Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands

Biochemistry

Volumn 50, Issue 25, 2011, Pages 5633-5647

  Kotsikorou, Evangelia ^a   Madrigal, Karla E ^a   Hurst, Dow P ^a   Sharir, Haleli ^b   Lynch, Diane L ^a   Heynen Genel, Susanne ^c   Milan, Loribelle B ^c   Chung, Thomas D Y ^c   Seltzman, Herbert H ^d   Bai, Yushi ^e   Caron, Marc G ^e   Barak, Larry ^e   Abood, Mary E ^b   Reggio, Patricia H ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b TEMPLE UNIVERSITY   (United States)

^c BURNHAM INSTITUTE   (United States)

^d RTI INTERNATIONAL   (United States)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGONIST BINDING SITE; ARRESTINS; BINDING CONFORMATIONS; BINDING POCKETS; CANNABINOID RECEPTORS; CANNABINOIDS; ELECTROSTATIC POTENTIAL DISTRIBUTION; EXTRACELLULAR LOOPS; HIGH-CONTENT; HIGH-THROUGHPUT; ILLEGAL DRUGS; MOLECULAR LIBRARIES; MOLECULAR SHAPES; OPTIMIZATION AND DESIGN; PHARMACOLOGICAL PROPERTIES; RECEPTOR BINDING; SELECTIVE LIGANDS;

THROUGHPUT;

LIGANDS;

3 ( 2METHOXYPHENYL) N [[4[METHYL(PHENYL)SULFAMOYL]PHENYL]CARBOMOTHIOYL]PROP 2 ENAMIDE; 3 [4 (2,3 DIMETHYLPHENYL)PIPERAZINE 1 CARBONYL] N,N DIMETHYL 4 PYRROLIDIN 1 YLBENZENESULFONAMIDE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BETA ARRESTIN; CID 1172084; CID 1792197; CID 2440433; G PROTEIN COUPLED RECEPTOR; LYSOPHOSPHATIDYLINOSITOL; N [4 (4 FLUOROPHENYL) 1,3 THIAZOL 2 YL] 2 [(8 METHOXY 4 METHYL[1,2,4]TRIAZOLO[4,3 A]QUINOLIN 1 YL)ACETAMIDE; PHOSPHATIDYLINOSITOL; PROTEIN GPR 55; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; STATIC ELECTRICITY;

AMINO ACID SEQUENCE; ARRESTINS; BINDING SITES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HEK293 CELLS; HUMANS; LIGANDS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, G-PROTEIN-COUPLED; STATIC ELECTRICITY;

CANNABIS SATIVA;

EID: 79959445835     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200010k     Document Type: Article

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