A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569

Journal of Biological Chemistry

Volumn 287, Issue 40, 2012, Pages 33873-33882

  Fay, Jonathan F ^a   Farrens, David L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID RECEPTORS; CONFORMATIONAL CHANGE; FLUORESCENCE LABELING; G PROTEIN COUPLED RECEPTORS; INTERMEDIATE STRUCTURES; RECEPTOR ACTIVATION; UNDERLYING MECHANISM;

BIOCHEMISTRY; BIOLOGY;

LIGANDS;

CANNABINOID 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CYTOPLASM; DISULFIDE BOND; FLUORESCENCE ANALYSIS; IMMUNOBLOTTING; LIGAND BINDING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE;

ALLOSTERIC SITE; ANIMALS; BUFFERS; CERCOPITHECUS AETHIOPS; COS CELLS; DETERGENTS; FLUORESCENT DYES; HUMANS; INDOLES; KINETICS; LIGANDS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PIPERIDINES; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR, CANNABINOID, CB1; TRANSFECTION;

EID: 84866952392     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.352328     Document Type: Article

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