-
2
-
-
73649096563
-
Trends in quality-adjusted life-years lost contributed by smoking and obesity
-
Jia H., Lubetkin E. I. Trends in quality-adjusted life-years lost contributed by smoking and obesity. Am. J. Prev. Med. 2010; 38: 138-144.
-
(2010)
Am. J. Prev. Med.
, vol.38
, pp. 138-144
-
-
Jia, H.1
Lubetkin, E.I.2
-
3
-
-
79961028580
-
Using brown adipose tissue to treat obesity the central issue
-
Whittle A. J., López M., Vidal-Puig A. Using brown adipose tissue to treat obesity the central issue. Trends Mol. Med. 2011; 17: 405-411.
-
(2011)
Trends Mol. Med.
, vol.17
, pp. 405-411
-
-
Whittle, A.J.1
López, M.2
Vidal-Puig, A.3
-
5
-
-
84860441011
-
Inflammation and lipid signaling in the etiology of insulin resistance
-
Glass C. K., Olefsky J. M. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 2012; 15: 635-645.
-
(2012)
Cell Metab.
, vol.15
, pp. 635-645
-
-
Glass, C.K.1
Olefsky, J.M.2
-
6
-
-
35348874911
-
Developmental origin of fat: Tracking obesity to its source
-
Gesta S., Tseng Y. H., Kahn C. R. Developmental origin of fat: tracking obesity to its source. Cell 2007; 131: 242-256.
-
(2007)
Cell
, vol.131
, pp. 242-256
-
-
Gesta, S.1
Tseng, Y.H.2
Kahn, C.R.3
-
7
-
-
0347989317
-
Brown adipose tissue: Function and physiological significance
-
Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 2004; 84: 277-359.
-
(2004)
Physiol. Rev.
, vol.84
, pp. 277-359
-
-
Cannon, B.1
Nedergaard, J.2
-
8
-
-
64349095231
-
Cold-activated brown adipose tissue in healthy men
-
Van Marken Lichtenbelt W. D., Vanhommerig J. W., Smulders N. M., Drossaerts J. M., Kemerink G. J., Bouvy N. D. et al. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 2009; 360: 1500-1508.
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1500-1508
-
-
Van Marken Lichtenbelt, W.D.1
Vanhommerig, J.W.2
Smulders, N.M.3
Drossaerts, J.M.4
Kemerink, G.J.5
Bouvy, N.D.6
-
9
-
-
64349123664
-
Functional brown adipose tissue in healthy adults
-
Virtanen K. A., Lidell M. E., Orava J., Heglind M., Westergren R., Niemi T. et al. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 2009; 360: 1518-1525..
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1518-1525
-
-
Virtanen, K.A.1
Lidell, M.E.2
Orava, J.3
Heglind, M.4
Westergren, R.5
Niemi, T.6
-
11
-
-
0030745159
-
Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist
-
Ghorbani M., Claus T. H., Himms-Hagen J. Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a beta3-adrenoceptor agonist. Biochem. Pharmacol. 1997; 54: 121-131.
-
(1997)
Biochem. Pharmacol.
, vol.54
, pp. 121-131
-
-
Ghorbani, M.1
Claus, T.H.2
Himms-Hagen, J.3
-
12
-
-
77953169046
-
Cellular bioenergetics as a target for obesity therapy
-
Tseng Y. H., Cypess A. M., Kahn C. R. Cellular bioenergetics as a target for obesity therapy. Nat. Rev. Drug Discov. 2010; 9: 465-482.
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 465-482
-
-
Tseng, Y.H.1
Cypess, A.M.2
Kahn, C.R.3
-
13
-
-
84857408775
-
Reversal of type 1 diabetes in mice by brown adipose tissue transplant
-
Gunawardana S. C., Piston D. W. Reversal of type 1 diabetes in mice by brown adipose tissue transplant. Diabetes 2012; 61: 674-682.
-
(2012)
Diabetes
, vol.61
, pp. 674-682
-
-
Gunawardana, S.C.1
Piston, D.W.2
-
14
-
-
0030021071
-
Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia
-
Hamann A., Flier J. S., Lowell B. B. Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 1996; 137: 21-29.
-
(1996)
Endocrinology
, vol.137
, pp. 21-29
-
-
Hamann, A.1
Flier, J.S.2
Lowell, B.B.3
-
15
-
-
77952958684
-
Brown adipose tissue - A new role in humans
-
Lidell M. E., Enerback S. Brown adipose tissue - a new role in humans? Nat. Rev. Endocrinol. 2010; 6: 319-325.
-
(2010)
Nat. Rev. Endocrinol.
, vol.6
, pp. 319-325
-
-
Lidell, M.E.1
Enerback, S.2
-
16
-
-
79751503329
-
Brown adipose tissue activity controls triglyceride clearance
-
Bartelt A., Bruns O. T., Reimer R., Hohenberg H., Ittrich H., Peldschus K. et al. Brown adipose tissue activity controls triglyceride clearance. Nat. Med. 2011; 17: 200-205.
-
(2011)
Nat. Med.
, vol.17
, pp. 200-205
-
-
Bartelt, A.1
Bruns, O.T.2
Reimer, R.3
Hohenberg, H.4
Ittrich, H.5
Peldschus, K.6
-
17
-
-
84860850964
-
BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions
-
Whittle A., Carobbio S., Martins L., Slawik M., Hondares E., Vázquez M. et al. BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 2012; 149: 871-885.
-
(2012)
Cell
, vol.149
, pp. 871-885
-
-
Whittle, A.1
Carobbio, S.2
Martins, L.3
Slawik, M.4
Hondares, E.5
Vázquez, M.6
-
18
-
-
0037066575
-
β-Adrenoceptor agonists: Potential, pitfalls and progress
-
Arch J. R. β-Adrenoceptor agonists: potential, pitfalls and progress. Eur. J. Pharmacol. 2002; 440: 99-107.
-
(2002)
Eur. J. Pharmacol.
, vol.440
, pp. 99-107
-
-
Arch, J.R.1
-
19
-
-
70350515669
-
Fighting fat with fat: The expanding field of adipose stem cells
-
Zeve D., Tang W., Graff J. Fighting fat with fat: the expanding field of adipose stem cells. Cell Stem Cell 2009; 5: 472-481.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 472-481
-
-
Zeve, D.1
Tang, W.2
Graff, J.3
-
20
-
-
84873518501
-
Adaptive thermogenesis in adipocytes: Is beige the new brown
-
Wu J., Cohen P., Spiegelman B. M. Adaptive thermogenesis in adipocytes: Is beige the new brown? Genes Dev. 2013; 27: 234-250.
-
(2013)
Genes Dev.
, vol.27
, pp. 234-250
-
-
Wu, J.1
Cohen, P.2
Spiegelman, B.M.3
-
21
-
-
84878239490
-
Anatomical locations of human brown adipose tissue: Functional relevance and implications in obesity and type 2 diabetes
-
Sacks H., Symonds M. E. Anatomical locations of human brown adipose tissue: functional relevance and implications in obesity and type 2 diabetes. Diabetes 2013; 62: 1783-1790.
-
(2013)
Diabetes
, vol.62
, pp. 1783-1790
-
-
Sacks, H.1
Symonds, M.E.2
-
22
-
-
50049122271
-
PRDM16 controls a brown fat/skeletal muscle switch
-
Seale P., Bjork B., Yang W., Kajimura S., Chin S., Kuang S. et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008; 454: 961-967.
-
(2008)
Nature
, vol.454
, pp. 961-967
-
-
Seale, P.1
Bjork, B.2
Yang, W.3
Kajimura, S.4
Chin, S.5
Kuang, S.6
-
23
-
-
46049112441
-
Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis
-
Gensch N., Borchardt T., Schneider A., Riethmacher D., Braun T. Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis. Development 2008; 135: 1597-1604.
-
(2008)
Development
, vol.135
, pp. 1597-1604
-
-
Gensch, N.1
Borchardt, T.2
Schneider, A.3
Riethmacher, D.4
Braun, T.5
-
24
-
-
84865792944
-
PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors
-
Sanchez-Gurmaches J., Hung C. M., Sparks C. A., Tang Y., Li H., Guertin D. A. PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors. Cell Metab. 2012; 16: 348-362.
-
(2012)
Cell Metab.
, vol.16
, pp. 348-362
-
-
Sanchez-Gurmaches, J.1
Hung, C.M.2
Sparks, C.A.3
Tang, Y.4
Li, H.5
Guertin, D.A.6
-
25
-
-
33745966038
-
B-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse
-
Atit R., Sgaier S. K., Mohamed O. A., Taketo M. M., Dufort D., Joyner A. L. et al. b-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse. Dev. Biol. 2006; 296: 164-176.
-
(2006)
Dev. Biol.
, vol.296
, pp. 164-176
-
-
Atit, R.1
Sgaier, S.K.2
Mohamed, O.A.3
Taketo, M.M.4
Dufort, D.5
Joyner, A.L.6
-
27
-
-
79958239247
-
PDGFRb signaling regulates mural cell plasticity and inhibits fat development
-
Olson L. E., Soriano P. PDGFRb signaling regulates mural cell plasticity and inhibits fat development. Dev. Cell 2011; 20: 815-826.
-
(2011)
Dev. Cell
, vol.20
, pp. 815-826
-
-
Olson, L.E.1
Soriano, P.2
-
28
-
-
84865489581
-
Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-g deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis
-
Chang L., Villacorta L., Li R., Hamblin M., Xu W., Dou C. et al. Loss of perivascular adipose tissue on peroxisome proliferator-activated receptor-g deletion in smooth muscle cells impairs intravascular thermoregulation and enhances atherosclerosis. Circulation 2012; 126: 1067-1078.
-
(2012)
Circulation
, vol.126
, pp. 1067-1078
-
-
Chang, L.1
Villacorta, L.2
Li, R.3
Hamblin, M.4
Xu, W.5
Dou, C.6
-
30
-
-
25144489034
-
Metabolic and cellular plasticity in white adipose tissue I: Effects of b3-adrenergic receptor activation
-
Granneman J. G., Li P., Zhu Z., Lu Y. Metabolic and cellular plasticity in white adipose tissue I: effects of b3-adrenergic receptor activation. Am. J. Physiol. Endocrinol. Metab. 2005; 289: E608-E616.
-
(2005)
Am. J. Physiol. Endocrinol. Metab.
, vol.289
-
-
Granneman, J.G.1
Li, P.2
Zhu, Z.3
Lu, Y.4
-
31
-
-
84872855956
-
Adipose tissue metabolism in 2012: Adipose tissue plasticity and new therapeutic targets
-
Enerback S. Adipose tissue metabolism in 2012: adipose tissue plasticity and new therapeutic targets. Nat. Rev. Endocrinol. 2013; 9: 69-70.
-
(2013)
Nat. Rev. Endocrinol.
, vol.9
, pp. 69-70
-
-
Enerback, S.1
-
32
-
-
84864287504
-
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human
-
Wu J., Bostrom P., Sparks L. M., Ye L., Choi J. H., Giang A. H. et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012; 150: 366-376.
-
(2012)
Cell
, vol.150
, pp. 366-376
-
-
Wu, J.1
Bostrom, P.2
Sparks, L.M.3
Ye, L.4
Choi, J.H.5
Giang, A.H.6
-
33
-
-
77950226740
-
Chronic peroxisome proliferator-activated receptor g (PPARg) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
-
Petrovic N., Walden T. B., Shabalina I. G., Timmons J. A., Cannon B., Nedergaard J. Chronic peroxisome proliferator-activated receptor g (PPARg) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J. Biol. Chem. 2010; 285: 7153-7164.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 7153-7164
-
-
Petrovic, N.1
Walden, T.B.2
Shabalina, I.G.3
Timmons, J.A.4
Cannon, B.5
Nedergaard, J.6
-
35
-
-
77952623888
-
The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation
-
Barbatelli G., Murano I., Madsen L., Hao Q., Jimenez M., Kristiansen K. et al. The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am. J. Physiol. Endocrinol. Metab. 2010; 298: E1244-E1253.
-
(2010)
Am. J. Physiol. Endocrinol. Metab.
, vol.298
-
-
Barbatelli, G.1
Murano, I.2
Madsen, L.3
Hao, Q.4
Jimenez, M.5
Kristiansen, K.6
-
36
-
-
70350443275
-
Transdifferentiation properties of adipocytes in the adipose organ
-
Cinti S. Transdifferentiation properties of adipocytes in the adipose organ. Am. J. Physiol. Endocrinol. Metab. 2009; 297: E977-E986.
-
(2009)
Am. J. Physiol. Endocrinol. Metab.
, vol.297
-
-
Cinti, S.1
-
37
-
-
0033825933
-
Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
-
Himms-Hagen J., Melnyk A., Zingaretti M. C., Ceresi E., Barbatelli G., Cinti S. Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes. Am. J. Physiol. Cell Physiol. 2000; 279: C670-C681.
-
(2000)
Am. J. Physiol. Cell Physiol.
, vol.279
-
-
Himms-Hagen, J.1
Melnyk, A.2
Zingaretti, M.C.3
Ceresi, E.4
Barbatelli, G.5
Cinti, S.6
-
38
-
-
84859465056
-
In vivo identification of bipotential adipocyte progenitors recruited by b3-adrenoceptor activation and high-fat feeding
-
Lee Y. H., Petkova A. P., Mottillo E. P., Granneman J. G. In vivo identification of bipotential adipocyte progenitors recruited by b3-adrenoceptor activation and high-fat feeding. Cell Metab. 2012; 15: 480-491.
-
(2012)
Cell Metab.
, vol.15
, pp. 480-491
-
-
Lee, Y.H.1
Petkova, A.P.2
Mottillo, E.P.3
Granneman, J.G.4
-
39
-
-
75949096894
-
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
-
Joe A. W., Yi L., Natarajan A., Le Grand F., So L., Wang J. et al. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat. Cell Biol. 2010; 12: 153-163.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 153-163
-
-
Joe, A.W.1
Yi, L.2
Natarajan, A.3
Le Grand, F.4
So, L.5
Wang, J.6
-
40
-
-
75949130333
-
Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle
-
Uezumi A., Fukada S. I., Yamamoto N., Takeda S. I., Tsuchida K. Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nat. Cell Biol. 2010; 12: 143-152.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 143-152
-
-
Uezumi, A.1
Fukada, S.I.2
Yamamoto, N.3
Takeda, S.I.4
Tsuchida, K.5
-
41
-
-
84883467905
-
Identification of an adipogenic niche for adipose tissue remodeling and restoration
-
Lee Y. H., Petkova A. P., Granneman J. G. Identification of an adipogenic niche for adipose tissue remodeling and restoration. Cell Metab. 2013; 18: 355-367.
-
(2013)
Cell Metab.
, vol.18
, pp. 355-367
-
-
Lee, Y.H.1
Petkova, A.P.2
Granneman, J.G.3
-
42
-
-
84877340732
-
Evidence for two types of brown adipose tissue in humans
-
Lidell M. E., Betz M. J., Leinhard O. D., Heglind M., Elander L., Slawik M. et al. Evidence for two types of brown adipose tissue in humans. Nat. Med. 2013; 19: 631-634.
-
(2013)
Nat. Med.
, vol.19
, pp. 631-634
-
-
Lidell, M.E.1
Betz, M.J.2
Leinhard, O.D.3
Heglind, M.4
Elander, L.5
Slawik, M.6
-
43
-
-
84877331455
-
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
-
Cypess A. M., White A. P., Vernochet C., Schulz T. J., Xue R., Sass C. A. et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat. Med. 2013; 19: 635-639.
-
(2013)
Nat. Med.
, vol.19
, pp. 635-639
-
-
Cypess, A.M.1
White, A.P.2
Vernochet, C.3
Schulz, T.J.4
Xue, R.5
Sass, C.A.6
-
44
-
-
84861872697
-
Adipogenesis: From stem cell to adipocyte
-
Tang Q. Q., Lane M. D. Adipogenesis: from stem cell to adipocyte. Annu. Rev. Biochem. 2012; 81: 715-736.
-
(2012)
Annu. Rev. Biochem.
, vol.81
, pp. 715-736
-
-
Tang, Q.Q.1
Lane, M.D.2
-
45
-
-
84855681355
-
Adipose tissue stem cells meet preadipocyte commitment: Going back to the future
-
Cawthorn W. P., Scheller E. L., Macdougald O. A. Adipose tissue stem cells meet preadipocyte commitment: going back to the future. J. Lipid Res. 2012; 53: 227-246..
-
(2012)
J. Lipid Res.
, vol.53
, pp. 227-246
-
-
Cawthorn, W.P.1
Scheller, E.L.2
Macdougald, O.A.3
-
46
-
-
84887431711
-
Brown and beige fat: Development, function and therapeutic potential
-
Harms M., Seale P. Brown and beige fat: development, function and therapeutic potential. Nat. Med. 2013; 19: 1252-1263.
-
(2013)
Nat. Med.
, vol.19
, pp. 1252-1263
-
-
Harms, M.1
Seale, P.2
-
47
-
-
84860284206
-
Controlling a master switch of adipocyte development and insulin sensitivity: Covalent modifications of PPARg
-
Floyd Z. E., Stephens J. M. Controlling a master switch of adipocyte development and insulin sensitivity: covalent modifications of PPARg. Biochim. Biophys. Acta 2012; 1822: 1090-1095.
-
(2012)
Biochim. Biophys. Acta
, vol.1822
, pp. 1090-1095
-
-
Floyd, Z.E.1
Stephens, J.M.2
-
48
-
-
84864615516
-
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of PPARgamma
-
Qiang L., Wang L., Kon N., Zhao W., Lee S., Zhang Y. et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of PPARgamma. Cell 2012; 150: 620-632.
-
(2012)
Cell
, vol.150
, pp. 620-632
-
-
Qiang, L.1
Wang, L.2
Kon, N.3
Zhao, W.4
Lee, S.5
Zhang, Y.6
-
49
-
-
79953748708
-
TLE3 is a dual-function transcriptional coregulator of adipogenesis
-
Villanueva C. J., Waki H., Godio C., Nielsen R., Chou W. L., Vargas L. et al. TLE3 is a dual-function transcriptional coregulator of adipogenesis. Cell Metab. 2011; 13: 413-427.
-
(2011)
Cell Metab.
, vol.13
, pp. 413-427
-
-
Villanueva, C.J.1
Waki, H.2
Godio, C.3
Nielsen, R.4
Chou, W.L.5
Vargas, L.6
-
50
-
-
84875900015
-
EBF2 determines and maintains brown adipocyte identity
-
Rajakumari S., Wu J., Ishibashi J., Lim H. W., Giang A. H., Won K. J. et al. EBF2 determines and maintains brown adipocyte identity. Cell Metab. 2013; 17: 562-574.
-
(2013)
Cell Metab.
, vol.17
, pp. 562-574
-
-
Rajakumari, S.1
Wu, J.2
Ishibashi, J.3
Lim, H.W.4
Giang, A.H.5
Won, K.J.6
-
51
-
-
79959824776
-
Epigenetic codes of PPARg in metabolic disease
-
Sugii S., Evans R. M. Epigenetic codes of PPARg in metabolic disease. FEBS Lett. 2011; 585: 2121-2128.
-
(2011)
FEBS Lett.
, vol.585
, pp. 2121-2128
-
-
Sugii, S.1
Evans, R.M.2
-
52
-
-
84866291650
-
Genome-wide profiling of peroxisome proliferatoractivated receptor g in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression
-
Siersbak M. S., Loft A., Aagaard M. M., Nielsen R., Schmidt S. F., Petrovic N. et al. Genome-wide profiling of peroxisome proliferatoractivated receptor g in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression. Mol. Cell Biol. 2012; 32: 3452-3463.
-
(2012)
Mol. Cell Biol.
, vol.32
, pp. 3452-3463
-
-
Siersbak, M.S.1
Loft, A.2
Aagaard, M.M.3
Nielsen, R.4
Schmidt, S.F.5
Petrovic, N.6
-
53
-
-
0032549811
-
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
-
Puigserver P., Wu Z., Park C. W., Graves R., Wright M., Spiegelman B. M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998; 92: 829-839.
-
(1998)
Cell
, vol.92
, pp. 829-839
-
-
Puigserver, P.1
Wu, Z.2
Park, C.W.3
Graves, R.4
Wright, M.5
Spiegelman, B.M.6
-
54
-
-
1642293248
-
P38 Mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
-
Cao W., Daniel K. W., Robidoux J., Puigserver P., Medvedev A. V., Bai X. et al. p38 Mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol. Cell. Biol. 2004; 24: 3057-3067.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 3057-3067
-
-
Cao, W.1
Daniel, K.W.2
Robidoux, J.3
Puigserver, P.4
Medvedev, A.V.5
Bai, X.6
-
55
-
-
34347326271
-
Transcriptional control of brown fat determination by PRDM16
-
Seale P. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007; 6: 38-54.
-
(2007)
Cell Metab.
, vol.6
, pp. 38-54
-
-
Seale, P.1
-
56
-
-
78650945931
-
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
-
Seale P., Conroe H. M., Estall J., Kajimura S., Frontini A., Ishibashi J. et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J. Clin. Inves. 2011; 121: 96-105.
-
(2011)
J. Clin. Inves.
, vol.121
, pp. 96-105
-
-
Seale, P.1
Conroe, H.M.2
Estall, J.3
Kajimura, S.4
Frontini, A.5
Ishibashi, J.6
-
57
-
-
69349088117
-
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex
-
Kajimura S. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature 2009; 460: 1154-1158.
-
(2009)
Nature
, vol.460
, pp. 1154-1158
-
-
Kajimura, S.1
-
58
-
-
44149113548
-
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
-
Kajimura S. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008; 22: 1397-1409.
-
(2008)
Genes Dev.
, vol.22
, pp. 1397-1409
-
-
Kajimura, S.1
-
59
-
-
84889604511
-
EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
-
Ohno H., Shinoda K., Ohyama K., Sharp L. Z., Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature 2013; 504: 163-167.
-
(2013)
Nature
, vol.504
, pp. 163-167
-
-
Ohno, H.1
Shinoda, K.2
Ohyama, K.3
Sharp, L.Z.4
Kajimura, S.5
-
60
-
-
84875358826
-
Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARg specifies lipid storage versus thermogenic gene programs
-
Villanueva C. J., Vergnes L., Wang J., Drew B. G., Hong C., Tu Y. et al. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARg specifies lipid storage versus thermogenic gene programs. Cell Metab. 2013; 17: 423-435..
-
(2013)
Cell Metab
, vol.17
, pp. 423-435
-
-
Villanueva, C.J.1
Vergnes, L.2
Wang, J.3
Drew, B.G.4
Hong, C.5
Tu, Y.6
-
61
-
-
84870595878
-
MyomiR-133 regulates brown fat differentiation through Prdm16
-
Trajkovski M., Ahmed K., Esau C. C., Stoffel M. MyomiR-133 regulates brown fat differentiation through Prdm16. Nat. Cell Biol. 2012; 14: 1330-1335.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 1330-1335
-
-
Trajkovski, M.1
Ahmed, K.2
Esau, C.C.3
Stoffel, M.4
-
62
-
-
84873327762
-
MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16
-
Yin H., Pasut A., Soleimani V. D., Bentzinger C. F., Antoun G., Thorn S. et al. MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16. Cell Metab. 2013; 17: 210-224.
-
(2013)
Cell Metab.
, vol.17
, pp. 210-224
-
-
Yin, H.1
Pasut, A.2
Soleimani, V.D.3
Bentzinger, C.F.4
Antoun, G.5
Thorn, S.6
-
63
-
-
84880812042
-
MiR-133a regulates adipocyte browning in vivo
-
Liu W., Bi P., Shan T., Yang X., Yin H., Wang Y. X. et al. miR-133a regulates adipocyte browning in vivo. PLoS Genet. 2013; 9: e1003626.
-
(2013)
PLoS Genet.
, vol.9
-
-
Liu, W.1
Bi, P.2
Shan, T.3
Yang, X.4
Yin, H.5
Wang, Y.X.6
-
64
-
-
0020051648
-
Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue of the rat
-
Young J. B., Saville E., Rothwell N. J., Stock M. J., Landsberg L. Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue of the rat. J. Clin. Invest. 1982; 69: 1061-1071.
-
(1982)
J. Clin. Invest.
, vol.69
, pp. 1061-1071
-
-
Young, J.B.1
Saville, E.2
Rothwell, N.J.3
Stock, M.J.4
Landsberg, L.5
-
65
-
-
58149337340
-
Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ
-
Murano I., Barbatelli G., Giordano A., Cinti S. Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ. J. Anat. 2009; 214: 171-178.
-
(2009)
J. Anat.
, vol.214
, pp. 171-178
-
-
Murano, I.1
Barbatelli, G.2
Giordano, A.3
Cinti, S.4
-
66
-
-
19444367043
-
Regional-dependent increase of sympathetic innervation in rat white adipose tissue during prolonged fasting
-
Giordano A., Frontini A., Murano I., Tonello C., Marino M. A., Carruba M. O. et al. Regional-dependent increase of sympathetic innervation in rat white adipose tissue during prolonged fasting. J. Histochem. Cytochem. 2005; 53: 679-687.
-
(2005)
J. Histochem. Cytochem.
, vol.53
, pp. 679-687
-
-
Giordano, A.1
Frontini, A.2
Murano, I.3
Tonello, C.4
Marino, M.A.5
Carruba, M.O.6
-
67
-
-
33646124709
-
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
-
Uldry M., Yang W., St-Pierre J., Lin J., Seale P., Spiegelman B. M. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 2006; 3: 333-341.
-
(2006)
Cell Metab.
, vol.3
, pp. 333-341
-
-
Uldry, M.1
Yang, W.2
St-Pierre, J.3
Lin, J.4
Seale, P.5
Spiegelman, B.M.6
-
68
-
-
84863361364
-
NT-PGC-1alpha protein is sufficient to link beta3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis
-
Chang J. S., Fernand V., Zhang Y., Shin J., Jun H. J., Joshi Y. et al. NT-PGC-1alpha protein is sufficient to link beta3-adrenergic receptor activation to transcriptional and physiological components of adaptive thermogenesis. J. Biol. Chem. 2012; 287: 9100-9111.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 9100-9111
-
-
Chang, J.S.1
Fernand, V.2
Zhang, Y.3
Shin, J.4
Jun, H.J.5
Joshi, Y.6
-
69
-
-
84864098852
-
Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) a and d in brown adipocytes to match fatty acid oxidation with supply
-
Mottillo E. P., Bloch A. E., Leff T., Granneman J. G. Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) a and d in brown adipocytes to match fatty acid oxidation with supply. J. Biol. Chem. 2012; 287: 25038-25048..
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 25038-25048
-
-
Mottillo, E.P.1
Bloch, A.E.2
Leff, T.3
Granneman, J.G.4
-
70
-
-
84877585823
-
Beyond the sympathetic tone: The new brown fat activators
-
Villarroya F., Vidal-Puig A. Beyond the sympathetic tone: the new brown fat activators. Cell Metab. 2013; 17: 638-643.
-
(2013)
Cell Metab.
, vol.17
, pp. 638-643
-
-
Villarroya, F.1
Vidal-Puig, A.2
-
71
-
-
77956431307
-
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
-
Lopez M., Varela L., Vazquez M. J., Rodriguez-Cuenca S., Gonzalez C. R., Velagapudi V. R. et al. Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nat. Med. 2010; 16: 1001-1008.
-
(2010)
Nat. Med.
, vol.16
, pp. 1001-1008
-
-
Lopez, M.1
Varela, L.2
Vazquez, M.J.3
Rodriguez-Cuenca, S.4
Gonzalez, C.R.5
Velagapudi, V.R.6
-
72
-
-
84855335544
-
Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes
-
Lee J. Y., Takahashi N., Yasubuchi M., Kim Y. I., Hashizaki H., Kim M. J. et al. Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes. Am. J. Physiol. Cell Physiol. 2012; 302: C463-C472.
-
(2012)
Am. J. Physiol. Cell Physiol.
, vol.302
-
-
Lee, J.Y.1
Takahashi, N.2
Yasubuchi, M.3
Kim, Y.I.4
Hashizaki, H.5
Kim, M.J.6
-
73
-
-
0037304599
-
Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone
-
Wilson-Fritch L., Burkart A., Bell G., Mendelson K., Leszyk J., Nicoloro S. et al. Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol. Cell. Biol. 2003; 23: 1085-1094.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 1085-1094
-
-
Wilson-Fritch, L.1
Burkart, A.2
Bell, G.3
Mendelson, K.4
Leszyk, J.5
Nicoloro, S.6
-
74
-
-
77952970098
-
-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes
-
Vegiopoulos A., Muller-Decker K., Strzoda D., Schmitt I., Chichelnitskiy E., Ostertag A. et al. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 2010; 328: 1158-1161.
-
(2010)
Science
, vol.328
, pp. 1158-1161
-
-
Vegiopoulos, A.1
Muller-Decker, K.2
Strzoda, D.3
Schmitt, I.4
Chichelnitskiy, E.5
Ostertag, A.6
-
75
-
-
84862776702
-
A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
-
Bostrom P., Wu J., Jedrychowski M. P., Korde A., Ye L., Lo J. C. et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012; 481: 463-468.
-
(2012)
Nature
, vol.481
, pp. 463-468
-
-
Bostrom, P.1
Wu, J.2
Jedrychowski, M.P.3
Korde, A.4
Ye, L.5
Lo, J.C.6
-
76
-
-
84888377939
-
Evidence against a beneficial effect of irisin in humans
-
Raschke S., Elsen M., Gassenhuber H., Sommerfeld M., Schwahn U., Brockmann B. et al. Evidence against a beneficial effect of irisin in humans. PLoS One 2013; 8: e73680.
-
(2013)
PLoS One
, vol.8
-
-
Raschke, S.1
Elsen, M.2
Gassenhuber, H.3
Sommerfeld, M.4
Schwahn, U.5
Brockmann, B.6
-
77
-
-
50049127055
-
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
-
Tseng Y. H. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008; 454: 1000-1004.
-
(2008)
Nature
, vol.454
, pp. 1000-1004
-
-
Tseng, Y.H.1
-
78
-
-
78651094465
-
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
-
Schulz T. J., Huang T. L., Tran T. T., Zhang H., Townsend K. L., Shadrach J. L. et al. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc. Natl Acad. Sci. USA 2011; 108: 143-148.
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 143-148
-
-
Schulz, T.J.1
Huang, T.L.2
Tran, T.T.3
Zhang, H.4
Townsend, K.L.5
Shadrach, J.L.6
-
79
-
-
84879548972
-
Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake
-
Townsend K. L., An D., Lynes M. D., Huang T. L., Zhang H., Goodyear L. J. et al. Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake. Antioxid. Redox Signal 2013; 19: 243-257.
-
(2013)
Antioxid. Redox Signal
, vol.19
, pp. 243-257
-
-
Townsend, K.L.1
An, D.2
Lynes, M.D.3
Huang, T.L.4
Zhang, H.5
Goodyear, L.J.6
-
80
-
-
84874450879
-
BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis
-
Qian S. W., Tang Y., Li X., Liu Y., Zhang Y. Y., Huang H. Y. et al. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc. Natl Acad. Sci. 2013; 110: E798-E807.
-
(2013)
Proc. Natl Acad. Sci.
, vol.110
-
-
Qian, S.W.1
Tang, Y.2
Li, X.3
Liu, Y.4
Zhang, Y.Y.5
Huang, H.Y.6
-
81
-
-
84863012022
-
FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis
-
Fisher F., Kleiner S., Douris N., Fox E., Mepani R., Verdeguer F. et al. FGF21 regulates PGC-1a and browning of white adipose tissues in adaptive thermogenesis. Genes Dev. 2012; 26: 271-281.
-
(2012)
Genes Dev.
, vol.26
, pp. 271-281
-
-
Fisher, F.1
Kleiner, S.2
Douris, N.3
Fox, E.4
Mepani, R.5
Verdeguer, F.6
-
82
-
-
79960743932
-
Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21
-
Chartoumpekis D., Habeos I., Ziros P., Psyrogiannis A., Kyriazopoulou V., Papavassiliou A. Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21. Mol. Med. 2011; 17: 736-740.
-
(2011)
Mol. Med.
, vol.17
, pp. 736-740
-
-
Chartoumpekis, D.1
Habeos, I.2
Ziros, P.3
Psyrogiannis, A.4
Kyriazopoulou, V.5
Papavassiliou, A.6
-
83
-
-
42949109612
-
Control of lipolysis by natriuretic peptides and cyclic GMP
-
Lafontan M., Moro C., Berlan M., Crampes F., Sengenes C., Galitzky J. Control of lipolysis by natriuretic peptides and cyclic GMP. Trends Endocrinol. Metab. 2008; 19: 130-137.
-
(2008)
Trends Endocrinol. Metab.
, vol.19
, pp. 130-137
-
-
Lafontan, M.1
Moro, C.2
Berlan, M.3
Crampes, F.4
Sengenes, C.5
Galitzky, J.6
-
84
-
-
84863229962
-
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
-
Bordicchia M., Liu D., Amri E. Z., Ailhaud G., Dessì-Fulgheri P., Zhang C. et al. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J. Clin. Invest. 2012; 122: 1022-1036..
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 1022-1036
-
-
Bordicchia, M.1
Liu, D.2
Amri, E.Z.3
Ailhaud, G.4
Dessì-Fulgheri, P.5
Zhang, C.6
-
85
-
-
30044438117
-
Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase
-
Moore H. P. H., Silver R. B., Mottillo E. P., Bernlohr D. A., Granneman J. G. Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase. J. Biol. Chem. 2005; 280: 43109-43120.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 43109-43120
-
-
Moore, H.P.H.1
Silver, R.B.2
Mottillo, E.P.3
Bernlohr, D.A.4
Granneman, J.G.5
-
86
-
-
79958047295
-
Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype
-
Ahmadian M., Abbott M. J., Tang T., Hudak C. S., Kim Y., Bruss M. et al. Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype. Cell Metab. 2011; 13: 739-748.
-
(2011)
Cell Metab.
, vol.13
, pp. 739-748
-
-
Ahmadian, M.1
Abbott, M.J.2
Tang, T.3
Hudak, C.S.4
Kim, Y.5
Bruss, M.6
-
87
-
-
77950190436
-
Distribution and development of brown adipocytes in the murine and human adipose organ
-
Frontini A., Cinti S. Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab. 2010; 11: 253-256.
-
(2010)
Cell Metab.
, vol.11
, pp. 253-256
-
-
Frontini, A.1
Cinti, S.2
-
88
-
-
67650242165
-
High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity
-
Saito M., Okamatsu-Ogura Y., Matsushita M., Watanabe K., Yoneshiro T., Nio-Kobayashi J. et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 2009; 58: 1526-1531.
-
(2009)
Diabetes
, vol.58
, pp. 1526-1531
-
-
Saito, M.1
Okamatsu-Ogura, Y.2
Matsushita, M.3
Watanabe, K.4
Yoneshiro, T.5
Nio-Kobayashi, J.6
-
89
-
-
78650098848
-
Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
-
Ouellet V., Routhier-Labadie A., Bellemare W., Lakhal-Chaieb L., Turcotte E., Carpentier A. C. et al. Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J. Clin. Endocrinol. Metab. 2011; 96: 192-199.
-
(2011)
J. Clin. Endocrinol. Metab.
, vol.96
, pp. 192-199
-
-
Ouellet, V.1
Routhier-Labadie, A.2
Bellemare, W.3
Lakhal-Chaieb, L.4
Turcotte, E.5
Carpentier, A.C.6
-
90
-
-
84856529575
-
Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
-
Ouellet V., Labbé S. M., Blondin D. P., Phoenix S., Guérin B., Haman F. et al. Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans. J. Clin. Invest. 2012; 122: 545-552.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 545-552
-
-
Ouellet, V.1
Labbé, S.M.2
Blondin, D.P.3
Phoenix, S.4
Guérin, B.5
Haman, F.6
-
91
-
-
84875794383
-
150 PET measurement of blood flow and oxygen consumption in cold-activated human brown fat
-
Muzik O., Mangner T. J., Leonard W. R., Kumar A., Janisse J., Granneman J. G. 150 PET measurement of blood flow and oxygen consumption in cold-activated human brown fat. J. Nucl. Med. 2013; 54: 523-531.
-
(2013)
J. Nucl. Med.
, vol.54
, pp. 523-531
-
-
Muzik, O.1
Mangner, T.J.2
Leonard, W.R.3
Kumar, A.4
Janisse, J.5
Granneman, J.G.6
-
92
-
-
84883481988
-
The Effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes
-
Gaich G., Chien J. Y., Fu H., Glass L. C., Deeg M. A., Holland W. L. et al. The Effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell Metab. 2013; 18: 333-340.
-
(2013)
Cell Metab.
, vol.18
, pp. 333-340
-
-
Gaich, G.1
Chien, J.Y.2
Fu, H.3
Glass, L.C.4
Deeg, M.A.5
Holland, W.L.6
-
93
-
-
84862777293
-
Programming human pluripotent stem cells into white and brown adipocytes
-
Ahfeldt T., Schinzel R. T., Lee Y. K., Hendrickson D., Kaplan A., Lum D. H. et al. Programming human pluripotent stem cells into white and brown adipocytes. Nat. Cell Biol. 2012; 14: 209-219.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 209-219
-
-
Ahfeldt, T.1
Schinzel, R.T.2
Lee, Y.K.3
Hendrickson, D.4
Kaplan, A.5
Lum, D.H.6
|