The role of the second and third extracellular loops of the adenosine A1 receptor in activation and allosteric modulation

Biochemical Pharmacology

Volumn 84, Issue 1, 2012, Pages 76-87

  Peeters, M C ^a   Wisse, L E ^a   Dinaj, A ^a   Vroling, B ^b   Vriend, G ^b   Ijzerman, A P ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adenosine A1 receptor; Extracellular loops; G protein coupled receptor; Receptor activation; S. cerevisiae

Indexed keywords

2 AMINO 4,5 DIMETHYL 3 (3 TRIFLUOROMETHYLBENZOYL)THIOPHENE; ADENOSINE A1 RECEPTOR; ALANINE; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; TRYPTOPHAN;

ALLOSTERISM; ARTICLE; FUNGAL STRAIN; LIGAND BINDING; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS;

ALANINE; ALLOSTERIC REGULATION; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; GLUTAMIC ACID; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, ADENOSINE A1; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; THIOPHENES; TRYPTOPHAN;

EID: 84860671694     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.03.008     Document Type: Article

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