abood, M.E.8
-
23
-
-
79959445835
-
Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands
-
Kotsikorou, E., Madrigal, K. E., Hurst, D. P., Sharir, H., Lynch, D. L., Heynen-Genel, S., Milan, L. B., Chung, T. D., Seltzman, H. H., Bai, Y., Caron, M. G., Barak, L., Abood, M. E., and Reggio, P. H. (2011) Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry 50, 5633-5647
-
(2011)
Biochemistry
, vol.50
, pp. 5633-5647
-
-
Kotsikorou, E.1
Madrigal, K.E.2
Hurst, D.P.3
Sharir, H.4
Lynch, D.L.5
Heynen-Genel, S.6
Milan, L.B.7
Chung, T.D.8
Seltzman, H.H.9
Bai, Y.10
Caron, M.G.11
Barak, L.12
Abood, M.E.13
Reggio, P.H.14
-
24
-
-
84866952392
-
A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand org 27569
-
Fay, J. F., and Farrens, D. L. (2012) A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand org 27569. J. Biol. Chem. 287, 33873-33882
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 33873-33882
-
-
Fay, J.F.1
Farrens, D.L.2
-
25
-
-
84876557408
-
Novel insights into CB1 cannabinoid receptor signaling: A key interaction identified between EC3-loop and TMH2
-
Marcu, J., Shore, D. M., Kapur, A., Trznadel, M., Makriyannis, A., Reggio, P. H., and Abood, M. E. (2013) Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between EC3-loop and TMH2. J. Pharmacol. Exp. Ther. 345, 189-197
-
(2013)
J. Pharmacol. Exp. Ther.
, vol.345
, pp. 189-197
-
-
Marcu, J.1
Shore, D.M.2
Kapur, A.3
Trznadel, M.4
Makriyannis, A.5
Reggio, P.H.6
Abood, M.E.7
-
26
-
-
0036892304
-
N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)- 4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor
-
DOI 10.1124/mol.62.6.1274
-
Hurst, D. P., Lynch, D. L., Barnett-Norris, J., Hyatt, S. M., Seltzman, H. H., Zhong, M., Song, Z. H., Nie, J., Lewis, D., and Reggio, P. H. (2002) N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1-H- pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor. Mol. Pharmacol. 62, 1274-1287 (Pubitemid 35403823)
-
(2002)
Molecular Pharmacology
, vol.62
, Issue.6
, pp. 1274-1287
-
-
Hurst, D.P.1
Lynch, D.L.2
Barnett-Norris, J.3
Hyatt, S.M.4
Seltzman, H.H.5
Zhong, M.6
Song, Z.-H.7
Nie, J.8
Lewis, D.9
Reggio, P.H.10
-
27
-
-
33749239422
-
Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: Importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction
-
DOI 10.1021/jm060446b
-
Hurst, D., Umejiego, U., Lynch, D., Seltzman, H., Hyatt, S., Roche, M., McAllister, S., Fleischer, D., Kapur, A., Abood, M., Shi, S., Jones, J., Lewis, D., and Reggio, P. (2006) Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction. J. Med. Chem. 49, 5969-5987 (Pubitemid 44484943)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.20
, pp. 5969-5987
-
-
Hurst, D.1
Umejiego, U.2
Lynch, D.3
Seltzman, H.4
Hyatt, S.5
Roche, M.6
McAllister, S.7
Fleischer, D.8
Kapur, A.9
Abood, M.10
Shi, S.11
Jones, J.12
Lewis, D.13
Reggio, P.14
-
28
-
-
84875974450
-
Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor one (CB1)
-
Ahn, K. H., Mahmoud, M. M., Shim, J. Y., and Kendall, D. A. (2013) Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor one (CB1). J. Biol. Chem. 288, 9790-9800
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 9790-9800
-
-
Ahn, K.H.1
Mahmoud, M.M.2
Shim, J.Y.3
Kendall, D.A.4
-
29
-
-
0033810049
-
Modeling of loops in protein structures
-
Fiser, A., Do, R. K., and Sali, A. (2000) Modeling of loops in protein structures. Protein Sci. 9, 1753-1773
-
(2000)
Protein Sci.
, vol.9
, pp. 1753-1773
-
-
Fiser, A.1
Do, R.K.2
Sali, A.3
-
30
-
-
0027136282
-
Comparative protein modelling by satisfaction of spatial restraints
-
DOI 10.1006/jmbi.1993.1626
-
Sali, A., and Blundell, T. L. (1993) Comparative protein modelling by satisfaction of spatial restraints. J. Mol. Biol. 234, 779-815 (Pubitemid 24007801)
-
(1993)
Journal of Molecular Biology
, vol.234
, Issue.3
, pp. 779-815
-
-
Sali, A.1
Blundell, T.L.2
-
31
-
-
68349132226
-
Structural analysis of the human cannabinoid receptor one carboxyl terminus identifies two amphipathic helices
-
Ahn, K. H., Pellegrini, M., Tsomaia, N., Yatawara, A. K., Kendall, D. A., and Mierke, D. F. (2009) Structural analysis of the human cannabinoid receptor one carboxyl terminus identifies two amphipathic helices. Biopolymers 91, 565-573
-
(2009)
Biopolymers
, vol.91
, pp. 565-573
-
-
Ahn, K.H.1
Pellegrini, M.2
Tsomaia, N.3
Yatawara, A.K.4
Kendall, D.A.5
Mierke, D.F.6
-
32
-
-
84862272370
-
Indole-2-carboxamides as allosteric modulators of the cannabinoid CB(1) receptor
-
Piscitelli, F., Ligresti, A., La Regina, G., Coluccia, A., Morera, L., Allarà, M., Novellino, E., Di Marzo, V., and Silvestri, R. (2012) Indole-2-carboxamides as allosteric modulators of the cannabinoid CB(1) receptor. J. Med. Chem. 55, 5627-5631
-
(2012)
J. Med. Chem.
, vol.55
, pp. 5627-5631
-
-
Piscitelli, F.1
Ligresti, A.2
La Regina, G.3
Coluccia, A.4
Morera, L.5
Allarà, M.6
Novellino, E.7
Di Marzo, V.8
Silvestri, R.9
-
33
-
-
0029866824
-
A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2
-
Song, Z. H., and Bonner, T. I. (1996) A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2. Mol. Pharmacol. 49, 891-896
-
(1996)
Mol. Pharmacol.
, vol.49
, pp. 891-896
-
-
Song, Z.H.1
Bonner, T.I.2
-
34
-
-
0033971119
-
2-adrenergic receptors control the equilibrium between active and inactive receptor states
-
Ambrosio, C., Molinari, P., Cotecchia, S., and Costa, T. (2000) Catecholbinding serines of β(2)-adrenergic receptors control the equilibrium between active and inactive receptor states. Mol. Pharmacol. 57, 198-210 (Pubitemid 30033276)
-
(2000)
Molecular Pharmacology
, vol.57
, Issue.1
, pp. 198-210
-
-
Ambrosio, C.1
Molinari, P.2
Cotecchia, S.3
Costa, T.4
-
35
-
-
34347352212
-
1 transmembrane helix 7
-
DOI 10.1124/mol.107.034645
-
Kapur, A., Hurst, D. P., Fleischer, D., Whitnell, R., Thakur, G. A., Samaniego, P., Makriyannis, A., Reggio, P. H., and Abood, M. E. (2007) Mutation studies of Ser7.39 and Ser2.60 in the human CB1 receptor: evidence for a serine-induced bend in cb1 transmembrane helix 7. Mol. Pharmacol. 71, 1512-1524 (Pubitemid 47010904)
-
(2007)
Molecular Pharmacology
, vol.71
, Issue.6
, pp. 1512-1524
-
-
Kapur, A.1
Hurst, D.P.2
Fleischer, D.3
Whitnell, R.4
Thakur, G.A.5
Makriyannis, A.6
Reggio, P.H.7
Abood, M.E.8
-
36
-
-
70349320141
-
Dual role of the second extracellular loop of the cannabinoid receptor 1: Ligand binding and receptor localization
-
Ahn, K. H., Bertalovitz, A. C., Mierke, D. F., and Kendall, D. A. (2009) Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization. Mol. Pharmacol. 76, 833-842
-
(2009)
Mol. Pharmacol.
, vol.76
, pp. 833-842
-
-
Ahn, K.H.1
Bertalovitz, A.C.2
Mierke, D.F.3
Kendall, D.A.4
-
37
-
-
78649680824
-
Ligand binding sensitivity of the extracellular loop two of the cannabinoid receptor 1
-
Bertalovitz, A. C., Ahn, K. H., and Kendall, D. A. (2010) Ligand binding sensitivity of the extracellular loop two of the cannabinoid receptor 1. Drug Dev. Res. 71, 404-411
-
(2010)
Drug Dev. Res.
, vol.71
, pp. 404-411
-
-
Bertalovitz, A.C.1
Ahn, K.H.2
Kendall, D.A.3
-
38
-
-
45749136445
-
Allosteric modulation of muscarinic acetylcholine receptors
-
DOI 10.2174/157015907781695946
-
Gregory, K. J., Sexton, P. M., and Christopoulos, A. (2007) Allosteric modulation of muscarinic acetylcholine receptors. Curr. Neuropharmacol. 5, 157-167 (Pubitemid 351863857)
-
(2007)
Current Neuropharmacology
, vol.5
, Issue.3
, pp. 157-167
-
-
Gregory, K.J.1
Sexton, P.M.2
Christopoulos, A.3
-
39
-
-
0027496941
-
Mutational analysis of muscarinic acetylcholine receptors: Structural basis of ligand/receptor/G protein interactions
-
Wess, J. (1993) Mutational analysis of muscarinic acetylcholine receptors: structural basis of ligand/receptor/G protein interactions. Life Sci. 53, 1447-1463
-
(1993)
Life Sci.
, vol.53
, pp. 1447-1463
-
-
Wess, J.1
-
40
-
-
0030445626
-
Allosteric regulation of muscarinic receptors
-
Birdsall, N. J., Lazareno, S., and Matsui, H. (1996) Allosteric regulation of muscarinic receptors. Prog. Brain Res. 109, 147-151 (Pubitemid 27047082)
-
(1996)
Progress in Brain Research
, vol.109
, pp. 147-151
-
-
Birdsall, N.J.M.1
Lazareno, S.2
Matsui, H.3
-
41
-
-
27844584316
-
Allosteric binding sites on muscarinic acetylcholine receptors
-
Wess, J. (2005) Allosteric binding sites on muscarinic acetylcholine receptors. Mol. Pharmacol. 68, 1506-1509
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 1506-1509
-
-
Wess, J.1
-
42
-
-
77952921531
-
A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor
-
Hurst, D. P., Grossfield, A., Lynch, D. L., Feller, S., Romo, T. D., Gawrisch, K., Pitman, M. C., and Reggio, P. H. (2010) A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor. J. Biol. Chem. 285, 17954-17964
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 17954-17964
-
-
Hurst, D.P.1
Grossfield, A.2
Lynch, D.L.3
Feller, S.4
Romo, T.D.5
Gawrisch, K.6
Pitman, M.C.7
Reggio, P.H.8
-
43
-
-
84857254248
-
Crystal structure of a lipid G protein-coupled receptor
-
Hanson, M. A., Roth, C. B., Jo, E., Griffith, M. T., Scott, F. L., Reinhart, G., Desale, H., Clemons, B., Cahalan, S. M., Schuerer, S. C., Sanna, M. G., Han, G. W., Kuhn, P., Rosen, H., and Stevens, R. C. (2012) Crystal structure of a lipid G protein-coupled receptor. Science 335, 851-855
-
(2012)
Science
, vol.335
, pp. 851-855
-
-
Hanson, M.A.1
Roth, C.B.2
Jo, E.3
Griffith, M.T.4
Scott, F.L.5
Reinhart, G.6
Desale, H.7
Clemons, B.8
Cahalan, S.M.9
Schuerer, S.C.10
Sanna, M.G.11
Han, G.W.12
Kuhn, P.13
Rosen, H.14
Stevens, R.C.15
-
44
-
-
78149496159
-
Allosteric modulation of G protein-coupled receptors: A pharmacological perspective
-
Keov, P., Sexton, P. M., and Christopoulos, A. (2011) Allosteric modulation of G protein-coupled receptors: a pharmacological perspective. Neuropharmacology 60, 24-35
-
(2011)
Neuropharmacology
, vol.60
, pp. 24-35
-
-
Keov, P.1
Sexton, P.M.2
Christopoulos, A.3
-
45
-
-
34447638166
-
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: Where do they bind and how do they act?
-
DOI 10.1016/j.tips.2007.06.008, PII S016561470700154X, Allosterism and Collateral Efficacy
-
Schwartz, T. W., and Holst, B. (2007) Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act? Trends Pharmacol. Sci. 8, 366-373 (Pubitemid 47087971)
-
(2007)
Trends in Pharmacological Sciences
, vol.28
, Issue.8
, pp. 366-373
-
-
Schwartz, T.W.1
Holst, B.2
-
46
-
-
84860671694
-
The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation
-
Peeters, M. C., Wisse, L. E., Dinaj, A., Vroling, B., Vriend, G., and Ijzerman, A. P. (2012) The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation. Biochem. Pharmacol. 84, 76-87
-
(2012)
Biochem. Pharmacol.
, vol.84
, pp. 76-87
-
-
Peeters, M.C.1
Wisse, L.E.2
Dinaj, A.3
Vroling, B.4
Vriend, G.5
Ijzerman, A.P.6
-
47
-
-
33847124943
-
Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric ligands
-
Huang, X. P., and Ellis, J. (2007) Mutational disruption of a conserved disulfide bond in muscarinic acetylcholine receptors attenuates positive homotropic cooperativity between multiple allosteric sites and has subtype-dependent effects on the affinities of muscarinic allosteric ligands. Mol. Pharmacol. 71, 759-768
-
(2007)
Mol. Pharmacol.
, vol.71
, pp. 759-768
-
-
Huang, X.P.1
Ellis, J.2
-
48
-
-
78650919353
-
Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation
-
Peeters, M. C., van Westen, G. J., Li, Q., and IJzerman, A. P. (2011) Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation. Trends Pharmacol. Sci. 32, 35-42
-
(2011)
Trends Pharmacol. Sci.
, vol.32
, pp. 35-42
-
-
Peeters, M.C.1
Van Westen, G.J.2
Li, Q.3
IJzerman, A.P.4
-
49
-
-
59649112109
-
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation
-
Ahuja, S., Hornak, V., Yan, E. C., Syrett, N., Goncalves, J. A., Hirshfeld, A., Ziliox, M., Sakmar, T. P., Sheves, M., Reeves, P. J., Smith, S. O., and Eilers, M. (2009) Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation. Nat. Struct. Mol. Biol. 16, 168-175
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 168-175
-
-
Ahuja, S.1
Hornak, V.2
Yan, E.C.3
Syrett, N.4
Goncalves, J.A.5
Hirshfeld, A.6
Ziliox, M.7
Sakmar, T.P.8
Sheves, M.9
Reeves, P.J.10
Smith, S.O.11
Eilers, M.12
-
50
-
-
77952350977
-
Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptor
-
Unal, H., Jagannathan, R., Bhat, M. B., and Karnik, S. S. (2010) Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptor. J. Biol. Chem. 285, 16341-16350
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 16341-16350
-
-
Unal, H.1
Jagannathan, R.2
Bhat, M.B.3
Karnik, S.S.4
-
51
-
-
84872065473
-
Long range effect of mutations on specific conformational changes in the extracellular loop 2 of angiotensin II type 1 receptor
-
Unal, H., Jagannathan, R., Bhatnagar, A., Tirupula, K., Desnoyer, R., and Karnik, S. S. (2013) Long range effect of mutations on specific conformational changes in the extracellular loop 2 of angiotensin II type 1 receptor. J. Biol. Chem. 288, 540-551
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 540-551
-
-
Unal, H.1
Jagannathan, R.2
Bhatnagar, A.3
Tirupula, K.4
Desnoyer, R.5
Karnik, S.S.6
-
52
-
-
20144385917
-
Molecular characterization of a purified 5-HT4 receptor: A structural basis for drug efficacy
-
DOI 10.1074/jbc.M412009200
-
Banères, J. L., Mesnier, D., Martin, A., Joubert, L., Dumuis, A., and Bockaert, J. (2005) Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy. J. Biol. Chem. 280, 20253-20260 (Pubitemid 40776722)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.21
, pp. 20253-20260
-
-
Baneres, J.-L.1
Mesnier, D.2
Martin, A.3
Joubert, L.4
Dumuis, A.5
Bockaert, J.6
-
53
-
-
77957765643
-
Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: Implications for an activation microswitch region
-
Rana, S., and Baranski, T. J. (2010) Third extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region. J. Biol. Chem. 285, 31472-31483
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 31472-31483
-
-
Rana, S.1
Baranski, T.J.2
-
54
-
-
0042624659
-
Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation
-
DOI 10.1038/nsb950
-
Décaillot, F. M., Befort, K., Filliol, D., Yue, S., Walker, P., and Kieffer, B. L. (2003) Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation. Nat. Struct. Biol. 10, 629-636 (Pubitemid 36944716)
-
(2003)
Nature Structural Biology
, vol.10
, Issue.8
, pp. 629-636
-
-
Decaillot, F.M.1
Befort, K.2
Filliol, D.3
Yue, S.Y.4
Walker, P.5
Kieffer, B.L.6
-
55
-
-
0023716027
-
Site of G protein binding to rhodopsin mapped with synthetic peptides from the α subunit
-
Hamm, H. E., Deretic, D., Arendt, A., Hargrave, P. A., Koenig, B., and Hofmann, K. P. (1988) Site of G protein binding to rhodopsin mapped with synthetic peptides from the α subunit. Science 241, 832-835
-
(1988)
Science
, vol.241
, pp. 832-835
-
-
Hamm, H.E.1
Deretic, D.2
Arendt, A.3
Hargrave, P.A.4
Koenig, B.5
Hofmann, K.P.6
-
56
-
-
33144459843
-
Molecular mechanism of 7TM receptor activation - A global toggle switch model
-
DOI 10.1146/annurev.pharmtox.46.120604.141218
-
Schwartz, T. W., Frimurer, T. M., Holst, B., Rosenkilde, M. M., and Elling, C. E. (2006) Molecular mechanism of 7TM receptor activation-a global toggle switch model. Annu. Rev. Pharmacol. Toxicol. 46, 481-519 (Pubitemid 43271198)
-
(2006)
Annual Review of Pharmacology and Toxicology
, vol.46
, pp. 481-519
-
-
Schwartz, T.W.1
Frimurer, T.M.2
Holst, B.3
Rosenkilde, M.M.4
Elling, C.E.5
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