Indole-2-carboxamides as allosteric modulators of the cannabinoid CB 1 receptor

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 5627-5631

  Piscitelli, Francesco ^a   Ligresti, Alessia ^b   La Regina, Giuseppe ^a   Coluccia, Antonio ^a   Morera, Ludovica ^a   Allarà, Marco ^b   Novellino, Ettore ^c   Di Marzo, Vincenzo ^b   Silvestri, Romano ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4(PIPERIDIN 1 YL)PHENYL]ETHYL 5 CHLORO 3 ETHYL 1H INDOLE 2 CARBOXYLATE; 5 CHLORO 3 (1 HYDROXYETHYL) N [2 [4 (PIPERIDIN 1 YL)PHENYL] ETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 ETHYL N [2 (4 METHYLAMINOPHENYL)ETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO 3 ETHYL N [2 [4 (PYRROLIDIN 1 YL)PHENYL]ETHYL] 1H INDOLE 2 CARBOXAMIDE; 5 CHLORO N [2 (4 DIMETHYLAMINOPHENYL)ETHYL] 1H INDOLE CARBOXAMIDE; AMIDE; CANNABINOID 1 RECEPTOR; CHLORINE; INDOLE; N [2 (4 AMINOPHENYL)ETHYL] 5 CHLORO 3 ETHYL 1H INDOLE 2 CARBOXAMIDE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; ATOM; DRUG RECEPTOR BINDING; HUMAN; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; AMIDES; CELL MEMBRANE; HUMANS; INDOLES; PIPERAZINES; PIPERIDINES; PYRROLIDINES; RADIOLIGAND ASSAY; RECEPTOR, CANNABINOID, CB1; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862272370     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201485c     Document Type: Article

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